Skip to main content
Top
Published in: Oral Radiology 1/2013

01-01-2013 | Original Article

Clinical significance of T2 mapping MRI for the evaluation of masseter muscle pain in patients with temporomandibular joint disorders

Authors: Yutaka Nikkuni, Hideyoshi Nishiyama, Takafumi Hayashi

Published in: Oral Radiology | Issue 1/2013

Login to get access

Abstract

Objectives

Masticatory muscle pain is one of the typical symptoms of temporomandibular joint disorders (TMD). T2 mapping (distribution of T2 values) is a notable MRI technique for evaluating water contents in tissues. We investigated the clinical significance of T2 mapping for the evaluation of masticator muscle conditions by comparing the difference in the T2 values between the painful and pain-free sides of the masseter muscle in patients with TMD.

Methods

Seventy-three patients clinically diagnosed with TMD were enrolled in this study. We divided the patients into two groups: a unilateral pain group (patients with unilateral masseter muscle pain) and a painless group (patients without muscle pain). There were 29 patients in the unilateral pain group and 44 patients in the painless group. We compared the difference in the mean T2 values between the painful and pain-free sides of the masseter muscle in the unilateral pain group and between the right and left sides in the painless group.

Results

The mean T2 values of the masseter muscle on the painful side were significantly higher than those on the pain-free side in the unilateral muscle pain group (p < 0.01). In the painless group, there was no significant difference in the mean T2 values between the right and left sides.

