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Published in: Neuropsychology Review 3/2007

01-09-2007

Neuropsychological Consequences of Opiate Use

Authors: Staci A. Gruber, Marisa M. Silveri, Deborah A. Yurgelun-Todd

Published in: Neuropsychology Review | Issue 3/2007

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Abstract

Approximately 3.7 million individuals have used heroin and other opiate substances in their lifetime. Despite increasing knowledge of the effects of heroin, it remains the most abused opiate and use among adults has recently increased. The empirical literature examining the neurocognitive effects of acute and chronic opioid use remains limited; however, findings to date suggest that the use of opiates has both acute and long-term effects on cognitive performance. Neuropsychological data indicate deficits in attention, concentration, recall, visuospatial skills and psychomotor speed with both acute and chronic opioid use. The long-term effects of opiate use appear to have the greatest impact on executive functions, including the ability to shift cognitive set and inhibit inappropriate response tendencies. Factors that contribute to addiction and recovery are also discussed, as it is difficult to disentangle the effects of opiate use on cognitive performance from other factors that may affect neurobehavioral measures.
Literature
go back to reference Amass, L., Nardin, R., Mendelson, J. H., Teoh, S. K., & Woods, B. T. (1992). Quantitative magnetic resonance imaging in heroin- and cocaine-dependent men: a preliminary study. Psychiatry Research, 45(1), 15–23.PubMedCrossRef Amass, L., Nardin, R., Mendelson, J. H., Teoh, S. K., & Woods, B. T. (1992). Quantitative magnetic resonance imaging in heroin- and cocaine-dependent men: a preliminary study. Psychiatry Research, 45(1), 15–23.PubMedCrossRef
go back to reference American Psychiatric Association, C. o. N. a. S. (1994). Diagnostic and statistical manual of mental disorders (4th ed). Washington DC: American Psychiatric Association. American Psychiatric Association, C. o. N. a. S. (1994). Diagnostic and statistical manual of mental disorders (4th ed). Washington DC: American Psychiatric Association.
go back to reference Appel, P. W., & Gordon, N. B. (1976). Digit-symbol performance in methadone-treated ex-heroin addicts. American Journal of Psychiatry, 133(11), 1337–1340.PubMed Appel, P. W., & Gordon, N. B. (1976). Digit-symbol performance in methadone-treated ex-heroin addicts. American Journal of Psychiatry, 133(11), 1337–1340.PubMed
go back to reference Bickel, W. K., Odum, A. L., & Madden, G. J. (1999). Impulsivity and cigarette smoking: Delay discounting in current, never, and ex-smokers. Psychopharmacology (Berl), 146(4), 447–454.CrossRef Bickel, W. K., Odum, A. L., & Madden, G. J. (1999). Impulsivity and cigarette smoking: Delay discounting in current, never, and ex-smokers. Psychopharmacology (Berl), 146(4), 447–454.CrossRef
go back to reference Brooner, R. K., King, V. L., Kidorf, M., Schmidt, C. W., Jr., & Bigelow, G. E. (1997). Psychiatric and substance use comorbidity among treatment-seeking opioid abusers. Archives of General Psychiatry, 54(1), 71–80.PubMed Brooner, R. K., King, V. L., Kidorf, M., Schmidt, C. W., Jr., & Bigelow, G. E. (1997). Psychiatric and substance use comorbidity among treatment-seeking opioid abusers. Archives of General Psychiatry, 54(1), 71–80.PubMed
go back to reference Bruhn, P., & Maage, N. (1975). Intellectual and neuropsychological functions in young men with heavy and long-term patterns of drug abuse. American Journal of Psychiatry, 132(4), 397–401.PubMed Bruhn, P., & Maage, N. (1975). Intellectual and neuropsychological functions in young men with heavy and long-term patterns of drug abuse. American Journal of Psychiatry, 132(4), 397–401.PubMed
go back to reference Carlin, A. S. (1986). Neuropsychological consequences of drug abuse. In I. Grant & K. M. Adams (Eds.), Neuropsychological assessment of neuropsychiatric disorders (pp. 486–503). New York: Oxford University Press. Carlin, A. S. (1986). Neuropsychological consequences of drug abuse. In I. Grant & K. M. Adams (Eds.), Neuropsychological assessment of neuropsychiatric disorders (pp. 486–503). New York: Oxford University Press.
