Skip to main content
Top
Published in: International Journal of Clinical Pharmacy 5/2016

01-10-2016 | Research Article

Potentially inappropriate medications in a sample of Portuguese nursing home residents: Does the choice of screening tools matter?

Authors: Filipa Alves da Costa, Catarina Periquito, Maria Clara Carneiro, Pedro Oliveira, Ana Isabel Fernandes, Patrícia Cavaco-Silva

Published in: International Journal of Clinical Pharmacy | Issue 5/2016

Login to get access

Abstract

Background Potentially inappropriate medications (PIMs) are often found in high proportion among the elderly population. The STOPP criteria have been suggested to detect more PIMs in European elderly than the Beers criteria. Objective This study aimed to determine the prevalence of PIMs and potential prescribing omissions (PPOs) in a sample of Portuguese nursing homes residents. Setting Four elderly facilities in mainland Portugal Method A descriptive cross-sectional study was used. Elderly polypharmacy patients were included in the study and their medication (registered in patient clinical records) analysed using the Beers (2012 original version and 2008 version adapted to Portugal), STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment) criteria. Data were analysed using univariate and bivariate descriptive statistics, considering a confidence interval of 95 %. Main outcome measures: Prevalence of PIMs and PPOs. Results The sample included 161 individuals, with a mean age of 84.7 years (SD = 6.35), 68.9 % being female. A total of 807 PIMs and 90 PPOs were identified through the application of the three set of criteria. The prevalence of PIMs using the most recent version of the Beers criteria was 85.1 and 42.1 % for independent and dependent of diagnosis, respectively. The Portuguese adaptation of this same tool indicated a lower prevalence of PIMs, 60.3 and 16.7 %, respectively. The prevalence of PIMs using the STOPP criteria was 75.4 %, whilst the prevalence of PPOs, using START, was 42.9 %. There were significant differences in the mean number of PIMs detected depending on the tool used. (p < 0.001). Conclusions The application of the studied criteria in an elderly sample enabled the identification of a notable amount of PIMs and PPOs, indicating there is room for improving the quality of care. The variation in prevalence indicates careful choice of the tool is a prerequisite for engaging in medication review. Using START/STOPP criteria enabled a more holistic approach to the quality of prescribing in the elderly, highlighting low levels of cardiovascular risk prevention and abuse of psychotropic drugs, aside with system failures largely preventable by electronic prescribing and alert generation.
Literature
2.
go back to reference Borges EP, Morgado M, Macedo AF. Prescribing omissions in elderly patients admitted to a stroke unit: descriptive study using START criteria. Int J Clin Pharm. 2012;34(3):481–9.CrossRefPubMed Borges EP, Morgado M, Macedo AF. Prescribing omissions in elderly patients admitted to a stroke unit: descriptive study using START criteria. Int J Clin Pharm. 2012;34(3):481–9.CrossRefPubMed
3.
go back to reference Gallagher P, Barry PJ, O´Mahony D. Inappropriate prescribing in the elderly. J Clin Pharm Ther. 2007;32(2):113–21.CrossRefPubMed Gallagher P, Barry PJ, O´Mahony D. Inappropriate prescribing in the elderly. J Clin Pharm Ther. 2007;32(2):113–21.CrossRefPubMed
4.
go back to reference Ryan C, O’Mahony D, Kennedy J, Weedle P, Byrne S. Potentially inappropriate prescribing in an Irish elderly population in primary care. Br J Clin Pharmacol. 2009;68(6):936–47.CrossRefPubMedPubMedCentral Ryan C, O’Mahony D, Kennedy J, Weedle P, Byrne S. Potentially inappropriate prescribing in an Irish elderly population in primary care. Br J Clin Pharmacol. 2009;68(6):936–47.CrossRefPubMedPubMedCentral
5.
