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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 1/2013

01-02-2013 | Research Article

Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer MR Imaging at 3-Tesla and Its Application to High-Grade Human Brain Tumors

Authors: Xuna Zhao, Zhibo Wen, Ge Zhang, Fanheng Huang, Shilong Lu, Xianlong Wang, Shuguang Hu, Min Chen, Jinyuan Zhou

Published in: Molecular Imaging and Biology | Issue 1/2013

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Abstract

Purpose

Amide proton transfer (APT) imaging is able to extend the achievable magnetic resonance imaging (MRI) contrast to the protein level. In this study, we demonstrate the feasibility of applying a turbo-spin-echo (TSE)-based, three-dimensional (3D) APT sequence into routine clinical practice for patients with brain tumors.

Procedures

Experiments were performed on a Philips 3-Tesla (3-T) MRI scanner using an eight-channel phased-array coil for reception. A fast 3D APT sequence with a TSE acquisition was proposed (saturation power, 2 μT; saturation time, 500 ms; 8 slices). The gradient echo (GRE)-based field-mapping technique or water-saturation-shift-referencing (WASSR) technique was used to acquire B0 maps to correct for B0-induced artifacts in APT images. The test was performed on a box of homogenous protein solution, four healthy volunteers, and eight patients with high-grade gliomas.

Results

The experimental data from a homogenous, protein-containing phantom and healthy volunteers show that the sequence produced a uniform contrast across all slices. The average MTRasym(3.5 ppm) values with GRE B0-corrected 3D APT imaging and WASSR-corrected 3D APT imaging were both comparable to the values obtained using the undemanding single-slice acquisition. The average APT image intensity was consistently higher in the tumor core than in the peripheral edema and in the contralateral normal-appearing white matter (both P < 0.001).

Conclusion

3D APT imaging of brain tumors can be performed in about 5 min at 3-T using a routine, commercial eight-channel SENSE coil.
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Metadata
Title
Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer MR Imaging at 3-Tesla and Its Application to High-Grade Human Brain Tumors
Authors
Xuna Zhao
Zhibo Wen
Ge Zhang
Fanheng Huang
Shilong Lu
Xianlong Wang
Shuguang Hu
Min Chen
Jinyuan Zhou
Publication date
01-02-2013
Publisher
Springer-Verlag
Published in
Molecular Imaging and Biology / Issue 1/2013
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-012-0563-1

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