go back to reference Christensen, O., Christensen, P., Sonnenschein, C., Nielsen, P. R., & Jacobsen, S. (1996). Analgesic effect of intraarticular morphine. A controlled, randomised and double-blind study. Acta Anaesthesiologica Scandinavica, 40(7), 842–846.PubMed Christensen, O., Christensen, P., Sonnenschein, C., Nielsen, P. R., & Jacobsen, S. (1996). Analgesic effect of intraarticular morphine. A controlled, randomised and double-blind study. Acta Anaesthesiologica Scandinavica, 40(7), 842–846.PubMed
go back to reference Cleeland, C. S., Nakamura, Y., Howland, E. W., Morgan, N. R., Edwards, K. R., & Backonja, M. (1996). Effects of oral morphine on cold pressor tolerance time and neuropsychological performance. Neuropsychopharmacology, 15(3), 252–262.PubMedCrossRef Cleeland, C. S., Nakamura, Y., Howland, E. W., Morgan, N. R., Edwards, K. R., & Backonja, M. (1996). Effects of oral morphine on cold pressor tolerance time and neuropsychological performance. Neuropsychopharmacology, 15(3), 252–262.PubMedCrossRef
go back to reference Correia, C. J., Walsh, S. L., Bigelow, G. E., & Strain, E. C. (2006). Effects associated with double-blind omission of buprenorphine/naloxone over a 98-h period. Psychopharmacology (Berl), 189(3), 297–306.CrossRef Correia, C. J., Walsh, S. L., Bigelow, G. E., & Strain, E. C. (2006). Effects associated with double-blind omission of buprenorphine/naloxone over a 98-h period. Psychopharmacology (Berl), 189(3), 297–306.CrossRef
go back to reference Cruz, S. L., Villarreal, J. E., & Volkow, N. D. (1996). Further evidence that naloxone acts as an inverse opiate agonist: Implications for drug dependence and withdrawal. Life Science, 58(26), PL381–PL389.CrossRef Cruz, S. L., Villarreal, J. E., & Volkow, N. D. (1996). Further evidence that naloxone acts as an inverse opiate agonist: Implications for drug dependence and withdrawal. Life Science, 58(26), PL381–PL389.CrossRef
go back to reference Curran, H. V., Kleckham, J., Bearn, J., Strang, J., & Wanigaratne, S. (2001). Effects of methadone on cognition, mood and craving in detoxifying opiate addicts: A dose-response study. Psychopharmacology (Berl), 154(2), 153–160.CrossRef Curran, H. V., Kleckham, J., Bearn, J., Strang, J., & Wanigaratne, S. (2001). Effects of methadone on cognition, mood and craving in detoxifying opiate addicts: A dose-response study. Psychopharmacology (Berl), 154(2), 153–160.CrossRef
go back to reference Daglish, M. R., Weinstein, A., Malizia, A. L., Wilson, S., Melichar, J. K., Lingford-Hughes, A., et al. (2003). Functional connectivity analysis of the neural circuits of opiate craving: “More” rather than “different”? Neuroimage, 20(4), 1964–1970.PubMedCrossRef Daglish, M. R., Weinstein, A., Malizia, A. L., Wilson, S., Melichar, J. K., Lingford-Hughes, A., et al. (2003). Functional connectivity analysis of the neural circuits of opiate craving: “More” rather than “different”? Neuroimage, 20(4), 1964–1970.PubMedCrossRef
go back to reference Danos, P., Van Roos, D., Kasper, S., Bromel, T., Broich, K., Krappel, C., et al. (1998). Enlarged cerebrospinal fluid spaces in opiate-dependent male patients: A stereological CT study. Neuropsychobiology, 38(2), 80–83.PubMedCrossRef Danos, P., Van Roos, D., Kasper, S., Bromel, T., Broich, K., Krappel, C., et al. (1998). Enlarged cerebrospinal fluid spaces in opiate-dependent male patients: A stereological CT study. Neuropsychobiology, 38(2), 80–83.PubMedCrossRef
go back to reference Darke, S., Sims, J., McDonald, S., & Wickes, W. (2000). Cognitive impairment among methadone maintenance patients. Addiction, 95(5), 687–695.PubMedCrossRef Darke, S., Sims, J., McDonald, S., & Wickes, W. (2000). Cognitive impairment among methadone maintenance patients. Addiction, 95(5), 687–695.PubMedCrossRef
go back to reference Davis, P. E., Liddiard, H., & McMillan, T. M. (2002). Neuropsychological deficits and opiate abuse. Drug and Alcohol Dependence, 67(1), 105–108.PubMedCrossRef Davis, P. E., Liddiard, H., & McMillan, T. M. (2002). Neuropsychological deficits and opiate abuse. Drug and Alcohol Dependence, 67(1), 105–108.PubMedCrossRef
go back to reference Dole, V. P., & Nyswander, M. (1965). A medical treatment for diacetylmorphine (heroin) addiction. A clinical trial with methadone hydrochloride. Journal of the American Medical Association, 193, 646–650.PubMed Dole, V. P., & Nyswander, M. (1965). A medical treatment for diacetylmorphine (heroin) addiction. A clinical trial with methadone hydrochloride. Journal of the American Medical Association, 193, 646–650.PubMed
go back to reference Ersche, K. D., Clark, L., London, M., Robbins, T. W., & Sahakian, B. J. (2006). Profile of executive and memory function associated with amphetamine and opiate dependence. Neuropsychopharmacology, 31(5), 1036–1047.PubMedCrossRef Ersche, K. D., Clark, L., London, M., Robbins, T. W., & Sahakian, B. J. (2006). Profile of executive and memory function associated with amphetamine and opiate dependence. Neuropsychopharmacology, 31(5), 1036–1047.PubMedCrossRef
