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01-04-2008 | Original Paper

Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

Authors: Toru Yagura, Tomoko Motomiya, Michiho Ito, Gisho Honda, Akira Iida, Fumiyuki Kiuchi, Harukuni Tokuda, Hoyoku Nishino

Published in: Journal of Natural Medicines | Issue 2/2008

Abstract

An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

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Title: Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum
Authors: Toru Yagura
Tomoko Motomiya
Michiho Ito
Gisho Honda
Akira Iida
Fumiyuki Kiuchi
Harukuni Tokuda
Hoyoku Nishino
Publication date: 01-04-2008
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 2/2008
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-007-0223-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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