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Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
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International Journal of Clinical Pharmacy
Published in: International Journal of Clinical Pharmacy 1/2014

01-02-2014 | Commentary

How do we better translate adherence research into improvements in patient care?

Authors: Adam La Caze, Gina Gujral, William Neil Cottrell

Published in: International Journal of Clinical Pharmacy | Issue 1/2014

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Excerpt

Adherence to medicines in patients with chronic disease remains poor despite better recognition of the challenges of non-adherence and a concerted effort to address these challenges. Adherence research has progressed in recent years, both conceptually with the recent development of a taxonomy of adherence [1] and improved, if still flawed, evidence for the efficacy of some interventions [2]. However, a key challenge remains unmet: the translation of adherence research into clear advice for health professionals of effective strategies to better support the medication adherence of their patients. We outline some of the difficulties of improving the translation of adherence research into improvements in the care of individuals with chronic disease, and consider possible solutions. We have two suggestions for improving translation of adherence research: (1) better incorporation of what we know about adherence into interventions to improve adherence and (2) more sophisticated measurements of adherence. Implementing these suggestions has implications for research and practice. …
Literature
1.
Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691–705.PubMedCrossRef
2.
Demonceau J, Ruppar T, Kristanto P, Hughes DA, Fargher E, Kardas P, et al. Identification and assessment of adherence-enhancing interventions in studies assessing medication adherence through electronically compiled drug dosing histories: a systematic literature review and meta-analysis. Drugs. 2013;73(6):545–62.PubMedCentralPubMedCrossRef
3.
Vervloet M, Linn AJ, van Weert JC, de Bakker DH, Bouvy ML, van Dijk L. The effectiveness of interventions using electronic reminders to improve adherence to chronic medication: a systematic review of the literature. J Am Med Inf Assoc. 2012;19(5):696–704.CrossRef
4.
Nunes V, Neilson J, O’Flynn N, Calvert N, Kuntze S, Smithson H, et al. Clinical guidelines and evidence review for medicines adherence: involving patients in decisions about prescribed medicines and supporting adherence. London: National Collaborating Centre for Primary Care and Royal College of General Practitioners; 2009.
5.
Garfield S, Clifford S, Eliasson L, Barber N, Willson A. Suitability of measures of self-reported medication adherence for routine clinical use: a systematic review. BMC Med Res Methodol. 2011;11:149.PubMedCentralPubMedCrossRef
6.
Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane database Syst Rev 2008;(2):CD000011.
7.
Johnson MO, Charlebois E, Morin SF, Remien RH, Chesney MA. Effects of a behavioral intervention on antiretroviral medication adherence among people living with HIV: the healthy living project randomized controlled study. J Acquir Immune Defic Syndr. 2007;46(5):574–80.PubMedCentralPubMedCrossRef
8.
Johnson SS, Driskell MM, Johnson JL, Dyment SJ, Prochaska JO, Prochaska JM, et al. Transtheoretical model intervention for adherence to lipid-lowering drugs. Dis Manag. 2006;9(2):102–14.PubMedCrossRef
9.
Ogedegbe G, Chaplin W, Schoenthaler A, Statman D, Berger D, Richardson T, et al. A practice-based trial of motivational interviewing and adherence in hypertensive African Americans. Am J Hypertens. 2008;21(10):1137–43.PubMedCentralPubMedCrossRef
10.
Stacy JN, Schwartz SM, Ershoff D, Shreve MS. Incorporating tailored interactive patient solutions using interactive voice response technology to improve statin adherence: results of a randomized clinical trial in a managed care setting. Popul Health Manag. 2009;12(5):241–54.PubMedCrossRef
11.
Bouvy ML, Heerdink ER, Urquhart J, Grobbee DE, Hoes AW, Leufkens HG. Effect of a pharmacist-led intervention on diuretic compliance in heart failure patients: a randomized controlled study. J Card Fail. 2003;9(5):404–11.PubMedCrossRef
12.
Faulkner MA, Wadibia EC, Lucas BD, Hilleman DE. Impact of pharmacy counseling on compliance and effectiveness of combination lipid-lowering therapy in patients undergoing coronary artery revascularization: a randomized, controlled trial. Pharmacotherapy. 2000;20(4):410–6.PubMedCrossRef
13.
Cutrona SL, Choudhry NK, Fischer MA, Servi AD, Stedman M, Liberman JN, et al. Targeting cardiovascular medication adherence interventions. J Am Pharm Assoc (2003) 2012;52(3):381-97.
14.
Viswanathan M, Golin CE, Jones CD, Ashok M, Blalock SJ, Wines RC, et al. Interventions to improve adherence to self-administered medications for chronic diseases in the United States: a systematic review. Ann Intern Med. 2012;157(11):785–95.PubMedCrossRef
15.
World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: WHO; 2003.
16.
Gearing RE, Townsend L, MacKenzie M, Charach A. Reconceptualizing medication adherence: six phases of dynamic adherence. Harv Rev Psychiatry. 2011;19(4):177–89.PubMedCrossRef
17.
Gadkari AS, McHorney CA. Medication nonfulfillment rates and reasons: narrative systematic review. Curr Med Res Opin. 2010;26(3):683–705.PubMedCrossRef
18.
Raebel MA, Carroll NM, Ellis JL, Schroeder EB, Bayliss EA. Importance of including early nonadherence in estimations of medication adherence. Ann Pharmacother. 2011;45(9):1053–60.PubMedCrossRef
19.
Fischer MA, Choudhry NK, Brill G, Avorn J, Schneeweiss S, Hutchins D, et al. Trouble getting started: predictors of primary medication nonadherence. Am J Med. 2011;124(11):1081.e9–22.PubMedCrossRef
20.
Cheetham TC, Niu F, Green K, Scott RD, Derose SF, Vansomphone SS, et al. Primary nonadherence to statin medications in a managed care organization. J Manag Care Pharm. 2013;19(5):367–73.PubMed
21.
Reeve J, Hosking R, Allinson Y. Personal electronic health records: the start of a journey. Australian Prescr. 2013;36(3):70–3.
22.
Nguyen TMU, LaCaze A, Cottrell WN. What are validated self-report adherence scales really measuring? A systematic review. Br J Clin Pharmacol 2013;In Press.
23.
Menckeberg TT, Bouvy ML, Bracke M, Kaptein AA, Leufkens HG, Raaijmakers JAM, et al. Beliefs about medicines predict refill adherence to inhaled corticosteroids. J Psychosom Res. 2008;64(1):47–54.PubMedCrossRef
24.
Ross S, Walker A, MacLeod MJ. Patient compliance in hypertension: role of illness perceptions and treatment beliefs. J Hum Hypertens. 2004;18(9):607–13.PubMedCrossRef
25.
Schuz B, Marx C, Wurm S, Warner LM, Ziegelmann JP, Schwarzer R, et al. Medication beliefs predict medication adherence in older adults with multiple illnesses. J Psychosom Res. 2011;70(2):179–87.PubMedCrossRef
26.
Horne R, Weinman J. Self-regulation and self-management in asthma: exploring the role of illness perceptions and treatment beliefs in explaining non-adherence to preventer medication. Psychol Health. 2002;17(1):17–32.CrossRef
Metadata
Title
How do we better translate adherence research into improvements in patient care?
Authors
Adam La Caze
Gina Gujral
William Neil Cottrell
Publication date
01-02-2014
Publisher
Springer Netherlands
Published in
International Journal of Clinical Pharmacy / Issue 1/2014
Print ISSN: 2210-7703
Electronic ISSN: 2210-7711
DOI
https://doi.org/10.1007/s11096-013-9869-6

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
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