go back to reference Forman, S. D., Dougherty, G. G., Casey, B. J., Siegle, G. J., Braver, T. S., Barch, D. M., et al. (2004). Opiate addicts lack error-dependent activation of rostral anterior cingulate. Biological Psychiatry, 55(5), 531–537.PubMedCrossRef Forman, S. D., Dougherty, G. G., Casey, B. J., Siegle, G. J., Braver, T. S., Barch, D. M., et al. (2004). Opiate addicts lack error-dependent activation of rostral anterior cingulate. Biological Psychiatry, 55(5), 531–537.PubMedCrossRef
go back to reference Franceschini, D., Lipartiti, M., & Giusti, P. (1999). Effect of acute and chronic tramadol on [3H]-norepinephrine-uptake in rat cortical synaptosomes. Progress in Neuro-psychopharmacology & Biological Psychiatry, 23(3), 485–496.CrossRef Franceschini, D., Lipartiti, M., & Giusti, P. (1999). Effect of acute and chronic tramadol on [3H]-norepinephrine-uptake in rat cortical synaptosomes. Progress in Neuro-psychopharmacology & Biological Psychiatry, 23(3), 485–496.CrossRef
go back to reference Gaertner, J., Radbruch, L., Giesecke, T., Gerbershagen, H., Petzke, F., Ostgathe, C., et al. (2006). Assessing cognition and psychomotor function under long-term treatment with controlled release oxycodone in non-cancer pain patients. Acta anaesthesiologica Scandinavica, 50(6), 664–672.PubMedCrossRef Gaertner, J., Radbruch, L., Giesecke, T., Gerbershagen, H., Petzke, F., Ostgathe, C., et al. (2006). Assessing cognition and psychomotor function under long-term treatment with controlled release oxycodone in non-cancer pain patients. Acta anaesthesiologica Scandinavica, 50(6), 664–672.PubMedCrossRef
go back to reference Galynker, I. I., Watras-Ganz, S., Miner, C., Rosenthal, R. N., Des Jarlais, D. C., Richman, B. L., et al. (2000). Cerebral metabolism in opiate-dependent subjects: Effects of methadone maintenance. Mount Sinai Journal of Medicine, 67(5–6), 381–387.PubMed Galynker, I. I., Watras-Ganz, S., Miner, C., Rosenthal, R. N., Des Jarlais, D. C., Richman, B. L., et al. (2000). Cerebral metabolism in opiate-dependent subjects: Effects of methadone maintenance. Mount Sinai Journal of Medicine, 67(5–6), 381–387.PubMed
go back to reference Gobbi, M., & Mennini, T. (1999). Release studies with rat brain cortical synaptosomes indicate that tramadol is a 5-hydroxytryptamine uptake blocker and not a 5-hydroxytryptamine releaser. European Journal of Pharmacology, 370(1), 23–26.PubMedCrossRef Gobbi, M., & Mennini, T. (1999). Release studies with rat brain cortical synaptosomes indicate that tramadol is a 5-hydroxytryptamine uptake blocker and not a 5-hydroxytryptamine releaser. European Journal of Pharmacology, 370(1), 23–26.PubMedCrossRef
go back to reference Gross, A., Jacobs, E. A., Petry, N. M., Badger, G. J., & Bickel, W. K. (2001). Limits to buprenorphine dosing: A comparison between quintuple and sextuple the maintenance dose every 5 days. Drug and Alcohol Dependence, 64(1), 111–116.PubMedCrossRef Gross, A., Jacobs, E. A., Petry, N. M., Badger, G. J., & Bickel, W. K. (2001). Limits to buprenorphine dosing: A comparison between quintuple and sextuple the maintenance dose every 5 days. Drug and Alcohol Dependence, 64(1), 111–116.PubMedCrossRef
go back to reference Gruber, S. A., Tzilos, G. K., Silveri, M. M., Pollack, M., Renshaw, P. F., Kaufman, M. J., et al. (2006). Methadone maintenance improves cognitive performance after two months of treatment. Experimental and Clinical Psychopharmacology, 14(2), 157–164.PubMedCrossRef Gruber, S. A., Tzilos, G. K., Silveri, M. M., Pollack, M., Renshaw, P. F., Kaufman, M. J., et al. (2006). Methadone maintenance improves cognitive performance after two months of treatment. Experimental and Clinical Psychopharmacology, 14(2), 157–164.PubMedCrossRef
go back to reference Guerra, D., Sole, A., Cami, J., & Tobena, A. (1987). Neuropsychological performance in opiate addicts after rapid detoxification. Drug and Alcohol Dependence, 20(3), 261–270.PubMedCrossRef Guerra, D., Sole, A., Cami, J., & Tobena, A. (1987). Neuropsychological performance in opiate addicts after rapid detoxification. Drug and Alcohol Dependence, 20(3), 261–270.PubMedCrossRef
go back to reference Guo, M., Xu, N. J., Li, Y. T., Yang, J. Y., Wu, C. F., & Pei, G. (2005). Morphine modulates glutamate release in the hippocampal CA1 area in mice. Neuroscience Letters, 381(1–2), 12–15.PubMedCrossRef Guo, M., Xu, N. J., Li, Y. T., Yang, J. Y., Wu, C. F., & Pei, G. (2005). Morphine modulates glutamate release in the hippocampal CA1 area in mice. Neuroscience Letters, 381(1–2), 12–15.PubMedCrossRef