Conclusions

It is suggested that T2 mapping is a promising method for evaluating masseter muscle pain caused by edematous change related to TMD through monitoring of the T2 values.
Literature
1.
go back to reference Bakke M, Thomsen CE, Vilmann A, Soneda K, Farella M, Moller E. Ultrasonographic assessment of the swelling of the human masseter muscle after static and dynamic activity. Arch Oral Biol. 1996;41:133–40.PubMedCrossRef Bakke M, Thomsen CE, Vilmann A, Soneda K, Farella M, Moller E. Ultrasonographic assessment of the swelling of the human masseter muscle after static and dynamic activity. Arch Oral Biol. 1996;41:133–40.PubMedCrossRef
2.
go back to reference Ariji Y, Sakuma S, Kimura Y, Kawamata A, Toyama M, Kurita K, et al. Colour Doppler sonographic analysis of blood-flow velocity in the human facial artery and changes in masseter muscle thickness during low-level static contraction. Arch Oral Biol. 2001;46:1059–64.PubMedCrossRef Ariji Y, Sakuma S, Kimura Y, Kawamata A, Toyama M, Kurita K, et al. Colour Doppler sonographic analysis of blood-flow velocity in the human facial artery and changes in masseter muscle thickness during low-level static contraction. Arch Oral Biol. 2001;46:1059–64.PubMedCrossRef
3.
go back to reference Ariji Y, Sakuma S, Izumi M, Sasaki J, Kurita K, Ogi N, et al. Ultrasonographic features of the masseter muscle in female patients with temporomandibular disorder associated with myofascial pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:337–41.PubMedCrossRef Ariji Y, Sakuma S, Izumi M, Sasaki J, Kurita K, Ogi N, et al. Ultrasonographic features of the masseter muscle in female patients with temporomandibular disorder associated with myofascial pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:337–41.PubMedCrossRef
4.
go back to reference Lam DK, Sessle BJ, Cairns BE, Hu JW. Neural mechanisms of temporomandibular joint and masticatory muscle pain: a possible role for peripheral glutamate receptor mechanisms. Pain Res Manag. 2005;10:145–52.PubMed Lam DK, Sessle BJ, Cairns BE, Hu JW. Neural mechanisms of temporomandibular joint and masticatory muscle pain: a possible role for peripheral glutamate receptor mechanisms. Pain Res Manag. 2005;10:145–52.PubMed
5.
go back to reference Ariji Y, Taguchi A, Sakuma S, Miki M, Asawa T, Uchida K, et al. Magnetic resonance T2-weighted IDEAL water imaging for assessing changes in masseter muscles caused by low-level static contraction. Oral Med Oral Pathol Oral Radiol Endod. 2010;109:908–16.CrossRef Ariji Y, Taguchi A, Sakuma S, Miki M, Asawa T, Uchida K, et al. Magnetic resonance T2-weighted IDEAL water imaging for assessing changes in masseter muscles caused by low-level static contraction. Oral Med Oral Pathol Oral Radiol Endod. 2010;109:908–16.CrossRef
6.
go back to reference Nagayama K, Suenaga S, Nagata J, Takada H, Majima HJ, Miyawaki S. Clinical significance of magnetization transfer contrast imaging for edematous changes in masticatory muscle. J Comput Assist Tomogr. 2010;34:233–41.PubMedCrossRef Nagayama K, Suenaga S, Nagata J, Takada H, Majima HJ, Miyawaki S. Clinical significance of magnetization transfer contrast imaging for edematous changes in masticatory muscle. J Comput Assist Tomogr. 2010;34:233–41.PubMedCrossRef
7.
go back to reference Ariji E, Ariji Y, Yoshida K, Kimura S, Horinouchi Y, Kanda S. Ultrasonographic evaluation of inflammatory changes in the masseter muscle. Oral Surg Oral Med Oral Pathol. 1994;78:797–801.PubMedCrossRef Ariji E, Ariji Y, Yoshida K, Kimura S, Horinouchi Y, Kanda S. Ultrasonographic evaluation of inflammatory changes in the masseter muscle. Oral Surg Oral Med Oral Pathol. 1994;78:797–801.PubMedCrossRef
8.
go back to reference Stahl R, Blumenkrantz G, Carballido-Gamio J, Zhao S, Munoz T, Le Graverand-Gastineau MPH, et al. MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up. Osteoarthr Cartil. 2007;15:1225–34.PubMedCrossRef Stahl R, Blumenkrantz G, Carballido-Gamio J, Zhao S, Munoz T, Le Graverand-Gastineau MPH, et al. MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up. Osteoarthr Cartil. 2007;15:1225–34.PubMedCrossRef
9.
