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Published in: International Urology and Nephrology 5/2014

Open Access 01-05-2014 | Nephrology - Review

Lipid, blood pressure and kidney update 2013

Authors: Maciej Banach, Corina Serban, Wilbert S. Aronow, Jacek Rysz, Simona Dragan, Edgar V. Lerma, Mugurel Apetrii, Adrian Covic

Published in: International Urology and Nephrology | Issue 5/2014

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Abstract

The year 2013 proved to be very exciting as far as landmark trials and new guidelines in the field of lipid disorders, blood pressure and kidney diseases. Among these are the International Atherosclerosis Society Global Recommendations for the Management of Dyslipidemia, European Society of Cardiology (ESC)/European Society of Hypertension Guidelines for the Management of Arterial Hypertension, American Diabetes Association Clinical Practice Recommendations, the Kidney Disease: Improving Global Outcomes Clinical Practice Guidelines for Managing Dyslipidemias in Chronic Kidney Disease (CKD) Patients, the American College of Cardiology/American Heart Association Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults, the Joint National Committee Expert Panel (JNC 8) Evidence-Based Guideline for the Management of High Blood Pressure in Adults, the American Society of Hypertension/International Society of Hypertension Clinical Practice Guidelines for the Management of Hypertension in the Community, the American College of Physicians Clinical Practice Guideline on Screening, Monitoring, and Treatment of Stage 1–3 CKD and many important trials presented among others during the ESC Annual Congress in Amsterdam and the American Society of Nephrology Annual Meeting—Kidney Week in Atlanta, GA. The paper is an attempt to summarize the most important events and reports in the mentioned areas in the passing year.
Footnotes
1
First phase II study report on polynuclear iron(III)-oxyhydroxide phosphate binder (PA21) in hyperphosphatemic hemodialysis patients.
 
2
Prospective, phase III, multicenter, open-label, randomized clinical trial using ferric citrate in hyperphosphatemic hemodialysis patients.
 
Literature
1.
go back to reference Banach M, Rysz J (2010) Current problems in hypertension and nephrology. Expert Opin Pharmacother 11(16):2575–2578PubMed Banach M, Rysz J (2010) Current problems in hypertension and nephrology. Expert Opin Pharmacother 11(16):2575–2578PubMed
2.
go back to reference Catapano AL, Reiner Z, De Backer G, Graham I, Taskinen MR, Wiklund O, Agewall S, Alegria E, Chapman M, Durrington P, Erdine S, Halcox J, Hobbs R, Kjekshus J, Filardi PP, Riccardi G, Storey RF, Wood D (2011) European Society of Cardiology (ESC); European Atherosclerosis Society (EAS). ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Atherosclerosis 217(1):3–46PubMed Catapano AL, Reiner Z, De Backer G, Graham I, Taskinen MR, Wiklund O, Agewall S, Alegria E, Chapman M, Durrington P, Erdine S, Halcox J, Hobbs R, Kjekshus J, Filardi PP, Riccardi G, Storey RF, Wood D (2011) European Society of Cardiology (ESC); European Atherosclerosis Society (EAS). ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Atherosclerosis 217(1):3–46PubMed
3.
go back to reference Tonelli M, Wanner C; for the Kidney Disease: Improving Global Outcomes Lipid Guideline Development Work Group Members (2014) Lipid management in chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2013 clinical practice guideline. Ann Intern Med. doi:10.7326/M13-2453 Tonelli M, Wanner C; for the Kidney Disease: Improving Global Outcomes Lipid Guideline Development Work Group Members (2014) Lipid management in chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2013 clinical practice guideline. Ann Intern Med. doi:10.​7326/​M13-2453
4.
go back to reference KDIGO (2013) clinical practice guideline for lipid management in chronic kidney disease. Kidney Int Suppl 3:259–305 KDIGO (2013) clinical practice guideline for lipid management in chronic kidney disease. Kidney Int Suppl 3:259–305
5.
go back to reference Stone NJ, Robinson J, Lichtenstein AH et al (2014) 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation. doi:10.1161/01.cir.0000437738.63853.7a Stone NJ, Robinson J, Lichtenstein AH et al (2014) 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation. doi:10.​1161/​01.​cir.​0000437738.​63853.​7a
8.
go back to reference Mark L, Paragh G, Karadi I, Reiber I, Pados G, Kiss Z (2012) How can we further improve the LDL-cholesterol target level achievement rate based on the Hungarian MULTI GAP 2011 study results and considering the new European dyslipidemia guidelines? Arch Med Sci 8(4):608–613PubMedPubMedCentral Mark L, Paragh G, Karadi I, Reiber I, Pados G, Kiss Z (2012) How can we further improve the LDL-cholesterol target level achievement rate based on the Hungarian MULTI GAP 2011 study results and considering the new European dyslipidemia guidelines? Arch Med Sci 8(4):608–613PubMedPubMedCentral
9.
go back to reference Mitka M (2013) Groups release new, updated guidelines to reduce heart disease risk factors. JAMA 310(24):2602–2604PubMed Mitka M (2013) Groups release new, updated guidelines to reduce heart disease risk factors. JAMA 310(24):2602–2604PubMed
10.
go back to reference Rizzo M, Banach M, Montalto G, Mikhailidis DP (2012) Lipid-lowering therapies and achievement of LDL-cholesterol targets. Arch Med Sci 8(4):598–600PubMedPubMedCentral Rizzo M, Banach M, Montalto G, Mikhailidis DP (2012) Lipid-lowering therapies and achievement of LDL-cholesterol targets. Arch Med Sci 8(4):598–600PubMedPubMedCentral
11.
go back to reference Rizzo M, Nikolic D, Banach M, Montalto G (2013) Statin treatment in the elderly: how much do we know? Arch Med Sci 9(4):585–588PubMedPubMedCentral Rizzo M, Nikolic D, Banach M, Montalto G (2013) Statin treatment in the elderly: how much do we know? Arch Med Sci 9(4):585–588PubMedPubMedCentral
12.
go back to reference Emerging Risk Factors C, Di Angelantonio E, Gao P, Pennells L, Kaptoge S, Caslake M et al (2012) Lipid-related markers and cardiovascular disease prediction. JAMA 307(23):2499–2506PubMed Emerging Risk Factors C, Di Angelantonio E, Gao P, Pennells L, Kaptoge S, Caslake M et al (2012) Lipid-related markers and cardiovascular disease prediction. JAMA 307(23):2499–2506PubMed
13.
go back to reference Lai HM, Aronow WS, Mercando AD, Kalen P, Desai HV, Gandhi K, Sharma M, Amin H, Lai TM (2012) The impact of statin therapy on long-term cardiovascular outcomes in an outpatient cardiology practice. Arch Med Sci 8(1):53–56PubMedPubMedCentral Lai HM, Aronow WS, Mercando AD, Kalen P, Desai HV, Gandhi K, Sharma M, Amin H, Lai TM (2012) The impact of statin therapy on long-term cardiovascular outcomes in an outpatient cardiology practice. Arch Med Sci 8(1):53–56PubMedPubMedCentral
14.
go back to reference Mark L, Paragh G, Karadi I, Reiber I, Pados G, Kiss Z (2011) An attempt to make lipid-lowering therapy more effective in Hungary. The results of MULTI GAP 2010 and the PLUS Program. Arch Med Sci 2011(7):760–766 Mark L, Paragh G, Karadi I, Reiber I, Pados G, Kiss Z (2011) An attempt to make lipid-lowering therapy more effective in Hungary. The results of MULTI GAP 2010 and the PLUS Program. Arch Med Sci 2011(7):760–766
15.
go back to reference Wiklund O, Pirazzi C, Romeo S (2013) Monitoring of lipids, enzymes, and creatine kinase in patients on lipid-lowering drug therapy. Curr Cardiol Rep 15(9):397PubMedPubMedCentral Wiklund O, Pirazzi C, Romeo S (2013) Monitoring of lipids, enzymes, and creatine kinase in patients on lipid-lowering drug therapy. Curr Cardiol Rep 15(9):397PubMedPubMedCentral
16.
go back to reference Smith JD (2010) Dysfunctional HDL as a diagnostic and therapeutic target. Arterioscler Thromb Vasc Biol 30(2):151–155PubMedPubMedCentral Smith JD (2010) Dysfunctional HDL as a diagnostic and therapeutic target. Arterioscler Thromb Vasc Biol 30(2):151–155PubMedPubMedCentral
17.
