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Published in:

01-07-2016 | Original Paper

Anti-inflammatory effects of alpinone 3-acetate from Alpinia japonica seeds

Authors: Tomohito Kakegawa, Aya Miyazaki, Ken Yasukawa

Published in: Journal of Natural Medicines | Issue 3/2016

Abstract

We aimed to investigate the bioactive components of Alpinia japonica as anti-inflammatory compounds using searches of the Alpinia genus, and subsequently demonstrated that alpinone 3-acetate markedly inhibits 12-O-tetradecanoyiphorbol 13-acetate-induced inflammation in a mouse model of ear edema. To assess other bioactivities of alpinone 3-acetate, we performed translatome analyses and compared them with those of hydrocortisone. Polysome-associated mRNAs were prepared from alpinone 3-acetate- or hydrocortisone-treated and control cells from 12-O-tetradecanoyiphorbol 13-acetate-induced THP-1-derived macrophages cultured in the presence of Escherichia coli O-111 lipopolysaccharide. Subsequent microarray analysis revealed that alpinone 3-acetate and hydrocortisone upregulated and downregulated the same 155 and 41 genes, respectively. Moreover, direct comparisons of translationally regulated genes indicated 5 and 10 gene probes that were upregulated and downregulated by alpinone 3-acetate and hydrocortisone, respectively. In conclusion, assays of 12-O-tetradecanoyiphorbol 13-acetate-induced inflammation ear edema in mice and polysome profiling of alpinone 3-acetate bioactivities indicated similar medicinal possibilities to those of hydrocortisone.

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Title: Anti-inflammatory effects of alpinone 3-acetate from Alpinia japonica seeds
Authors: Tomohito Kakegawa
Aya Miyazaki
Ken Yasukawa
Publication date: 01-07-2016
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 3/2016
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-016-0997-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Anti-inflammatory effects of alpinone 3-acetate from Alpinia japonica seeds

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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