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Published in: Neuropsychology Review 2/2015

01-06-2015 | Review

The Potential Utility of Eye Movements in the Detection and Characterization of Everyday Functional Difficulties in Mild Cognitive Impairment

Authors: Sarah C. Seligman, Tania Giovannetti

Published in: Neuropsychology Review | Issue 2/2015

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Abstract

Mild cognitive impairment (MCI) refers to the intermediate period between the typical cognitive decline of normal aging and more severe decline associated with dementia, and it is associated with greater risk for progression to dementia. Research has suggested that functional abilities are compromised in MCI, but the degree of impairment and underlying mechanisms remain poorly understood. The development of sensitive measures to assess subtle functional decline poses a major challenge for characterizing functional limitations in MCI. Eye-tracking methodology has been used to describe visual processes in everyday, naturalistic action among healthy older adults as well as several case studies of severely impaired individuals, and it has successfully differentiated healthy older adults from those with MCI on specific visual tasks. These studies highlight the promise of eye-tracking technology as a method to characterize subtle functional decline in MCI. However, to date no studies have examined visual behaviors during completion of naturalistic tasks in MCI. This review describes the current understanding of functional ability in MCI, summarizes findings of eye-tracking studies in healthy individuals, severe impairment, and MCI, and presents future research directions to aid with early identification and prevention of functional decline in disorders of aging.
Literature
go back to reference Aggarwal, N. T., Wilson, R. S., Beck, T. L., Bienias, J. L., & Bennett, D. A. (2005). Mild cognitive impairment in different functional domains and incident Alzheimer’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 76(11), 1479–1484. doi:10.1136/jnnp.2004.053561.PubMedCentralPubMed Aggarwal, N. T., Wilson, R. S., Beck, T. L., Bienias, J. L., & Bennett, D. A. (2005). Mild cognitive impairment in different functional domains and incident Alzheimer’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 76(11), 1479–1484. doi:10.​1136/​jnnp.​2004.​053561.PubMedCentralPubMed
go back to reference Albert, S. M., Tabert, M. H., Dienstag, A., Pelton, G., & Devanand, D. (2002). The impact of mild cognitive impairment on functional abilities in the elderly. Current Psychiatry Reports, 4(1), 64–68.PubMed Albert, S. M., Tabert, M. H., Dienstag, A., Pelton, G., & Devanand, D. (2002). The impact of mild cognitive impairment on functional abilities in the elderly. Current Psychiatry Reports, 4(1), 64–68.PubMed
go back to reference Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., & Phelps, C. H. (2011). The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement, 7(3), 270–279. doi:10.1016/j.jalz.2011.03.008.PubMedCentralPubMed Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., & Phelps, C. H. (2011). The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement, 7(3), 270–279. doi:10.​1016/​j.​jalz.​2011.​03.​008.PubMedCentralPubMed
go back to reference Alexopoulos, P., Grimmer, T., Perneczky, R., Domes, G., & Kurz, A. (2006). Progression to dementia in clinical subtypes of mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 22(1), 27–34. doi:10.1159/000093101.PubMed Alexopoulos, P., Grimmer, T., Perneczky, R., Domes, G., & Kurz, A. (2006). Progression to dementia in clinical subtypes of mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 22(1), 27–34. doi:10.​1159/​000093101.PubMed
go back to reference Allaire, J. C., Gamaldo, A., Ayotte, B. J., Sims, R., & Whitfield, K. (2009). Mild cognitive impairment and objective instrumental everyday functioning: the everyday cognition battery memory test. Journal of American Geriatrics Society, 57(1), 120–125. doi:10.1111/j.1532-5415.2008.02054.x. Allaire, J. C., Gamaldo, A., Ayotte, B. J., Sims, R., & Whitfield, K. (2009). Mild cognitive impairment and objective instrumental everyday functioning: the everyday cognition battery memory test. Journal of American Geriatrics Society, 57(1), 120–125. doi:10.​1111/​j.​1532-5415.​2008.​02054.​x.
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington: American Psychiatric Publishing. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington: American Psychiatric Publishing.
go back to reference Aretouli, E., & Brandt, J. (2010). Everyday functioning in mild cognitive impairment and its relationship with executive cognition. International Journal of Geriatric Psychiatry, 25(3), 224–233. doi:10.1002/gps.2325.PubMedCentralPubMed Aretouli, E., & Brandt, J. (2010). Everyday functioning in mild cognitive impairment and its relationship with executive cognition. International Journal of Geriatric Psychiatry, 25(3), 224–233. doi:10.​1002/​gps.​2325.PubMedCentralPubMed
go back to reference Arguelles, S., Loewenstein, D. A., Eisdorfer, C., & Arguelles, T. (2001). Caregivers’ judgments of the functional abilities of the Alzheimer’s disease patient: impact of caregivers’ depression and perceived burden. Journal of Geriatric Psychiatry and Neurology, 14(2), 91–98.PubMed Arguelles, S., Loewenstein, D. A., Eisdorfer, C., & Arguelles, T. (2001). Caregivers’ judgments of the functional abilities of the Alzheimer’s disease patient: impact of caregivers’ depression and perceived burden. Journal of Geriatric Psychiatry and Neurology, 14(2), 91–98.PubMed
go back to reference Artero, S., Touchon, J., & Ritchie, K. (2001). Disability and mild cognitive impairment: a longitudinal population-based study. International Journal of Geriatric Psychiatry, 16(11), 1092–1097.PubMed Artero, S., Touchon, J., & Ritchie, K. (2001). Disability and mild cognitive impairment: a longitudinal population-based study. International Journal of Geriatric Psychiatry, 16(11), 1092–1097.PubMed
go back to reference Artero, S., Petersen, R., Touchon, J., & Ritchie, K. (2006). Revised criteria for mild cognitive impairment: validation within a longitudinal population study. Dementia and Geriatric Cognitive Disorders, 22(5–6), 465–470. doi:10.1159/000096287.PubMed Artero, S., Petersen, R., Touchon, J., & Ritchie, K. (2006). Revised criteria for mild cognitive impairment: validation within a longitudinal population study. Dementia and Geriatric Cognitive Disorders, 22(5–6), 465–470. doi:10.​1159/​000096287.PubMed
go back to reference Ballard, D. H., Hayhoe, M. M., Li, F., & Whitehead, S. D. (1992). Hand-eye coordination during sequential tasks. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 337(1281), 331–338. doi:10.1098/rstb.1992.0111. discussion 338–339.PubMed Ballard, D. H., Hayhoe, M. M., Li, F., & Whitehead, S. D. (1992). Hand-eye coordination during sequential tasks. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 337(1281), 331–338. doi:10.​1098/​rstb.​1992.​0111. discussion 338–339.PubMed
go back to reference Bangen, K. J., Jak, A. J., Schiehser, D. M., Delano-Wood, L., Tuminello, E., Han, S. D., & Bondi, M. W. (2010). Complex activities of daily living vary by mild cognitive impairment subtype. Journal of the International Neuropsychological Society, 16(4), 630–639. doi:10.1017/S1355617710000330.PubMedCentralPubMed Bangen, K. J., Jak, A. J., Schiehser, D. M., Delano-Wood, L., Tuminello, E., Han, S. D., & Bondi, M. W. (2010). Complex activities of daily living vary by mild cognitive impairment subtype. Journal of the International Neuropsychological Society, 16(4), 630–639. doi:10.​1017/​S135561771000033​0.PubMedCentralPubMed
go back to reference Barberger-Gateau, P., Fabrigoule, C., Rouch, I., Letenneur, L., & Dartigues, J. F. (1999). Neuropsychological correlates of self-reported performance in instrumental activities of daily living and prediction of dementia. Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 54(5), 293–303. Barberger-Gateau, P., Fabrigoule, C., Rouch, I., Letenneur, L., & Dartigues, J. F. (1999). Neuropsychological correlates of self-reported performance in instrumental activities of daily living and prediction of dementia. Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, 54(5), 293–303.