go back to reference Prior BM, Foley JM, Jayaraman RC, Meyer RA. Pixel T2 distribution in functional magnetic resonance images of muscle. J Appl Physiol. 1999;87:2107–14.PubMed Prior BM, Foley JM, Jayaraman RC, Meyer RA. Pixel T2 distribution in functional magnetic resonance images of muscle. J Appl Physiol. 1999;87:2107–14.PubMed
10.
go back to reference Chikui T, Shiraishi T, Tokumori K, Inatomi D, Hatakenaka M, Yuasa K, et al. Assessment of the sequential change of the masseter muscle by clenching: a quantitative analysis of T1, T2, and the signal intensity of the balanced steady-state free precession. Acta Radiol. 2010;6:669–78.CrossRef Chikui T, Shiraishi T, Tokumori K, Inatomi D, Hatakenaka M, Yuasa K, et al. Assessment of the sequential change of the masseter muscle by clenching: a quantitative analysis of T1, T2, and the signal intensity of the balanced steady-state free precession. Acta Radiol. 2010;6:669–78.CrossRef
11.
go back to reference Hazlewood CF, Chang DC, Nichols BL, Woessner DE. Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle. Biophys J. 1974;14:583–606.PubMedCrossRef Hazlewood CF, Chang DC, Nichols BL, Woessner DE. Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle. Biophys J. 1974;14:583–606.PubMedCrossRef
12.
go back to reference Saab G, Thompson RT, Marsh GD. Multicomponent T2 relaxation of in vivo skeletal muscle. Magn Reson Med. 1999;42:150–7.PubMedCrossRef Saab G, Thompson RT, Marsh GD. Multicomponent T2 relaxation of in vivo skeletal muscle. Magn Reson Med. 1999;42:150–7.PubMedCrossRef
13.
go back to reference Ababneh Z, Beloeil H, Berde CB, Gambarota G, Maier SE, Mulkern RV. Biexponential parameterization of diffusion and T2 relaxation decay curves in a rat muscle edema model: decay curve components and water compartments. Magn Reson Med. 2005;54:524–31.PubMedCrossRef Ababneh Z, Beloeil H, Berde CB, Gambarota G, Maier SE, Mulkern RV. Biexponential parameterization of diffusion and T2 relaxation decay curves in a rat muscle edema model: decay curve components and water compartments. Magn Reson Med. 2005;54:524–31.PubMedCrossRef
14.
go back to reference Saab G, Thompson RT, Marsh GD. Effect of exercise on muscle transverse relaxation determined by MR imaging and in vivo relaxometry. J Appl Physiol. 2000;88:226–33.PubMed Saab G, Thompson RT, Marsh GD. Effect of exercise on muscle transverse relaxation determined by MR imaging and in vivo relaxometry. J Appl Physiol. 2000;88:226–33.PubMed
15.
go back to reference Ariji Y, Kimura Y, Gotoh Y, Sakuma S, Zhao Y, Ariji E. Blood flow in and around the masseter muscle: normal and pathologic features demonstrated by color Doppler sonography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:472–82.PubMedCrossRef Ariji Y, Kimura Y, Gotoh Y, Sakuma S, Zhao Y, Ariji E. Blood flow in and around the masseter muscle: normal and pathologic features demonstrated by color Doppler sonography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:472–82.PubMedCrossRef
16.
go back to reference Cairns BE, Gambarota G, Svensson P, Arendt-Nielsen L, Berde CB. Glutamate-induced sensitization of rat masseter muscle fibers. Neuroscience. 2002;109:389–99.PubMedCrossRef Cairns BE, Gambarota G, Svensson P, Arendt-Nielsen L, Berde CB. Glutamate-induced sensitization of rat masseter muscle fibers. Neuroscience. 2002;109:389–99.PubMedCrossRef
17.
go back to reference Babenko V, Graven-Nielsena T, Svensson P, Drewes AM, Jensen TS, Arendt-Nielsen L. Experimental human muscle pain induced by intramuscular injections of bradykinin, serotonin, and substance P. Eur J Pain. 1999;3:93–102.PubMedCrossRef Babenko V, Graven-Nielsena T, Svensson P, Drewes AM, Jensen TS, Arendt-Nielsen L. Experimental human muscle pain induced by intramuscular injections of bradykinin, serotonin, and substance P. Eur J Pain. 1999;3:93–102.PubMedCrossRef
18.
go back to reference Torisu T, Wang K, Svensson P, De Laat A, Fujii H, Arendt-Nielsen L. Effects of muscle fatigue induced by low-level clenching on experimental muscle pain and resting jaw muscle activity gender differences. Exp Brain Res. 2006;174:566–74.PubMedCrossRef Torisu T, Wang K, Svensson P, De Laat A, Fujii H, Arendt-Nielsen L. Effects of muscle fatigue induced by low-level clenching on experimental muscle pain and resting jaw muscle activity gender differences. Exp Brain Res. 2006;174:566–74.PubMedCrossRef
