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Open Access 20-06-2022 | Osteoarthrosis

Clinical and radiographic assessment of peripheral joints in controlled acromegaly

Authors: Iris C. M. Pelsma, Herman M. Kroon, Victoria R. van Trigt, Alberto M. Pereira, Margreet Kloppenburg, Nienke R. Biermasz, Kim M. J. A. Claessen

Published in: Pituitary | Issue 4/2022

Abstract

Purpose

Acromegalic arthropathy is a well-known phenomenon, occurring in most patients regardless of disease status. To date, solely hips, knees, hands, and spinal joints have been radiographically assessed. Therefore, this study aimed to assess the prevalence of joint symptoms and radiographic osteoarthritis (OA) of new, and established peripheral joint sites in well-controlled acromegaly.

Methods

Fifty-one acromegaly patients (56% female, mean age 64 ± 12 years) in long-term remission for 18.3 years (median, IQR 7.2–25.4) were included. Nineteen patients currently received pharmacological treatment. Self-reported joint complaints were assessed using standardized interviews. Self-reported disability of the upper and lower limbs, and health-related quality of life (HR-QoL) were evaluated using validated questionnaires. Radiographic OA [defined as Kellgren & Lawrence (KL) ≥ 2] was scored using (modified) KL methods.

Results

Radiographic signs of OA were present in 46 patients (90.2%) with ≥ 2 joints affected in virtually all of these patients (N = 44; 95.7%). Radiographic MTP1 OA was as prevalent as radiographic knee OA (N = 26, 51.0%), and radiographic glenohumeral OA was similarly prevalent as hip OA [N = 21 (41.2%) vs. N = 24 (47.1%)]. Risk factors for radiographic glenohumeral OA were higher pre-treatment IGF-1 levels [OR 1.06 (1.01–1.12), P = 0.021], and current pharmacological treatment [OR 5.01 (1.03–24.54), P = 0.047], whereas no risk factors for MTP1 joint OA could be identified.

Conclusion

Similar to previously-assessed peripheral joints, clinical and radiographic arthropathy of the shoulder and feet were prevalent in controlled acromegaly. Further studies on adequate management strategies of acromegalic arthropathy are needed.

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Title: Clinical and radiographic assessment of peripheral joints in controlled acromegaly
Authors: Iris C. M. Pelsma
Herman M. Kroon
Victoria R. van Trigt
Alberto M. Pereira
Margreet Kloppenburg
Nienke R. Biermasz
Kim M. J. A. Claessen
Publication date: 20-06-2022
Publisher: Springer US
Keywords: Osteoarthrosis
Acromegaly
Insulins
Osteoarthrosis
Insulins
Published in: Pituitary / Issue 4/2022
Print ISSN: 1386-341X
Electronic ISSN: 1573-7403
DOI: https://doi.org/10.1007/s11102-022-01233-z

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