go back to reference Hanks, G. W., O’Neill, W. M., Simpson, P., & Wesnes, K. (1995). The cognitive and psychomotor effects of opioid analgesics. II. A randomized controlled trial of single doses of morphine, lorazepam and placebo in healthy subjects. European Journal of Clinical Pharmacology, 48(6), 455–460.PubMedCrossRef Hanks, G. W., O’Neill, W. M., Simpson, P., & Wesnes, K. (1995). The cognitive and psychomotor effects of opioid analgesics. II. A randomized controlled trial of single doses of morphine, lorazepam and placebo in healthy subjects. European Journal of Clinical Pharmacology, 48(6), 455–460.PubMedCrossRef
go back to reference Joseph, H., Stancliff, S., & Langrod, J. (2000). Methadone maintenance treatment (MMT): A review of historical and clinical issues. Mount Sinai Journal of Medicine, 67(5–6), 347–364.PubMed Joseph, H., Stancliff, S., & Langrod, J. (2000). Methadone maintenance treatment (MMT): A review of historical and clinical issues. Mount Sinai Journal of Medicine, 67(5–6), 347–364.PubMed
go back to reference Kalivas, P. W., & Volkow, N. D. (2005). The neural basis of addiction: A pathology of motivation and choice. American Journal of Psychiatry, 162(8), 1403–1413.PubMedCrossRef Kalivas, P. W., & Volkow, N. D. (2005). The neural basis of addiction: A pathology of motivation and choice. American Journal of Psychiatry, 162(8), 1403–1413.PubMedCrossRef
go back to reference Kaufman, M. J., Pollack, M. H., Villafuerte, R. A., Kukes, T. J., Rose, S. L., Mendelson, J. H., et al. (1999). Cerebral phosphorus metabolite abnormalities in opiate-dependent polydrug abusers in methadone maintenance. Psychiatry Research, 90(3), 143–152.PubMedCrossRef Kaufman, M. J., Pollack, M. H., Villafuerte, R. A., Kukes, T. J., Rose, S. L., Mendelson, J. H., et al. (1999). Cerebral phosphorus metabolite abnormalities in opiate-dependent polydrug abusers in methadone maintenance. Psychiatry Research, 90(3), 143–152.PubMedCrossRef
go back to reference Kerr, B., Hill, H., Coda, B., Calogero, M., Chapman, C. R., Hunt, E., et al. (1991). Concentration-related effects of morphine on cognition and motor control in human subjects. Neuropsychopharmacology, 5(3), 157–166.PubMed Kerr, B., Hill, H., Coda, B., Calogero, M., Chapman, C. R., Hunt, E., et al. (1991). Concentration-related effects of morphine on cognition and motor control in human subjects. Neuropsychopharmacology, 5(3), 157–166.PubMed
go back to reference Koob, G. F. (1987). Neural substrates of opioid tolerance and dependence. NIDA Research Monograph, 76, 46–52.PubMed Koob, G. F. (1987). Neural substrates of opioid tolerance and dependence. NIDA Research Monograph, 76, 46–52.PubMed
go back to reference Koob, G. F. (2003). Neuroadaptive mechanisms of addiction: studies on the extended amygdala. European Neuropsychopharmacology, 13(6), 442–452.PubMedCrossRef Koob, G. F. (2003). Neuroadaptive mechanisms of addiction: studies on the extended amygdala. European Neuropsychopharmacology, 13(6), 442–452.PubMedCrossRef
go back to reference Koob, G. F., Ahmed, S. H., Boutrel, B., Chen, S. A., Kenny, P. J., Markou, A., et al. (2004). Neurobiological mechanisms in the transition from drug use to drug dependence. Neuroscience and Biobehavioral Reviews, 27(8), 739–749.PubMedCrossRef Koob, G. F., Ahmed, S. H., Boutrel, B., Chen, S. A., Kenny, P. J., Markou, A., et al. (2004). Neurobiological mechanisms in the transition from drug use to drug dependence. Neuroscience and Biobehavioral Reviews, 27(8), 739–749.PubMedCrossRef
go back to reference Koob, G. F., & Le Moal, M. (2001). Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology, 24(2), 97–129.PubMedCrossRef Koob, G. F., & Le Moal, M. (2001). Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology, 24(2), 97–129.PubMedCrossRef
go back to reference Koob, G. F., Stinus, L., Le Moal, M., & Bloom, F. E. (1989). Opponent process theory of motivation: Neurobiological evidence from studies of opiate dependence. Neuroscience and Biobehavioral Reviews, 13(2–3), 135–140.PubMedCrossRef Koob, G. F., Stinus, L., Le Moal, M., & Bloom, F. E. (1989). Opponent process theory of motivation: Neurobiological evidence from studies of opiate dependence. Neuroscience and Biobehavioral Reviews, 13(2–3), 135–140.PubMedCrossRef
go back to reference Kosten, T. R., Schottenfeld, R., Ziedonis, D., & Falcioni, J. (1993). Buprenorphine versus methadone maintenance for opioid dependence. Journal of Nervous and Mental Disease, 181(6), 358–364.PubMedCrossRef Kosten, T. R., Schottenfeld, R., Ziedonis, D., & Falcioni, J. (1993). Buprenorphine versus methadone maintenance for opioid dependence. Journal of Nervous and Mental Disease, 181(6), 358–364.PubMedCrossRef
