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01-06-2014 | Urology – Review

A translational medicine appraisal of specialized andrology testing in unexplained male infertility

Authors: Sandro C. Esteves, Rakesh K. Sharma, Jaime Gosálvez, Ashok Agarwal

Published in: International Urology and Nephrology | Issue 6/2014

Abstract

The diagnostic and prognostic validity of sperm function biomarkers is particularly relevant for males with unexplained infertility in which routine semen analysis fails to detect subcellular sperm dysfunctions. In this general review, we examine the role and significance of specialized andrology laboratory tests from past to present and provide a glance toward the future. We concluded that the assessment of sperm DNA damage and oxidative stress provide a relatively independent measure of fertility that yields diagnostic and prognostic information complementary to, but distinct and more significant than, standard sperm parameters. Since none of the available methods for such testing have been fully translated, further research is necessary to evaluate their cost-effectiveness when applied in large scale to daily medical practice. Application of translational medicine concepts would also be useful to accelerate the clinical application of recent discoveries in the fields of genomics, proteomics and metabolomics.

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Title: A translational medicine appraisal of specialized andrology testing in unexplained male infertility
Authors: Sandro C. Esteves
Rakesh K. Sharma
Jaime Gosálvez
Ashok Agarwal
Publication date: 01-06-2014
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue 6/2014
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-014-0715-0

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Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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Other articles of this Issue 6/2014

Calcitriol resistance in hemodialysis patients with secondary hyperparathyroidism

Caecum perforation after renal transplantation: a case report and review of literature

Evaluation of methods based on creatinine and cystatin C to estimate glomerular filtration rate in chronic kidney disease

Antioxidant therapy prevents ethylene glycol-induced renal calcium oxalate crystal deposition in Wistar rats

Pretreatment differentiation of renal cell carcinoma subtypes by CT: the influence of different tumor enhancement measurement approaches

Penetrating injury of the vagina, bladder and omentum in a woman with 5 months gestation: case report and review of the literature

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials