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Published in: International Urology and Nephrology 2/2008

01-06-2008 | Case Report

De novo nephrotic syndrome following pegylated interferon alfa 2b/ribavirin therapy for chronic hepatitis C infection

Authors: Jose L. Tovar, Maria Buti, Alfonso Segarra, Joaquim Majó, Rafael Esteban

Published in: International Urology and Nephrology | Issue 2/2008

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Abstract

This paper describes the case of a patient with HCV, without previous evidence of nephropathy, who following two well-tolerated cycles of treatment with interferon alone developed nephrotic syndrome after a third attempt with ribavirin associated with peginterferon alfa 2b. The patient exhibited a total remission when the antiviral treatment was discontinued.
Literature
1.
go back to reference Alter MJ, Kruszon-Moran D, Nainan OV et al (1999) The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Eng J Med 341:556–562CrossRef Alter MJ, Kruszon-Moran D, Nainan OV et al (1999) The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Eng J Med 341:556–562CrossRef
2.
go back to reference Kumar D, Wallington_Beddoe C, George J, Lin R, Samarasinhe D, Liddle C, Farrel G (2003) Effectiveness of interferon alfa 2b/ribavirin combination therapy for chronic hepatitis C in a clinical setting. Med J Aust 178:267–271PubMed Kumar D, Wallington_Beddoe C, George J, Lin R, Samarasinhe D, Liddle C, Farrel G (2003) Effectiveness of interferon alfa 2b/ribavirin combination therapy for chronic hepatitis C in a clinical setting. Med J Aust 178:267–271PubMed
3.
go back to reference Fried MW, Shiffman ML, Reddy RK, Smith C, Marinos G, Goncales FL et al (2002) Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 347:975–982PubMedCrossRef Fried MW, Shiffman ML, Reddy RK, Smith C, Marinos G, Goncales FL et al (2002) Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 347:975–982PubMedCrossRef
4.
go back to reference Russo MW, Fried MW (2003) Side effects of therapy for chronic hepatitis C. Gastroenterology 124:1711–1719PubMedCrossRef Russo MW, Fried MW (2003) Side effects of therapy for chronic hepatitis C. Gastroenterology 124:1711–1719PubMedCrossRef
5.
go back to reference Willson RA (2002) Nephrotoxicity of interferon alfa-ribavirin therapy for chronic hepatitis C. J Clin Gastroenterol 35:89–92PubMedCrossRef Willson RA (2002) Nephrotoxicity of interferon alfa-ribavirin therapy for chronic hepatitis C. J Clin Gastroenterol 35:89–92PubMedCrossRef
6.
go back to reference Bruchfeld A, Lindahl K, Stale L, Söderberg M, Schvarcz R (2003) Interferon and ribavirin treatment in patients with hepatitis C-associated renal disease and renal insufficiency. Nephrol Dial Transplant 18:1573–1580PubMedCrossRef Bruchfeld A, Lindahl K, Stale L, Söderberg M, Schvarcz R (2003) Interferon and ribavirin treatment in patients with hepatitis C-associated renal disease and renal insufficiency. Nephrol Dial Transplant 18:1573–1580PubMedCrossRef
7.
go back to reference Covic A , Maftei I-D, Mardare NGI et al (2006) Analysis of safety and efficacy of pegylated-interferon alpha-2a in hepatitis C virus positive hemodyalisis patients: results from a large, multicenter audit. J Nephrol 19:794–801PubMed Covic A , Maftei I-D, Mardare NGI et al (2006) Analysis of safety and efficacy of pegylated-interferon alpha-2a in hepatitis C virus positive hemodyalisis patients: results from a large, multicenter audit. J Nephrol 19:794–801PubMed
8.
go back to reference Gluud C, Gluud LL, Brok J (2006) Ribavirin monotherapy for chronic hepatitis C infection: a Chochrane hepato-biliary group systematic review and meta-analysis of randomised trials. Am J Gastroenrol 101:842–847CrossRef Gluud C, Gluud LL, Brok J (2006) Ribavirin monotherapy for chronic hepatitis C infection: a Chochrane hepato-biliary group systematic review and meta-analysis of randomised trials. Am J Gastroenrol 101:842–847CrossRef
9.
go back to reference D’Amico G (1998) Renal involvement in hepatitis C infection: cryoglobulinemic glomerulonephritis. Kidney Int 54:650–671PubMedCrossRef D’Amico G (1998) Renal involvement in hepatitis C infection: cryoglobulinemic glomerulonephritis. Kidney Int 54:650–671PubMedCrossRef
10.
go back to reference Ohta S, Yokoyama H, Wada T et al (1999) Exacerbation of glomerulonephritis in subjects with chronic hepatitis C virus infection and interferon therapy. Am J Kidney Dis 33:1040–1048PubMedCrossRef Ohta S, Yokoyama H, Wada T et al (1999) Exacerbation of glomerulonephritis in subjects with chronic hepatitis C virus infection and interferon therapy. Am J Kidney Dis 33:1040–1048PubMedCrossRef
11.
go back to reference Clive DM, Stoff JS (1984) Renal syndromes associated with nonsteroidal antiinflamatory drugs. N Engl J Med 310:663–572CrossRef Clive DM, Stoff JS (1984) Renal syndromes associated with nonsteroidal antiinflamatory drugs. N Engl J Med 310:663–572CrossRef
12.
go back to reference Schlam SW, Hanson BE, Chemello L et al (1997) Ribavirin enhances the efficacy but not the adverse effects of interferon in chronic hepatitis C: meta-analysis of individual patient data from European centers. J Hepatol 26:961–966CrossRef Schlam SW, Hanson BE, Chemello L et al (1997) Ribavirin enhances the efficacy but not the adverse effects of interferon in chronic hepatitis C: meta-analysis of individual patient data from European centers. J Hepatol 26:961–966CrossRef
13.
go back to reference Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD et al (2001) Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358:958–965PubMedCrossRef Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD et al (2001) Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358:958–965PubMedCrossRef
14.
go back to reference Izzedine H, Lanuay-Vacher V, Bourry E et al (2006) Drug-induced glomerulopathies. Expert Opin Drug Saf 5:1–12CrossRef Izzedine H, Lanuay-Vacher V, Bourry E et al (2006) Drug-induced glomerulopathies. Expert Opin Drug Saf 5:1–12CrossRef
15.
go back to reference Brok J, Gluud LL, Gluud C (2005) Effects of adding ribavirin to interferon to treat chronic hepatitis C infection: a systematic review and meta-analysis of randomised trials. Arch Intern Med 165:2206–2212PubMedCrossRef Brok J, Gluud LL, Gluud C (2005) Effects of adding ribavirin to interferon to treat chronic hepatitis C infection: a systematic review and meta-analysis of randomised trials. Arch Intern Med 165:2206–2212PubMedCrossRef
Metadata
Title
De novo nephrotic syndrome following pegylated interferon alfa 2b/ribavirin therapy for chronic hepatitis C infection
Authors
Jose L. Tovar
Maria Buti
Alfonso Segarra
Joaquim Majó
Rafael Esteban
Publication date
01-06-2008
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 2/2008
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-007-9241-7

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