go back to reference Becker, W., & Jurgens, R. (1979). An analysis of the saccadic system by means of double step stimuli. Vision Research, 19(9), 967–983.PubMed Becker, W., & Jurgens, R. (1979). An analysis of the saccadic system by means of double step stimuli. Vision Research, 19(9), 967–983.PubMed
go back to reference Bettcher, B. M., Giovannetti, T., Macmullen, L., & Libon, D. J. (2008). Error detection and correction patterns in dementia: a breakdown of error monitoring processes and their neuropsychological correlates. Journal of the International Neuropsychological Society, 14(2), 199–208. doi:10.1017/S1355617708080193.PubMed Bettcher, B. M., Giovannetti, T., Macmullen, L., & Libon, D. J. (2008). Error detection and correction patterns in dementia: a breakdown of error monitoring processes and their neuropsychological correlates. Journal of the International Neuropsychological Society, 14(2), 199–208. doi:10.​1017/​S135561770808019​3.PubMed
go back to reference Bombin, I., Santiago-Ramajo, S., Garolera, M., Vega-Gonzalez, E. M., Cerulla, N., Caracuel, A., & Bobes, J. (2012). Functional impairment as a defining feature of: amnestic MCI cognitive, emotional, and demographic correlates. International Psychogeriatrics, 24(9), 1494–1504. doi:10.1017/S1041610212000622.PubMed Bombin, I., Santiago-Ramajo, S., Garolera, M., Vega-Gonzalez, E. M., Cerulla, N., Caracuel, A., & Bobes, J. (2012). Functional impairment as a defining feature of: amnestic MCI cognitive, emotional, and demographic correlates. International Psychogeriatrics, 24(9), 1494–1504. doi:10.​1017/​S104161021200062​2.PubMed
go back to reference Burton, C. L., Strauss, E., Bunce, D., Hunter, M. A., & Hultsch, D. F. (2009). Functional abilities in older adults with mild cognitive impairment. Gerontology, 55(5), 570–581. doi:10.1159/000228918.PubMed Burton, C. L., Strauss, E., Bunce, D., Hunter, M. A., & Hultsch, D. F. (2009). Functional abilities in older adults with mild cognitive impairment. Gerontology, 55(5), 570–581. doi:10.​1159/​000228918.PubMed
go back to reference Buswell, G.T. (1920). An experimental study of the eye-voice span in reading. Supplementary Educational Monographs. No. 17 Chicago: Chicago University Press. Buswell, G.T. (1920). An experimental study of the eye-voice span in reading. Supplementary Educational Monographs. No. 17 Chicago: Chicago University Press.
go back to reference Buswell, G. T. (1935). How people look at pictures: A study of the psychology of perception in art. Chicago: Chicago University Press. Buswell, G. T. (1935). How people look at pictures: A study of the psychology of perception in art. Chicago: Chicago University Press.
go back to reference Butsch, R. L. C. (1932). Eye movements and the eye-hand span in typewriting. Journal of Educational Psychology, 23, 104–121. Butsch, R. L. C. (1932). Eye movements and the eye-hand span in typewriting. Journal of Educational Psychology, 23, 104–121.
go back to reference Corbetta, M., Akbudak, E., Conturo, T. E., Snyder, A. Z., Ollinger, J. M., Drury, H. A., & Shulman, G. L. (1998). A common network of functional areas for attention and eye movements. Neuron, 21(4), 761–773.PubMed Corbetta, M., Akbudak, E., Conturo, T. E., Snyder, A. Z., Ollinger, J. M., Drury, H. A., & Shulman, G. L. (1998). A common network of functional areas for attention and eye movements. Neuron, 21(4), 761–773.PubMed
go back to reference Crutcher, M. D., Calhoun-Haney, R., Manzanares, C. M., Lah, J. J., Levey, A. I., & Zola, S. M. (2009). Eye tracking during a visual paired comparison task as a predictor of early dementia. American Journal of Alzheimer’s Disease and Other Dementias, 24(3), 258–266. doi:10.1177/1533317509332093.PubMedCentralPubMed Crutcher, M. D., Calhoun-Haney, R., Manzanares, C. M., Lah, J. J., Levey, A. I., & Zola, S. M. (2009). Eye tracking during a visual paired comparison task as a predictor of early dementia. American Journal of Alzheimer’s Disease and Other Dementias, 24(3), 258–266. doi:10.​1177/​1533317509332093​.PubMedCentralPubMed
go back to reference Dodge, R., & Cline, T. S. (1901). The angle velocity of eye movements. Psychological Review, 8, 145–157. Dodge, R., & Cline, T. S. (1901). The angle velocity of eye movements. Psychological Review, 8, 145–157.
go back to reference Findlay, J. M., & Gilchrist, I. D. (2003). Active vision: The psychology of looking and seeing. Oxford: Oxford University Press. Findlay, J. M., & Gilchrist, I. D. (2003). Active vision: The psychology of looking and seeing. Oxford: Oxford University Press.