go back to reference Kreek, M. J. (1997). Opiate and cocaine addictions: Challenge for pharmacotherapies. Pharmacology, Biochemistry and Behavior, 57(3), 551–569.CrossRef Kreek, M. J. (1997). Opiate and cocaine addictions: Challenge for pharmacotherapies. Pharmacology, Biochemistry and Behavior, 57(3), 551–569.CrossRef
go back to reference Krystal, J. H., Woods, S. W., Kosten, T. R., Rosen, M. I., Seibyl, J. P., van Dyck, C. C., et al. (1995). Opiate dependence and withdrawal: Preliminary assessment using single photon emission computerized tomography (SPECT). American Journal of Drug and Alcohol Abuse, 21(1), 47–63.PubMed Krystal, J. H., Woods, S. W., Kosten, T. R., Rosen, M. I., Seibyl, J. P., van Dyck, C. C., et al. (1995). Opiate dependence and withdrawal: Preliminary assessment using single photon emission computerized tomography (SPECT). American Journal of Drug and Alcohol Abuse, 21(1), 47–63.PubMed
go back to reference Lalovic, B., Kharasch, E., Hoffer, C., Risler, L., Liu-Chen, L. Y., & Shen, D. D. (2006). Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites. Clinical Pharmacology & Therapeutics, 79(5), 461–479.CrossRef Lalovic, B., Kharasch, E., Hoffer, C., Risler, L., Liu-Chen, L. Y., & Shen, D. D. (2006). Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites. Clinical Pharmacology & Therapeutics, 79(5), 461–479.CrossRef
go back to reference Laviolette, S. R., Gallegos, R. A., Henriksen, S. J., & van der Kooy, D. (2004). Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area. Nature Neuroscience, 7(2), 160–169.PubMedCrossRef Laviolette, S. R., Gallegos, R. A., Henriksen, S. J., & van der Kooy, D. (2004). Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area. Nature Neuroscience, 7(2), 160–169.PubMedCrossRef
go back to reference Lee, C. R., McTavish, D., & Sorkin, E. M. (1993). Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states. Drugs, 46(2), 313–340.PubMed Lee, C. R., McTavish, D., & Sorkin, E. M. (1993). Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states. Drugs, 46(2), 313–340.PubMed
go back to reference Lee, T. M., & Pau, C. W. (2002). Impulse control differences between abstinent heroin users and matched controls. Brain Injury, 16(10), 885–889.PubMedCrossRef Lee, T. M., & Pau, C. W. (2002). Impulse control differences between abstinent heroin users and matched controls. Brain Injury, 16(10), 885–889.PubMedCrossRef
go back to reference Lee, T. M., Zhou, W. H., Luo, X. J., Yuen, K. S., Ruan, X. Z., & Weng, X. C. (2005). Neural activity associated with cognitive regulation in heroin users: A fMRI study. Neuroscience Letters, 382(3), 211–216.PubMedCrossRef Lee, T. M., Zhou, W. H., Luo, X. J., Yuen, K. S., Ruan, X. Z., & Weng, X. C. (2005). Neural activity associated with cognitive regulation in heroin users: A fMRI study. Neuroscience Letters, 382(3), 211–216.PubMedCrossRef
go back to reference Lenne, M. G., Dietze, P., Rumbold, G. R., Redman, J. R., & Triggs, T. J. (2003). The effects of the opioid pharmacotherapies methadone, LAAM and buprenorphine, alone and in combination with alcohol, on simulated driving. Drug and Alcohol Dependence, 72(3), 271–278.PubMedCrossRef Lenne, M. G., Dietze, P., Rumbold, G. R., Redman, J. R., & Triggs, T. J. (2003). The effects of the opioid pharmacotherapies methadone, LAAM and buprenorphine, alone and in combination with alcohol, on simulated driving. Drug and Alcohol Dependence, 72(3), 271–278.PubMedCrossRef
go back to reference Levin, J. M., Mendelson, J. H., Holman, B. L., Teoh, S. K., Garada, B., Schwartz, R. B., et al. (1995). Improved regional cerebral blood flow in chronic cocaine polydrug users treated with buprenorphine. Journal of Nuclear Medicine, 36(7), 1211–1215.PubMed Levin, J. M., Mendelson, J. H., Holman, B. L., Teoh, S. K., Garada, B., Schwartz, R. B., et al. (1995). Improved regional cerebral blood flow in chronic cocaine polydrug users treated with buprenorphine. Journal of Nuclear Medicine, 36(7), 1211–1215.PubMed
go back to reference Ling, W., Wesson, D. R., Charuvastra, C., & Klett, C. J. (1996). A controlled trial comparing buprenorphine and methadone maintenance in opioid dependence. Archives of General Psychiatry, 53(5), 401–407.PubMed Ling, W., Wesson, D. R., Charuvastra, C., & Klett, C. J. (1996). A controlled trial comparing buprenorphine and methadone maintenance in opioid dependence. Archives of General Psychiatry, 53(5), 401–407.PubMed
go back to reference London, E., Margolin, R. A., Wong, D. F., Links, J., La France, N. D., Cascella, N. G., et al. (1989). Cerebral glucose utilization in human heroine addicts: case reports from a position emission tomographic study. Research Communications in Substance Abuse, 10, 141–144. London, E., Margolin, R. A., Wong, D. F., Links, J., La France, N. D., Cascella, N. G., et al. (1989). Cerebral glucose utilization in human heroine addicts: case reports from a position emission tomographic study. Research Communications in Substance Abuse, 10, 141–144.
