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Molecular Imaging and Biology

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Open Access 01-11-2007 | Research Article

2-Deoxy-2-[F-18]fluoro-D-glucose Joint Uptake on Positron Emission Tomography Images: Rheumatoid Arthritis Versus Osteoarthritis

Authors: E. H. Elzinga, C. J. van der Laken, E. F. I. Comans, A. A. Lammertsma, B. A. C. Dijkmans, A. E. Voskuyl

Published in: Molecular Imaging and Biology | Issue 6/2007

Abstract

Purpose

Previous positron emission tomography (PET) studies have shown increased 2-deoxy-2-[18F]fluoro-d-glucose (FDG) uptake in joints of patients with osteoarthritis (OA) and inflamed joints of patients with rheumatoid arthritis (RA). This study compares FDG uptake in joints of RA and OA patients and FDG-uptake with clinical signs of inflammation.

Procedures

FDG-PET scans of hands and wrists were performed in patients with RA and primary OA. PET data were compared with clinical data.

Results

29% of RA joints and 6% of OA joints showed elevated FDG-uptake. The level of uptake in PET-positive OA joints was not significantly different from that in RA joints. The majority of PET results of RA joints corresponded with clinical findings. Clinical synovitis was found some OA joints with FDG-uptake.

Conclusions

FDG-uptake was observed in the majority of clinically inflamed RA joints and in a few OA joints with no significant difference in uptake level. The latter may be due to secondary synovitis.

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Title: 2-Deoxy-2-[F-18]fluoro-D-glucose Joint Uptake on Positron Emission Tomography Images: Rheumatoid Arthritis Versus Osteoarthritis
Authors: E. H. Elzinga
C. J. van der Laken
E. F. I. Comans
A. A. Lammertsma
B. A. C. Dijkmans
A. E. Voskuyl
Publication date: 01-11-2007
Publisher: Springer-Verlag
Published in: Molecular Imaging and Biology / Issue 6/2007
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-007-0113-4

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2-Deoxy-2-[F-18]fluoro-D-glucose Joint Uptake on Positron Emission Tomography Images: Rheumatoid Arthritis Versus Osteoarthritis

Abstract

Purpose

Procedures

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Procedures

Results

Conclusions

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