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Neuropsychology Review
Published in: Neuropsychology Review 4/2015

01-12-2015 | Review

High Frequency Deep Brain Stimulation and Neural Rhythms in Parkinson’s Disease

Authors: Zack Blumenfeld, Helen Brontë-Stewart

Published in: Neuropsychology Review | Issue 4/2015

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Abstract

High frequency (HF) deep brain stimulation (DBS) is an established therapy for the treatment of Parkinson’s disease (PD). It effectively treats the cardinal motor signs of PD, including tremor, bradykinesia, and rigidity. The most common neural target is the subthalamic nucleus, located within the basal ganglia, the region most acutely affected by PD pathology. Using chronically-implanted DBS electrodes, researchers have been able to record underlying neural rhythms from several nodes in the PD network as well as perturb it using DBS to measure the ensuing neural and behavioral effects, both acutely and over time. In this review, we provide an overview of the PD neural network, focusing on the pathophysiological signals that have been recorded from PD patients as well as the mechanisms underlying the therapeutic benefits of HF DBS. We then discuss evidence for the relationship between specific neural oscillations and symptoms of PD, including the aberrant relationships potentially underlying functional connectivity in PD as well as the use of different frequencies of stimulation to more specifically target certain symptoms. Finally, we briefly describe several current areas of investigation and how the ability to record neural data in ecologically-valid settings may allow researchers to explore the relationship between brain and behavior in an unprecedented manner, culminating in the future automation of neurostimulation therapy for the treatment of a variety of neuropsychiatric diseases.
Literature
Afshar, P., Khambhati, A., Stanslaski, S., Carlson, D., Jensen, R., Linde, D., et al. (2012). A translational platform for prototyping closed-loop neuromodulation systems. Frontiers in Neural Circuits, 6(117), 1–15.
Alexander, G. E., & Crutcher, M. D. (1990). Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends in Neurosciences, 13(7), 266–271.PubMedCrossRef
Anderson, M. E., Postupna, N., & Ruffo, M. (2003). Effects of high-frequency stimulation in the internal globus pallidus on the activity of thalamic neurons in the awake monkey. Journal of Neurophysiology, 89(2), 1150–1160.PubMedCrossRef
Andrew, J. (1984). Surgical treatment of tremor. In L. J. Findley & R. Capildeo (Eds.), Movement disorders: Tremor (pp. 339–351). London: Macmillan.CrossRef
Androulidakis, A. G., Kühn, A. A., Chen, C. C., Blomstedt, P., Kempf, F., Kupsch, A., et al. (2007). Dopaminergic therapy promotes lateralized motor activity in the subthalamic area in Parkinson’s disease. Brain, 130(2), 457–468.PubMedCrossRef
Benabid, A. L., Pollak, P., Gervason, C., Hoffmann, D., Gao, D. M., Hommel, M., et al. (1991). Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet, 337(8738), 403–406.PubMedCrossRef
Benabid, A. L., Pollak, P., Gross, C., Hoffmann, D., Benazzouz, A., Gao, D. M., et al. (1994). Acute and long-term effects of subthalamic nucleus stimulation in Parkinson’s disease. Stereotactic and Functional Neurosurgery, 62(1–4), 76–84.PubMedCrossRef
Benabid, A. L., Pollak, P., Gao, D., Hoffmann, D., Limousin, P., Gay, E., et al. (1996). Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. Journal of Neurosurgery, 84(2), 203–214.PubMedCrossRef
Bergman, H., Wichmann, T., & DeLong, M. R. (1990). Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science, 249(4975), 1436–1438.PubMedCrossRef
Bergman, H., Wichmann, T., Karmon, B., & DeLong, M. (1994). The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism. Journal of Neurophysiology, 72, 507–520.PubMed
Bergman, H., Feingold, A., Nini, A., Raz, A., Slovin, H., Abeles, M., et al. (1998). Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates. Trends in Neurosciences, 21(1), 32–38.PubMedCrossRef
Beurrier, C., Bioulac, B., Audin, J., & Hammond, C. (2001). High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons. Journal of Neurophysiology, 85(4), 1351–1356.PubMed
Bezard, E., Boraud, T., Bioulac, B., & Gross, C. E. (1997). Presymptomatic revelation of experimental parkinsonism. NeuroReport, 8(2), 435–438.PubMedCrossRef
Birdno, M. J., & Grill, W. M. (2008). Mechanisms of deep brain stimulation in movement disorders as revealed by changes in stimulus frequency. Neurotherapeutics, 5(1), 14–25.PubMedCentralPubMedCrossRef
Blumenfeld, Z., Velisar, A., Miller Koop, M., Hill, B. C., Shreve, L. A., Quinn, E. J., et al. (2015). Sixty hertz neurostimulation amplifies subthalamic neural synchrony in Parkinson’s disease. PLoS ONE. doi:10.​1371/​journal.​pone.​0121067.
Bouyer, J., Joh, T., & Pickel, V. (1984). Ultrastructural localization of tyrosine hydroxylase in rat nucleus accumbens. Journal of Comparative Neurology, 227, 92–103.PubMedCrossRef
Bronte-Stewart, H., Barberini, C., Koop, M. M., Hill, B. C., Henderson, J. M., & Wingeier, B. (2009). The STN beta-band profile in Parkinson’s disease is stationary and shows prolonged attenuation after deep brain stimulation. Experimental Neurology, 215, 20–28.PubMedCrossRef
Brown, P. (2007). Abnormal oscillatory synchronisation in the motor system leads to impaired movement. Current Opinion in Neurobiology, 17(6), 656–664.PubMedCrossRef
Brown, P., & Williams, D. (2005). Basal ganglia local field potential activity: character and functional significance in the human. Clinical Neurophysiology, 116(11), 2510–2519.PubMedCrossRef
Brown, P., Oliviero, A., Mazzone, P., Insola, A., Tonali, P., & Di Lazzaro, V. (2001). Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson’s disease. Journal of Neuroscience, 21(3), 1033–1038.PubMed
Brown, P., Mazzone, P., Oliviero, A., Altibrandi, M. G., Pilato, F., Tonali, P. A., et al. (2004). Effects of stimulation of the subthalamic area on oscillatory pallidal activity in Parkinson’s disease. Experimental Neurology, 188, 480–490.PubMedCrossRef
Brozova, H., Barnaure, I., Alterman, R. L., & Tagliati, M. (2009). STN-DBS frequency effects on freezing of gait in advanced Parkinson disease. Neurology, 72(8), 770–771.PubMedCrossRef
Carlson, D., Linde, D., Isaacson, B., Afshar, P., Bourget, D., Stanslaski, S., et al. (2013). A flexible algorithm framework for closed-loop neuromodulation research systems. IEEE Engineering in Medicine and Biology Society, 6146–6150.
Carron, R., Chaillet, A., Filipchuk, A., Pasillas-Lépine, W., & Hammond, C. (2013). Closing the loop of deep brain stimulation. Frontiers in Systems Neuroscience, 7(112), 1–18.
Cassidy, M., Mazzone, P., Oliviero, A., Insola, A., Tonali, P., et al. (2002). Movement-related changes in synchronization in the human basal ganglia. Brain, 125, 1235–1246.PubMedCrossRef
Castrioto, A., Lozano, A. M., Poon, Y. Y., Lang, A. E., Fallis, M., & Moro, E. (2011). Ten-year outcome of subthalamic stimulation in Parkinson disease: a blinded evaluation. Archives of Neurology, 68(12), 1550–1556.PubMedCrossRef
Chen, C. C., Litvak, V., Gilbertson, T., Kühn, A., Lu, C. S., Lee, S. T., et al. (2007). Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson’s disease. Experimental Neurology, 205(1), 214–221.PubMedCrossRef
Chen, C. C., Lin, W. Y., Chan, H. L., Hsu, Y. T., Tu, P. H., Lee, S. T., et al. (2011). Stimulation of the subthalamic region at 20 Hz slows the development of grip force in Parkinson’s disease. Experimental Neurology, 231(1), 91–96.PubMedCrossRef
Costa, R. M., Lin, S. C., Sotnikova, T. D., Cyr, M., Gainetdinov, R. R., Caron, M. G., et al. (2006). Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. Neuron, 52, 359–369.PubMedCrossRef
Courtemanche, R., Fujii, N., & Graybiel, A. M. (2003). Synchronous, focally modulated beta-band oscillations characterize local field potential activity in the striatum of awake behaving monkeys. Journal of Neuroscience, 23(37), 11741–11752.PubMed
Crossman, A. R., Mitchell, I. J., & Sambrook, M. A. (1985). Regional brain uptake of 2-deoxyglucose in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the macaque monkey. Neuropharmacology, 24(6), 587–591.PubMedCrossRef
de Hemptinne, C., Ryapolova-Webb, E. S., Air, E. L., Garcia, P. A., Miller, K. J., Ojemann, J. G., et al. (2013). Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease. Proceedings of the National Academy of Sciences, 110(12), 4780–4785.CrossRef
de Hemptinne, C., Swann, N. C., Ostrem, J. L., Ryapolova-Webb, E. S., San Luciano, M., Galifianakis, N. B., et al. (2015). Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson’s disease. Nature Neuroscience, 18(5), 779–786.PubMedCentralPubMedCrossRef
de Solages, C., Hill, B. C., Koop, M. M., Henderson, J. M., & Brontë-Stewart, H. (2010). Bilateral symmetry and coherence of subthalamic nuclei beta band activity in Parkinson’s disease. Experimental Neurology, 221, 260–266.PubMedCrossRef
Deiber, M. P., Pollak, P., Passingham, R., Landais, P., Gervason, C., Cinotti, L., et al. (1993). Thalamic stimulation and suppression of parkinsonian tremor. Evidence of a cerebellar deactivation using positron emission tomography. Brain, 116(1), 267–279.PubMedCrossRef
DeLong, M. (1990). Primate models of movement disorders of basal ganglia origin. Trends in Neurosciences, 13(7), 281–285.PubMedCrossRef
Deuschl, G., Schade-Brittinger, C., Krack, P., Volkmann, J., Schäfer, H., Bötzel, K., et al. (2006). A randomized trial of deep-brain stimulation for Parkinson’s disease. New England Journal of Medicine, 355(9), 896–908.PubMedCrossRef
Dostrovsky, J. O., Levy, R., Wu, J. P., Hutchison, W. D., Tasker, R. R., & Lozano, A. M. (2000). Microstimulation-induced inhibition of neuronal firing in human globus pallidus. Journal of Neurophysiology, 84(1), 570–574.PubMed
Doyle, L. M., Kühn, A. A., Hariz, M., Kupsch, A., Schneider, G. H., & Brown, P. (2005). Levodopa-induced modulation of subthalamic beta oscillations during self-paced movements in patients with Parkinson’s disease. European Journal of Neuroscience, 21(5), 1403–1412.PubMedCrossRef
Eusebio, A., Chen, C. C., Lu, C. S., Lee, S. T., Tsai, C. H., Limousin, P., et al. (2008). Effects of low-frequency stimulation of the subthalamic nucleus on movement in Parkinson’s disease. Experimental Neurology, 209(1), 125–130.PubMedCentralPubMedCrossRef
Eusebio, A., Thevathasan, W., Doyle Gaynor, L., Pogosyan, A., Bye, E., Foltynie, T., et al. (2011). Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients. Journal of Neurology, Neurosurgery & Psychiatry, 82(5), 569–573.CrossRef
Fasano, A., Romito, L. M., Daniele, A., Piano, C., Zinno, M., Bentivoglio, A. R., et al. (2010). Motor and cognitive outcome in patients with Parkinson’s disease 8 years after subthalamic implants. Brain, 133(9), 2664–2676.PubMedCrossRef
Féger, J., Hassani, O. K., & Mouroux, M. (1997). The subthalamic nucleus and its connections. New electrophysiological and pharmacological data. Advances in Neurology, 74, 31–43.PubMed
Feingold, J., Gibson, D. J., DePasquale, B., & Graybiel, A. M. (2015). Bursts of beta oscillation differentiate postperformance activity in the striatum and motor cortex of monkeys performing movement tasks. Proceedings of the National Academy of Sciences. doi:10.​1073/​pnas.​1517629112.