go back to reference Rothblat GH, Phillips MC (2010) High-density lipoprotein heterogeneity and function in reverse cholesterol transport. Curr Opin Lipidol 21(3):229–238PubMedPubMedCentral Rothblat GH, Phillips MC (2010) High-density lipoprotein heterogeneity and function in reverse cholesterol transport. Curr Opin Lipidol 21(3):229–238PubMedPubMedCentral
18.
go back to reference Rosenson RS, Brewer HB Jr, Chapman MJ, Fazio S, Hussain MM, Kontush A et al (2011) HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events. Clin Chem 57(3):392–410PubMed Rosenson RS, Brewer HB Jr, Chapman MJ, Fazio S, Hussain MM, Kontush A et al (2011) HDL measures, particle heterogeneity, proposed nomenclature, and relation to atherosclerotic cardiovascular events. Clin Chem 57(3):392–410PubMed
19.
go back to reference Otocka-Kmiecik A, Mikhailidis DP, Nicholls SJ, Davidson M, Rysz J, Banach M (2012) Dysfunctional HDL: a novel important diagnostic and therapeutic target in cardiovascular disease? Prog Lipid Res 51(4):314–324PubMed Otocka-Kmiecik A, Mikhailidis DP, Nicholls SJ, Davidson M, Rysz J, Banach M (2012) Dysfunctional HDL: a novel important diagnostic and therapeutic target in cardiovascular disease? Prog Lipid Res 51(4):314–324PubMed
20.
go back to reference Banach M, Hering D, Narkiewicz K, Mysliwiec M, Rysz J, Malyszko J (2012) Lipids, blood pressure, kidney-what was new in 2012? Int J Pharmacol 8:659–678 Banach M, Hering D, Narkiewicz K, Mysliwiec M, Rysz J, Malyszko J (2012) Lipids, blood pressure, kidney-what was new in 2012? Int J Pharmacol 8:659–678
21.
go back to reference Oravec S, Dukat A, Gavornik P, Lovasova Z, Gruber K (2011) Atherogenic normolipidemia—a new phenomenon in the lipoprotein profile of clinically healthy subjects. Neuro Endocrinol Lett 32(3):317–321PubMed Oravec S, Dukat A, Gavornik P, Lovasova Z, Gruber K (2011) Atherogenic normolipidemia—a new phenomenon in the lipoprotein profile of clinically healthy subjects. Neuro Endocrinol Lett 32(3):317–321PubMed
22.
go back to reference Kucera M, Oravec S, Hirnerova E, Huckova N, Celecova Z, Gaspar L, Banach M (2014) Effect of atorvastatin on low density lipoprotein subpopulations and comparison between indicators of plasma atherogenicity—A pilot study. Angiology. doi:10.1177/0003319713507476 Kucera M, Oravec S, Hirnerova E, Huckova N, Celecova Z, Gaspar L, Banach M (2014) Effect of atorvastatin on low density lipoprotein subpopulations and comparison between indicators of plasma atherogenicity—A pilot study. Angiology. doi:10.​1177/​0003319713507476​
23.
go back to reference Mikhailidis DP, Elisaf M, Rizzo M, Berneis K, Griffin B, Zambon A et al (2011) “European panel on low density lipoprotein (LDL) subclasses”: a statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses: executive summary. Curr Vasc Pharmacol 9(5):531–532PubMed Mikhailidis DP, Elisaf M, Rizzo M, Berneis K, Griffin B, Zambon A et al (2011) “European panel on low density lipoprotein (LDL) subclasses”: a statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses: executive summary. Curr Vasc Pharmacol 9(5):531–532PubMed
24.
go back to reference Paraskevas KI, Koupidis S, Gentimi F, Tzovaras AA (2011) Statin discontinuation: counterbalancing the benefits with the potential risks. Arch Med Sci 7(6):1076–1077PubMedPubMedCentral Paraskevas KI, Koupidis S, Gentimi F, Tzovaras AA (2011) Statin discontinuation: counterbalancing the benefits with the potential risks. Arch Med Sci 7(6):1076–1077PubMedPubMedCentral
25.
26.
go back to reference Olechnowicz-Tietz S, Gluba A, Paradowska A, Banach M, Rysz J (2013) The risk of atherosclerosis in patients with chronic kidney disease. Int Urol Nephrol 45(6):1605–1612PubMedPubMedCentral Olechnowicz-Tietz S, Gluba A, Paradowska A, Banach M, Rysz J (2013) The risk of atherosclerosis in patients with chronic kidney disease. Int Urol Nephrol 45(6):1605–1612PubMedPubMedCentral
27.
go back to reference Kowalski J, Barylski M, Banach M, Grycewicz J, Irzmański R, Pawlicki L (2006) Neutrophil superoxide anion generation during atorvastatin and fluvastatin therapy used in coronary heart disease primary prevention. J Cardiovasc Pharmacol 48(4):143–147PubMed Kowalski J, Barylski M, Banach M, Grycewicz J, Irzmański R, Pawlicki L (2006) Neutrophil superoxide anion generation during atorvastatin and fluvastatin therapy used in coronary heart disease primary prevention. J Cardiovasc Pharmacol 48(4):143–147PubMed
28.
go back to reference Bielecka-Dabrowa A, Mikhailidis DP, Rizzo M, von Haehling S, Rysz J, Banach M (2013) The influence of atorvastatin on parameters of inflammation left ventricular function, hospitalizations and mortality in patients with dilated cardiomyopathy—5-year follow-up. Lipids Health Dis 12(1):47PubMedPubMedCentral Bielecka-Dabrowa A, Mikhailidis DP, Rizzo M, von Haehling S, Rysz J, Banach M (2013) The influence of atorvastatin on parameters of inflammation left ventricular function, hospitalizations and mortality in patients with dilated cardiomyopathy—5-year follow-up. Lipids Health Dis 12(1):47PubMedPubMedCentral
30.
go back to reference Sattar N, Preiss D, Murray HM, Welsh P, Buckley BM, de Craen AJ et al (2010) Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet 375(9716):735–742PubMed Sattar N, Preiss D, Murray HM, Welsh P, Buckley BM, de Craen AJ et al (2010) Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet 375(9716):735–742PubMed
31.
go back to reference Rajpathak SN, Kumbhani DJ, Crandall J, Barzilai N, Alderman M, Ridker PM (2009) Statin therapy and risk of developing type 2 diabetes: a meta-analysis. Diabetes Care 32(10):1924–1929PubMedPubMedCentral Rajpathak SN, Kumbhani DJ, Crandall J, Barzilai N, Alderman M, Ridker PM (2009) Statin therapy and risk of developing type 2 diabetes: a meta-analysis. Diabetes Care 32(10):1924–1929PubMedPubMedCentral
32.
go back to reference Shah RV, Goldfine AB (2012) Statins and risk of new-onset diabetes mellitus. Circulation 126(18):e282–e284PubMed Shah RV, Goldfine AB (2012) Statins and risk of new-onset diabetes mellitus. Circulation 126(18):e282–e284PubMed
33.
go back to reference Axsom K, Berger JS, Schwartzbard AZ (2013) Statins and diabetes: the good, the bad, and the unknown. Curr Atheroscler Rep 15(2):299PubMed Axsom K, Berger JS, Schwartzbard AZ (2013) Statins and diabetes: the good, the bad, and the unknown. Curr Atheroscler Rep 15(2):299PubMed
34.
go back to reference Banach M, Mikhailidis DP (2013) Statin therapy and new-onset diabetes: an attempt at recommendations. Exp Rev Endocrinol Metab 8(3):213–216 Banach M, Mikhailidis DP (2013) Statin therapy and new-onset diabetes: an attempt at recommendations. Exp Rev Endocrinol Metab 8(3):213–216
35.
go back to reference Banach M, Malodobra-Mazur M, Gluba A, Katsiki N, Rysz J, Dobrzyn A (2013) Statin therapy and new-onset diabetes: molecular mechanisms and clinical relevance. Curr Pharm Des 19(27):4904–4912PubMed Banach M, Malodobra-Mazur M, Gluba A, Katsiki N, Rysz J, Dobrzyn A (2013) Statin therapy and new-onset diabetes: molecular mechanisms and clinical relevance. Curr Pharm Des 19(27):4904–4912PubMed
37.
