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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 4/2023

27-03-2023 | Research Article

Improved Quantitative Analysis Method for Magnetic Particle Imaging Based on Deblurring and Region Scalable Fitting

Authors: Lu Wang, Yan Huang, Yishen Zhao, Jie Tian, Lu Zhang, Yang Du

Published in: Molecular Imaging and Biology | Issue 4/2023

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Abstract   

Purpose

Magnetic particle imaging (MPI) is a technique for imaging magnetic particle concentration distribution. It has the advantages of high sensitivity, no signal attenuation with depth, and no ionizing radiation. Although MPI has been widely used in the biomedical field, accurate image analysis has been challenging due to its anisotropic point spread function (PSF). The purpose of this study is to propose an MPI image restoring and segmentation method to facilitate a more precise quantitative evaluation of the magnetic particle imaging in vivo.

Procedures

We proposed a DeRSF method that combined deblurring and region scalable fitting (RSF) to determine the imaging tracer distribution. Then a uniform erosion and scaling criterion was established based on simulation experiments to correct the segmentation results, which was further validated on phantom imaging. Finally, we imaged the MPI tracer at gradient concentrations to establish the calibration curve between the MPI signal and iron mass for iron quantification in phantom and in vivo imaging.

Results

The phantom imaging experiments showed that our method achieved improved segmentation performance. The mean value of the dice coefficients for segmentation was up to 0.86, demonstrating that our method can accurately map and quantify the distribution of the tracer. Moreover, the iron quantification on both phantom and in vivo mouse imaging was realized with the minimal error of 5.50%, by our established calibration curve.

