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Published in: Molecular Imaging and Biology 4/2013

Open Access 01-08-2013 | Review Article

Summary Report of the First International Workshop on PET/MR Imaging, March 19–23, 2012, Tübingen, Germany

Authors: Dale L. Bailey, Henryk Barthel, Thomas Beyer, Ronald Boellaard, Brigitte Gückel, Dirk Hellwig, Hans Herzog, Bernd J. Pichler, Harald H. Quick, Osama Sabri, Klaus Scheffler, Heinz P. Schlemmer, Nina F. Schwenzer, Hans F. Wehrl

Published in: Molecular Imaging and Biology | Issue 4/2013

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Abstract

We report from the First International Workshop on positron emission tomography/magnetic resonance imaging (PET/MRI) that was organized by the University of Tübingen in March 2012. Approximately 100 imaging experts in MRI, PET and PET/computed tomography (CT), among them early adopters of pre-clinical and clinical PET/MRI technology, gathered from March 19 to 24, 2012 in Tübingen, Germany. The objective of the workshop was to provide a forum for sharing first-hand methodological and clinical know-how and to assess the potential of combined PET/MRI in various applications from pre-clinical research to scientific as well as clinical applications in humans. The workshop was comprised of pro-active sessions including tutorials, specific discussion panels and grand rounds. Pre-selected experts moderated the sessions, and feedback from the subsequent discussions is presented here to a greater readership. Naturally, the summaries provided herein are subjective descriptions of the hopes and challenges of PET/MR imaging as seen by the workshop attendees at a very early point in time of adopting PET/MRI technology and, as such, represent only a snapshot of current approaches.
Literature
1.
go back to reference Pichler BJ, Kolb A, Nägele T et al (2010) PET/MRI: paving the way for the next generation of clinical multimodality imaging applications. J Nucl Med 51(3):333–6PubMedCrossRef Pichler BJ, Kolb A, Nägele T et al (2010) PET/MRI: paving the way for the next generation of clinical multimodality imaging applications. J Nucl Med 51(3):333–6PubMedCrossRef
2.
go back to reference Beyer T, Freudenberg LS, Czernin J et al (2011) The future of hybrid imaging-part 3: PET/MR, small-animal imaging and beyond. Insights Imaging 2(3):235–246PubMedCrossRef Beyer T, Freudenberg LS, Czernin J et al (2011) The future of hybrid imaging-part 3: PET/MR, small-animal imaging and beyond. Insights Imaging 2(3):235–246PubMedCrossRef
3.
go back to reference Martinez-Möller A, Souvatzoglou M, Delso G et al (2009) Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data. J Nucl Med 50(4):520–6PubMedCrossRef Martinez-Möller A, Souvatzoglou M, Delso G et al (2009) Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data. J Nucl Med 50(4):520–6PubMedCrossRef
4.
go back to reference Zenge MO, Vogt FM, Brauck K et al (2006) High-resolution continuously acquired peripheral MR angiography featuring partial parallel imaging GRAPPA. Magn Reson Med 56(4):859–65PubMedCrossRef Zenge MO, Vogt FM, Brauck K et al (2006) High-resolution continuously acquired peripheral MR angiography featuring partial parallel imaging GRAPPA. Magn Reson Med 56(4):859–65PubMedCrossRef
5.
go back to reference Delso G, Fürst S, Jakoby B et al (2011) Performance measurements of the Siemens mMR integrated whole-body PET/MR scanner. J Nucl Med 52(12):1914–22PubMedCrossRef Delso G, Fürst S, Jakoby B et al (2011) Performance measurements of the Siemens mMR integrated whole-body PET/MR scanner. J Nucl Med 52(12):1914–22PubMedCrossRef
6.