Filion, M., Tremblay, L., & Bédard, P. J. (1988). Abnormal influences of passive limb movement on the activity of globus pallidus neurons in parkinsonian monkeys. Brain Research, 444(1), 165–176.PubMedCrossRef
Foffani, G., Priori, A., Egidi, M., Rampini, P., Tamma, F., Caputo, E., et al. (2003). 300-Hz subthalamic oscillations in Parkinson’s disease. Brain, 126(10), 2153–2163.PubMedCrossRef
Foffani, G., Ardolino, G., Meda, B., Egidi, M., Rampini, P., Caputo, E., et al. (2005). Altered subthalamo-pallidal synchronisation in parkinsonian dyskinesias. Journal of Neurology, Neurosurgery & Psychiatry, 76(3), 426–428.CrossRef
Foffani, G., Ardolino, G., Egidi, M., Caputo, E., Bossi, B., & Priori, A. (2006). Subthalamic oscillatory activities at beta or higher frequency do not change after high-frequency DBS in Parkinson’s disease. Brain Research Bulletin, 69(2), 123–130.PubMedCrossRef
Fogelson, N., Kühn, A. A., Silberstein, P., Limousin, P. D., Hariz, M., Trottenberg, T., et al. (2005a). Frequency dependent effects of subthalamic nucleus stimulation in Parkinson’s disease. Neuroscience Letters, 382(1–2), 5–9.PubMedCrossRef
Fogelson, N., Pogosyan, A., Kühn, A. A., Kupsch, A., van Bruggen, G., Speelman, H., et al. (2005b). Reciprocal interactions between oscillatory activities of different frequencies in the subthalamic region of patients with Parkinson’s disease. European Journal of Neuroscience, 22(1), 257–266.PubMedCrossRef
Galati, S., Mazzone, P., Fedele, E., Pisani, A., Peppe, A., Pierantozzi, M., et al. (2006). Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson’s disease. European Journal of Neuroscience, 23(11), 2923–2928.PubMedCrossRef
Gatev, P., & Wichmann, T. (2009). Interactions between cortical rhythms and spiking activity of single basal ganglia neurons in the normal and parkinsonian state. Cerebral Cortex, 19(6), 1330–1344.PubMedCentralPubMedCrossRef
Gervais-Bernard, H., Xie-Brustolin, J., Mertens, P., Polo, G., Klinger, H., Adamec, D., et al. (2009). Bilateral subthalamic nucleus stimulation in advanced Parkinson’s disease: five year follow-up. Neurology, 256(2), 225–233.CrossRef
Ghika, J., Villemure, J. G., Fankhauser, H., Favre, J., Assal, G., & Ghika-Schmid, F. (1998). Efficiency and safety of bilateral contemporaneous pallidal stimulation (deep brain stimulation) in levodopa-responsive patients with Parkinson’s disease with severe motor fluctuations: a 2-year follow-up review. Journal of Neurosurgery, 89(5), 713–718.PubMedCrossRef
Giannicola, G., Marceglia, S., Rossi, L., Mrakic-Sposta, S., Rampini, P., Tamma, F., et al. (2010). The effects of levodopa and ongoing deep brain stimulation on subthalamic beta oscillations in Parkinson’s disease. Experimental Neurology, 226(1), 120–127.PubMedCrossRef
Giannicola, G., Rosa, M., Servello, D., Menghetti, C., Carrabba, G., Pacchetti, C., et al. (2012). Subthalamic local field potentials after seven-year deep brain stimulation in Parkinson’s disease. Experimental Neurology, 237(2), 312–317.PubMedCrossRef
Gradinaru, V., Mogri, M., Thompson, K. R., Henderson, J. M., & Deisseroth, K. (2009). Optical deconstruction of parkinsonian neural circuitry. Science, 324(5925), 354–359.PubMedCrossRef
Grill, W. M., & Mclntyre, C. C. (2001). Extracellular excitation of central neurons: implications for the mechanisms of deep brain stimulation. Thalamus & Related Systems, 1(3), 269–277.