go back to reference Folk, C. L., Remington, R. W., & Johnston, J. C. (1992). Involuntary covert orienting is contingent on attentional control settings. Journal of Experimental Psychology: Human Perception and Performance, 18(4), 1030–1044.PubMed Folk, C. L., Remington, R. W., & Johnston, J. C. (1992). Involuntary covert orienting is contingent on attentional control settings. Journal of Experimental Psychology: Human Perception and Performance, 18(4), 1030–1044.PubMed
go back to reference Gilbert, C. D. (1998). Adult cortical dynamics. Physiological Reviews, 78(2), 467–485.PubMed Gilbert, C. D. (1998). Adult cortical dynamics. Physiological Reviews, 78(2), 467–485.PubMed
go back to reference Giovannetti, T., Bettcher, B. M., Brennan, L., Libon, D. J., Burke, M., Duey, K., & Wambach, D. (2008). Characterization of everyday functioning in mild cognitive impairment: a direct assessment approach. Dementia and Geriatric Cognitive Disorders, 25(4), 359–365. doi:10.1159/000121005.PubMed Giovannetti, T., Bettcher, B. M., Brennan, L., Libon, D. J., Burke, M., Duey, K., & Wambach, D. (2008). Characterization of everyday functioning in mild cognitive impairment: a direct assessment approach. Dementia and Geriatric Cognitive Disorders, 25(4), 359–365. doi:10.​1159/​000121005.PubMed
go back to reference Gold, D. A. (2012). An examination of instrumental activities of daily living assessment in older adults and mild cognitive impairment. Journal of Clinical and Experimental Neuropsychology, 34(1), 11–34. doi:10.1080/13803395.2011.614598.PubMed Gold, D. A. (2012). An examination of instrumental activities of daily living assessment in older adults and mild cognitive impairment. Journal of Clinical and Experimental Neuropsychology, 34(1), 11–34. doi:10.​1080/​13803395.​2011.​614598.PubMed
go back to reference Gold, D. A., Park, N. W., Troyer, A. K., & Murphy, K. J. (2014). Compromised naturalistic action performance in amnestic mild cognitive impairment. Neuropsychology. doi:10.1037/neu0000132. Gold, D. A., Park, N. W., Troyer, A. K., & Murphy, K. J. (2014). Compromised naturalistic action performance in amnestic mild cognitive impairment. Neuropsychology. doi:10.​1037/​neu0000132.
go back to reference Gomar, J. J., Bobes-Bascaran, M. T., Conejero-Goldberg, C., Davies, P., Goldberg, T. E., & Alzheimer’s Disease Neuroimaging, Initiative. (2011). Utility of combinations of biomarkers, cognitive markers, and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer’s disease neuroimaging initiative. Archives of General Psychiatry, 68(9), 961–969. doi:10.1001/archgenpsychiatry.2011.96.PubMed Gomar, J. J., Bobes-Bascaran, M. T., Conejero-Goldberg, C., Davies, P., Goldberg, T. E., & Alzheimer’s Disease Neuroimaging, Initiative. (2011). Utility of combinations of biomarkers, cognitive markers, and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer’s disease neuroimaging initiative. Archives of General Psychiatry, 68(9), 961–969. doi:10.​1001/​archgenpsychiatr​y.​2011.​96.PubMed
go back to reference Griffith, H. R., Belue, K., Sicola, A., Krzywanski, S., Zamrini, E., Harrell, L., & Marson, D. C. (2003). Impaired financial abilities in mild cognitive impairment: a direct assessment approach. Neurology, 60(3), 449–457.PubMed Griffith, H. R., Belue, K., Sicola, A., Krzywanski, S., Zamrini, E., Harrell, L., & Marson, D. C. (2003). Impaired financial abilities in mild cognitive impairment: a direct assessment approach. Neurology, 60(3), 449–457.PubMed
go back to reference Hayhoe, M. M. (2000). Vision using routines: a functional account of vision. Visual Cognition, 7(1/2/3), 43–64. Hayhoe, M. M. (2000). Vision using routines: a functional account of vision. Visual Cognition, 7(1/2/3), 43–64.
go back to reference Hayhoe, M. M., Bensinger, D. G., & Ballard, D. H. (1998). Task constraints in visual working memory. Vision Research, 38(1), 125–137.PubMed Hayhoe, M. M., Bensinger, D. G., & Ballard, D. H. (1998). Task constraints in visual working memory. Vision Research, 38(1), 125–137.PubMed
go back to reference Hayhoe, M. M., Shrivastava, A., Mruczek, R., & Pelz, J. B. (2003). Visual memory and motor planning in a natural task. Journal of Vision, 3(10:1167/3.1.6), 49–63.PubMed Hayhoe, M. M., Shrivastava, A., Mruczek, R., & Pelz, J. B. (2003). Visual memory and motor planning in a natural task. Journal of Vision, 3(10:1167/3.1.6), 49–63.PubMed
go back to reference Heine, A., Thaler, V., Tamm, S., Hawelka, S., Schneider, M., Torbeyns, J., & Jacobs, A. M. (2010). What the eyes already ‘know’: using eye movement measurement to tap into children’s implicit numerical magnitude representations. Infant and Child Development, 19(2), 175–186. Heine, A., Thaler, V., Tamm, S., Hawelka, S., Schneider, M., Torbeyns, J., & Jacobs, A. M. (2010). What the eyes already ‘know’: using eye movement measurement to tap into children’s implicit numerical magnitude representations. Infant and Child Development, 19(2), 175–186.
go back to reference Humphreys, G. W., & Forde, E. M. (1998). Disordered action schema and action disorganization syndrome. Cognitive Neuropsychology, 15, 771–811. Humphreys, G. W., & Forde, E. M. (1998). Disordered action schema and action disorganization syndrome. Cognitive Neuropsychology, 15, 771–811.
go back to reference Irwin, D. E. (1991). Information integration across saccadic eye movements. Cognitive Psychology, 23(3), 420–456.PubMed Irwin, D. E. (1991). Information integration across saccadic eye movements. Cognitive Psychology, 23(3), 420–456.PubMed
go back to reference Irwin, D. E., Zacks, J. L., & Brown, J. S. (1990). Visual memory and the perception of a stable visual environment. Perception & Psychophysics, 47(1), 35–46. Irwin, D. E., Zacks, J. L., & Brown, J. S. (1990). Visual memory and the perception of a stable visual environment. Perception & Psychophysics, 47(1), 35–46.