go back to reference San-José A, Agustí A, Vidal X, Formiga F, López-Soto A, Fernández-Moyano A, et al. Inappropriate prescribing to older patients admitted to hospital: a comparison of different tools of misprescribing and underprescribing. Eur J Intern Med. 2014;25(8):710–6.CrossRefPubMed San-José A, Agustí A, Vidal X, Formiga F, López-Soto A, Fernández-Moyano A, et al. Inappropriate prescribing to older patients admitted to hospital: a comparison of different tools of misprescribing and underprescribing. Eur J Intern Med. 2014;25(8):710–6.CrossRefPubMed
6.
go back to reference Liu CL, Peng LN, Chen YT, Lin MH, Liu LK, Chen LK. Potentially inappropriate prescribing (IP) for elderly medical inpatients in Taiwan: a hospital-based study. Arch Gerontol Geriatr. 2012;55(1):148–51.CrossRefPubMed Liu CL, Peng LN, Chen YT, Lin MH, Liu LK, Chen LK. Potentially inappropriate prescribing (IP) for elderly medical inpatients in Taiwan: a hospital-based study. Arch Gerontol Geriatr. 2012;55(1):148–51.CrossRefPubMed
7.
go back to reference Retamal CG, Fernández RG, Espínola SF, Serrato AR, Ordóñez MA, Marín VP. Prevalence of potentially inappropriate medication in hospitalized elderly patients by using explicit criteria. Farm Hosp. 2014;38(4):305–16. Retamal CG, Fernández RG, Espínola SF, Serrato AR, Ordóñez MA, Marín VP. Prevalence of potentially inappropriate medication in hospitalized elderly patients by using explicit criteria. Farm Hosp. 2014;38(4):305–16.
8.
go back to reference Hill-Taylor B, Sketris I, Hayden J, Byrne S, O’Sullivan D, Christie R. Application of the STOPP/START criteria: a systematic review of the prevalence of potentially inappropriate prescribing in older adults, and evidence of clinical, humanistic and economic impact. J Clin Pharm and Ther. 2013;38(5):360–72.CrossRef Hill-Taylor B, Sketris I, Hayden J, Byrne S, O’Sullivan D, Christie R. Application of the STOPP/START criteria: a systematic review of the prevalence of potentially inappropriate prescribing in older adults, and evidence of clinical, humanistic and economic impact. J Clin Pharm and Ther. 2013;38(5):360–72.CrossRef
9.
go back to reference Gillespie U, Alassaad A, Hammarlund-Udenaes M, Mörlin C, Henrohn D, Bertilsson M, Melhus H. Effects of pharmacists’ interventions on appropriateness of prescribing and evaluation of the instruments’ (MAI, STOPP and STARTs’) ability to predict hospitalization–analyses from a randomized controlled trial. PLoS ONE. 2013;8(5):e62401.CrossRefPubMedPubMedCentral Gillespie U, Alassaad A, Hammarlund-Udenaes M, Mörlin C, Henrohn D, Bertilsson M, Melhus H. Effects of pharmacists’ interventions on appropriateness of prescribing and evaluation of the instruments’ (MAI, STOPP and STARTs’) ability to predict hospitalization–analyses from a randomized controlled trial. PLoS ONE. 2013;8(5):e62401.CrossRefPubMedPubMedCentral
10.
go back to reference Karandikar YS, Chaudhari SR, Dalal NP, Sharma M, Pandit VA. Inappropriate prescribing in the elderly: a comparison of two validated screening tools. JCGG. 2013;4(4):109–14. Karandikar YS, Chaudhari SR, Dalal NP, Sharma M, Pandit VA. Inappropriate prescribing in the elderly: a comparison of two validated screening tools. JCGG. 2013;4(4):109–14.
11.
go back to reference Beers MH, Ouslander J, Rollingher I, Reuben D, Brooks J, Beck J. Explicit criteria for determining in—appropriate medication use in nursing homes. Arch Intern Med. 1991;151(9):1825–32.CrossRefPubMed Beers MH, Ouslander J, Rollingher I, Reuben D, Brooks J, Beck J. Explicit criteria for determining in—appropriate medication use in nursing homes. Arch Intern Med. 1991;151(9):1825–32.CrossRefPubMed
12.
go back to reference Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly. Arch Intern Med. 1997;157(14):1531–6.CrossRefPubMed Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly. Arch Intern Med. 1997;157(14):1531–6.CrossRefPubMed
13.
go back to reference Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH. Updating the Beers criteria for potentially inappropriate medication use in older adults. Arch Intern Med. 2003;163(22):2716–24.CrossRefPubMed Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH. Updating the Beers criteria for potentially inappropriate medication use in older adults. Arch Intern Med. 2003;163(22):2716–24.CrossRefPubMed