go back to reference London, E. D., Broussolle, E. P., Links, J. M., Wong, D. F., Cascella, N. G., Dannals, R. F., et al. (1990). Morphine-induced metabolic changes in human brain. Studies with positron emission tomography and [fluorine 18]fluorodeoxyglucose. Archives of General Psychiatry, 47(1), 73–81.PubMed London, E. D., Broussolle, E. P., Links, J. M., Wong, D. F., Cascella, N. G., Dannals, R. F., et al. (1990). Morphine-induced metabolic changes in human brain. Studies with positron emission tomography and [fluorine 18]fluorodeoxyglucose. Archives of General Psychiatry, 47(1), 73–81.PubMed
go back to reference Lubman, D. I., Peters, L. A., Mogg, K., Bradley, B. P., & Deakin, J. F. (2000). Attentional bias for drug cues in opiate dependence. Psychological Medicine, 30(1), 169–175.PubMedCrossRef Lubman, D. I., Peters, L. A., Mogg, K., Bradley, B. P., & Deakin, J. F. (2000). Attentional bias for drug cues in opiate dependence. Psychological Medicine, 30(1), 169–175.PubMedCrossRef
go back to reference Lyoo, I. K., Pollack, M. H., Silveri, M. M., Ahn, K. H., Diaz, C. I., Hwang, J., et al. (2006). Prefrontal and temporal gray matter density decreases in opiate dependence. Psychopharmacology (Berl), 184(2), 139–144.CrossRef Lyoo, I. K., Pollack, M. H., Silveri, M. M., Ahn, K. H., Diaz, C. I., Hwang, J., et al. (2006). Prefrontal and temporal gray matter density decreases in opiate dependence. Psychopharmacology (Berl), 184(2), 139–144.CrossRef
go back to reference McLellan, A. T., Luborsky, L., O’Brien, C. P., Barr, H. L., & Evans, F. (1986). Alcohol and drug abuse treatment in three different populations: Is there improvement and is it predictable? American Journal of Drug and Alcohol Abuse, 12(1–2), 101–120.PubMed McLellan, A. T., Luborsky, L., O’Brien, C. P., Barr, H. L., & Evans, F. (1986). Alcohol and drug abuse treatment in three different populations: Is there improvement and is it predictable? American Journal of Drug and Alcohol Abuse, 12(1–2), 101–120.PubMed
go back to reference McLellan, A. T., Luborsky, L., Woody, G. E., O’Brien, C. P., & Druley, K. A. (1983). Predicting response to alcohol and drug abuse treatments. Role of psychiatric severity. Archives of General Psychiatry, 40(6), 620–625.PubMed McLellan, A. T., Luborsky, L., Woody, G. E., O’Brien, C. P., & Druley, K. A. (1983). Predicting response to alcohol and drug abuse treatments. Role of psychiatric severity. Archives of General Psychiatry, 40(6), 620–625.PubMed
go back to reference Mintzer, M. Z., Copersino, M. L., & Stitzer, M. L. (2005). Opioid abuse and cognitive performance. Drug and Alcohol Dependence, 78(2), 225–230.PubMedCrossRef Mintzer, M. Z., Copersino, M. L., & Stitzer, M. L. (2005). Opioid abuse and cognitive performance. Drug and Alcohol Dependence, 78(2), 225–230.PubMedCrossRef
go back to reference Mintzer, M. Z., Correia, C. J., & Strain, E. C. (2004). A dose-effect study of repeated administration of buprenorphine/naloxone on performance in opioid-dependent volunteers. Drug and Alcohol Dependence, 74(2), 205–209.PubMedCrossRef Mintzer, M. Z., Correia, C. J., & Strain, E. C. (2004). A dose-effect study of repeated administration of buprenorphine/naloxone on performance in opioid-dependent volunteers. Drug and Alcohol Dependence, 74(2), 205–209.PubMedCrossRef
go back to reference Mintzer, M. Z., & Stitzer, M. L. (2002). Cognitive impairment in methadone maintenance patients. Drug and Alcohol Dependence, 67(1), 41–51.PubMedCrossRef Mintzer, M. Z., & Stitzer, M. L. (2002). Cognitive impairment in methadone maintenance patients. Drug and Alcohol Dependence, 67(1), 41–51.PubMedCrossRef
go back to reference Mitchell, S. H. (1999). Measures of impulsivity in cigarette smokers and non-smokers. Psychopharmacology (Berl), 146(4), 455–464.CrossRef Mitchell, S. H. (1999). Measures of impulsivity in cigarette smokers and non-smokers. Psychopharmacology (Berl), 146(4), 455–464.CrossRef
go back to reference Nestler, E. J. (1993). Cellular responses to chronic treatment with drugs of abuse. Critical Reviews in Neurobiology, 7(1), 23–39.PubMed Nestler, E. J. (1993). Cellular responses to chronic treatment with drugs of abuse. Critical Reviews in Neurobiology, 7(1), 23–39.PubMed
go back to reference Ng, K. F., Yuen, T. S., & Ng, V. M. (2006). A comparison of postoperative cognitive function and pain relief with fentanyl or tramadol patient-controlled analgesia. Journal of Clinical Anesthesia, 18(3), 205–210.PubMedCrossRef Ng, K. F., Yuen, T. S., & Ng, V. M. (2006). A comparison of postoperative cognitive function and pain relief with fentanyl or tramadol patient-controlled analgesia. Journal of Clinical Anesthesia, 18(3), 205–210.PubMedCrossRef