go back to reference Itti, L., & Koch, C. (2000). A saliency-based search mechanism for overt and covert shifts of visual attention. Vision Research, 40(10–12), 1489–1506.PubMed Itti, L., & Koch, C. (2000). A saliency-based search mechanism for overt and covert shifts of visual attention. Vision Research, 40(10–12), 1489–1506.PubMed
go back to reference Jefferson, A. L., Byerly, L. K., Vanderhill, S., Lambe, S., Wong, S., Ozonoff, A., & Karlawish, J. H. (2008). Characterization of activities of daily living in individuals with mild cognitive impairment. The American Journal of Geriatric Psychiatry, 16(5), 375–383. doi:10.1097/JGP.0b013e318162f197.PubMedCentralPubMed Jefferson, A. L., Byerly, L. K., Vanderhill, S., Lambe, S., Wong, S., Ozonoff, A., & Karlawish, J. H. (2008). Characterization of activities of daily living in individuals with mild cognitive impairment. The American Journal of Geriatric Psychiatry, 16(5), 375–383. doi:10.​1097/​JGP.​0b013e318162f197​.PubMedCentralPubMed
go back to reference Johansson, R. S., Westling, G., Backstrom, A., & Flanagan, J. R. (2001). Eye-hand coordination in object manipulation. Journal of Neuroscience, 21(17), 6917–6932.PubMed Johansson, R. S., Westling, G., Backstrom, A., & Flanagan, J. R. (2001). Eye-hand coordination in object manipulation. Journal of Neuroscience, 21(17), 6917–6932.PubMed
go back to reference Jovancevic, J., Sullivan, B., & Hayhoe, M. (2006). Control of attention and gaze in complex environments. Journal of Vision, 6(12), 1431–1450. doi:10.1167/6.12.9.PubMed Jovancevic, J., Sullivan, B., & Hayhoe, M. (2006). Control of attention and gaze in complex environments. Journal of Vision, 6(12), 1431–1450. doi:10.​1167/​6.​12.​9.PubMed
go back to reference Kapoula, Z., Yang, Q., Otero-Millan, J., Xiao, S., Macknik, S. L., Lang, A., & Martinez-Conde, S. (2014). Distinctive features of microsaccades in Alzheimer’s disease and in mild cognitive impairment. Age (Dordrecht, Netherlands), 36(2), 535–543. doi:10.1007/s11357-013-9582-3. Kapoula, Z., Yang, Q., Otero-Millan, J., Xiao, S., Macknik, S. L., Lang, A., & Martinez-Conde, S. (2014). Distinctive features of microsaccades in Alzheimer’s disease and in mild cognitive impairment. Age (Dordrecht, Netherlands), 36(2), 535–543. doi:10.​1007/​s11357-013-9582-3.
go back to reference Kirchberg, B. C., Cohen, J. R., Adelsky, M. B., Buthorn, J. J., Gomar, J. J., Gordon, M., & Goldberg, T. E. (2012). Semantic distance abnormalities in mild cognitive impairment: their nature and relationship to function. The American Journal of Psychiatry, 169(12), 1275–1283. doi:10.1176/appi.ajp.2012.12030383.PubMed Kirchberg, B. C., Cohen, J. R., Adelsky, M. B., Buthorn, J. J., Gomar, J. J., Gordon, M., & Goldberg, T. E. (2012). Semantic distance abnormalities in mild cognitive impairment: their nature and relationship to function. The American Journal of Psychiatry, 169(12), 1275–1283. doi:10.​1176/​appi.​ajp.​2012.​12030383.PubMed
go back to reference Kohler, S., Hamel, R., Sistermans, N., Koene, T., Pijnenburg, Y. A., van der Flier, W. M., & Ramakers, I. (2013). Progression to dementia in memory clinic patients without dementia: a latent profile analysis. Neurology, 81(15), 1342–1349. doi:10.1212/WNL.0b013e3182a82536.PubMed Kohler, S., Hamel, R., Sistermans, N., Koene, T., Pijnenburg, Y. A., van der Flier, W. M., & Ramakers, I. (2013). Progression to dementia in memory clinic patients without dementia: a latent profile analysis. Neurology, 81(15), 1342–1349. doi:10.​1212/​WNL.​0b013e3182a82536​.PubMed
go back to reference Land, M. F., & Hayhoe, M. (2001). In what ways do eye movements contribute to everyday activities? Vision Research, 41(25–26), 3559–3565.PubMed Land, M. F., & Hayhoe, M. (2001). In what ways do eye movements contribute to everyday activities? Vision Research, 41(25–26), 3559–3565.PubMed
go back to reference Land, M. F., Mennie, N., & Rusted, J. (1999). The roles of vision and eye movements in the control of activities of daily living. Perception, 28(11), 1311–1328.PubMed Land, M. F., Mennie, N., & Rusted, J. (1999). The roles of vision and eye movements in the control of activities of daily living. Perception, 28(11), 1311–1328.PubMed
go back to reference Libon, D. J., Xie, S. X., Eppig, J., Wicas, G., Lamar, M., Lippa, C., & Wambach, D. M. (2010). The heterogeneity of mild cognitive impairment: a neuropsychological analysis. Journal of the International Neuropsychological Society, 16(1), 84–93. doi:10.1017/S1355617709990993.PubMed Libon, D. J., Xie, S. X., Eppig, J., Wicas, G., Lamar, M., Lippa, C., & Wambach, D. M. (2010). The heterogeneity of mild cognitive impairment: a neuropsychological analysis. Journal of the International Neuropsychological Society, 16(1), 84–93. doi:10.​1017/​S135561770999099​3.PubMed
go back to reference Luck, T., Luppa, M., Angermeyer, M. C., Villringer, A., Konig, H. H., & Riedel-Heller, S. G. (2011). Impact of impairment in instrumental activities of daily living and mild cognitive impairment on time to incident dementia: results of the Leipzig Longitudinal Study of the Aged. Psychological Medicine, 41(5), 1087–1097. doi:10.1017/S003329171000142X.PubMed Luck, T., Luppa, M., Angermeyer, M. C., Villringer, A., Konig, H. H., & Riedel-Heller, S. G. (2011). Impact of impairment in instrumental activities of daily living and mild cognitive impairment on time to incident dementia: results of the Leipzig Longitudinal Study of the Aged. Psychological Medicine, 41(5), 1087–1097. doi:10.​1017/​S003329171000142​X.PubMed
go back to reference Mariani, E., Monastero, R., Ercolani, S., Rinaldi, P., Mangialasche, F., Costanzi, E., & Mecocci, P. (2008). Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGAl project. International Journal of Geriatric Psychiatry, 23(5), 523–530. doi:10.1002/gps.1932.PubMed Mariani, E., Monastero, R., Ercolani, S., Rinaldi, P., Mangialasche, F., Costanzi, E., & Mecocci, P. (2008). Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic mild cognitive impairment: results from the ReGAl project. International Journal of Geriatric Psychiatry, 23(5), 523–530. doi:10.​1002/​gps.​1932.PubMed
go back to reference Mogg, K., Bradley, B. P., Field, M., & De Houwer, J. (2003). Eye movements to smoking-related pictures in smokers: relationship between attentional biases and implicit and explicit measures of stimulus valence. Addiction, 98(6), 825–836.PubMed Mogg, K., Bradley, B. P., Field, M., & De Houwer, J. (2003). Eye movements to smoking-related pictures in smokers: relationship between attentional biases and implicit and explicit measures of stimulus valence. Addiction, 98(6), 825–836.PubMed
go back to reference Molitor, R. J., Ko, P. C., & Ally, B. A. (2015). Eye movements in Alzheimer’s disease. Journal of Alzheimer’s Disease, 44(1), 1–12.PubMed Molitor, R. J., Ko, P. C., & Ally, B. A. (2015). Eye movements in Alzheimer’s disease. Journal of Alzheimer’s Disease, 44(1), 1–12.PubMed
go back to reference Morady, K., & Humphreys, G. W. (2011a). Eye movements in action disorganization syndrome: a single case analysis. Visual Cognition, 19(6), 817–831. Morady, K., & Humphreys, G. W. (2011a). Eye movements in action disorganization syndrome: a single case analysis. Visual Cognition, 19(6), 817–831.