Grill, W. M., Snyder, A. N., & Miocinovic, S. (2004). Deep brain stimulation creates an informational lesion of the stimulated nucleus. NeuroReport, 15(7), 1137–1140.PubMedCrossRef
Gross, C., Rougier, A., Guehl, D., Boraud, T., Julien, J., & Bioulac, B. (1997). High-frequency stimulation of the globus pallidus internalis in Parkinson’s disease: a study of seven cases. Journal of Neurosurgery, 87(4), 491–498.PubMedCrossRef
Hammond, C., Deniau, J., Rizk, A., & Féger, J. (1978). Electrophysiological demonstration of an excitatory subthalamonigral pathway in the rat. Brain Research, 151, 235–244.PubMedCrossRef
Hammond, C., Bergman, H., & Brown, P. (2007). Pathological synchronization in Parkinson’s disease: networks, models and treatments. Trends in Neurosciences, 30(7), 357–364.PubMedCrossRef
Hashimoto, T., Elder, C. M., Okun, M. S., Patrick, S. K., & Vitek, J. L. (2003). Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons. Journal of Neuroscience, 23(5), 1916–1923.PubMed
Haynes, W. I. A., & Haber, S. N. (2013). The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: implications for basal ganglia models and deep brain stimulation. The Journal of Neuroscience, 33(11), 4804–4814.PubMedCentralPubMedCrossRef
He, B. J., Zempel, J. M., Snyder, A. Z., & Raichle, M. E. (2010). The temporal structures and functional significance of scale-free brain activity. Neuron, 66, 353–369.PubMedCentralPubMedCrossRef
Hebb, A. O., Zhang, J. J., Mahoor, M. H., Tsiokos, C., Matlack, C., Chizeck, H. J., et al. (2014). Creating the feedback loop: closed-loop neurostimulation. Neurosurgery Clinics of North America, 25(1), 187–204.PubMedCentralPubMedCrossRef
Hellwig, B., Häussler, S., Lauk, M., Guschlbauer, B., Köster, B., Kristeva-Feige, R., et al. (2000). Tremor-correlated cortical activity detected by electroencephalography. Clinical Neurophysiology, 111(5), 806–809.PubMedCrossRef
Huang, H., Watts, R. L., & Montgomery, E. B. (2014). Effects of deep brain stimulation frequency on bradykinesia of Parkinson’s disease. Movement Disorders, 29(2), 203–206.PubMedCrossRef
Hutchison, W. D., Dostrovsky, J. O., Walters, J. R., Courtemanche, R., Boraud, T., Goldberg, J., et al. (2004). Neuronal oscillations in the basal ganglia and movement disorders: evidence from whole animal and human recordings. Journal of Neuroscience, 24(42), 9240–9243.PubMedCrossRef
Iacono, R. P., Lonser, R. R., Mandybur, G., & Yamada, S. (1995). Stimulation of the globus pallidus in Parkinson’s disease. British Journal of Neurosurgery, 9(4), 505–510.PubMedCrossRef
Ingham, C. A., Hood, S. H., Taggart, P., & Arbuthnott, G. W. (1998). Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway. Journal of Neuroscience, 18(12), 4732–4743.PubMed
Joundi, R. A., Brittain, J. S., Green, A. L., Aziz, T. Z., Brown, P., & Jenkinson, N. (2012). Oscillatory activity in the subthalamic nucleus during arm reaching in Parkinson’s disease. Experimental Neurology, 236(2), 319–326.PubMedCrossRef
Kang, G., & Lowery, M. M. (2014). Effects of antidromic and orthodromic activation of STN afferent axons during DBS in Parkinson’s disease: a simulation study. Frontiers in Computational Neuroscience, 8(32), 1–12.
Khoo, H. M., Kishima, H., Hosomi, K., Maruo, T., Tani, N., Oshino, S., et al. (2014). Low-frequency subthalamic nucleus stimulation in Parkinson’s disease: a randomized clinical trial. Movement Disorders, 29(2), 270–274.PubMedCrossRef
Kita, H., & Kitai, S. T. (1991). Intracellular study of rat globus pallidus neurons: membrane properties and responses to neostriatal, subthalamic and nigral stimulation. Brain Research, 564(2), 296–305.PubMedCrossRef
Kleiner-Fisman, G., Herzog, J., Fisman, D. N., Tamma, F., Lyons, K. E., Pahwa, R., et al. (2006). Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes. Movement Disorders, 21(Suppl 14), S290–S304.PubMedCrossRef
Krack, P., Batir, A., Van Blercom, N., Chabardes, S., Fraix, V., Ardouin, C., et al. (2003). Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. New England Journal of Medicine, 349(20), 1925–1934.PubMedCrossRef
Kühn, A. A., Williams, D., Kupsch, A., Limousin, P., Hariz, M., Schneider, G. H., et al. (2004). Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance. Brain, 127(4), 735–746.PubMedCrossRef
Kühn, A. A., Kupsch, A., Schneider, G. H., & Brown, P. (2006). Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson’s disease. European Journal of Neuroscience, 23(7), 1956–1960.PubMedCrossRef
Kühn, A. A., Kempf, F., Brücke, C., Gaynor Doyle, L., Martinez-Torres, I., Pogosyan, A., et al. (2008). High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson’s disease in parallel with improvement in motor performance. Journal of Neuroscience, 28(24), 6165–6173.PubMedCrossRef
Kühn, A. A., Tsui, A., Aziz, T., Ray, N., Brücke, C., Kupsch, A., et al. (2009). Pathological synchronisation in the subthalamic nucleus of patients with Parkinson’s disease relates to both bradykinesia and rigidity. Experimental Neurology, 215(2), 380–387.PubMedCrossRef
Kumar, R., Lozano, A. M., Kim, Y. J., Hutchison, W. D., Sime, E., Halket, E., et al. (1998). Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson’s disease. Neurology, 51(3), 850–855.PubMedCrossRef
Lalo, E., Thobois, S., Sharott, A., Polo, G., Mertens, P., Pogosyan, A., et al. (2008). Patterns of bidirectional communication between cortex and basal ganglia during movement in patients with Parkinson disease. Journal of Neuroscience, 28(12), 3008–3016.PubMedCrossRef
Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983). Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science, 219(4587), 979–980.PubMedCrossRef
Levy, R., Ashby, P., Hutchison, W. D., Lang, A. E., Lozano, A. M., & Dostrovsky, J. O. (2002). Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson’s disease. Brain, 125(6), 1196–1209.PubMedCrossRef
Limousin, P., Pollak, P., Benazzouz, A., Hoffmann, D., Le Bas, J. F., Broussolle, E., et al. (1995). Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation. Lancet, 345, 91–95.PubMedCrossRef
Limousin, P., Krack, P., Pollak, P., Benazzouz, A., Ardouin, C., Hoffmann, D., et al. (1998). Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. New England Journal of Medicine, 339(16), 1105–1111.PubMedCrossRef
Little, S., & Brown, P. (2012). What brain signals are suitable for feedback control of deep brain stimulation in Parkinson’s disease? Annals of the New York Academy of Sciences, 1265, 9–24.PubMedCentralPubMedCrossRef
Little, S., Pogosyan, A., Neal, S., Zavala, B., Zrinzo, L., Hariz, M., et al. (2013). Adaptive deep brain stimulation in advanced Parkinson disease. Annals of Neurology, 74(3), 449–457.PubMedCentralPubMedCrossRef
Little, S., Beudel, M., Zrinzo, L., Foltynie, T., Limousin, P., Hariz, M., et al. (2015). Bilateral adaptive deep brain stimulation is effective in Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry. doi:10.​1136/​jnnp-2015-310972.
Litvak, V., Jha, A., Eusebio, A., Oostenveld, R., Foltynie, T., Limousin, P., et al. (2011). Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson’s disease. Brain, 134(2), 359–374.PubMedCrossRef
Loher, T. J., Burgunder, J. M., Pohle, T., Weber, S., Sommerhalder, R., & Krauss, J. K. (2002). Long-term pallidal deep brain stimulation in patients with advanced Parkinson disease: 1-year follow-up study. Journal of Neurosurgery, 96(5), 844–853.PubMedCrossRef
López-Azcárate, J., Tainta, M., Rodríguez-Oroz, M. C., Valencia, M., González, R., Guridi, J., et al. (2010). Coupling between beta and high-frequency activity in the human subthalamic nucleus may be a pathophysiological mechanism in Parkinson’s disease. Journal of Neuroscience, 30(19), 6667–6677.PubMedCrossRef
Lozano, A., Hutchison, W., Kiss, Z., Tasker, R., Davis, K., & Dostrovsky, J. (1996). Methods for microelectrode-guided posteroventral pallidotomy. Journal of Neurosurgery, 84(2), 194–202.PubMedCrossRef
Magill, P. J., Bolam, J. P., & Bevan, M. D. (2001). Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network. Journal of Neuroscience, 106(2), 313–330.CrossRef
Malekmohammadi, M., Herron, J., Velisar, A., Blumenfeld, Z., Trager, M.H., Chizeck, H.J., et al. (2015). Kinematic adaptive deep brain stimulation for resting tremor in Parkinson’s disease. Movement Disorders, in press.
Mazzone, P., Lozano, A., Stanzione, P., Galati, S., Scarnati, E., Peppe, A., et al. (2005). Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson’s disease. NeuroReport, 16(17), 1877–1881.PubMedCrossRef
McIntyre, C. C., & Grill, W. M. (1999). Excitation of central nervous system neurons by nonuniform electric fields. Biophysics Journal, 76(2), 878–888.CrossRef
McIntyre, C. C., & Grill, W. M. (2002). Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output. Journal of Neurophysiology, 88(4), 1592–1604.PubMed
McIntyre, C. C., Grill, W. M., Sherman, D. L., & Thakor, N. V. (2004). Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition. Journal of Neurophysiology, 91(4), 1457–1469.PubMedCrossRef
Meissner, W., Leblois, A., Hansel, D., Bioulac, B., Gross, C. E., Benazzouz, A., et al. (2005). Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations. Brain, 128(10), 2372–2382.PubMedCrossRef
Merola, A., Zibetti, M., Angrisano, S., Rizzi, L., Ricchi, V., Artusi, C. A., et al. (2011). Parkinson’s disease progression at 30 years: a study of subthalamic deep brain-stimulated patients. Brain, 134(7), 2074–2084.PubMedCrossRef
Mitchell, I. J., Cross, A. J., Sambrook, M. A., & Crossman, A. R. (1986). N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the monkey: neurochemical pathology and regional brain metabolism. Journal of Neural Transmission. Supplementum, 20, 41–46.PubMed
Montgomery, E. B. (2007). Basal ganglia physiology and pathophysiology: a reappraisal. Parkinsonism & Related Disorders, 13, 455–465.CrossRef
Moreau, C., Defebvre, L., Destée, A., Bleuse, S., Clement, F., Blatt, J. L., et al. (2008). STN-DBS frequency effects on freezing of gait in advanced Parkinson disease. Neurology, 71(2), 80–84.PubMedCrossRef
Moro, E., Scerrati, M., Romito, L. M., Roselli, R., Tonali, P., & Albanese, A. (1999). Chronic subthalamic nucleus stimulation reduces medication requirements in Parkinson’s disease. Neurology, 53(1), 85–90.PubMedCrossRef
Moro, E., Lozano, A. M., Pollak, P., Agid, Y., Rehncrona, S., Volkmann, J., et al. (2010). Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson’s disease. Movement Disorders, 25(5), 578–586.PubMedCrossRef
Morrell, M. J. (2011). Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology, 77(13), 1295–1304.PubMedCrossRef
Nambu, A., Tokuno, H., Hamada, I., Kita, H., Imanishi, M., Akazawa, T., et al. (2000). Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey. Journal of Neurophysiology, 84(1), 289–300.PubMed
Narabayashi, H. (1989). Stereotaxic Vim thalamotomy for treatment of tremor. European Neurology, 29(Suppl 1), 29–32.PubMedCrossRef
Neumann, W.-J., Staub, F., Horn, A., Schanda, J., Mueller, J., Schneider, G.-H., et al. (2015). Deep brain recordings using an implanted pulse generator in Parkinson’s disease. Neuromodulation. doi:10.​1111/​ner.​12348.PubMed
Nieuwboer, A., & Giladi, N. (2013). Characterizing freezing of gait in Parkinson’s disease: models of an episodic phenomenon. Movement Disorders, 28(11), 1509–1519.PubMedCrossRef
Nini, A., Feingold, A., Slovin, H., & Bergman, H. (1995). Neurons in the globus pallidus do not show correlated activity in the normal monkey, but phase-locked oscillations appear in the MPTP model of parkinsonism. Journal of Neurophysiology, 74(4), 1800–1805.PubMed
Nowak, L. G., & Bullier, J. (1998). Axons, but not cell bodies, are activated by electrical stimulation in cortical gray matter. I. Evidence from chronaxie measurements. Experimental Brain Research, 118, 477–488.PubMedCrossRef
Ohye, C., & Narabayashi, H. (1979). Physiological study of presumed ventralis intermedius neurons in the human thalamus. Journal of Neurosurgery, 50(3), 290–297.PubMedCrossRef
Ohye, C., Hirai, T., Miyazaki, M., Shibazaki, T., & Nakajima, H. (1982). Vim thalamotomy for the treatment of various kinds of tremor. Appled Neurophysiology, 45(3), 275–280.
