Top

Published in:

01-01-2006 | Note

Anti-staphylococcal activity of ent-kaurane-type diterpenoids from Croton tonkinensis

Authors: Phan Minh Giang, Phan Tong Son, Katsuyoshi Matsunami, Hideaki Otsuka

Published in: Journal of Natural Medicines | Issue 1/2006

Abstract

Ent-kaurane-type diterpenpoids 1–11, isolated from the dried leaves of the endemic Vietnamese medicinal plant Croton tonkinensis Gagnep. (Euphorbiaceae), were evaluated for inhibitory activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) strains. The most active diterpenoids, 2, 3, and 8, exhibited minimum inhibitory concentrations (MICs) of 32, 500, and 125 μg/ml, respectively, against MRSA strains.

Vo VC (1997) Dictionary of Vietnamese medicinal plants. Medicine, Ho Chi Minh City

Le Van Truyen, Nguyen Gia Tran (eds) (1999) Selected medicinal plants in Vietnam. Science and Technology, Hanoi

Phan MG, Jin HZ, Phan TS, Lee JH, Hong YS, Lee JJ (2003) Ent-kaurane diterpenoids from Croton tonkinensis inhibit LPS-induced NF-κB activation and NO production. J Nat Prod 66:1217–1220PubMed

Phan MG, Phan TS, Lee JJ, Otsuka H (2004) Four ent-kaurane-type diterpenoids from Croton tonkinensis Gagnep. Chem Pharm Bull 52:879–882CrossRefPubMed

Phan MG, Phan TS, Hamada Y, Otsuka H (2005) Cytotoxic diterepenoids from Vietnemese medicinal plant Croton tonkinensis Gagnep. Chem Pharm Bull 53:296–300CrossRefPubMed

Archer GL (1998) Staphylococcus aureus: a well-armed pathogen. Clin Infect Dis 26:1179–1181PubMed

Velikova M, Bankova V, Tsvekova I, Kujumgiev A, Marcucci MC (2000) Antibacterial ent-kaurene from Brazilian propolis of native stingless bees. Fitoterapia 71:693–696CrossRefPubMed

Kubo I, Xu Y, Shimizu K (2004) Antibacterial activity of ent-kaurene diterpenoids from Rabdosia rosthornii. Phytother Res 18:180–183CrossRefPubMed

Gibbons S (2004) Anti-staphylococcal plant natural products. Nat Prod Rep 21:263-277CrossRefPubMed

10.

Machado TB, Pinto AV, Pinto MCFR, Leal ICR, Silva MG, Amaral ACF, Kuster RM, Netto-dosSantos KR (2003) In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus. Int J Antimicrob Agents 21:279–284CrossRefPubMed

11.

Hecker SJ, Glinka TW, Cho A, Zhang ZJ, Price ME, Chamberland S, Griffith D, Lee VJ (2000) Discovery of RWJ-54428 (MC-02, 479), a new cephalosporin active against resistant gram-positive bacteria. J Antibiot 53:127–1281

Title: Anti-staphylococcal activity of ent-kaurane-type diterpenoids from Croton tonkinensis
Authors: Phan Minh Giang
Phan Tong Son
Katsuyoshi Matsunami
Hideaki Otsuka
Publication date: 01-01-2006
Publisher: Springer-Verlag
Published in: Journal of Natural Medicines / Issue 1/2006
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-005-0011-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Anti-staphylococcal activity of ent-kaurane-type diterpenoids from Croton tonkinensis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2006

Hepatoprotective constituents in plants 15: protective effects of natural-occurring flavonoids and miscellaneous phenolic compounds as determined in an HepG2 cell cytotoxicity assay

Identification of the main aroma compounds in dried seeds of Brassica hirta

New staining methodology: Eastern blotting for glycosides in the field of Kampo medicines

Inhibitory activity of Chinese herbal medicines toward histamine release from mast cells and nitric oxide production by macrophage-like cell line, RAW 264.7

Four new diterpenoids from Salvia fulgens Cav.

Sesquiterpenoids from Ferula fukanensis and their inhibitory effects on nitric oxide production