go back to reference Norbury, C. F., Brock, J., Cragg, L., Einav, S., Griffiths, H., & Nation, K. (2009). Eye-movement patterns are associated with communicative competence in autistic spectrum disorders. Journal of Child Psychology and Psychiatry, 50(7), 834–842. doi:10.1111/j.1469-7610.2009.02073.x.PubMed Norbury, C. F., Brock, J., Cragg, L., Einav, S., Griffiths, H., & Nation, K. (2009). Eye-movement patterns are associated with communicative competence in autistic spectrum disorders. Journal of Child Psychology and Psychiatry, 50(7), 834–842. doi:10.​1111/​j.​1469-7610.​2009.​02073.​x.PubMed
go back to reference Nygard, L. (2003). Instrumental activities of daily living: a stepping-stone towards Alzheimer’s disease diagnosis in subjects with mild cognitive impairment? Acta Neurologica Scandinavica. Supplementum, 179, 42–46.PubMed Nygard, L. (2003). Instrumental activities of daily living: a stepping-stone towards Alzheimer’s disease diagnosis in subjects with mild cognitive impairment? Acta Neurologica Scandinavica. Supplementum, 179, 42–46.PubMed
go back to reference O’Regan, J. K. (1992). Solving the “real” mysteries of visual perception: the world as an outside memory. Canadian Journal of Psychology, 46(3), 461–488.PubMed O’Regan, J. K. (1992). Solving the “real” mysteries of visual perception: the world as an outside memory. Canadian Journal of Psychology, 46(3), 461–488.PubMed
go back to reference O’Regan, J. K., & Levy-Schoen, A. (1983). Integrating visual information from successive fixations: does trans-saccadic fusion exist? Vision Research, 23(8), 765–768.PubMed O’Regan, J. K., & Levy-Schoen, A. (1983). Integrating visual information from successive fixations: does trans-saccadic fusion exist? Vision Research, 23(8), 765–768.PubMed
go back to reference Okonkwo, O. C., Wadley, V. G., Griffith, H. R., Ball, K., & Marson, D. C. (2006). Cognitive correlates of financial abilities in mild cognitive impairment. Journal of American Geriatrics Society, 54(11), 1745–1750. doi:10.1111/j.1532-5415.2006.00916.x. Okonkwo, O. C., Wadley, V. G., Griffith, H. R., Ball, K., & Marson, D. C. (2006). Cognitive correlates of financial abilities in mild cognitive impairment. Journal of American Geriatrics Society, 54(11), 1745–1750. doi:10.​1111/​j.​1532-5415.​2006.​00916.​x.
go back to reference Olivia, A., Torralba, A., Castelhano, M. S., & Henderson, J. M. (2003). Top-down control of visual attention in object detection. Paper presented at the International Conference on Image Processing—ICIP. Olivia, A., Torralba, A., Castelhano, M. S., & Henderson, J. M. (2003). Top-down control of visual attention in object detection. Paper presented at the International Conference on Image Processing—ICIP.
go back to reference Peltsch, A., Hemraj, A., Garcia, A., & Munoz, D. P. (2014). Saccade deficits in amnestic mild cognitive impairment resemble mild Alzheimer’s disease. European Journal of Neuroscience, 39(11), 2000–2013. doi:10.1111/ejn.12617.PubMed Peltsch, A., Hemraj, A., Garcia, A., & Munoz, D. P. (2014). Saccade deficits in amnestic mild cognitive impairment resemble mild Alzheimer’s disease. European Journal of Neuroscience, 39(11), 2000–2013. doi:10.​1111/​ejn.​12617.PubMed
go back to reference Pelz, J. B., & Canosa, R. (2001). Oculomotor behavior and perceptual strategies in complex tasks. Vision Research, 41(25–26), 3587–3596.PubMed Pelz, J. B., & Canosa, R. (2001). Oculomotor behavior and perceptual strategies in complex tasks. Vision Research, 41(25–26), 3587–3596.PubMed
go back to reference Pereira, F. S., Yassuda, M. S., Oliveira, A. M., Diniz, B. S., Radanovic, M., Talib, L. L., & Forlenza, O. V. (2010). Profiles of functional deficits in mild cognitive impairment and dementia: benefits from objective measurement. Journal of the International Neuropsychological Society, 16(2), 297–305. doi:10.1017/S1355617709991330.PubMed Pereira, F. S., Yassuda, M. S., Oliveira, A. M., Diniz, B. S., Radanovic, M., Talib, L. L., & Forlenza, O. V. (2010). Profiles of functional deficits in mild cognitive impairment and dementia: benefits from objective measurement. Journal of the International Neuropsychological Society, 16(2), 297–305. doi:10.​1017/​S135561770999133​0.PubMed
go back to reference Pereira, M. L., Camargo, M., Aprahamian, I., & Forlenza, O. V. (2014). Eye movement analysis and cognitive processing: detecting indicators of conversion to Alzheimer’s disease. Neuropsychiatric Disease and Treatment, 10, 1273–1285. doi:10.2147/NDT.S55371.PubMedCentralPubMed Pereira, M. L., Camargo, M., Aprahamian, I., & Forlenza, O. V. (2014). Eye movement analysis and cognitive processing: detecting indicators of conversion to Alzheimer’s disease. Neuropsychiatric Disease and Treatment, 10, 1273–1285. doi:10.​2147/​NDT.​S55371.PubMedCentralPubMed
go back to reference Peres, K., Helmer, C., Amieva, H., Orgogozo, J. M., Rouch, I., Dartigues, J. F., & Barberger-Gateau, P. (2008). Natural history of decline in instrumental activities of daily living performance over the 10 years preceding the clinical diagnosis of dementia: a prospective population-based study. Journal of American Geriatrics Society, 56(1), 37–44. doi:10.1111/j.1532-5415.2007.01499.x. Peres, K., Helmer, C., Amieva, H., Orgogozo, J. M., Rouch, I., Dartigues, J. F., & Barberger-Gateau, P. (2008). Natural history of decline in instrumental activities of daily living performance over the 10 years preceding the clinical diagnosis of dementia: a prospective population-based study. Journal of American Geriatrics Society, 56(1), 37–44. doi:10.​1111/​j.​1532-5415.​2007.​01499.​x.