Oswal, A., Brown, P., & Litvak, V. (2013). Synchronized neural oscillations and the pathophysiology of Parkinson’s disease. Current Opinions in Neurology, 26(6), 662–670.CrossRef
Özkurt, T. E., Butz, M., Homburger, M., Elben, S., Vesper, J., Wojtecki, L., et al. (2011). High frequency oscillations in the subthalamic nucleus: a neurophysiological marker of the motor state in Parkinson’s disease. Experimental Neurology, 229(2), 324–331.PubMedCrossRef
Pahwa, R., Wilkinson, S., Smith, D., Lyons, K., Miyawaki, E., & Koller, W. C. (1997). High-frequency stimulation of the globus pallidus for the treatment of Parkinson’s disease. Neurology, 49(1), 249–253.PubMedCrossRef
Pan, H. S., Frey, K. A., Young, A. B., & Penney, J. B. (1983). Changes in [3H] muscimol binding in substantia nigra, entopeduncular nucleus, globus pallidus, and thalamus after striatal lesions as demonstrated by quantitative receptor autoradiography. Journal of Neuroscience, 3(6), 1189–1198.PubMed
Pan, H. S., Penney, J. B., & Young, A. B. (1985). Gamma-aminobutyric acid and benzodiazepine receptor changes induced by unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. Journal of Neurochemistry, 45(5), 1396–1404.PubMedCrossRef
Parent, A., & Hazrati, L. N. (1995). Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Research Reviews, 20, 91–127.PubMedCrossRef
Piboolnurak, P., Lang, A. E., Lozano, A. M., Miyasaki, J. M., Saint-Cyr, J. A., Poon, Y. Y., et al. (2007). Levodopa response in long-term bilateral subthalamic stimulation for Parkinson’s disease. Movement Disorders, 22(7), 990–997.PubMedCrossRef
Plaha, P., & Gill, S. S. (2005). Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson’s disease. NeuroReport, 16(17), 1883–1887.PubMedCrossRef
Priori, A., Foffani, G., Pesenti, A., Bianchi, A., Chiesa, V., Baselli, G., et al. (2002). Movement-related modulation of neural activity in human basal ganglia and its L-DOPA dependency: recordings from deep brain stimulation electrodes in patients with Parkinson’s disease. Neurological Sciences, 23(2), S101–S102.PubMedCrossRef
Priori, A., Foffani, G., Pesenti, A., Tamma, F., Bianchi, A. M., Pellegrini, M., et al. (2004). Rhythm-specific pharmacological modulation of subthalamic activity in Parkinson’s disease. Experimental Neurology, 189, 369–379.PubMedCrossRef
Priori, A., Foffani, G., Rossi, L., & Marceglia, S. (2012). Adaptive deep brain stimulation (aDBS) controlled by local field potential oscillations. Experimental Neurology, 245, 77–86.PubMedCrossRef
Quinn, E. J., Blumenfeld, Z., Velisar, A., Koop, M. M., Shreve, L. A., Trager, M. H., et al. (2015). Beta oscillations in freely moving Parkinson’s subjects are attenuated during deep brain stimulation. Movement Disorders. doi:10.​1002/​mds.​26376.
Ramdhani, R. A., Patel, A., Swope, D., & Kopell, B. H. (2015). Early use of 60 Hz frequency subthalamic stimulation in Parkinson’s disease: a case series and review. Neuromodulation. doi:10.​1111/​ner.​12288.PubMed
Ray, N. J., Jenkinson, N., Wang, S., Holland, P., Brittain, J. S., Joint, C., et al. (2008). Local field potential beta activity in the subthalamic nucleus of patients with Parkinson’s disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. Experimental Neurology, 213, 108–113.PubMedCrossRef
Raz, A., Frechter-Mazar, V., Feingold, A., Abeles, M., Vaadia, E., & Bergman, H. (2001). Activity of pallidal and striatal tonically active neurons is correlated in MPTP-treated monkeys but not in normal monkeys. Journal of Neuroscience, 21(3), 1–5.