go back to reference Schulz V, Torres-Espallardo I, Renisch S et al (2011) Automatic, three-segment, MR-based attenuation correction for whole-body PET/MR data. Eur J Nucl Med Mol Imaging 38(1):138–52PubMedCrossRef Schulz V, Torres-Espallardo I, Renisch S et al (2011) Automatic, three-segment, MR-based attenuation correction for whole-body PET/MR data. Eur J Nucl Med Mol Imaging 38(1):138–52PubMedCrossRef
7.
go back to reference Shao Y, Cherry SR, Farahani K et al (1997) Simultaneous PET and MR imaging. Phys Med Biol 42(10):1965–70PubMedCrossRef Shao Y, Cherry SR, Farahani K et al (1997) Simultaneous PET and MR imaging. Phys Med Biol 42(10):1965–70PubMedCrossRef
8.
go back to reference Slates RB, Farahani K, Shao Y et al (1999) A study of artefacts in simultaneous PET and MR imaging using a prototype MR compatible PET scanner. Phys Med Biol 44(8):2015–27PubMedCrossRef Slates RB, Farahani K, Shao Y et al (1999) A study of artefacts in simultaneous PET and MR imaging using a prototype MR compatible PET scanner. Phys Med Biol 44(8):2015–27PubMedCrossRef
9.
go back to reference Marsden PK, Strul D, Keevil SF et al (2002) Simultaneous PET and NMR. Br J Radiol 75(Spec No):S53–9PubMed Marsden PK, Strul D, Keevil SF et al (2002) Simultaneous PET and NMR. Br J Radiol 75(Spec No):S53–9PubMed
10.
go back to reference Wehrl HF, Judenhofer MS, Wiehr S et al (2009) Pre-clinical PET/MR: technological advances and new perspectives in biomedical research. Eur J Nucl Med Mol Imaging 36(Suppl 1):56–68CrossRef Wehrl HF, Judenhofer MS, Wiehr S et al (2009) Pre-clinical PET/MR: technological advances and new perspectives in biomedical research. Eur J Nucl Med Mol Imaging 36(Suppl 1):56–68CrossRef
11.
go back to reference Pichler B, Lorenz E, Mirzoyan R et al. (1997) Performance test of a LSO-APD PET module in a 9.4 tesla magnet. Nuclear Science Symposium, 1997. IEEE Date of Conference: 9–15 Nov 1997, Volume: 2 Page(s): 1237–1239 Pichler B, Lorenz E, Mirzoyan R et al. (1997) Performance test of a LSO-APD PET module in a 9.4 tesla magnet. Nuclear Science Symposium, 1997. IEEE Date of Conference: 9–15 Nov 1997, Volume: 2 Page(s): 1237–1239
12.
go back to reference Boone JM, Velazquez O, Cherry SR (2004) Small-animal X-ray dose from micro-CT. Mol Imaging 3(3):149–58PubMedCrossRef Boone JM, Velazquez O, Cherry SR (2004) Small-animal X-ray dose from micro-CT. Mol Imaging 3(3):149–58PubMedCrossRef
13.
go back to reference Badea CT, Drangova M, Holdsworth DW et al (2008) In vivo small animal imaging using micro-CT and digital subtraction angiography. Phys Med Biol 53(19):319–350CrossRef Badea CT, Drangova M, Holdsworth DW et al (2008) In vivo small animal imaging using micro-CT and digital subtraction angiography. Phys Med Biol 53(19):319–350CrossRef
14.
go back to reference Funk T, Sun M, Hasegawa BH (2004) Radiation dose estimate in small animal SPECT and PET. Med Phys 31(9):2680–6PubMedCrossRef Funk T, Sun M, Hasegawa BH (2004) Radiation dose estimate in small animal SPECT and PET. Med Phys 31(9):2680–6PubMedCrossRef
15.
go back to reference Hofmann M, Pichler B, Schölkopf B et al (2009) Towards quantitative PET/MRI: a review of MR-based attenuation correction techniques. Eur J Nucl Med Mol Imaging 36(Suppl 1):S93–104PubMedCrossRef Hofmann M, Pichler B, Schölkopf B et al (2009) Towards quantitative PET/MRI: a review of MR-based attenuation correction techniques. Eur J Nucl Med Mol Imaging 36(Suppl 1):S93–104PubMedCrossRef
16.
go back to reference Defrise M, Rezaei A, Nuyts J (2012) Time-of-flight PET data determine the attenuation sinogram up to a constant. Phys Med Biol 57(4):885–99PubMedCrossRef Defrise M, Rezaei A, Nuyts J (2012) Time-of-flight PET data determine the attenuation sinogram up to a constant. Phys Med Biol 57(4):885–99PubMedCrossRef
17.