go back to reference Perneczky, R., Pohl, C., Sorg, C., Hartmann, J., Komossa, K., Alexopoulos, P., & Kurz, A. (2006a). Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues. Age and Ageing, 35(3), 240–245. doi:10.1093/ageing/afj054.PubMed Perneczky, R., Pohl, C., Sorg, C., Hartmann, J., Komossa, K., Alexopoulos, P., & Kurz, A. (2006a). Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues. Age and Ageing, 35(3), 240–245. doi:10.​1093/​ageing/​afj054.PubMed
go back to reference Perneczky, R., Pohl, C., Sorg, C., Hartmann, J., Tosic, N., Grimmer, T., & Kurz, A. (2006b). Impairment of activities of daily living requiring memory or complex reasoning as part of the MCI syndrome. International Journal of Geriatric Psychiatry, 21(2), 158–162. doi:10.1002/gps.1444.PubMed Perneczky, R., Pohl, C., Sorg, C., Hartmann, J., Tosic, N., Grimmer, T., & Kurz, A. (2006b). Impairment of activities of daily living requiring memory or complex reasoning as part of the MCI syndrome. International Journal of Geriatric Psychiatry, 21(2), 158–162. doi:10.​1002/​gps.​1444.PubMed
go back to reference Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999). Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology, 56(3), 303–308.PubMed Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999). Mild cognitive impairment: clinical characterization and outcome. Archives of Neurology, 56(3), 303–308.PubMed
go back to reference Purser, J. L., Fillenbaum, G. G., Pieper, C. F., & Wallace, R. B. (2005). Mild cognitive impairment and 10-year trajectories of disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly cohort. Journal of American Geriatrics Society, 53(11), 1966–1972. doi:10.1111/j.1532-5415.2005.53566.x. Purser, J. L., Fillenbaum, G. G., Pieper, C. F., & Wallace, R. B. (2005). Mild cognitive impairment and 10-year trajectories of disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly cohort. Journal of American Geriatrics Society, 53(11), 1966–1972. doi:10.​1111/​j.​1532-5415.​2005.​53566.​x.
go back to reference Reppermund, S., Sachdev, P. S., Crawford, J., Kochan, N. A., Slavin, M. J., Kang, K., & Brodaty, H. (2011). The relationship of neuropsychological function to instrumental activities of daily living in mild cognitive impairment. International Journal of Geriatric Psychiatry, 26(8), 843–852. doi:10.1002/gps.2612.PubMed Reppermund, S., Sachdev, P. S., Crawford, J., Kochan, N. A., Slavin, M. J., Kang, K., & Brodaty, H. (2011). The relationship of neuropsychological function to instrumental activities of daily living in mild cognitive impairment. International Journal of Geriatric Psychiatry, 26(8), 843–852. doi:10.​1002/​gps.​2612.PubMed
go back to reference Rothkopf, C. A., Ballard, D. H., & Hayhoe, M. M. (2007). Task and context determine where you look. Journal of Vision, 7(14), 16 11–20. doi:10.1167/7.14.16. Rothkopf, C. A., Ballard, D. H., & Hayhoe, M. M. (2007). Task and context determine where you look. Journal of Vision, 7(14), 16 11–20. doi:10.​1167/​7.​14.​16.
go back to reference Royall, D. R., Lauterbach, E. C., Kaufer, D., Malloy, P., Coburn, K. L., Black, K. J., & Committee on Research of the American Neuropsychiatric, Association. (2007). The cognitive correlates of functional status: a review from the Committee on Research of the American Neuropsychiatric Association. Journal of Neuropsychiatry and Clinical Neurosciences, 19(3), 249–265. doi:10.1176/appi.neuropsych.19.3.249.PubMed Royall, D. R., Lauterbach, E. C., Kaufer, D., Malloy, P., Coburn, K. L., Black, K. J., & Committee on Research of the American Neuropsychiatric, Association. (2007). The cognitive correlates of functional status: a review from the Committee on Research of the American Neuropsychiatric Association. Journal of Neuropsychiatry and Clinical Neurosciences, 19(3), 249–265. doi:10.​1176/​appi.​neuropsych.​19.​3.​249.PubMed
go back to reference Rueda, A. D., Lau, K. M., Saito, N., Harvey, D., Risacher, S. L., Aisen, P. S., . . . Alzheimer’s Disease Neuroimaging, Initiative (2014). Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer’s disease. Alzheimers Dement. doi:10.1016/j.jalz.2014.09.002. Rueda, A. D., Lau, K. M., Saito, N., Harvey, D., Risacher, S. L., Aisen, P. S., . . . Alzheimer’s Disease Neuroimaging, Initiative (2014). Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer’s disease. Alzheimers Dement. doi:10.​1016/​j.​jalz.​2014.​09.​002.
