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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 1/2007

01-01-2007 | Research Article

“Magnetic Resonance Imaging Negative Positron Emission Tomography Positive” Temporal Lobe Epilepsy: FDG-PET Pattern Differs from Mesial Temporal Lobe Epilepsy

Authors: R. P. Carne, MD, M. J. Cook, MD, L. R. MacGregor, MBBS, MMedSci, C. J. Kilpatrick, MD, R. J. Hicks, MD, T. J. O’Brien, MD

Published in: Molecular Imaging and Biology | Issue 1/2007

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Abstract

Purpose

Some patients with temporal lobe epilepsy (TLE) lack evidence of hippocampal sclerosis (HS) on MRI (HS-ve). We hypothesized that this group would have a different pattern of 2-deoxy-2-[F-18]fluoro-d-glucose (FDG)-positron emission tomography (PET) hypometabolism than typical mesial TLE/HS patients with evidence of hippocampal atrophy on magnetic resonance imaging (MRI) (HS+ve), with a lateral temporal neocortical rather than mesial focus.

Procedures

Thirty consecutive HS-ve patients and 30 age- and sex-matched HS+ve patients with well-lateralized EEG were identified. FDG-PET was performed on 28 HS-ve patients and 24 HS+ve patients. Both groups were compared using statistical parametric mapping (SPM), directly and with FDG-PET from 20 healthy controls.

Results

Both groups showed lateralized temporal hypometabolism compared to controls. In HS+ve, this was antero–infero–mesial (T = 17.13); in HS-ve the main clustering was inferolateral (T = 17.63). When directly compared, HS+ve had greater hypometabolism inmesial temporal/hippocampal regions (T = 4.86); HS-ve had greater inferolateral temporal hypometabolism (T = 4.18).

Conclusions

These data support the hypothesis that focal hypometabolism involves primarily lateal neocortical rather than mesial temporal structures in ‘MRI-negative PET-positive TLE.’
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Metadata
Title
“Magnetic Resonance Imaging Negative Positron Emission Tomography Positive” Temporal Lobe Epilepsy: FDG-PET Pattern Differs from Mesial Temporal Lobe Epilepsy
Authors
R. P. Carne, MD
M. J. Cook, MD
L. R. MacGregor, MBBS, MMedSci
C. J. Kilpatrick, MD
R. J. Hicks, MD
T. J. O’Brien, MD
Publication date
01-01-2007
Publisher
Springer-Verlag
Published in
Molecular Imaging and Biology / Issue 1/2007
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-006-0073-0

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