Conclusions

Our proposed DeRSF method was successfully used for improved MPI quantitative analysis. More importantly, this method also showed accurate quantitative results on images with different shapes and tracer concentrations in both phantom and in vivo data, which laid the foundation for the biomedical study of MPI.
Appendix
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Literature
1.
Gleich B, Weizenecker J (2005) Tomographic imaging using the nonlinear response of magnetic particles. Nature 7046:1214–1217CrossRef
2.
Goodwill PW, Saritas EU, Croft LR et al (2012) X-space MPI: magnetic nanoparticles for safe medical imaging. Adv Mater 28:3870–3877CrossRef
3.
Knopp T, Sattel TF, Biederer S et al (2010) Model-based reconstruction for magnetic particle imaging. IEEE Trans Med Imaging 1:12–18CrossRef
4.
Vogel P, Lother S, Rückert MA et al (2014) MRI meets MPI: a bimodal MPI-MRI tomograph. IEEE Trans Med Imaging 10:1954–1959CrossRef
5.
Goodwill PW, Conolly SM (2010) The formulation of the magnetic particle imaging process: 1-D signal, resolution, bandwidth, SNR, SAR, and magnetostimulation. IEEE Trans Med Imaging 11:1851–1859CrossRef
6.
Konkle JJ, Goodwill PW, Carrasco-Zevallos OM, Conolly SM (2013) Projection reconstruction magnetic particle imaging. IEEE Trans Med Imaging 2:338–347CrossRef
7.
Knopp T, Weber A (2013) Sparse reconstruction of the magnetic particle imaging system matrix. IEEE Trans Med Imaging 8:1473–1480CrossRef
8.
Yin L, Li W, Du Y et al (2022) Recent developments of the reconstruction in magnetic particle imaging. Vis Comput Ind Biomed Art 1:24CrossRef
9.
Parkins KM, Melo KP, Chen Y, Ronald JA, Foster PJ (2021) Visualizing tumor self-homing with magnetic particle imaging. Nanoscale 12:6016–6023CrossRef
10.
Wang G, Li W, Shi G et al (2022) Sensitive and specific detection of breast cancer lymph node metastasis through dual-modality magnetic particle imaging and fluorescence molecular imaging: a preclinical evaluation. Eur J Nucl Med Mol Imaging 8:2723–2734CrossRef
11.
Zhang W, Liang X, Zhu L et al (2022) Optical magnetic multimodality imaging of plectin-1-targeted imaging agent for the precise detection of orthotopic pancreatic ductal adenocarcinoma in mice. EBioMedicine 80:104040CrossRefPubMedPubMedCentral
12.
Jiang Z, Han X, Du Y et al (2021) Mixed metal metal-organic frameworks derived carbon supporting ZnFe2O4/C for high-performance magnetic particle imaging. Nano Lett 7:2730–2737CrossRef
13.
Du Y, Liu X, Liang Q, Liang X, Tian J (2019) Optimization and design of magnetic ferrite nanoparticles with uniform tumor distribution for highly sensitive MRI/MPI performance and improved magnetic hyperthermia therapy. Nano Lett 6:3618–3626CrossRef
14.
Hayat H, Sun A, Hayat H et al (2021) Artificial intelligence analysis of magnetic particle imaging for islet transplantation in a mouse model. Mol Imaging Biol 1:18–29CrossRef
15.
Sun A, Hayat H, Liu S et al (2021) 3D in vivo magnetic particle imaging of human stem cell-derived islet organoid transplantation using a machine learning algorithm. Front Cell Dev Biol 9:704483CrossRefPubMedPubMedCentral
16.
Shen YS, Hu CE, Zhang P, Tian J, Hui H (2022) A novel software framework for magnetic particle imaging reconstruction. Int J Imaging Syst Tech 4:1119–1132CrossRef
17.
Liu S, Chiu-Lam A, Rivera-Rodriguez A et al (2021) Long circulating tracer tailored for magnetic particle imaging. Nanotheranostics 3:348–361CrossRef
18.
Lu K, Goodwill P, Zheng B, Conolly S (2018) Multi-channel acquisition for isotropic resolution in magnetic particle imaging. IEEE Trans Med Imaging 9:1989–1998CrossRef
19.
Chan T, Wong C (1998) Total variation blind deconvolution. IEEE Trans Image Process 3:370–375CrossRef
20.
Wen F, Ying R, Liu Y, Tk T (2020) A simple local minimal intensity prior and an improved algorithm for blind image deblurring. IEEE Trans Circuits Syst Video Technol 99:1–1
21.
Pan J, Sun D, Pfister H, Yang M-H (2016) Blind image deblurring using dark channel prior [abstract]. In: 2016 IEEE Conference on Computer Vision and Pattern Recognition. CVPR, Las Vegas, Nevada, pp 1628–1636
22.
Oh K, Shin CS, Kim J, Yoo SK (2019) Level-set segmentation-based respiratory volume estimation using a depth camera. IEEE J Biomed Health Inform 4:1674–1682CrossRef
23.
Ma J, Nie Z, Wang C et al (2020) Active contour regularized semi-supervised learning for COVID-19 CT infection segmentation with limited annotations. Phys Med Biol 22:225034CrossRef
24.
Li C, Kao C, Gore JC, Ding Z (2008) Minimization of region-scalable fitting energy for image segmentation. IEEE Trans Image Process 10:1940–1949
25.
Sanchez-Salvador JL, Campano C, Lopez-Exposito P et al (2021) Enhanced morphological characterization of cellulose nano/microfibers through image skeleton analysis. Nanomaterials (Basel) 8:2077CrossRef
26.
Cheng H, Xue M, Shi X (2003) Contrast enhancement based on a novel homogeneity measurement. Pattern Recogn 11:2687–2697CrossRef
Metadata
Title
Improved Quantitative Analysis Method for Magnetic Particle Imaging Based on Deblurring and Region Scalable Fitting
Authors
Lu Wang
Yan Huang
Yishen Zhao
Jie Tian
Lu Zhang
Yang Du
Publication date
27-03-2023
Publisher
Springer International Publishing
Published in
Molecular Imaging and Biology / Issue 4/2023
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-023-01812-x

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