go back to reference Sacco, G., Joumier, V., Darmon, N., Dechamps, A., Derreumaux, A., Lee, J. H., & Robert, P. (2012). Detection of activities of daily living impairment in Alzheimer’s disease and mild cognitive impairment using information and communication technology. Clinical Interventions in Aging, 7, 539–549. doi:10.2147/CIA.S36297.PubMedCentralPubMed Sacco, G., Joumier, V., Darmon, N., Dechamps, A., Derreumaux, A., Lee, J. H., & Robert, P. (2012). Detection of activities of daily living impairment in Alzheimer’s disease and mild cognitive impairment using information and communication technology. Clinical Interventions in Aging, 7, 539–549. doi:10.​2147/​CIA.​S36297.PubMedCentralPubMed
go back to reference Salek, Y., Anderson, N. D., & Sergio, L. (2011). Mild cognitive impairment is associated with impaired visual-motor planning when visual stimuli and actions are incongruent. European Neurology, 66(5), 283–293. doi:10.1159/000331049.PubMed Salek, Y., Anderson, N. D., & Sergio, L. (2011). Mild cognitive impairment is associated with impaired visual-motor planning when visual stimuli and actions are incongruent. European Neurology, 66(5), 283–293. doi:10.​1159/​000331049.PubMed
go back to reference Schmitter-Edgecombe, M., McAlister, C., & Weakley, A. (2012). Naturalistic assessment of everyday functioning in individuals with mild cognitive impairment: the day-out task. Neuropsychology, 26(5), 631–641. doi:10.1037/a0029352.PubMedCentralPubMed Schmitter-Edgecombe, M., McAlister, C., & Weakley, A. (2012). Naturalistic assessment of everyday functioning in individuals with mild cognitive impairment: the day-out task. Neuropsychology, 26(5), 631–641. doi:10.​1037/​a0029352.PubMedCentralPubMed
go back to reference Schwartz, M. F., Segal, M., Veramonti, R., Ferraro, M., & Buxbaum, L. J. (2002). The naturalistic action test: a standardised assessment for everyday action impairment. Neuropsychological Rehabilitation, 12, 311–339. Schwartz, M. F., Segal, M., Veramonti, R., Ferraro, M., & Buxbaum, L. J. (2002). The naturalistic action test: a standardised assessment for everyday action impairment. Neuropsychological Rehabilitation, 12, 311–339.
go back to reference Schwartz, M. F., Buxbaum, L. J., Ferraro, M., Veramonti, R., & Segal, M. (2003). The naturalistic action test. Bury St. Edmunds: Thames Valley Test Company. Schwartz, M. F., Buxbaum, L. J., Ferraro, M., Veramonti, R., & Segal, M. (2003). The naturalistic action test. Bury St. Edmunds: Thames Valley Test Company.
go back to reference Seelye, A. M., Schmitter-Edgecombe, M., Cook, D. J., & Crandall, A. (2013). Naturalistic assessment of everyday activities and prompting technologies in mild cognitive impairment. Journal of the International Neuropsychological Society, 19(4), 442–452. doi:10.1017/S135561771200149X.PubMedCentralPubMed Seelye, A. M., Schmitter-Edgecombe, M., Cook, D. J., & Crandall, A. (2013). Naturalistic assessment of everyday activities and prompting technologies in mild cognitive impairment. Journal of the International Neuropsychological Society, 19(4), 442–452. doi:10.​1017/​S135561771200149​X.PubMedCentralPubMed
go back to reference Seligman, S. C., Giovannetti, T., Sestito, J., & Libon, D. J. (2014). A new approach to the characterization of subtle errors in everyday action: implications for mild cognitive impairment. Clinical Neuropsychology, 28(1), 97–115. doi:10.1080/13854046.2013.852624. Seligman, S. C., Giovannetti, T., Sestito, J., & Libon, D. J. (2014). A new approach to the characterization of subtle errors in everyday action: implications for mild cognitive impairment. Clinical Neuropsychology, 28(1), 97–115. doi:10.​1080/​13854046.​2013.​852624.
go back to reference Shinoda, H., Hayhoe, M. M., & Shrivastava, A. (2001). What controls attention in natural environments? Vision Research, 41(25–26), 3535–3545.PubMed Shinoda, H., Hayhoe, M. M., & Shrivastava, A. (2001). What controls attention in natural environments? Vision Research, 41(25–26), 3535–3545.PubMed
go back to reference Tabert, M. H., Albert, S. M., Borukhova-Milov, L., Camacho, Y., Pelton, G., Liu, X., & Devanand, D. P. (2002). Functional deficits in patients with mild cognitive impairment: prediction of AD. Neurology, 58(5), 758–764.PubMed Tabert, M. H., Albert, S. M., Borukhova-Milov, L., Camacho, Y., Pelton, G., Liu, X., & Devanand, D. P. (2002). Functional deficits in patients with mild cognitive impairment: prediction of AD. Neurology, 58(5), 758–764.PubMed
go back to reference Tam, C. W., Lam, L. C., Chiu, H. F., & Lui, V. W. (2007). Characteristic profiles of instrumental activities of daily living in Chinese older persons with mild cognitive impairment. American Journal of Alzheimer’s Disease and Other Dementias, 22(3), 211–217. doi:10.1177/1533317507301597.PubMed Tam, C. W., Lam, L. C., Chiu, H. F., & Lui, V. W. (2007). Characteristic profiles of instrumental activities of daily living in Chinese older persons with mild cognitive impairment. American Journal of Alzheimer’s Disease and Other Dementias, 22(3), 211–217. doi:10.​1177/​1533317507301597​.PubMed
go back to reference Teng, E., Becker, B. W., Woo, E., Cummings, J. L., & Lu, P. H. (2010). Subtle deficits in instrumental activities of daily living in subtypes of mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 30(3), 189–197. doi:10.1159/000313540.PubMedCentralPubMed Teng, E., Becker, B. W., Woo, E., Cummings, J. L., & Lu, P. H. (2010). Subtle deficits in instrumental activities of daily living in subtypes of mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 30(3), 189–197. doi:10.​1159/​000313540.PubMedCentralPubMed
go back to reference Thomas, L. E., & Lleras, A. (2007). Moving eyes and moving thought: on the spatial compatibility between eye movements and cognition. Psychonomic Bulletin Review, 14(4), 663–668.PubMed Thomas, L. E., & Lleras, A. (2007). Moving eyes and moving thought: on the spatial compatibility between eye movements and cognition. Psychonomic Bulletin Review, 14(4), 663–668.PubMed
go back to reference Tomaszewski Farias, S., Cahn-Weiner, D. A., Harvey, D. J., Reed, B. R., Mungas, D., Kramer, J. H., & Chui, H. (2009). Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults. Clinical Neuropsychology, 23(3), 446–461. doi:10.1080/13854040802360558. Tomaszewski Farias, S., Cahn-Weiner, D. A., Harvey, D. J., Reed, B. R., Mungas, D., Kramer, J. H., & Chui, H. (2009). Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults. Clinical Neuropsychology, 23(3), 446–461. doi:10.​1080/​1385404080236055​8.
go back to reference Wade, N. J., & Tatler, B. W. (2005). The moving tablet of the ey: The origins of modern eye movement research. Oxford University Press. Wade, N. J., & Tatler, B. W. (2005). The moving tablet of the ey: The origins of modern eye movement research. Oxford University Press.
