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Open Access 01-06-2010 | Research Article

⁶⁸Ga-Chloride PET Reveals Human Pancreatic Adenocarcinoma Xenografts in Rats—Comparison with FDG

Authors: Tiina Ujula, Satu Salomäki, Anu Autio, Pauliina Luoto, Tuula Tolvanen, Pertti Lehikoinen, Tapio Viljanen, Hannu Sipilä, Pirkko Härkönen, Anne Roivainen

Published in: Molecular Imaging and Biology | Issue 3/2010

Abstract

Purpose

The aim of the study was to compare ⁶⁸Ga-chloride with 2-[¹⁸F]fluoro-2-deoxy-d-glucose (FDG) for the imaging of pancreatic xenografts.

Procedures

Rats with subcutaneous human pancreatic adenocarcinoma xenografts were evaluated in vivo by dynamic positron emission tomography (PET) and ex vivo by measuring radioactivity of excised tissues and by digital autoradiography of tumor cryosections.

Results

Both tracers were capable of delineating all subcutaneous tumors from surrounding tissues by PET. The standardized uptake values of tumors by PET were 0.9 ± 0.3 (mean ± SD) for ⁶⁸Ga-chloride (n = 13) and 1.8 ± 1.2 for FDG (n = 11). Ex vivo studies showed tumor-to-muscle ratio of 4.0 ± 0.3 for ⁶⁸Ga-chloride (n = 4) and 7.9 ± 3.2 for FDG (n = 4).

Conclusions

⁶⁸Ga-chloride delineated subcutaneously implanted pancreatic adenocarcinoma xenografts by PET, but the uptake was lower than FDG. Further studies to clarify the value of ⁶⁸Ga-chloride for PET imaging of tumors are warranted.

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Title: 68Ga-Chloride PET Reveals Human Pancreatic Adenocarcinoma Xenografts in Rats—Comparison with FDG
Authors: Tiina Ujula
Satu Salomäki
Anu Autio
Pauliina Luoto
Tuula Tolvanen
Pertti Lehikoinen
Tapio Viljanen
Hannu Sipilä
Pirkko Härkönen
Anne Roivainen
Publication date: 01-06-2010
Publisher: Springer-Verlag
Published in: Molecular Imaging and Biology / Issue 3/2010
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-009-0267-3

2024 ASCO Annual Meeting

Springer Medicine

⁶⁸Ga-Chloride PET Reveals Human Pancreatic Adenocarcinoma Xenografts in Rats—Comparison with FDG

Abstract

Purpose

Procedures

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Procedures

Results

Conclusions

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