go back to reference Zaharan NL, Williams D, Bennett K (2013) Statins and risk of treated incident diabetes in a primary care population. Brit J Clin Pharmacol 75(4):1118–1124 Zaharan NL, Williams D, Bennett K (2013) Statins and risk of treated incident diabetes in a primary care population. Brit J Clin Pharmacol 75(4):1118–1124
38.
go back to reference Chen CW, Chen TC, Huang KY, Chou P, Chen PF, Lee CC (2013) Differential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an Asian country. PLoS One 8(8):e71817PubMedPubMedCentral Chen CW, Chen TC, Huang KY, Chou P, Chen PF, Lee CC (2013) Differential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an Asian country. PLoS One 8(8):e71817PubMedPubMedCentral
39.
go back to reference Carter AA, Gomes T, Camacho X, Juurlink DN, Shah BR, Mamdani MM (2013) Risk of incident diabetes among patients treated with statins: population based study. BMJ 346:f2610PubMedPubMedCentral Carter AA, Gomes T, Camacho X, Juurlink DN, Shah BR, Mamdani MM (2013) Risk of incident diabetes among patients treated with statins: population based study. BMJ 346:f2610PubMedPubMedCentral
40.
go back to reference Izzo R, de Simone G, Trimarco V, Giudice R, De Marco M, Di Renzo G et al (2013) Primary prevention with statins and incident diabetes in hypertensive patients at high cardiovascular risk. Nutr Metab Cardiovasc Dis. doi:10.1016/j.numecd.2012.11.002 Izzo R, de Simone G, Trimarco V, Giudice R, De Marco M, Di Renzo G et al (2013) Primary prevention with statins and incident diabetes in hypertensive patients at high cardiovascular risk. Nutr Metab Cardiovasc Dis. doi:10.​1016/​j.​numecd.​2012.​11.​002
42.
go back to reference Katsiki N, Banach M (2012) Statins and the risk of diabetes: the debate. Arch Intern Med 172(11):895–896PubMed Katsiki N, Banach M (2012) Statins and the risk of diabetes: the debate. Arch Intern Med 172(11):895–896PubMed
43.
go back to reference Athyros VG, Hatzitolios AI, Karagiannis A, Savopoulos C, Katsiki N, Tziomalos K, Papagianni A, Kakafika A, Gossios TD, Mikhailidis DP, IMPERATIVE Collaborative Group (2011) IMproving the imPlemEntation of cuRrent guidelines for the mAnagement of major coronary hearT disease rIsk factors by multifactorial interVEntion. The IMPERATIVE renal analysis. Arch Med Sci 7(6):984–992PubMedPubMedCentral Athyros VG, Hatzitolios AI, Karagiannis A, Savopoulos C, Katsiki N, Tziomalos K, Papagianni A, Kakafika A, Gossios TD, Mikhailidis DP, IMPERATIVE Collaborative Group (2011) IMproving the imPlemEntation of cuRrent guidelines for the mAnagement of major coronary hearT disease rIsk factors by multifactorial interVEntion. The IMPERATIVE renal analysis. Arch Med Sci 7(6):984–992PubMedPubMedCentral
44.
go back to reference Kostapanos MS, Milionis HJ, Elisaf MS (2010) Current role of statins in the treatment of essential hypertension. Expert Opin Pharmacother 11(16):2635–2650PubMed Kostapanos MS, Milionis HJ, Elisaf MS (2010) Current role of statins in the treatment of essential hypertension. Expert Opin Pharmacother 11(16):2635–2650PubMed
45.
go back to reference Kalinowski L, Dobrucki IT, Malinski T (2002) Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis. J Physiol Pharmacol 53(4 Pt 1):585–595PubMed Kalinowski L, Dobrucki IT, Malinski T (2002) Cerivastatin potentiates nitric oxide release and enos expression through inhibition of isoprenoids synthesis. J Physiol Pharmacol 53(4 Pt 1):585–595PubMed
46.
go back to reference John S, Schneider MP, Delles C, Jacobi J, Schmieder RE (2005) Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients. Am Heart J 149(3):473PubMed John S, Schneider MP, Delles C, Jacobi J, Schmieder RE (2005) Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients. Am Heart J 149(3):473PubMed
47.
go back to reference Stepien M, Banach M, Mikhailidis DP, Gluba A, Kjeldsen SE, Rysz J (2009) Role and significance of statins in the treatment of hypertensive patients. Curr Med Res Opin 25(8):1995–2005PubMed Stepien M, Banach M, Mikhailidis DP, Gluba A, Kjeldsen SE, Rysz J (2009) Role and significance of statins in the treatment of hypertensive patients. Curr Med Res Opin 25(8):1995–2005PubMed
48.
go back to reference Banach M, Mikhailidis DP, Kjeldsen SE, Rysz J (2009) Time for new indications for statins? Med Sci Monit 15(12):MS1–5PubMed Banach M, Mikhailidis DP, Kjeldsen SE, Rysz J (2009) Time for new indications for statins? Med Sci Monit 15(12):MS1–5PubMed
49.
go back to reference Rikitake Y, Kawashima S, Takeshita S, Yamashita T, Azumi H, Yasuhara M et al (2001) Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 154(1):87–96PubMed Rikitake Y, Kawashima S, Takeshita S, Yamashita T, Azumi H, Yasuhara M et al (2001) Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 154(1):87–96PubMed
50.
go back to reference Aydin U, Ugurlucan M, Gungor F, Ziyade S, Inan B, Banach M et al (2009) Effects of atorvastatin on vascular intimal hyperplasia: an experimental rodent model. Angiology 60(3):370–377PubMed Aydin U, Ugurlucan M, Gungor F, Ziyade S, Inan B, Banach M et al (2009) Effects of atorvastatin on vascular intimal hyperplasia: an experimental rodent model. Angiology 60(3):370–377PubMed
51.
go back to reference Tycinska AM, Janica J, Mroczko B, Musial WJ, Sawicki R, Sobkowicz B, Kaminski K, Lebkowska U, Szmitkowski M (2011) Hypotensive effect of atorvastatin in hypertensive patients: the association among flow-mediated dilation, oxidative stress and endothelial dysfunction. Arch Med Sci 7(6):955–962PubMedPubMedCentral Tycinska AM, Janica J, Mroczko B, Musial WJ, Sawicki R, Sobkowicz B, Kaminski K, Lebkowska U, Szmitkowski M (2011) Hypotensive effect of atorvastatin in hypertensive patients: the association among flow-mediated dilation, oxidative stress and endothelial dysfunction. Arch Med Sci 7(6):955–962PubMedPubMedCentral
52.
go back to reference Feldstein CA (2010) Statins in hypertension: are they a new class of antihypertensive agents? Am J Ther 17(3):255–262PubMed Feldstein CA (2010) Statins in hypertension: are they a new class of antihypertensive agents? Am J Ther 17(3):255–262PubMed
53.
go back to reference Katsiki N, Mikhailidis DP, Banach M (2011) Effects of statin treatment on endothelial function, oxidative stress and inflammation in patients with arterial hypertension and normal cholesterol levels. J Hypertens 29(12):2493–2494PubMed Katsiki N, Mikhailidis DP, Banach M (2011) Effects of statin treatment on endothelial function, oxidative stress and inflammation in patients with arterial hypertension and normal cholesterol levels. J Hypertens 29(12):2493–2494PubMed
54.
go back to reference Banach M, Nikfar S, Rahimi R, Bielecka-Dabrowa A, Pencina MJ, Mikhailidis DP, Lipid and Blood Pressure Meta-Analysis Collaboration Group et al (2013) The effects of statins on blood pressure in normotensive or hypertensive subjects—a meta-analysis of randomized controlled trials. Int J Cardiol 168(3):2816–2824PubMed Banach M, Nikfar S, Rahimi R, Bielecka-Dabrowa A, Pencina MJ, Mikhailidis DP, Lipid and Blood Pressure Meta-Analysis Collaboration Group et al (2013) The effects of statins on blood pressure in normotensive or hypertensive subjects—a meta-analysis of randomized controlled trials. Int J Cardiol 168(3):2816–2824PubMed
55.
go back to reference Gluba A, Mikhailidis DP, Lip GY, Hannam S, Rysz J, Banach M (2013) Metabolic syndrome and renal disease. Int J Cardiol 164(2):141–150PubMed Gluba A, Mikhailidis DP, Lip GY, Hannam S, Rysz J, Banach M (2013) Metabolic syndrome and renal disease. Int J Cardiol 164(2):141–150PubMed
56.