go back to reference Wade, N. J., Tatler, B. W., & Heller, D. (2003). Dodge-ing the issue: Dodge, Javal, Hering, and the measurement of saccades in eye-movement research. Perception, 32(7), 793–804.PubMed Wade, N. J., Tatler, B. W., & Heller, D. (2003). Dodge-ing the issue: Dodge, Javal, Hering, and the measurement of saccades in eye-movement research. Perception, 32(7), 793–804.PubMed
go back to reference Wadley, V. G., Harrell, L. E., & Marson, D. C. (2003). Self- and informant report of financial abilities in patients with Alzheimer’s disease: reliable and valid? Journal of American Geriatrics Society, 51(11), 1621–1626. Wadley, V. G., Harrell, L. E., & Marson, D. C. (2003). Self- and informant report of financial abilities in patients with Alzheimer’s disease: reliable and valid? Journal of American Geriatrics Society, 51(11), 1621–1626.
go back to reference Wadley, V. G., Crowe, M., Marsiske, M., Cook, S. E., Unverzagt, F. W., Rosenberg, A. L., & Rexroth, D. (2007). Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study. Journal of American Geriatrics Society, 55(8), 1192–1198. doi:10.1111/j.1532-5415.2007.01245.x. Wadley, V. G., Crowe, M., Marsiske, M., Cook, S. E., Unverzagt, F. W., Rosenberg, A. L., & Rexroth, D. (2007). Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the Advanced Cognitive Training for Independent and Vital Elderly Study. Journal of American Geriatrics Society, 55(8), 1192–1198. doi:10.​1111/​j.​1532-5415.​2007.​01245.​x.
go back to reference Wadley, V. G., Okonkwo, O., Crowe, M., & Ross-Meadows, L. A. (2008). Mild cognitive impairment and everyday function: evidence of reduced speed in performing instrumental activities of daily living. The American Journal of Geriatric Psychiatry, 16(5), 416–424. doi:10.1097/JGP.0b013e31816b7303.PubMed Wadley, V. G., Okonkwo, O., Crowe, M., & Ross-Meadows, L. A. (2008). Mild cognitive impairment and everyday function: evidence of reduced speed in performing instrumental activities of daily living. The American Journal of Geriatric Psychiatry, 16(5), 416–424. doi:10.​1097/​JGP.​0b013e31816b7303​.PubMed
go back to reference Wallis, G., & Buthoff, H. (2000). What’s scene and not seen: influences of movement and task upon what we see. Visual Cognition, 7, 175–190. Wallis, G., & Buthoff, H. (2000). What’s scene and not seen: influences of movement and task upon what we see. Visual Cognition, 7, 175–190.
go back to reference Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. O., & Petersen, R. C. (2004). Mild cognitive impairment–beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256(3), 240–246. doi:10.1111/j.1365-2796.2004.01380.x.PubMed Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. O., & Petersen, R. C. (2004). Mild cognitive impairment–beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256(3), 240–246. doi:10.​1111/​j.​1365-2796.​2004.​01380.​x.PubMed
go back to reference Yang, Q., Wang, T., Su, N., Liu, Y., Xiao, S., & Kapoula, Z. (2011). Long latency and high variability in accuracy-speed of prosaccades in Alzheimer’s disease at mild to moderate stage. Dementia and Geriatric Cognitive Disorders EXTRA, 1(1), 318–329. doi:10.1159/000333080.PubMedCentralPubMed Yang, Q., Wang, T., Su, N., Liu, Y., Xiao, S., & Kapoula, Z. (2011). Long latency and high variability in accuracy-speed of prosaccades in Alzheimer’s disease at mild to moderate stage. Dementia and Geriatric Cognitive Disorders EXTRA, 1(1), 318–329. doi:10.​1159/​000333080.PubMedCentralPubMed
go back to reference Yang, Q., Wang, T., Su, N., Xiao, S., & Kapoula, Z. (2013). Specific saccade deficits in patients with Alzheimer’s disease at mild to moderate stage and in patients with amnestic mild cognitive impairment. Age (Dordrecht, Netherlands), 35(4), 1287–1298. doi:10.1007/s11357-012-9420-z. Yang, Q., Wang, T., Su, N., Xiao, S., & Kapoula, Z. (2013). Specific saccade deficits in patients with Alzheimer’s disease at mild to moderate stage and in patients with amnestic mild cognitive impairment. Age (Dordrecht, Netherlands), 35(4), 1287–1298. doi:10.​1007/​s11357-012-9420-z.
go back to reference Yarbus, A. L. (1967). Eye movements during perception of complex objects. In Eye movements and vision (pp. 171–211). USA: Springer. Yarbus, A. L. (1967). Eye movements during perception of complex objects. In Eye movements and vision (pp. 171–211). USA: Springer.
go back to reference Zanetti, O., Geroldi, C., Frisoni, G. B., Bianchetti, A., & Trabucchi, M. (1999). Contrasting results between caregiver’s report and direct assessment of activities of daily living in patients affected by mild and very mild dementia: the contribution of the caregiver’s personal characteristics. Journal of American Geriatrics Society, 47(2), 196–202. Zanetti, O., Geroldi, C., Frisoni, G. B., Bianchetti, A., & Trabucchi, M. (1999). Contrasting results between caregiver’s report and direct assessment of activities of daily living in patients affected by mild and very mild dementia: the contribution of the caregiver’s personal characteristics. Journal of American Geriatrics Society, 47(2), 196–202.
go back to reference Zola, S. M., Manzanares, C. M., Clopton, P., Lah, J. J., & Levey, A. I. (2013). A behavioral task predicts conversion to mild cognitive impairment and Alzheimer’s disease. American Journal of Alzheimer’s Disease and Other Dementias, 28(2), 179–184. doi:10.1177/1533317512470484.PubMedCentralPubMed Zola, S. M., Manzanares, C. M., Clopton, P., Lah, J. J., & Levey, A. I. (2013). A behavioral task predicts conversion to mild cognitive impairment and Alzheimer’s disease. American Journal of Alzheimer’s Disease and Other Dementias, 28(2), 179–184. doi:10.​1177/​1533317512470484​.PubMedCentralPubMed
Metadata
Title
The Potential Utility of Eye Movements in the Detection and Characterization of Everyday Functional Difficulties in Mild Cognitive Impairment
Authors
Sarah C. Seligman
Tania Giovannetti
Publication date
01-06-2015
Publisher
Springer US
Published in
Neuropsychology Review / Issue 2/2015
Print ISSN: 1040-7308
Electronic ISSN: 1573-6660
DOI
https://doi.org/10.1007/s11065-015-9283-z

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