Ricchi, V., Zibetti, M., Angrisano, S., Merola, A., Arduino, N., Artusi, C. A., et al. (2012). Transient effects of 80 Hz stimulation on gait in STN DBS treated PD patients: a 15 months follow-up study. Brain Stimulation, 5(3), 388–392.PubMedCrossRef
Robledo, P., & Féger, J. (1990). Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological data. Brain Research, 518, 47–54.PubMedCrossRef
Rodriguez-Oroz, M. C., Obeso, J. A., Lang, A. E., Houeto, J. L., Pollak, P., Rehncrona, S., et al. (2005). Bilateral deep brain stimulation in Parkinson’s disease: a multicentre study with 4 years follow-up. Brain, 128(10), 2240–2249.PubMedCrossRef
Rodriguez-Oroz, M. C., Moro, E., & Krack, P. (2012). Long-term outcomes of surgical therapies for Parkinson’s disease. Movement Disorders, 27(14), 1718–1728.PubMedCrossRef
Romito, L. M., Contarino, M. F., Vanacore, N., Bentivoglio, A. R., Scerrati, M., & Albanese, A. (2009). Replacement of dopaminergic medication with subthalamic nucleus stimulation in Parkinson’s disease: long-term observation. Movement Disorders, 24(4), 557–563.PubMedCrossRef
Rosa, M., Giannicola, G., Servello, D., Marceglia, S., Pacchetti, C., Porta, M., et al. (2011). Subthalamic local field beta oscillations during ongoing deep brain stimulation in Parkinson’s disease in hyperacute and chronic phases. Neurosignals, 19(3), 151–162.PubMedCrossRef
Rosa, M., Arlotti, M., Ardolino, G., Cogiamanian, F., Marceglia, S., Di Fonzo, A., et al. (2015). Adaptive deep brain stimulation in a freely moving Parkinsonian patient. Movement Disorders, 30(7), 1003–1005.PubMedCrossRef
Rosin, B., Slovik, M., Mitelman, R., Rivlin-Etzion, M., Haber, S. N., Israel, Z., et al. (2011). Closed-loop deep brain stimulation is superior in ameliorating parkinsonism. Neuron, 72(2), 370–384.PubMedCrossRef
Schüpbach, W. M., Chastan, N., Welter, M. L., Houeto, J. L., Mesnage, V., Bonnet, A. M., et al. (2005). Stimulation of the subthalamic nucleus in Parkinson’s disease: a 5 year follow up. Journal of Neurology, Neurosurgery & Psychiatry, 76(12), 1640–1644.CrossRef
Sharott, A., Magill, P. J., Harnack, D., Kupsch, A., Meissner, W., & Brown, P. (2005). Dopamine depletion increases the power and coherence of beta-oscillations in the cerebral cortex and subthalamic nucleus of the awake rat. European Journal of Neuroscience, 21(5), 1413–1422.PubMedCrossRef
Sidiropoulos, C., Walsh, R., Meaney, C., Poon, Y. Y., Fallis, M., & Moro, E. (2013). Low-frequency subthalamic nucleus deep brain stimulation for axial symptoms in advanced Parkinson’s disease. Neurology, 260(9), 2306–2311.CrossRef
Siegfried, J., & Lippitz, B. (1994). Chronic electrical stimulation of the VL-VPL complex and of the pallidum in the treatment of movement disorders: personal experience since 1982. Stereotactic and Functional Neurosurgery, 62, 71–75.PubMedCrossRef
Silberstein, P., Oliviero, A., Di Lazzaro, V., Insola, A., Mazzone, P., & Brown, P. (2005). Oscillatory pallidal local field potential activity inversely correlates with limb dyskinesias in Parkinson’s disease. Experimental Neurology, 194(2), 523–529.PubMedCrossRef
Singh, A., Plate, A., Kammermeier, S., Mehrkens, J. H., Ilmberger, J., & Bötzel, K. (2013). Freezing of gait-related oscillatory activity in the human subthalamic nucleus. Basal Ganglia, 3, 25–32.CrossRef
Stanslaski, S., Afshar, P., Cong, P., Giftakis, J., Stypulkowski, P., Carlson, D., et al. (2012). Design and validation of a fully implantable, chronic, closed-loop neuromodulation device with concurrent sensing and stimulation. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 20(4), 410–421.PubMedCrossRef
Stefani, A., Lozano, A. M., Peppe, A., Stanzione, P., Galati, S., Tropepi, D., et al. (2007). Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson’s disease. Brain, 130(6), 1596–1607.PubMedCrossRef
Stegemöller, E. L., Vallabhajosula, S., Haq, I., Hwynn, N., Hass, C. J., & Okun, M. S. (2013). Selective use of low frequency stimulation in Parkinson’s disease based on absence of tremor. NeuroRehabilitation, 33(2), 305–312.PubMed
Stypulkowski, P. H., Stanslaski, S. R., Denison, T. J., & Giftakis, J. E. (2013). Chronic evaluation of a clinical system for deep brain stimulation and recording of neural network activity. Stereotactic and Functional Neurosurgery, 91(4), 220–232.PubMedCrossRef
Stypulkowski, P. H., Stanslaski, S. R., Jensen, R. M., Denison, T. J., & Giftakis, J. E. (2014). Brain stimulation for epilepsy--local and remote modulation of network excitability. Brain Stimulation, 7(3), 350–358.PubMedCrossRef
The Deep Brain Stimulation for Parkinson’s Disease Study Group. (2001). Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson’s disease. New England Journal of Medicine, 345(13), 956–963.CrossRef
Timmermann, L., Gross, J., Dirks, M., Volkmann, J., Freund, H. J., & Schnitzler, A. (2003). The cerebral oscillatory network of parkinsonian resting tremor. Brain, 126(1), 199–212.PubMedCrossRef