go back to reference Franczyk-Skora B, Gluba A, Banach M, Rozentryt P, Polonski L, Rysz J (2013) Acute coronary syndromes in patients with chronic kidney disease. Curr Vasc Pharmacol 11(5):758–767PubMed Franczyk-Skora B, Gluba A, Banach M, Rozentryt P, Polonski L, Rysz J (2013) Acute coronary syndromes in patients with chronic kidney disease. Curr Vasc Pharmacol 11(5):758–767PubMed
57.
go back to reference Stępien M, Stępien A, Wlazel RN, Paradowski M, Banach M, Rysz M, Rysz J (2013) Obesity indices and adipokines in non-diabetic obese patients with early stages of chronic kidney disease. Med Sci Monit 19:1063–1072PubMedPubMedCentral Stępien M, Stępien A, Wlazel RN, Paradowski M, Banach M, Rysz M, Rysz J (2013) Obesity indices and adipokines in non-diabetic obese patients with early stages of chronic kidney disease. Med Sci Monit 19:1063–1072PubMedPubMedCentral
58.
go back to reference Franczyk-Skora B, Gluba A, Banach M, Rysz J (2013) Treatment of non-ST-elevation myocardial infarction and ST-elevation myocardial infarction in patients with chronic kidney disease. Arch Med Sci 9(6):1019–1027PubMedPubMedCentral Franczyk-Skora B, Gluba A, Banach M, Rysz J (2013) Treatment of non-ST-elevation myocardial infarction and ST-elevation myocardial infarction in patients with chronic kidney disease. Arch Med Sci 9(6):1019–1027PubMedPubMedCentral
59.
go back to reference Rysz J, Aronow WS, Stolarek RS, Hannam S, Mikhailidis DP, Banach M (2009) Nephroprotective and clinical potential of statins in dialyzed patients. Expert Opin Ther Targets 13(5):541–550PubMed Rysz J, Aronow WS, Stolarek RS, Hannam S, Mikhailidis DP, Banach M (2009) Nephroprotective and clinical potential of statins in dialyzed patients. Expert Opin Ther Targets 13(5):541–550PubMed
60.
go back to reference Athyros VG, Katsiki N, Tziomalos K, Gossios TD, Theocharidou E, Gkaliagkousi E, Anagnostis P, Pagourelias ED, Karagiannis A, Mikhailidis DP, GREACE Study Collaborative Group (2013) Statins and cardiovascular outcomes in elderly and younger patients with coronary artery disease: a post hoc analysis of the GREACE study. Arch Med Sci 9(3):418–426PubMedPubMedCentral Athyros VG, Katsiki N, Tziomalos K, Gossios TD, Theocharidou E, Gkaliagkousi E, Anagnostis P, Pagourelias ED, Karagiannis A, Mikhailidis DP, GREACE Study Collaborative Group (2013) Statins and cardiovascular outcomes in elderly and younger patients with coronary artery disease: a post hoc analysis of the GREACE study. Arch Med Sci 9(3):418–426PubMedPubMedCentral
61.
go back to reference Gluba A, Rysz J, Banach M (2010) Statins in patients with chronic kidney disease: why, who and when? Expert Opin Pharmacother 11(16):2665–2674PubMed Gluba A, Rysz J, Banach M (2010) Statins in patients with chronic kidney disease: why, who and when? Expert Opin Pharmacother 11(16):2665–2674PubMed
62.
go back to reference Nikolic D, Nikfar S, Salari P, Rizzo M, Ray KK, Pencina MJ, Lipid and Blood Pressure Meta-Analysis Collaboration Group et al (2013) Effects of statins on lipid profile in chronic kidney disease patients: a meta-analysis of randomized controlled trials. Curr Med Res Opin 29(5):435–451PubMed Nikolic D, Nikfar S, Salari P, Rizzo M, Ray KK, Pencina MJ, Lipid and Blood Pressure Meta-Analysis Collaboration Group et al (2013) Effects of statins on lipid profile in chronic kidney disease patients: a meta-analysis of randomized controlled trials. Curr Med Res Opin 29(5):435–451PubMed
63.
go back to reference Nikolic D, Banach M, Nikfar S, Salari P, Mikhailidis DP, Toth PP, Lipid and Blood Pressure Meta-Analysis Collaboration Group et al (2013) A meta-analysis of the role of statins on renal outcomes in patients with chronic kidney disease. Is the duration of therapy important? Int J Cardiol 168(6):5437–5447PubMed Nikolic D, Banach M, Nikfar S, Salari P, Mikhailidis DP, Toth PP, Lipid and Blood Pressure Meta-Analysis Collaboration Group et al (2013) A meta-analysis of the role of statins on renal outcomes in patients with chronic kidney disease. Is the duration of therapy important? Int J Cardiol 168(6):5437–5447PubMed
64.
go back to reference Barylski M, Nikfar S, Mikhailidis DP, Toth PP, Salari P, Ray KK, Lipid and Blood Pressure Meta-Analysis Collaboration Group et al (2013) Statins decrease all-cause mortality only in CKD patients not requiring dialysis therapy—a meta-analysis of 11 randomized controlled trials involving 21,295 participants. Pharmacol Res 72:35–44PubMed Barylski M, Nikfar S, Mikhailidis DP, Toth PP, Salari P, Ray KK, Lipid and Blood Pressure Meta-Analysis Collaboration Group et al (2013) Statins decrease all-cause mortality only in CKD patients not requiring dialysis therapy—a meta-analysis of 11 randomized controlled trials involving 21,295 participants. Pharmacol Res 72:35–44PubMed
66.
go back to reference Banach M, Lipid, Blood Pressure Meta-Analysis Collaboration Group (2013) Statins in patients with chronic kidney disease—an attempt at recommendations. Curr Med Res Opin 29(11):1419–1422PubMed Banach M, Lipid, Blood Pressure Meta-Analysis Collaboration Group (2013) Statins in patients with chronic kidney disease—an attempt at recommendations. Curr Med Res Opin 29(11):1419–1422PubMed
67.
go back to reference Shekhar Pandey A, Bissonnette S, Boukas S, Rampakakis E, Sampalis JS (2011) Effectiveness and tolerability of ezetimibe co-administered with statins versus statin dose-doubling in high-risk patients with persistent hyperlipidemia: the EZE(STAT)2 trial. Arch Med Sci 7(5):767–775PubMedPubMedCentral Shekhar Pandey A, Bissonnette S, Boukas S, Rampakakis E, Sampalis JS (2011) Effectiveness and tolerability of ezetimibe co-administered with statins versus statin dose-doubling in high-risk patients with persistent hyperlipidemia: the EZE(STAT)2 trial. Arch Med Sci 7(5):767–775PubMedPubMedCentral
68.
go back to reference Huijgen R, Boekholdt SM, Arsenault BJ, Bao W, Davaine JM, Tabet F et al (2012) Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) trial: a nested case-control study. J Am Coll Cardiol 59(20):1778–1784PubMed Huijgen R, Boekholdt SM, Arsenault BJ, Bao W, Davaine JM, Tabet F et al (2012) Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) trial: a nested case-control study. J Am Coll Cardiol 59(20):1778–1784PubMed
69.
go back to reference Stein EA, Raal FJ (2013) Insights into PCSK9, low-density lipoprotein receptor, and low-density lipoprotein cholesterol metabolism: of mice and man. Circulation 127(24):2372–2374PubMed Stein EA, Raal FJ (2013) Insights into PCSK9, low-density lipoprotein receptor, and low-density lipoprotein cholesterol metabolism: of mice and man. Circulation 127(24):2372–2374PubMed
70.
go back to reference Luna Saavedra YG, Zhang J, Seidah NG (2013) PCSK9 prosegment chimera as novel inhibitors of LDLR degradation. PloS One 8(8):e72113PubMedPubMedCentral Luna Saavedra YG, Zhang J, Seidah NG (2013) PCSK9 prosegment chimera as novel inhibitors of LDLR degradation. PloS One 8(8):e72113PubMedPubMedCentral
71.
go back to reference Poirier S, Mayer G (2013) The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol. Drug Des Devel Ther 7:1135–1148PubMedPubMedCentral Poirier S, Mayer G (2013) The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol. Drug Des Devel Ther 7:1135–1148PubMedPubMedCentral
72.