14.
go back to reference Campanelli CM. American Geriatrics Society updated beers criteria for potentially inappropriate medication use in older adults: American Geriatrics Society 2012 Beers Criteria Update Expert Panel. J Am Geriatr Soc. 2012;60(4):616–31.CrossRefPubMedCentral Campanelli CM. American Geriatrics Society updated beers criteria for potentially inappropriate medication use in older adults: American Geriatrics Society 2012 Beers Criteria Update Expert Panel. J Am Geriatr Soc. 2012;60(4):616–31.CrossRefPubMedCentral
15.
go back to reference American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society. Updated Beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;2015(63):2227–46.CrossRef American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society. Updated Beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2015;2015(63):2227–46.CrossRef
16.
go back to reference Soares MA, Fernandez-Llimós F, Lança C, Cabrita J, Morais JA. Operacionalização para Portugal: Critérios de Beers de Medicamentos Inapropriados nos Doentes Idosos. Acta Med Port. 2008;21(5):441–52.PubMed Soares MA, Fernandez-Llimós F, Lança C, Cabrita J, Morais JA. Operacionalização para Portugal: Critérios de Beers de Medicamentos Inapropriados nos Doentes Idosos. Acta Med Port. 2008;21(5):441–52.PubMed
17.
go back to reference Cahir C, Moriarty F, Teljeur C, Fahey T, Bennett K. Potentially inappropriate prescribing and vulnerability and hospitalization in older community-dwelling patients. Ann Pharmacother. 2014;48(12):1546–54.CrossRefPubMed Cahir C, Moriarty F, Teljeur C, Fahey T, Bennett K. Potentially inappropriate prescribing and vulnerability and hospitalization in older community-dwelling patients. Ann Pharmacother. 2014;48(12):1546–54.CrossRefPubMed
18.
go back to reference Hudhra K, García-Caballos M, Jucja B, Casado-Fernández E, Espigares-Rodriguez E, Bueno-Cavanillas A. Frequency of potentially inappropriate prescriptions in older people at discharge according to Beers and STOPP criteria. Int J Clin Pharm. 2014;36(3):596–603.CrossRefPubMed Hudhra K, García-Caballos M, Jucja B, Casado-Fernández E, Espigares-Rodriguez E, Bueno-Cavanillas A. Frequency of potentially inappropriate prescriptions in older people at discharge according to Beers and STOPP criteria. Int J Clin Pharm. 2014;36(3):596–603.CrossRefPubMed
19.
go back to reference Miquel MD, Cuervo MS, Silveira ED, Machuca IS, González-Blazquez S, Errasquin BM, Cruz-Jentoft AJ. Potentially inappropriate drug prescription in older subjects across health care settings. Eur Geriatr Med. 2010;1(1):9–14.CrossRef Miquel MD, Cuervo MS, Silveira ED, Machuca IS, González-Blazquez S, Errasquin BM, Cruz-Jentoft AJ. Potentially inappropriate drug prescription in older subjects across health care settings. Eur Geriatr Med. 2010;1(1):9–14.CrossRef
20.
go back to reference Lang PO, Hasso Y, Belmin J, Pavot I, Bayens JP, Vogt-Ferrier N, Gallagher P, O’Mahony D, Michel JP. STOPP-START: adaptation of a French language screening tool for detecting inappropriate prescriptions in older people. Can J Public Health. 2009;100(6):426–31 [Article in French].PubMed Lang PO, Hasso Y, Belmin J, Pavot I, Bayens JP, Vogt-Ferrier N, Gallagher P, O’Mahony D, Michel JP. STOPP-START: adaptation of a French language screening tool for detecting inappropriate prescriptions in older people. Can J Public Health. 2009;100(6):426–31 [Article in French].PubMed
21.
go back to reference Delgado Silveira E, Montero Errasquín B, Muñoz-Garcia M, Vélez-Díaz-Pallarés M, Lozano Montoya I, Sánchez-Castellano C, et al. Improving drug prescribing in the elderly: a new edition of STOPP/START criteria. Esp Geriatr Gerontol. 2015;50(2):89–96 [Article in Spanish].CrossRef Delgado Silveira E, Montero Errasquín B, Muñoz-Garcia M, Vélez-Díaz-Pallarés M, Lozano Montoya I, Sánchez-Castellano C, et al. Improving drug prescribing in the elderly: a new edition of STOPP/START criteria. Esp Geriatr Gerontol. 2015;50(2):89–96 [Article in Spanish].CrossRef
