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Open Access 01-06-2015 | Research Article

Characterization and Evaluation of the Artemis Camera for Fluorescence-Guided Cancer Surgery

Authors: P. B. A. A. van Driel, M. van de Giessen, M. C. Boonstra, T. J. A. Snoeks, S. Keereweer, S. Oliveira, C. J. H. van de Velde, B. P. F. Lelieveldt, A. L. Vahrmeijer, C. W. G. M. Löwik, J. Dijkstra

Published in: Molecular Imaging and Biology | Issue 3/2015

Abstract

Purpose

Near-infrared (NIR) fluorescence imaging can provide the surgeon with real-time visualization of, e.g., tumor margins and lymph nodes. We describe and evaluate the Artemis, a novel, handheld NIR fluorescence camera.

Procedures

We evaluated minimal detectable cell numbers (FaDu-luc2, 7D12-IRDye 800CW), preclinical intraoperative detection of sentinel lymph nodes (SLN) using indocyanine green (ICG), and of orthotopic tongue tumors using 7D12-800CW. Results were compared with the Pearl imager. Clinically, three patients with liver metastases were imaged using ICG.

Results

Minimum detectable cell counts for Artemis and Pearl were 2 × 10⁵ and 4 × 10⁴ cells, respectively. In vivo, seven SLNs were detected in four mice with both cameras. Orthotopic OSC-19-luc2-cGFP tongue tumors were clearly identifiable, and a minimum FaDu-luc2 tumor size of 1 mm³ could be identified. Six human malignant lesions were identified during three liver surgery procedures.

Conclusions

Based on this study, the Artemis system has demonstrated its utility in fluorescence-guided cancer surgery.

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Title: Characterization and Evaluation of the Artemis Camera for Fluorescence-Guided Cancer Surgery
Authors: P. B. A. A. van Driel
M. van de Giessen
M. C. Boonstra
T. J. A. Snoeks
S. Keereweer
S. Oliveira
C. J. H. van de Velde
B. P. F. Lelieveldt
A. L. Vahrmeijer
C. W. G. M. Löwik
J. Dijkstra
Publication date: 01-06-2015
Publisher: Springer US
Published in: Molecular Imaging and Biology / Issue 3/2015
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-014-0799-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Characterization and Evaluation of the Artemis Camera for Fluorescence-Guided Cancer Surgery

Abstract

Purpose

Procedures

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Procedures

Results

Conclusions

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