go back to reference Banach M, Rizzo M, Obradovic M, Montalto G, Rysz J, Mikhailidis DP et al (2013) PCSK9 inhibition—a novel mechanism to treat lipid disorders? Curr Pharm Des 19(21):3869–3877PubMed Banach M, Rizzo M, Obradovic M, Montalto G, Rysz J, Mikhailidis DP et al (2013) PCSK9 inhibition—a novel mechanism to treat lipid disorders? Curr Pharm Des 19(21):3869–3877PubMed
73.
go back to reference Mayne J, Ooi TC, Raymond A, Cousins M, Bernier L, Dewpura T et al (2013) Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations. Lipids Health Dis 12:70PubMedPubMedCentral Mayne J, Ooi TC, Raymond A, Cousins M, Bernier L, Dewpura T et al (2013) Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations. Lipids Health Dis 12:70PubMedPubMedCentral
74.
go back to reference Canuel M, Sun X, Asselin MC, Paramithiotis E, Prat A, Seidah NG (2013) Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1). PLoS One 8(5):e64145PubMedPubMedCentral Canuel M, Sun X, Asselin MC, Paramithiotis E, Prat A, Seidah NG (2013) Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1). PLoS One 8(5):e64145PubMedPubMedCentral
75.
go back to reference Catapano AL, Papadopoulos N (2013) The safety of therapeutic monoclonal antibodies: implications for cardiovascular disease and targeting the PCSK9 pathway. Atherosclerosis 228(1):18–28PubMed Catapano AL, Papadopoulos N (2013) The safety of therapeutic monoclonal antibodies: implications for cardiovascular disease and targeting the PCSK9 pathway. Atherosclerosis 228(1):18–28PubMed
76.
go back to reference Desai NR, Kohli P, Giugliano RP, O’Donoghue ML, Somaratne R, Zhou J, Hoffman EB, Huang F, Rogers WJ, Wasserman SM, Scott R, Sabatine MS (2013) AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-C Assessment with Proprotein Convertase Subtilisin Kexin Type 9 Monoclonal Antibody Inhibition Combined with Statin Therapy (LAPLACE)-Thrombolysis in Myocardial Infarction (TIMI) 57 trial. Circulation 128(9):962–969PubMed Desai NR, Kohli P, Giugliano RP, O’Donoghue ML, Somaratne R, Zhou J, Hoffman EB, Huang F, Rogers WJ, Wasserman SM, Scott R, Sabatine MS (2013) AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-C Assessment with Proprotein Convertase Subtilisin Kexin Type 9 Monoclonal Antibody Inhibition Combined with Statin Therapy (LAPLACE)-Thrombolysis in Myocardial Infarction (TIMI) 57 trial. Circulation 128(9):962–969PubMed
77.
go back to reference Koren MJ, Scott R, Kim JB, Knusel B, Liu T, Lei L, Bolognese M, Wasserman SM (2012) Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study. Lancet 380(9858):1995–2006PubMed Koren MJ, Scott R, Kim JB, Knusel B, Liu T, Lei L, Bolognese M, Wasserman SM (2012) Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study. Lancet 380(9858):1995–2006PubMed
78.
go back to reference Sullivan D, Olsson AG, Scott R, Kim JB, Xue A, Gebski V, Wasserman SM, Stein EA (2012) Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial. JAMA 308(23):2497–2506PubMed Sullivan D, Olsson AG, Scott R, Kim JB, Xue A, Gebski V, Wasserman SM, Stein EA (2012) Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial. JAMA 308(23):2497–2506PubMed
79.
go back to reference Aronow WS, Fleg JL, Pepine CJ et al (2011) ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Developed in collaboration with the American Academy of Neurology, American Geriatrics Society, American Society for Preventive Cardiology, American Society of Hypertension, American Society of Nephrology, Association of Black Cardiologists, and European Society of Hypertension. J Am Coll Cardiol 57:2037–2114PubMed Aronow WS, Fleg JL, Pepine CJ et al (2011) ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Developed in collaboration with the American Academy of Neurology, American Geriatrics Society, American Society for Preventive Cardiology, American Society of Hypertension, American Society of Nephrology, Association of Black Cardiologists, and European Society of Hypertension. J Am Coll Cardiol 57:2037–2114PubMed
80.
go back to reference Beckett NS, Peters R, Fletcher AE et al (2008) Treatment of hypertension in patients 80 years of age or older. N Eng J Med 358:1887–1898 Beckett NS, Peters R, Fletcher AE et al (2008) Treatment of hypertension in patients 80 years of age or older. N Eng J Med 358:1887–1898
81.
go back to reference Aronow WS (2011) Hypertension guidelines. Hypertension 58:347–348PubMed Aronow WS (2011) Hypertension guidelines. Hypertension 58:347–348PubMed
82.
go back to reference Aronow WS, Banach M (2012) Ten most important things to learn from the ACCF/AHA 2011 expert consensus document on hypertension in the elderly. Blood Press 21:3–5PubMed Aronow WS, Banach M (2012) Ten most important things to learn from the ACCF/AHA 2011 expert consensus document on hypertension in the elderly. Blood Press 21:3–5PubMed
83.
go back to reference Banach M, Michalska M, Kjeldsen SE et al (2011) What should be the optimal levels of blood pressure: does the J-curve phenomenon really exist? Expert Opin Pharmacother 12:1835–1844PubMed Banach M, Michalska M, Kjeldsen SE et al (2011) What should be the optimal levels of blood pressure: does the J-curve phenomenon really exist? Expert Opin Pharmacother 12:1835–1844PubMed
84.
go back to reference Aronow WS (2012) What should the optimal blood pressure goal be in patients with diabetes mellitus or chronic kidney disease? Arch Med Sci 8:399–402PubMedPubMedCentral Aronow WS (2012) What should the optimal blood pressure goal be in patients with diabetes mellitus or chronic kidney disease? Arch Med Sci 8:399–402PubMedPubMedCentral
85.
go back to reference Banach M, Aronow WS (2011) Should we have any doubts about hypertension therapy in elderly patients. ACCF/AHA 2011 expert consensus document on hypertension in the elderly. Pol Arch Med Wewn 2011(121):253–258 Banach M, Aronow WS (2011) Should we have any doubts about hypertension therapy in elderly patients. ACCF/AHA 2011 expert consensus document on hypertension in the elderly. Pol Arch Med Wewn 2011(121):253–258
86.
go back to reference Aronow WS (2014) Ten key points from the American College of Cardiology Foundation/American Heart Association 2011 expert consensus document on hypertension in the elderly. Am J Therap. doi:10.1097/MJT.Ob013e3182217894 Aronow WS (2014) Ten key points from the American College of Cardiology Foundation/American Heart Association 2011 expert consensus document on hypertension in the elderly. Am J Therap. doi:10.​1097/​MJT.​Ob013e3182217894​
88.
go back to reference Banach M, Aronow WS (2012) Hypertension therapy in the elderly-do we know the answers to all the questions? The status after publication of the ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly. J Hum Hypertens 26:641–643PubMed Banach M, Aronow WS (2012) Hypertension therapy in the elderly-do we know the answers to all the questions? The status after publication of the ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly. J Hum Hypertens 26:641–643PubMed
89.
go back to reference Barylski M, Malyszko J, Rysz J et al (2011) Lipids, blood pressure, kidney-what was new in 2011? Arch Med Sci 7:1055–1066PubMedPubMedCentral Barylski M, Malyszko J, Rysz J et al (2011) Lipids, blood pressure, kidney-what was new in 2011? Arch Med Sci 7:1055–1066PubMedPubMedCentral
90.
go back to reference Egan BM, Li J, Qanungo S, Wolfman TE (2013) Blood pressure and cholesterol control in hypertensive hypercholesterolemic patients: national health and nutrition examination surveys 1988–2010. Circulation 128(1):29–41PubMed Egan BM, Li J, Qanungo S, Wolfman TE (2013) Blood pressure and cholesterol control in hypertensive hypercholesterolemic patients: national health and nutrition examination surveys 1988–2010. Circulation 128(1):29–41PubMed
91.
go back to reference Rizzo M, Montalto G, Banach M (2012) The effects of statins on blood pressure: current knowledge and future perspectives. Arch Med Sci 8:1–3PubMedPubMedCentral Rizzo M, Montalto G, Banach M (2012) The effects of statins on blood pressure: current knowledge and future perspectives. Arch Med Sci 8:1–3PubMedPubMedCentral
92.