19.
go back to reference Svensson P, Burgaard A, Schlosser S. Fatigue and pain in human jaw muscles during a sustained, low-intensity clenching task. Arch Oral Biol. 2001;46:773–7.PubMedCrossRef Svensson P, Burgaard A, Schlosser S. Fatigue and pain in human jaw muscles during a sustained, low-intensity clenching task. Arch Oral Biol. 2001;46:773–7.PubMedCrossRef
20.
go back to reference Svensson P, Wang K, Sessle BJ, Arendt-Nielsen L. Associations between pain and neuromuscular activity in the human jaw and neck muscles. Pain. 2004;109:225–32.PubMedCrossRef Svensson P, Wang K, Sessle BJ, Arendt-Nielsen L. Associations between pain and neuromuscular activity in the human jaw and neck muscles. Pain. 2004;109:225–32.PubMedCrossRef
21.
go back to reference Wang K, Sessle BJ, Svensson P, Arendt-Nielsen L. Glutamate evoked neck and jaw muscle pain facilitate the human jaw stretch reflex. Clin Neurophysiol. 2004;115:1288–95.PubMedCrossRef Wang K, Sessle BJ, Svensson P, Arendt-Nielsen L. Glutamate evoked neck and jaw muscle pain facilitate the human jaw stretch reflex. Clin Neurophysiol. 2004;115:1288–95.PubMedCrossRef
22.
go back to reference Torisu T, Wang K, Svensson P, De Laat A, Fujii H, Arendt-Nielsen L. Effect of low-level clenching and subsequent muscle pain on exteroceptive suppression and resting muscle activity in human jaw muscles. Clin Neurophysiol. 2007;118:999–1009.PubMedCrossRef Torisu T, Wang K, Svensson P, De Laat A, Fujii H, Arendt-Nielsen L. Effect of low-level clenching and subsequent muscle pain on exteroceptive suppression and resting muscle activity in human jaw muscles. Clin Neurophysiol. 2007;118:999–1009.PubMedCrossRef
23.
go back to reference Gambarota G, Philippens M, Cairns BE, Dong XD, Renema WKJ, Heerschap A. MRS assessment of glutamate clearance in a novel masticatory muscle pain model. NMR Biomed. 2005;18:345–51.PubMedCrossRef Gambarota G, Philippens M, Cairns BE, Dong XD, Renema WKJ, Heerschap A. MRS assessment of glutamate clearance in a novel masticatory muscle pain model. NMR Biomed. 2005;18:345–51.PubMedCrossRef
24.
go back to reference Castrillon EE, Cairns BE, Ernberg M, Wang K, Sessle B, Svensson P, et al. Glutamate-evoked jaw muscle pain as a model of persistent myofascial TMD pain. Arch Oral Biol. 2008;53:666–76.PubMedCrossRef Castrillon EE, Cairns BE, Ernberg M, Wang K, Sessle B, Svensson P, et al. Glutamate-evoked jaw muscle pain as a model of persistent myofascial TMD pain. Arch Oral Biol. 2008;53:666–76.PubMedCrossRef
25.
go back to reference Svensson P, Cairns BE, Wang K, Hu JW, Graven-Nielsen T, Arendt-Nielsen L, et al. Glutamate-evoked pain and mechanical allodynia in the human masseter muscle. Pain. 2003;101:221–7.PubMedCrossRef Svensson P, Cairns BE, Wang K, Hu JW, Graven-Nielsen T, Arendt-Nielsen L, et al. Glutamate-evoked pain and mechanical allodynia in the human masseter muscle. Pain. 2003;101:221–7.PubMedCrossRef
26.
go back to reference Cheng HA, Robergs RA, Letellier JP, Caprihan A, Icenogle MV, Haseler LJ. Changes in muscle proton transverse relaxation times and acidosis during exercise and recovery. J Appl Physiol. 1995;79:1370–8.PubMed Cheng HA, Robergs RA, Letellier JP, Caprihan A, Icenogle MV, Haseler LJ. Changes in muscle proton transverse relaxation times and acidosis during exercise and recovery. J Appl Physiol. 1995;79:1370–8.PubMed
27.
go back to reference Flechenstein JL, Haller RG, Bertocci LA, Parkey RW, Peshock RM. Glycogenolysis, not perfusion, is the critical mediator of exercise-induced muscle modifications on MR images. Radiology. 1992;183:25–6. Flechenstein JL, Haller RG, Bertocci LA, Parkey RW, Peshock RM. Glycogenolysis, not perfusion, is the critical mediator of exercise-induced muscle modifications on MR images. Radiology. 1992;183:25–6.
28.
go back to reference Yanagisawa O, Niitsu M, Takahashi H, Goto K, Itai Y. Evaluation of cooling exercised muscle with MR imaging and 3P MR spectroscopy. Med Sci Sports Exerc. 2003;35:1517–23.PubMedCrossRef Yanagisawa O, Niitsu M, Takahashi H, Goto K, Itai Y. Evaluation of cooling exercised muscle with MR imaging and 3P MR spectroscopy. Med Sci Sports Exerc. 2003;35:1517–23.PubMedCrossRef
29.
go back to reference Price TB, Gore JC. Effect of muscle glycogen content on exercise-induced changes in muscle T2 times. J Appl Physiol. 1998;84:1178–84.PubMed Price TB, Gore JC. Effect of muscle glycogen content on exercise-induced changes in muscle T2 times. J Appl Physiol. 1998;84:1178–84.PubMed
30.
go back to reference Pan JW, Hamm JR, Hetherington HP, Rothman DL, Shulman RG. Correlation of lactate and pH in human skeletal muscle after exercise by 1H NMR. Magn Reson Med. 1991;20:57–65.PubMedCrossRef Pan JW, Hamm JR, Hetherington HP, Rothman DL, Shulman RG. Correlation of lactate and pH in human skeletal muscle after exercise by 1H NMR. Magn Reson Med. 1991;20:57–65.PubMedCrossRef
31.
go back to reference Vandenborne K, Walter G, Ploutz-Snyder L, Dudley G, Elliot MA, Meirleir KD. Relationship between muscle T2* relaxation properties and metabolic state: a combined localized 31P-spectroscopy and 1H-imaging study. Eur J Appl Physiol. 2000;82:76–82.PubMedCrossRef Vandenborne K, Walter G, Ploutz-Snyder L, Dudley G, Elliot MA, Meirleir KD. Relationship between muscle T2* relaxation properties and metabolic state: a combined localized 31P-spectroscopy and 1H-imaging study. Eur J Appl Physiol. 2000;82:76–82.PubMedCrossRef
32.
go back to reference Nygren AT, Kaijser L. Water exchange induced by unilateral exercise in active and inactive skeletal muscles. J Appl Physiol. 2002;93:1716–22.PubMed Nygren AT, Kaijser L. Water exchange induced by unilateral exercise in active and inactive skeletal muscles. J Appl Physiol. 2002;93:1716–22.PubMed
33.
go back to reference Louie EA, Gochberg DF, Does MD, Damon BM. Transverse relaxation and magnetization transfer in skeletal muscle: effect of pH. Magn Reson Med. 2009;61:560–9.PubMedCrossRef Louie EA, Gochberg DF, Does MD, Damon BM. Transverse relaxation and magnetization transfer in skeletal muscle: effect of pH. Magn Reson Med. 2009;61:560–9.PubMedCrossRef
34.
go back to reference Kubota J, Ono T, Araki M, Tawara N, Torii S, Okuwaki T, et al. Relationship between the MRI and EMG measurements. Int J Sports Med. 2009;30:533–7.PubMedCrossRef Kubota J, Ono T, Araki M, Tawara N, Torii S, Okuwaki T, et al. Relationship between the MRI and EMG measurements. Int J Sports Med. 2009;30:533–7.PubMedCrossRef
35.
go back to reference Schraml C, Schwenzer NF, Martirosian P, Claussen CD, Schick F. Temporal course of perfusion in human masseter muscle during isometric contraction assessed by arterial spin labeling at 3T. MAGMA. 2011;24:201–9.PubMedCrossRef Schraml C, Schwenzer NF, Martirosian P, Claussen CD, Schick F. Temporal course of perfusion in human masseter muscle during isometric contraction assessed by arterial spin labeling at 3T. MAGMA. 2011;24:201–9.PubMedCrossRef
36.
go back to reference Sakurai Y, Tamura Y, Takeno K, Sato F, Fujitani Y, Hirose T, et al. Association of T2 relaxation time determined by magnetic resonance imaging and intramyocellular lipid content of the soleus muscle in healthy subjects. J Diabetes Invest. 2011;2:356–8.CrossRef Sakurai Y, Tamura Y, Takeno K, Sato F, Fujitani Y, Hirose T, et al. Association of T2 relaxation time determined by magnetic resonance imaging and intramyocellular lipid content of the soleus muscle in healthy subjects. J Diabetes Invest. 2011;2:356–8.CrossRef
37.
go back to reference Schwenzer NF, Martirosian P, Machann J, Schraml C, Steidle G, Claussen CD, et al. Aging effects on human calf muscle properties assessed by MRI at 3 Tesla. J Magn Reson Imaging. 2009;29:1346–54.PubMedCrossRef Schwenzer NF, Martirosian P, Machann J, Schraml C, Steidle G, Claussen CD, et al. Aging effects on human calf muscle properties assessed by MRI at 3 Tesla. J Magn Reson Imaging. 2009;29:1346–54.PubMedCrossRef
38.
go back to reference Polak JF, Jolesz FA, Adams DF. Magnetic resonance imaging of skeletal muscle. Prolongation of T1 and T2 subsequent to denervation. Invest Radiol. 1988;23:365–9.PubMedCrossRef Polak JF, Jolesz FA, Adams DF. Magnetic resonance imaging of skeletal muscle. Prolongation of T1 and T2 subsequent to denervation. Invest Radiol. 1988;23:365–9.PubMedCrossRef
39.