go back to reference Nye, H. E., & Nestler, E. J. (1996). Induction of chronic Fos-related antigens in rat brain by chronic morphine administration. Molecular Pharmacology, 49(4), 636–645.PubMed Nye, H. E., & Nestler, E. J. (1996). Induction of chronic Fos-related antigens in rat brain by chronic morphine administration. Molecular Pharmacology, 49(4), 636–645.PubMed
go back to reference O’Brien, C. P., Volkow, N., & Li, T. K. (2006). What’s in a word? Addiction versus dependence in DSM-V. American Journal of Psychiatry, 163(5), 764–765.PubMedCrossRef O’Brien, C. P., Volkow, N., & Li, T. K. (2006). What’s in a word? Addiction versus dependence in DSM-V. American Journal of Psychiatry, 163(5), 764–765.PubMedCrossRef
go back to reference Ornstein, T. J., Iddon, J. L., Baldacchino, A. M., Sahakian, B. J., London, M., Everitt, B. J., et al. (2000). Profiles of cognitive dysfunction in chronic amphetamine and heroin abusers. Neuropsychopharmacology, 23(2), 113–126.PubMedCrossRef Ornstein, T. J., Iddon, J. L., Baldacchino, A. M., Sahakian, B. J., London, M., Everitt, B. J., et al. (2000). Profiles of cognitive dysfunction in chronic amphetamine and heroin abusers. Neuropsychopharmacology, 23(2), 113–126.PubMedCrossRef
go back to reference Pakesch, G., Loimer, N., Grunberger, J., Pfersmann, D., Linzmayer, L., & Mayerhofer, S. (1992). Neuropsychological findings and psychiatric symptoms in HIV-1 infected and noninfected drug users. Psychiatry Research, 41(2), 163–177.PubMedCrossRef Pakesch, G., Loimer, N., Grunberger, J., Pfersmann, D., Linzmayer, L., & Mayerhofer, S. (1992). Neuropsychological findings and psychiatric symptoms in HIV-1 infected and noninfected drug users. Psychiatry Research, 41(2), 163–177.PubMedCrossRef
go back to reference Petry, N. M., Bickel, W. K., & Arnett, M. (1998). Shortened time horizons and insensitivity to future consequences in heroin addicts. Addiction, 93(5), 729–738.PubMedCrossRef Petry, N. M., Bickel, W. K., & Arnett, M. (1998). Shortened time horizons and insensitivity to future consequences in heroin addicts. Addiction, 93(5), 729–738.PubMedCrossRef
go back to reference Pickens, R. W., Preston, K. L., Miles, D. R., Gupman, A. E., Johnson, E. O., Newlin, D. B., et al. (2001). Family history influence on drug abuse severity and treatment outcome. Drug and Alcohol Dependence, 61(3), 261–270.PubMedCrossRef Pickens, R. W., Preston, K. L., Miles, D. R., Gupman, A. E., Johnson, E. O., Newlin, D. B., et al. (2001). Family history influence on drug abuse severity and treatment outcome. Drug and Alcohol Dependence, 61(3), 261–270.PubMedCrossRef
go back to reference Pirastu, R., Fais, R., Messina, M., Bini, V., Spiga, S., Falconieri, D., et al. (2006). Impaired decision-making in opiate-dependent subjects: Effect of pharmacological therapies. Drug and Alcohol Dependence, 83(2), 163–168.PubMedCrossRef Pirastu, R., Fais, R., Messina, M., Bini, V., Spiga, S., Falconieri, D., et al. (2006). Impaired decision-making in opiate-dependent subjects: Effect of pharmacological therapies. Drug and Alcohol Dependence, 83(2), 163–168.PubMedCrossRef
go back to reference Preston, K. L., Jasinski, D. R., & Testa, M. (1991). Abuse potential and pharmacological comparison of tramadol and morphine. Drug and Alcohol Dependence, 27(1), 7–17.PubMedCrossRef Preston, K. L., Jasinski, D. R., & Testa, M. (1991). Abuse potential and pharmacological comparison of tramadol and morphine. Drug and Alcohol Dependence, 27(1), 7–17.PubMedCrossRef
go back to reference Rapeli, P., Kivisaari, R., Autti, T., Kahkonen, S., Puuskari, V., Jokela, O., et al. (2006). Cognitive function during early abstinence from opioid dependence: A comparison to age, gender, and verbal intelligence matched controls. BMC Psychiatry, 6, 9.PubMedCrossRef Rapeli, P., Kivisaari, R., Autti, T., Kahkonen, S., Puuskari, V., Jokela, O., et al. (2006). Cognitive function during early abstinence from opioid dependence: A comparison to age, gender, and verbal intelligence matched controls. BMC Psychiatry, 6, 9.PubMedCrossRef
go back to reference Ridenour, T. A., Maldonado-Molina, M., Compton, W. M., Spitznagel, E. L., & Cottler, L. B. (2005). Factors associated with the transition from abuse to dependence among substance abusers: Implications for a measure of addictive liability. Drug and Alcohol Dependence, 80(1), 1–14.PubMedCrossRef Ridenour, T. A., Maldonado-Molina, M., Compton, W. M., Spitznagel, E. L., & Cottler, L. B. (2005). Factors associated with the transition from abuse to dependence among substance abusers: Implications for a measure of addictive liability. Drug and Alcohol Dependence, 80(1), 1–14.PubMedCrossRef