go back to reference Therasse P, Eisenhauer EA, Verweij J (2006) RECIST revisited: a review of validation studies on tumour assessment. Eur J Cancer 42(8):1031–9PubMedCrossRef Therasse P, Eisenhauer EA, Verweij J (2006) RECIST revisited: a review of validation studies on tumour assessment. Eur J Cancer 42(8):1031–9PubMedCrossRef
18.
go back to reference Eisenhauer EA, Therasse P, Bogaerts J et al (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45(2):228–47PubMedCrossRef Eisenhauer EA, Therasse P, Bogaerts J et al (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45(2):228–47PubMedCrossRef
19.
go back to reference Young H, Baum R, Cremerius U et al (1999) Measurement of clinical and subclinical tumour response using [18 F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations. European Organization for Research and Treatment of Cancer (EORTC) PET Study Group. Eur J Cancer 35(13):1773–82PubMedCrossRef Young H, Baum R, Cremerius U et al (1999) Measurement of clinical and subclinical tumour response using [18 F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations. European Organization for Research and Treatment of Cancer (EORTC) PET Study Group. Eur J Cancer 35(13):1773–82PubMedCrossRef
20.
go back to reference Wahl RL, Jacene H, Kasamon Y et al (2009) From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J of Nucl Med 50(5):122S–50SCrossRef Wahl RL, Jacene H, Kasamon Y et al (2009) From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J of Nucl Med 50(5):122S–50SCrossRef
21.
go back to reference Boellaard R (2009) Standards for PET image acquisition and quantitative data analysis. J Nucl Med 50(Suppl 1):11S–20SPubMedCrossRef Boellaard R (2009) Standards for PET image acquisition and quantitative data analysis. J Nucl Med 50(Suppl 1):11S–20SPubMedCrossRef
22.
go back to reference Boellaard R (2011) Need for standardization of 18 F-FDG PET/CT for treatment response assessments. J Nucl Med 52(Suppl 2):93S–100SPubMedCrossRef Boellaard R (2011) Need for standardization of 18 F-FDG PET/CT for treatment response assessments. J Nucl Med 52(Suppl 2):93S–100SPubMedCrossRef
23.
go back to reference Beyer T, Czernin J, Freudenberg LS (2011) Variations in clinical PET/CT operations: results of an international survey of active PET/CT users. J Nucl Med 52(2):303–10PubMedCrossRef Beyer T, Czernin J, Freudenberg LS (2011) Variations in clinical PET/CT operations: results of an international survey of active PET/CT users. J Nucl Med 52(2):303–10PubMedCrossRef
24.
go back to reference Herder GJ, Kramer H, Hoekstra OS et al (2006) Traditional versus up-front [18 F] fluorodeoxyglucose-positron emission tomography staging of non-small-cell lung cancer: a Dutch cooperative randomized study. J Clin Oncol 24(12):1800–6PubMedCrossRef Herder GJ, Kramer H, Hoekstra OS et al (2006) Traditional versus up-front [18 F] fluorodeoxyglucose-positron emission tomography staging of non-small-cell lung cancer: a Dutch cooperative randomized study. J Clin Oncol 24(12):1800–6PubMedCrossRef
25.
go back to reference Delso G, Martinez-Möller A, Bundschuh RA et al (2010) The effect of limited MR field of view in MR/PET attenuation correction. Med Phys 37(6):2804–12PubMedCrossRef Delso G, Martinez-Möller A, Bundschuh RA et al (2010) The effect of limited MR field of view in MR/PET attenuation correction. Med Phys 37(6):2804–12PubMedCrossRef
Metadata
Title
Summary Report of the First International Workshop on PET/MR Imaging, March 19–23, 2012, Tübingen, Germany
Authors
Dale L. Bailey
Henryk Barthel
Thomas Beyer
Ronald Boellaard
Brigitte Gückel
Dirk Hellwig
Hans Herzog
Bernd J. Pichler
Harald H. Quick
Osama Sabri
Klaus Scheffler
Heinz P. Schlemmer
Nina F. Schwenzer
Hans F. Wehrl
Publication date
01-08-2013
Publisher
Springer US
Published in
Molecular Imaging and Biology / Issue 4/2013
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-013-0623-1

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