go back to reference Hayashi Y, Ikata T, Takai H, Takata S, Ishikawa M, Sogabe T, et al. Effect of peripheral nerve injury on nuclear magnetic resonance relaxation times of rat skeletal muscle. Invest Radiol. 1997;32:135–9.PubMedCrossRef Hayashi Y, Ikata T, Takai H, Takata S, Ishikawa M, Sogabe T, et al. Effect of peripheral nerve injury on nuclear magnetic resonance relaxation times of rat skeletal muscle. Invest Radiol. 1997;32:135–9.PubMedCrossRef
40.
go back to reference Kim HK, Laor T, Horn PS, Racadio JM, Wong B, Dardzinski BJ. T2 mapping in Duchenne muscular dystrophy: distribution of disease activity and correlation with clinical assessments. Radiology. 2010;255:899–908.PubMedCrossRef Kim HK, Laor T, Horn PS, Racadio JM, Wong B, Dardzinski BJ. T2 mapping in Duchenne muscular dystrophy: distribution of disease activity and correlation with clinical assessments. Radiology. 2010;255:899–908.PubMedCrossRef
41.
go back to reference Maillard SM, Jones R, Owens C, Pilkington C, Woo P, Wedderburn LR, et al. Quantitative assessment of MRI T2 relaxation time of thigh muscles in juvenile dermatomyositis. Rheumatology. 2004;43:603–8.PubMedCrossRef Maillard SM, Jones R, Owens C, Pilkington C, Woo P, Wedderburn LR, et al. Quantitative assessment of MRI T2 relaxation time of thigh muscles in juvenile dermatomyositis. Rheumatology. 2004;43:603–8.PubMedCrossRef
42.
go back to reference Reiter DA, Lin PC, Fishbein KW, Spencer RG. Multicomponent T2 relaxation analysis in cartilage. Magn Reson Med. 2009;61:803–9.PubMedCrossRef Reiter DA, Lin PC, Fishbein KW, Spencer RG. Multicomponent T2 relaxation analysis in cartilage. Magn Reson Med. 2009;61:803–9.PubMedCrossRef
43.
go back to reference Stelzeneder D, Welsch GH, Kovács BK, Goed S, Paternostro-Sluga T, Vlychou M, et al. Quantitative T2 evaluation at 3.0 T compared to morphological grading of the lumbar intervertebral disc: a standardized evaluation approach in patients with low back pain. Eur J Radiol. 2012;81:324–30.PubMedCrossRef Stelzeneder D, Welsch GH, Kovács BK, Goed S, Paternostro-Sluga T, Vlychou M, et al. Quantitative T2 evaluation at 3.0 T compared to morphological grading of the lumbar intervertebral disc: a standardized evaluation approach in patients with low back pain. Eur J Radiol. 2012;81:324–30.PubMedCrossRef
44.
go back to reference Takashima H, Takebayashi T, Yoshimoto M, Terashima Y, Tsuda H, Ida K, et al. Correlation between T2 relaxation time and intervertebral disk degeneration. Skeletal Radiol. 2012;41:163–7.PubMedCrossRef Takashima H, Takebayashi T, Yoshimoto M, Terashima Y, Tsuda H, Ida K, et al. Correlation between T2 relaxation time and intervertebral disk degeneration. Skeletal Radiol. 2012;41:163–7.PubMedCrossRef
45.
go back to reference Meyerspeer M, Mandl T, Reichel M, Mayr W, Hofer C, Kern H, et al. Effects of functional electrical stimulation in denervated thigh muscles of paraplegic patients mapped with T2 imaging. MAGMA. 2008;21:219–26.PubMedCrossRef Meyerspeer M, Mandl T, Reichel M, Mayr W, Hofer C, Kern H, et al. Effects of functional electrical stimulation in denervated thigh muscles of paraplegic patients mapped with T2 imaging. MAGMA. 2008;21:219–26.PubMedCrossRef
46.
go back to reference Mandl T, Meyerspeer M, Reichel M, Kern H, Hofer C, Mayr W, et al. Functional electrical stimulation of long-term denervated, degenerated human skeletal muscle: estimating activation using T2-parameter magnetic resonance imaging methods. Artif Organs. 2008;32:604–8.PubMedCrossRef Mandl T, Meyerspeer M, Reichel M, Kern H, Hofer C, Mayr W, et al. Functional electrical stimulation of long-term denervated, degenerated human skeletal muscle: estimating activation using T2-parameter magnetic resonance imaging methods. Artif Organs. 2008;32:604–8.PubMedCrossRef
Metadata
Title
Clinical significance of T2 mapping MRI for the evaluation of masseter muscle pain in patients with temporomandibular joint disorders
Authors
Yutaka Nikkuni
Hideyoshi Nishiyama
Takafumi Hayashi
Publication date
01-01-2013
Publisher
Springer Japan
Published in
Oral Radiology / Issue 1/2013
Print ISSN: 0911-6028
Electronic ISSN: 1613-9674
DOI
https://doi.org/10.1007/s11282-012-0108-y

Other articles of this Issue 1/2013

Oral Radiology 1/2013 Go to the issue