22.
go back to reference Vermeulen Windsant-van den Tweel AM, Verduijn MM, Derijks HJ, van Marum RJ. Detection of inappropriate medication use in the elderly; will the STOPP and START criteria become the new Dutch standards? Ned Tijdschr Geneeskd. 2012;156(40):A5076 [Article in Dutch].PubMed Vermeulen Windsant-van den Tweel AM, Verduijn MM, Derijks HJ, van Marum RJ. Detection of inappropriate medication use in the elderly; will the STOPP and START criteria become the new Dutch standards? Ned Tijdschr Geneeskd. 2012;156(40):A5076 [Article in Dutch].PubMed
23.
go back to reference Morin L, Fastbom J, Laroche ML, Johnell K. Potentially inappropriate drug use in older people: a nationwide comparison of different explicit criteria for population-based estimates. Br J Clin Pharmacol. 2015;80(2):315–24.CrossRefPubMedPubMedCentral Morin L, Fastbom J, Laroche ML, Johnell K. Potentially inappropriate drug use in older people: a nationwide comparison of different explicit criteria for population-based estimates. Br J Clin Pharmacol. 2015;80(2):315–24.CrossRefPubMedPubMedCentral
24.
go back to reference Oliveira-Martins S, Soares MA, van Mil JWF, Cabrita J. Inappropriate drug use by Portuguese elderly outpatients—effects of the Beers criteria update. Pharm World Sci. 2006;28:296–301.CrossRefPubMed Oliveira-Martins S, Soares MA, van Mil JWF, Cabrita J. Inappropriate drug use by Portuguese elderly outpatients—effects of the Beers criteria update. Pharm World Sci. 2006;28:296–301.CrossRefPubMed
25.
go back to reference Gouveia Pinto C, Carrageta MO, Miguel LS. Cost-effectiveness of rosuvastatin in the prevention of ischemic heart disease in Portugal. Value Health. 2008;11(2):154–9.CrossRef Gouveia Pinto C, Carrageta MO, Miguel LS. Cost-effectiveness of rosuvastatin in the prevention of ischemic heart disease in Portugal. Value Health. 2008;11(2):154–9.CrossRef
26.
go back to reference Chang C-B, Chen J-H, Wen C-J, Kuo H-K, Lu I-S, Chiu L-S, Wu S-C, Chan D-C. Potentially inappropriate medications in geriatric outpatients with polypharmacy: application of six sets of published explicit criteria. Br J Clin Pharmacol. 2011;72(3):482–9.CrossRefPubMedPubMedCentral Chang C-B, Chen J-H, Wen C-J, Kuo H-K, Lu I-S, Chiu L-S, Wu S-C, Chan D-C. Potentially inappropriate medications in geriatric outpatients with polypharmacy: application of six sets of published explicit criteria. Br J Clin Pharmacol. 2011;72(3):482–9.CrossRefPubMedPubMedCentral
27.
go back to reference Rocha O, Lunet N, Costa L, Barros H. Tratamento da osteoporose em Portugal: Tendência e variação geográfica. Acta Med Port. 2006;19:373–80.PubMed Rocha O, Lunet N, Costa L, Barros H. Tratamento da osteoporose em Portugal: Tendência e variação geográfica. Acta Med Port. 2006;19:373–80.PubMed
28.
go back to reference Ravera S, Hummel SA, Stolk P, Heerdink RE, de Jong–van den Berg LTW, de Gier JJ. The use of driving impairing medicines: a European survey. Eur J Clin Pharmacol. 2009;65:1139–47.CrossRefPubMedPubMedCentral Ravera S, Hummel SA, Stolk P, Heerdink RE, de Jong–van den Berg LTW, de Gier JJ. The use of driving impairing medicines: a European survey. Eur J Clin Pharmacol. 2009;65:1139–47.CrossRefPubMedPubMedCentral
29.
go back to reference Kojima G, Bell CL, Tamura B, Davis J, Inaba M, Masaki K. Combining quality improvement and geriatrics training: the nursing home polypharmacy outcomes project. Gerontol Geriatr Educ. 2014;35(4):395–408.CrossRefPubMedPubMedCentral Kojima G, Bell CL, Tamura B, Davis J, Inaba M, Masaki K. Combining quality improvement and geriatrics training: the nursing home polypharmacy outcomes project. Gerontol Geriatr Educ. 2014;35(4):395–408.CrossRefPubMedPubMedCentral
30.
go back to reference Pugh MJ, Hanlon JT, Zeber JE, et al. Assessing potentially inappropriate prescribing in the elderly Veterans Affairs population using the HEDIS 2006 quality measure. J Manag Care Pharm. 2006;12:537.PubMed Pugh MJ, Hanlon JT, Zeber JE, et al. Assessing potentially inappropriate prescribing in the elderly Veterans Affairs population using the HEDIS 2006 quality measure. J Manag Care Pharm. 2006;12:537.PubMed