go back to reference Gharipour M, Kelishadi R, Khosravi A et al (2012) The impact of a community trial on the pharmacological treatment in the individuals with the metabolic syndrome: findings from the Isfahan Healthy Heart Program, 2001–2007. Arch Med Sci 8:1009–1017PubMedPubMedCentral Gharipour M, Kelishadi R, Khosravi A et al (2012) The impact of a community trial on the pharmacological treatment in the individuals with the metabolic syndrome: findings from the Isfahan Healthy Heart Program, 2001–2007. Arch Med Sci 8:1009–1017PubMedPubMedCentral
93.
go back to reference Malyszko J, Bachorzewska-Gajewska H, Malyszko J et al (2011) Markers of kidney function in the elderly in relation to the new CKD-EPI formula for estimation of glomerular filtration rate. Arch Med Sci 7:658–664PubMedPubMedCentral Malyszko J, Bachorzewska-Gajewska H, Malyszko J et al (2011) Markers of kidney function in the elderly in relation to the new CKD-EPI formula for estimation of glomerular filtration rate. Arch Med Sci 7:658–664PubMedPubMedCentral
94.
go back to reference Gluba A, Bielecka-Dabrowa A, Mikhailidis DP, Wong ND, Franklin SS, Rysz J, Banach M (2012) An update on biomarkers of heart failure in hypertensive patients. J Hypertens 30(9):1681–1689PubMed Gluba A, Bielecka-Dabrowa A, Mikhailidis DP, Wong ND, Franklin SS, Rysz J, Banach M (2012) An update on biomarkers of heart failure in hypertensive patients. J Hypertens 30(9):1681–1689PubMed
95.
go back to reference Mozdzan M, Wierzbowska-Drabik K, Kurpesa M et al (2013) Echocardiographic indices of left ventricular hypertrophy and diastolic function in hypertensive patients with preserved LVEF classified as dippers and non-dippers. Arch Med Sci 9:268–275PubMedPubMedCentral Mozdzan M, Wierzbowska-Drabik K, Kurpesa M et al (2013) Echocardiographic indices of left ventricular hypertrophy and diastolic function in hypertensive patients with preserved LVEF classified as dippers and non-dippers. Arch Med Sci 9:268–275PubMedPubMedCentral
96.
go back to reference Bielecka-Dabrowa A, Aronow WS, Rysz J, Banach M (2011) The Rise and Fall of Hypertension: lessons Learned from Eastern Europe. Curr Cardiovasc Risk Rep 5(2):174–179PubMedPubMedCentral Bielecka-Dabrowa A, Aronow WS, Rysz J, Banach M (2011) The Rise and Fall of Hypertension: lessons Learned from Eastern Europe. Curr Cardiovasc Risk Rep 5(2):174–179PubMedPubMedCentral
97.
go back to reference Dorobanţu M, Darabont R, Ghiorghe S, Arsenescu-Georgescu C, Macarie C, Mitu F, Lighezan D, Musetescu R, Pop C, Ardeleanu E, Craiu E (2014) T Latin Small Letter A With Caron Utu OF. Hypertension prevalence and control in Romania at a seven-year interval. Comparison of SEPHAR I and II surveys. J Hypertens 32(1):39–47PubMed Dorobanţu M, Darabont R, Ghiorghe S, Arsenescu-Georgescu C, Macarie C, Mitu F, Lighezan D, Musetescu R, Pop C, Ardeleanu E, Craiu E (2014) T Latin Small Letter A With Caron Utu OF. Hypertension prevalence and control in Romania at a seven-year interval. Comparison of SEPHAR I and II surveys. J Hypertens 32(1):39–47PubMed
98.
go back to reference Stępień M, Wlazeł RN, Paradowski M, Banach M, Rysz M, Misztal M, Rysz J (2012) Serum concentrations of adiponectin, leptin, resistin, ghrelin and insulin and their association with obesity indices in obese normo- and hypertensive patients—pilot study. Arch Med Sci 8(3):431–436PubMedPubMedCentral Stępień M, Wlazeł RN, Paradowski M, Banach M, Rysz M, Misztal M, Rysz J (2012) Serum concentrations of adiponectin, leptin, resistin, ghrelin and insulin and their association with obesity indices in obese normo- and hypertensive patients—pilot study. Arch Med Sci 8(3):431–436PubMedPubMedCentral
99.
go back to reference Jaffe MG, Lee GA, Young JD et al (2013) Improved blood pressure control associated with a large-scale hypertension program. JAMA 310:699–705PubMed Jaffe MG, Lee GA, Young JD et al (2013) Improved blood pressure control associated with a large-scale hypertension program. JAMA 310:699–705PubMed
100.
go back to reference Liu L, An Y, Chen M et al (2013) Trends in the prevalence of hospitalization attributable to hypertensive diseases among United States adults aged 35 and older from 1980 to 2007. Am J Cardiol 112:694–699PubMed Liu L, An Y, Chen M et al (2013) Trends in the prevalence of hospitalization attributable to hypertensive diseases among United States adults aged 35 and older from 1980 to 2007. Am J Cardiol 112:694–699PubMed
101.
go back to reference Juhola J, Magnussen CG, Berenson GS et al (2013) Combined effects of child and adult elevated blood pressure on subclinical atherosclerosis. The International Childhood Cardiovascular Cohort Consortium. Circulation 128:217–224PubMed Juhola J, Magnussen CG, Berenson GS et al (2013) Combined effects of child and adult elevated blood pressure on subclinical atherosclerosis. The International Childhood Cardiovascular Cohort Consortium. Circulation 128:217–224PubMed
102.
go back to reference The SPS3 Study Group (2013) Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial. Lancet 382:507–515 The SPS3 Study Group (2013) Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial. Lancet 382:507–515
103.
go back to reference Zanchetti A, Liu L, Mancia G, Parati G, Grassi G, Stramba-Badiale M et al (2013) Stroke in hypertension optimal treatment (SHOT) trial: protocol and organization. J Hypertens 31(e-Suppl A):e255 Zanchetti A, Liu L, Mancia G, Parati G, Grassi G, Stramba-Badiale M et al (2013) Stroke in hypertension optimal treatment (SHOT) trial: protocol and organization. J Hypertens 31(e-Suppl A):e255
104.
go back to reference Malyszko J, Muntner P, Rysz J, Banach M (2013) Blood pressure levels and stroke—J-curve phenomenon? Curr Hypertens Rep 15(6):575–581 Malyszko J, Muntner P, Rysz J, Banach M (2013) Blood pressure levels and stroke—J-curve phenomenon? Curr Hypertens Rep 15(6):575–581
105.
go back to reference Siebert J, Gutknecht P, Molisz A, Trzeciak B, Nyka W (2012) Hemodynamic findings in patients with brain stroke. Arch Med Sci 8(2):371–374PubMedPubMedCentral Siebert J, Gutknecht P, Molisz A, Trzeciak B, Nyka W (2012) Hemodynamic findings in patients with brain stroke. Arch Med Sci 8(2):371–374PubMedPubMedCentral
106.
go back to reference American Diabetes Association. Position statement. Standards of Medical Care in Diabetes-2013. Diabetes Care 2013; 36(Suppl 1):S11–S66 American Diabetes Association. Position statement. Standards of Medical Care in Diabetes-2013. Diabetes Care 2013; 36(Suppl 1):S11–S66
107.
go back to reference KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Chapter 3. Blood pressure management in CKD ND patients without diabetes mellitus. Kidney Int Suppl 2:357–362 (2012) KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Chapter 3. Blood pressure management in CKD ND patients without diabetes mellitus. Kidney Int Suppl 2:357–362 (2012)
108.
go back to reference KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Chapter 4. Blood pressure management in CKD ND patients with diabetes mellitus. Kidney Int Suppl 2:363–369 (2012) KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Chapter 4. Blood pressure management in CKD ND patients with diabetes mellitus. Kidney Int Suppl 2:363–369 (2012)
109.
go back to reference Mancia G, Fagard R, Narkiewicz K et al (2013) 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 31:1281–1357PubMed Mancia G, Fagard R, Narkiewicz K et al (2013) 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 31:1281–1357PubMed
110.
go back to reference Gowin E, Avonts D, Horst-Sikorska W, Dytfeld J, Michalak M (2012) Stimulating preventive procedures in primary care. Effect of PIUPOZ program on the delivery of preventive procedures. Arch Med Sci 8(4):704–710PubMedPubMedCentral Gowin E, Avonts D, Horst-Sikorska W, Dytfeld J, Michalak M (2012) Stimulating preventive procedures in primary care. Effect of PIUPOZ program on the delivery of preventive procedures. Arch Med Sci 8(4):704–710PubMedPubMedCentral
111.
go back to reference Alagiakrishnan K, Banach M, Jones LG, Ahmed A, Aronow WS (2013) Medication management of chronic heart failure in older adults. Drugs Aging 30(10):765–782PubMed Alagiakrishnan K, Banach M, Jones LG, Ahmed A, Aronow WS (2013) Medication management of chronic heart failure in older adults. Drugs Aging 30(10):765–782PubMed
112.
go back to reference Rogowicz-Frontczak A, Araszkiewicz A, Pilacinski S, Zozulinska-Ziolkiewicz D, Wykretowicz A, Wierusz-Wysocka B (2012) Carotid intima-media thickness and arterial stiffness in type 1 diabetic patients with and without microangiopathy. Arch Med Sci 8:484–490PubMedPubMedCentral Rogowicz-Frontczak A, Araszkiewicz A, Pilacinski S, Zozulinska-Ziolkiewicz D, Wykretowicz A, Wierusz-Wysocka B (2012) Carotid intima-media thickness and arterial stiffness in type 1 diabetic patients with and without microangiopathy. Arch Med Sci 8:484–490PubMedPubMedCentral
113.
go back to reference Chandy D, Aronow WS, Banach M (2013) Current perspectives on treatment of hypertensive patients with chronic obstructive pulmonary disease. Integr Blood Press Control 6:101–109PubMedPubMedCentral Chandy D, Aronow WS, Banach M (2013) Current perspectives on treatment of hypertensive patients with chronic obstructive pulmonary disease. Integr Blood Press Control 6:101–109PubMedPubMedCentral
114.
go back to reference Banach M, Bromfield S, Howard G et al (2013) Optimal blood pressure levels in elderly persons in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study. Presented at 2013 European Society of Cardiology (ESC) Meeting, Amsterdam, The Netherlands Banach M, Bromfield S, Howard G et al (2013) Optimal blood pressure levels in elderly persons in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort study. Presented at 2013 European Society of Cardiology (ESC) Meeting, Amsterdam, The Netherlands
115.
go back to reference James PA, Oparil S, Carter BL et al (2013) 2014 Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth joint national committee (JNC 8). JAMA. doi:10.1001/jama.2013.284427 James PA, Oparil S, Carter BL et al (2013) 2014 Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth joint national committee (JNC 8). JAMA. doi:10.​1001/​jama.​2013.​284427
116.
go back to reference Mann JF, Schmieder RE, McQueen M, ONTARGET Investigators et al (2008) Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 372(9638):547–553PubMed Mann JF, Schmieder RE, McQueen M, ONTARGET Investigators et al (2008) Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 372(9638):547–553PubMed
117.
go back to reference Parving HH, Brenner BM, McMurray JJ, ALTITUDE Investigators et al (2012) Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med 367(23):2204–2213PubMed Parving HH, Brenner BM, McMurray JJ, ALTITUDE Investigators et al (2012) Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med 367(23):2204–2213PubMed
118.
go back to reference Fried LF, Emanuele N, Zhang JH, VA NEPHRON-D Investigators et al (2013) Combined angiotensin inhibition for the treatment of diabetic nephropathy. N Engl J Med 369(20):1892–1903PubMed Fried LF, Emanuele N, Zhang JH, VA NEPHRON-D Investigators et al (2013) Combined angiotensin inhibition for the treatment of diabetic nephropathy. N Engl J Med 369(20):1892–1903PubMed
119.
go back to reference Weber MA, Schiffrin EL, White WB et al (2014) Clinical practice guidelines for the management of hypertension in the community: a statement by the American society of hypertension and the international society of hypertension. J Clin Hypertens (Greenwich) 16(1):14–26 Weber MA, Schiffrin EL, White WB et al (2014) Clinical practice guidelines for the management of hypertension in the community: a statement by the American society of hypertension and the international society of hypertension. J Clin Hypertens (Greenwich) 16(1):14–26
120.
go back to reference ASTRAL Investigators, Wheatley K, Ives N, Gray R et al (2009) Revascularization versus medical therapy for renal-artery stenosis. N Engl J Med 361(20):1953–1962PubMed ASTRAL Investigators, Wheatley K, Ives N, Gray R et al (2009) Revascularization versus medical therapy for renal-artery stenosis. N Engl J Med 361(20):1953–1962PubMed
121.
go back to reference Bax L, Woittiez AJ, Kouwenberg HJ et al (2009) Stent placement in patients with atherosclerotic renal artery stenosis and impaired renal function: a randomized trial. Ann Intern Med 150(12):840–848 (W150-1)PubMed Bax L, Woittiez AJ, Kouwenberg HJ et al (2009) Stent placement in patients with atherosclerotic renal artery stenosis and impaired renal function: a randomized trial. Ann Intern Med 150(12):840–848 (W150-1)PubMed
122.
go back to reference Cooper CJ, Murphy TP, Cutlip DE, CORAL Investigators et al (2014) Stenting and medical therapy for atherosclerotic renal-artery stenosis. N Engl J Med 370(1):13–22PubMed Cooper CJ, Murphy TP, Cutlip DE, CORAL Investigators et al (2014) Stenting and medical therapy for atherosclerotic renal-artery stenosis. N Engl J Med 370(1):13–22PubMed
123.
go back to reference Krum H, Schlaich M, Whitbourn R et al (2009) Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373(9671):1275–1281PubMed Krum H, Schlaich M, Whitbourn R et al (2009) Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373(9671):1275–1281PubMed
124.
go back to reference Esler MD, Krum H, Schlaich M, Symplicity HTN-2 Investigators et al (2012) Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial. Circulation 126(25):2976–2982PubMed Esler MD, Krum H, Schlaich M, Symplicity HTN-2 Investigators et al (2012) Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial. Circulation 126(25):2976–2982PubMed
127.
go back to reference Qaseem A, Hopkins RH, Sweet DE, Starkey M, Shekelle P (2013) Screening, monitoring, and treatment of stage 1 to 3 chronic kidney disease: a clinical practice guideline from the clinical guidelines committee of the American college of physicians. Ann Intern Med. doi:10.7326/0003-4819-159-12-201312170-00726 Qaseem A, Hopkins RH, Sweet DE, Starkey M, Shekelle P (2013) Screening, monitoring, and treatment of stage 1 to 3 chronic kidney disease: a clinical practice guideline from the clinical guidelines committee of the American college of physicians. Ann Intern Med. doi:10.​7326/​0003-4819-159-12-201312170-00726
129.
go back to reference Delmez JA, Slatopolsky E et al (1992) Hyperphosphatemia: its consequences and treatment in patients with chronic renal disease. Am J Kidney Dis 19(4):303PubMed Delmez JA, Slatopolsky E et al (1992) Hyperphosphatemia: its consequences and treatment in patients with chronic renal disease. Am J Kidney Dis 19(4):303PubMed
130.
go back to reference Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group (2009) KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl S1 Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group (2009) KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl S1
131.
go back to reference Jamal SA, Vandermeer B, Raggi P, Mendelssohn DC, Chatterley T, Dorgan M, Lok CE, Fitchett D, Tsuyuki RT (2013) Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis. Lancet 382(9900):1268PubMed Jamal SA, Vandermeer B, Raggi P, Mendelssohn DC, Chatterley T, Dorgan M, Lok CE, Fitchett D, Tsuyuki RT (2013) Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis. Lancet 382(9900):1268PubMed
132.
go back to reference Locatelli F, Dimkovic N, Pontoriero G et al (2010) Effect of MCI-196 on serum phosphate and cholesterol levels in haemodialysis patients with hyperphosphataemia: a double-blind, randomized, placebo-controlled study. Nephrol Dial Transpl 25:574–581 Locatelli F, Dimkovic N, Pontoriero G et al (2010) Effect of MCI-196 on serum phosphate and cholesterol levels in haemodialysis patients with hyperphosphataemia: a double-blind, randomized, placebo-controlled study. Nephrol Dial Transpl 25:574–581
133.
go back to reference Wüthrich RP, Chonchol M, Covic A et al (2013) Randomized clinical trial of the iron-based phosphate binder PA21 in hemodialysis patients. Clin J Am Soc Nephrol 8:280–289PubMedPubMedCentral Wüthrich RP, Chonchol M, Covic A et al (2013) Randomized clinical trial of the iron-based phosphate binder PA21 in hemodialysis patients. Clin J Am Soc Nephrol 8:280–289PubMedPubMedCentral
134.
go back to reference Dwyer JP, Sika M, Schulman G et al (2013) Collaborative Study GroupDose-response and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: a short-term randomized trial. Am J Kidney Dis 61:759–766PubMed Dwyer JP, Sika M, Schulman G et al (2013) Collaborative Study GroupDose-response and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: a short-term randomized trial. Am J Kidney Dis 61:759–766PubMed
135.
go back to reference Asif A, Epstein M et al (2004) Prevention of radiocontrast-induced nephropathy. Am J Kidney Dis 44(1):12PubMed Asif A, Epstein M et al (2004) Prevention of radiocontrast-induced nephropathy. Am J Kidney Dis 44(1):12PubMed
136.
go back to reference Garlid KD, Costa ADT, Quinlan CL, Pierre SV, Dos Santos P (2009) Cardioprotective signaling to mitochondria. J Mol Cell Cardiol 46:858–866PubMedPubMedCentral Garlid KD, Costa ADT, Quinlan CL, Pierre SV, Dos Santos P (2009) Cardioprotective signaling to mitochondria. J Mol Cell Cardiol 46:858–866PubMedPubMedCentral
137.
go back to reference Er F, Nia AM, Dopp H, Hellmich M, Dahlem KM, Caglayan E, Kubacki T, Benzing T, Erdmann E, Burst V, Gassanov N (2012) Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized pilot RenPro Trial (Renal Protection Trial). Circulation 126(3):296PubMed Er F, Nia AM, Dopp H, Hellmich M, Dahlem KM, Caglayan E, Kubacki T, Benzing T, Erdmann E, Burst V, Gassanov N (2012) Ischemic preconditioning for prevention of contrast medium-induced nephropathy: randomized pilot RenPro Trial (Renal Protection Trial). Circulation 126(3):296PubMed
138.
go back to reference Deftereos S, Giannopoulos G, Tzalamouras V, Raisakis K et al (2013) Renoprotective effect of remote ischemic post-conditioning by intermittent balloon inflations in patients undergoing percutaneous coronary intervention. J Am Coll Cardiol 61(19):1949–1955 (Epub 2013 Mar 14)PubMed Deftereos S, Giannopoulos G, Tzalamouras V, Raisakis K et al (2013) Renoprotective effect of remote ischemic post-conditioning by intermittent balloon inflations in patients undergoing percutaneous coronary intervention. J Am Coll Cardiol 61(19):1949–1955 (Epub 2013 Mar 14)PubMed
140.
go back to reference Sterns RH, Rojas M, Bernstein P, Chennupati S (2010) Ion-exchange resins for the treatment of hyperkalemia: are they safe and effective? J Am Soc Nephrol 21(5):733–735PubMed Sterns RH, Rojas M, Bernstein P, Chennupati S (2010) Ion-exchange resins for the treatment of hyperkalemia: are they safe and effective? J Am Soc Nephrol 21(5):733–735PubMed
143.
go back to reference Stead RB, Lambert J, Wessels D, Iwashita JS, Leuther KK, Woodburn KW, Schatz PJ, Okamoto DM, Naso R, Duliege AM (2006) Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers. Blood 108(6):1830–1834PubMed Stead RB, Lambert J, Wessels D, Iwashita JS, Leuther KK, Woodburn KW, Schatz PJ, Okamoto DM, Naso R, Duliege AM (2006) Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers. Blood 108(6):1830–1834PubMed
144.
go back to reference Yao S (2012) FDA approves Omontys to treat anemia in adult patients on dialysis (press release). US FDA. Retrieved April 29, 2012 Yao S (2012) FDA approves Omontys to treat anemia in adult patients on dialysis (press release). US FDA. Retrieved April 29, 2012
145.
go back to reference Fishbane S, Schiller B, Locatelli F, Covic AC, Provenzano R, Wiecek A, Levin NW, Kaplan M, Macdougall IC, Francisco C, Mayo MR, Polu KR, Duliege AM, Besarab A (2013) Peginesatide in patients with anemia undergoing hemodialysis. N Engl J Med 368(4):307–319PubMed Fishbane S, Schiller B, Locatelli F, Covic AC, Provenzano R, Wiecek A, Levin NW, Kaplan M, Macdougall IC, Francisco C, Mayo MR, Polu KR, Duliege AM, Besarab A (2013) Peginesatide in patients with anemia undergoing hemodialysis. N Engl J Med 368(4):307–319PubMed
146.
go back to reference Macdougall IC, Provenzano R, Sharma A, Spinowitz BS, Schmidt RJ, Pergola PE, Zabaneh RI, Tong-Starksen S, Mayo MR, Tang H, Polu KR, Duliege AM, Fishbane S (2013) Peginesatide for anemia in patients with chronic kidney disease not receiving dialysis. N Engl J Med 368(4):320–332PubMed Macdougall IC, Provenzano R, Sharma A, Spinowitz BS, Schmidt RJ, Pergola PE, Zabaneh RI, Tong-Starksen S, Mayo MR, Tang H, Polu KR, Duliege AM, Fishbane S (2013) Peginesatide for anemia in patients with chronic kidney disease not receiving dialysis. N Engl J Med 368(4):320–332PubMed
147.
go back to reference Torres VE, Chapman AB, Devuyst O et al (2012) Tolvaptan in patients with autosomal dominant polycystic kidney disease. N Engl J Med 367:2407PubMedPubMedCentral Torres VE, Chapman AB, Devuyst O et al (2012) Tolvaptan in patients with autosomal dominant polycystic kidney disease. N Engl J Med 367:2407PubMedPubMedCentral
148.
go back to reference Hussain JA, Mooney A, Russon L et al (2013) Comparison of survival analysis and palliative care involvement in patients aged over 70 years choosing conservative management or renal replacement therapy in advanced chronic kidney disease. Palliat Med 27(9):829–839PubMed Hussain JA, Mooney A, Russon L et al (2013) Comparison of survival analysis and palliative care involvement in patients aged over 70 years choosing conservative management or renal replacement therapy in advanced chronic kidney disease. Palliat Med 27(9):829–839PubMed
149.
go back to reference Hirsch HH, Knowles W, Dickenmann M, Passweg J, Klimkait T, Mihatsch MJ, Steiger J (2002) Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 347(7):488PubMed Hirsch HH, Knowles W, Dickenmann M, Passweg J, Klimkait T, Mihatsch MJ, Steiger J (2002) Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 347(7):488PubMed
150.
go back to reference Hirsch HH, Vincenti F, Friman S et al (2013) Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cysclosporine: a prospective, randomized, multicenter study. Am J Transpl 13(1):136–145 Hirsch HH, Vincenti F, Friman S et al (2013) Polyomavirus BK replication in de novo kidney transplant patients receiving tacrolimus or cysclosporine: a prospective, randomized, multicenter study. Am J Transpl 13(1):136–145
151.
go back to reference Acott PD, O’Regan PA, Lee HS, Crocke JF (2008) In vitro effect of cyclosporine A on primary and chronic BK polyoma virus infection in Vero E6 cells. Transpl Infect Dis 10:385–390PubMed Acott PD, O’Regan PA, Lee HS, Crocke JF (2008) In vitro effect of cyclosporine A on primary and chronic BK polyoma virus infection in Vero E6 cells. Transpl Infect Dis 10:385–390PubMed
152.
go back to reference Pereyra F, Rubin RH (2004) Prevention and treatment of cytomegalovirus infection in solid organ transplant recipients. Curr Opin Infect Dis 17(4):357PubMed Pereyra F, Rubin RH (2004) Prevention and treatment of cytomegalovirus infection in solid organ transplant recipients. Curr Opin Infect Dis 17(4):357PubMed
153.
go back to reference Kotton CN, Kumar D, Caliendo AM et al (2013) Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation. Transplantation 96:333–360PubMed Kotton CN, Kumar D, Caliendo AM et al (2013) Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation. Transplantation 96:333–360PubMed
Metadata
Title
Lipid, blood pressure and kidney update 2013
Authors
Maciej Banach
Corina Serban
Wilbert S. Aronow
Jacek Rysz
Simona Dragan
Edgar V. Lerma
Mugurel Apetrii
Adrian Covic
Publication date
01-05-2014
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 5/2014
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-014-0657-6

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