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International Urology and Nephrology
Published in: International Urology and Nephrology 4/2014

01-04-2014 | Urology - Original article

Change in renal parenchymal volume in living kidney transplant donors

Authors: Turun Song, Lei Fu, Zixing Huang, Shaofeng He, Ruining Zhao, Tao Lin, Qiang Wei

Published in: International Urology and Nephrology | Issue 4/2014

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Abstract

Purpose

Uninephrectomy would induce compensatory hypertrophy in the remaining kidney. We investigated the relationship between changes in renal parenchymal volume (RPV) and renal function after nephrectomy in living kidney donors.

Methods

From July 2011 and January 2012, 45 kidney donors were enrolled in this study. Magnetic resonance scanning was performed before surgery, 3 and 7 days postoperatively, and RPV was calculated through disc summarize methods. Participants were followed up for 1 year.

Results

The RPV of the remaining kidney was 118.06 ± 23.51 cm3 and then increased by 21.23 % to 143.13 ± 25.52 cm3 at 3 days and by 24.17 % to 146.60 ± 25.86 cm3 at 7 days. Multivariate regression analysis showed that preoperative RPV is positively related to its initial function (p = 0.037); the RPV at 7 days is directly related to its initial, preoperative size (p < 0.001). With respect to change in postoperative RPV, there is bigger gain in size in smaller kidneys (p = 0.005). The kidneys that has ≥20 % increase RPV after 7 days are more likely to show further increase in GFR at 1 year (p = 0.024).

Conclusions

Uninephrectomy induced immediately increment in RPV of the remaining kidney. Donors with RPV increase of ≥20 % at 1 week have a more favourable renal function adaptation at 1 year.
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Metadata
Title
Change in renal parenchymal volume in living kidney transplant donors
Authors
Turun Song
Lei Fu
Zixing Huang
Shaofeng He
Ruining Zhao
Tao Lin
Qiang Wei
Publication date
01-04-2014
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 4/2014
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-013-0592-y

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