31.
go back to reference Cahir C, Bennett K, Teljeur C, Fahey T. Potentially inappropriate prescribing and adverse health outcomes in community dwelling older patients. Br J Clin Pharmacol. 2013;77(1):201–10.CrossRefPubMedCentral Cahir C, Bennett K, Teljeur C, Fahey T. Potentially inappropriate prescribing and adverse health outcomes in community dwelling older patients. Br J Clin Pharmacol. 2013;77(1):201–10.CrossRefPubMedCentral
32.
go back to reference O’Mahony D, O’Sullivan D, Byrne S, O’Connor MN, Ryan C, Gallagher P. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015;44:213–8.CrossRefPubMed O’Mahony D, O’Sullivan D, Byrne S, O’Connor MN, Ryan C, Gallagher P. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015;44:213–8.CrossRefPubMed
33.
go back to reference Tommelein E, Petrovic M, Somers A, Mehuys E, van der Cammen T, Boussery K. Older patients’ prescriptions screening in the community pharmacy: development of the Ghent Older People’s Prescriptions community Pharmacy Screening (GheOP3S) tool. J Public Health. 2016;38(2):e158–70.CrossRef Tommelein E, Petrovic M, Somers A, Mehuys E, van der Cammen T, Boussery K. Older patients’ prescriptions screening in the community pharmacy: development of the Ghent Older People’s Prescriptions community Pharmacy Screening (GheOP3S) tool. J Public Health. 2016;38(2):e158–70.CrossRef
34.
go back to reference Costa FA, Duggan C, Bates I. Validation of a survey tool for use in cross-cultural studies. Pharm Pract (Internet). 2008;6(3):121–7. Costa FA, Duggan C, Bates I. Validation of a survey tool for use in cross-cultural studies. Pharm Pract (Internet). 2008;6(3):121–7.
35.
go back to reference Endres HG, Kaufmann-Kolle P, Steeb V, Bauer E, Böttner C, Thürmann P. Association between potentially inappropriate medication (PIM) use and risk of hospitalization in older adults: an observational study based on routine data comparing PIM use with use of PIM alternatives. PLoS ONE. 2016;11(2):e0146811. doi:10.1371/journal.pone.0146811 CrossRefPubMedPubMedCentral Endres HG, Kaufmann-Kolle P, Steeb V, Bauer E, Böttner C, Thürmann P. Association between potentially inappropriate medication (PIM) use and risk of hospitalization in older adults: an observational study based on routine data comparing PIM use with use of PIM alternatives. PLoS ONE. 2016;11(2):e0146811. doi:10.​1371/​journal.​pone.​0146811 CrossRefPubMedPubMedCentral
36.
go back to reference Bjerre LM, Halil R, Catley C, Farrel B, Hogel M, Blacks C, et al. Potentially inappropriate prescribing (PIP) in long-term care (LTC) patients: validation of the 2014 STOPP–START and 2012 Beers criteria in a LTC population—a protocol for a cross-sectional comparison of clinical and health administrative data. BMJ Open. 2015;5:e009715. doi:10.1136/bmjopen-2015009715.CrossRefPubMedPubMedCentral Bjerre LM, Halil R, Catley C, Farrel B, Hogel M, Blacks C, et al. Potentially inappropriate prescribing (PIP) in long-term care (LTC) patients: validation of the 2014 STOPP–START and 2012 Beers criteria in a LTC population—a protocol for a cross-sectional comparison of clinical and health administrative data. BMJ Open. 2015;5:e009715. doi:10.​1136/​bmjopen-2015009715.CrossRefPubMedPubMedCentral
Metadata
Title
Potentially inappropriate medications in a sample of Portuguese nursing home residents: Does the choice of screening tools matter?
Authors
Filipa Alves da Costa
Catarina Periquito
Maria Clara Carneiro
Pedro Oliveira
Ana Isabel Fernandes
Patrícia Cavaco-Silva
Publication date
01-10-2016
Publisher
Springer International Publishing
Published in
International Journal of Clinical Pharmacy / Issue 5/2016
Print ISSN: 2210-7703
Electronic ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-016-0337-y

Other articles of this Issue 5/2016

International Journal of Clinical Pharmacy 5/2016 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine