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22-03-2022 | Antimalaria | Original Paper

Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium

Authors: Ai Ogasawara, Ryo Noguchi, Takuya Shigi, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Takahiro Tougan, Toshihiro Horii, A. Hamid A. Hadi, Hiroshi Morita

Published in: Journal of Natural Medicines | Issue 3/2022

Abstract

Bioactivity-guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of five new pyranocoumarins, caloforines A–E (1–5) and two new coumarins, caloforines F and G (6 and 7). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. Caloforines A–F (1–6) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain.

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Title: Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium
Authors: Ai Ogasawara
Ryo Noguchi
Takuya Shigi
Alfarius Eko Nugroho
Yusuke Hirasawa
Toshio Kaneda
Takahiro Tougan
Toshihiro Horii
A. Hamid A. Hadi
Hiroshi Morita
Publication date: 22-03-2022
Publisher: Springer Nature Singapore
Keywords: Antimalaria
Coumarin
Published in: Journal of Natural Medicines / Issue 3/2022
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-022-01613-6

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Caloforines A–G, coumarins from the bark of Calophyllum scriblitifolium

Abstract

Graphical abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Graphical abstract

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