Timmermann, L., Wojtecki, L., Gross, J., Lehrke, R., Voges, J., Maarouf, M., et al. (2004). Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson’s disease. Movement Disorders, 19(11), 1328–1333.PubMedCrossRef
Toledo, J. B., López-Azcárate, J., Garcia-Garcia, D., Guridi, J., Valencia, M., Artieda, J., et al. (2014). High beta activity in the subthalamic nucleus and freezing of gait in Parkinson’s disease. Neurobiology of Disease, 64, 60–65.PubMedCrossRef
Tort, A. B., Komorowski, R., Eichenbaum, H., & Kopell, N. (2010). Measuring phase-amplitude coupling between neuronal oscillations of different frequencies. Journal of Neurophysiology, 104(2), 1195–1210.PubMedCentralPubMedCrossRef
van Wijk, B. C., Jha, A., Penny, W., & Litvak, V. (2015). Parametric estimation of cross-frequency coupling. Journal of Neuroscience Methods, 243, 94–102.PubMedCentralPubMedCrossRef
Vitek, J., Bakay, R., Hashimoto, T., Kaneoke, Y., Mewes, K., Zhang, J. Y., et al. (1998). Microelectrode guided pallidotomy: technical approach and its application in medically intractable Parkinson’s disease. Journal of Neurosurgery, 88, 1027–1043.PubMedCrossRef
Volkmann, J., Joliot, M., Mogilner, A., Ioannides, A. A., Lado, F., Fazzini, E., et al. (1996). Central motor loop oscillations in parkinsonian resting tremor revealed by magnetoencephalography. Neurology, 46(5), 1359–1370.PubMedCrossRef
Volkmann, J., Sturm, V., Weiss, P., Kappler, J., Voges, J., Koulousakis, A., et al. (1998). Bilateral high-frequency stimulation of the internal globus pallidus in advanced Parkinson’s disease. Annals of Neurology, 44(6), 953–961.PubMedCrossRef
Volkmann, J., Allert, N., Voges, J., Weiss, P. H., Freund, H. J., & Sturm, V. (2001). Safety and efficacy of pallidal or subthalamic nucleus stimulation in advanced PD. Neurology, 56(4), 548–551.PubMedCrossRef
Volkmann, J., Allert, N., Voges, J., Sturm, V., Schnitzler, A., & Freund, H. J. (2004). Long-term results of bilateral pallidal stimulation in Parkinson’s disease. Annals of Neurology, 55(6), 871–875.PubMedCrossRef
Vyas, S., Huang, H., Gale, J., Sarma, S., & Montgomery, E. (2015). Neuronal complexity in subthalamic nucleus is reduced in Parkinson’s disease. IEEE Transactions on Neural Systems and Rehabilitation Engineering. doi:10.​1109/​TNSRE.​2015.​2453254.PubMed
Weaver, F. M., Follett, K. A., Stern, M., Luo, P., Harris, C. L., Hur, K., et al. (2012). Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes. Neurology, 79(1), 55–65.PubMedCentralPubMedCrossRef
Weinberger, M., Mahant, N., Hutchison, W. D., Lozano, A. M., Moro, E., Hodaie, M., et al. (2006). Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson’s disease. Journal of Neurophysiology, 96, 3248–3256.PubMedCrossRef
Whitmer, D., de Solages, C., Hill, B., Yu, H., Henderson, J. M., & Bronte-Stewart, H. (2012). High frequency deep brain stimulation attenuates subthalamic and cortical rhythms in Parkinson’s disease. Frontiers in Human Neuroscience, 6(155), 1–18.
Wichmann, T., Bergman, H., & DeLong, M. (1994). The primate subthalamic nucleus. I. Functional properties in intact animals. Journal of Neurophysiology, 72(2), 494–506.PubMed
Wider, C., Pollo, C., Bloch, J., Burkhard, P. R., & Vingerhoets, F. J. (2008). Long-term outcome of 50 consecutive Parkinson’s disease patients treated with subthalamic deep brain stimulation. Parkinsonism & Related Disorders, 14(2), 114–119.CrossRef
Williams, D., Tijssen, M., van Bruggen, G., Bosch, A., Insola, A., Di Lazzaro, V., et al. (2002). Dopamine-dependent changes in the functional connectivity between basal ganglia and cerebral cortex in humans. Brain, 125, 1558–1569.PubMedCrossRef
Wingeier, B., Tcheng, T., Koop, M. M., Hill, B. C., Heit, G., & Bronte-Stewart, H. (2006). Intra-operative STN DBS attenuates the prominent beta rhythm in the STN in Parkinson’s disease. Experimental Neurology, 197, 244–251.PubMedCrossRef
Xu, W., Russo, G. S., Hashimoto, T., Zhang, J., & Vitek, J. L. (2008). Subthalamic nucleus stimulation modulates thalamic neuronal activity. Journal of Neuroscience, 28(46), 11916–11924.PubMedCentralPubMedCrossRef
Yang, A. I., Vanegas, N., Lungu, C., & Zaghloul, K. A. (2014). Beta-coupled high-frequency activity and beta-locked neuronal spiking in the subthalamic nucleus of Parkinson’s disease. Journal of Neuroscience, 34(38), 12816–12827.PubMedCentralPubMedCrossRef
Zibetti, M., Merola, A., Rizzi, L., Ricchi, V., Angrisano, S., Azzaro, C., et al. (2011). Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson’s disease. Movement Disorders, 26(13), 2327–2334.PubMedCrossRef
Metadata
Title
High Frequency Deep Brain Stimulation and Neural Rhythms in Parkinson’s Disease
Authors
Zack Blumenfeld
Helen Brontë-Stewart
Publication date
01-12-2015
Publisher
Springer US
Published in
Neuropsychology Review / Issue 4/2015
Print ISSN: 1040-7308
Electronic ISSN: 1573-6660
DOI
https://doi.org/10.1007/s11065-015-9308-7

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