go back to reference Rodriguez-Llera, M. C., Domingo-Salvany, A., Brugal, M. T., Silva, T. C., Sanchez-Niubo, A., & Torrens, M. (2006). Psychiatric comorbidity in young heroin users. Drug and Alcohol Dependence, 84(1), 48–55.PubMedCrossRef Rodriguez-Llera, M. C., Domingo-Salvany, A., Brugal, M. T., Silva, T. C., Sanchez-Niubo, A., & Torrens, M. (2006). Psychiatric comorbidity in young heroin users. Drug and Alcohol Dependence, 84(1), 48–55.PubMedCrossRef
go back to reference Rose, J. S., Branchey, M., Buydens-Branchey, L., Stapleton, J. M., Chasten, K., Werrell, A., et al. (1996). Cerebral perfusion in early and late opiate withdrawal: A technetium-99m-HMPAO SPECT study. Psychiatry Research, 67(1), 39–47.PubMedCrossRef Rose, J. S., Branchey, M., Buydens-Branchey, L., Stapleton, J. M., Chasten, K., Werrell, A., et al. (1996). Cerebral perfusion in early and late opiate withdrawal: A technetium-99m-HMPAO SPECT study. Psychiatry Research, 67(1), 39–47.PubMedCrossRef
go back to reference Rotheram-Fuller, E., Shoptaw, S., Berman, S. M., & London, E. D. (2004). Impaired performance in a test of decision-making by opiate-dependent tobacco smokers. Drug and Alcohol Dependence, 73(1), 79–86.PubMedCrossRef Rotheram-Fuller, E., Shoptaw, S., Berman, S. M., & London, E. D. (2004). Impaired performance in a test of decision-making by opiate-dependent tobacco smokers. Drug and Alcohol Dependence, 73(1), 79–86.PubMedCrossRef
go back to reference Rounsaville, B. J., Jones, C., Novelly, R. A., & Kleber, H. (1982). Neuropsychological functioning in opiate addicts. Journal of Nervous and Mental Disease, 170(4), 209–216.PubMedCrossRef Rounsaville, B. J., Jones, C., Novelly, R. A., & Kleber, H. (1982). Neuropsychological functioning in opiate addicts. Journal of Nervous and Mental Disease, 170(4), 209–216.PubMedCrossRef
go back to reference Rounsaville, B. J., Kosten, T. R., Weissman, M. M., Prusoff, B., Pauls, D., Anton, S. F., et al. (1991). Psychiatric disorders in relatives of probands with opiate addiction. Archives of General Psychiatry, 48(1), 33–42.PubMed Rounsaville, B. J., Kosten, T. R., Weissman, M. M., Prusoff, B., Pauls, D., Anton, S. F., et al. (1991). Psychiatric disorders in relatives of probands with opiate addiction. Archives of General Psychiatry, 48(1), 33–42.PubMed
go back to reference SAMHSA (2006). Results from the 2005 national survey on drug use and health: National findings. Rockville, MD. SAMHSA (2006). Results from the 2005 national survey on drug use and health: National findings. Rockville, MD.
go back to reference SAMHSA (2007). The DASIS report: Heroin—changes in how it is used: 1995–2005. Rockville, MD: SAMHSA. SAMHSA (2007). The DASIS report: Heroin—changes in how it is used: 1995–2005. Rockville, MD: SAMHSA.
go back to reference Schottenfeld, M. A. (1999). Open capsulorrhaphy with suture anchors for recurrent anterior dislocation of the shoulder. American Journal of Sports Medicine, 27(1), 122.PubMed Schottenfeld, M. A. (1999). Open capsulorrhaphy with suture anchors for recurrent anterior dislocation of the shoulder. American Journal of Sports Medicine, 27(1), 122.PubMed
go back to reference Sedo, M. A. (2004a). [‘5 digit test’: a multilinguistic non-reading alternative to the Stroop test]. Revista de Neurologia, 38(9), 824–828.PubMed Sedo, M. A. (2004a). [‘5 digit test’: a multilinguistic non-reading alternative to the Stroop test]. Revista de Neurologia, 38(9), 824–828.PubMed
go back to reference Sedo, M. A. (2004b). [SENTREP test: two lists of sentences of equal length to check the attention and the presence of linguistic maturity problems]. Revista de Neurologia, 38(10), 924–927.PubMed Sedo, M. A. (2004b). [SENTREP test: two lists of sentences of equal length to check the attention and the presence of linguistic maturity problems]. Revista de Neurologia, 38(10), 924–927.PubMed
go back to reference Sell, L. A., Morris, J., Bearn, J., Frackowiak, R. S., Friston, K. J., & Dolan, R. J. (1999). Activation of reward circuitry in human opiate addicts. European Journal of Neuroscience, 11(3), 1042–1048.PubMedCrossRef Sell, L. A., Morris, J., Bearn, J., Frackowiak, R. S., Friston, K. J., & Dolan, R. J. (1999). Activation of reward circuitry in human opiate addicts. European Journal of Neuroscience, 11(3), 1042–1048.PubMedCrossRef
go back to reference Silvasti, M., Svartling, N., Pitkanen, M., & Rosenberg, P. H. (2000). Comparison of intravenous patient-controlled analgesia with tramadol versus morphine after microvascular breast reconstruction. European Journal of Anaesthesiology, 17(7), 448–455.PubMedCrossRef Silvasti, M., Svartling, N., Pitkanen, M., & Rosenberg, P. H. (2000). Comparison of intravenous patient-controlled analgesia with tramadol versus morphine after microvascular breast reconstruction. European Journal of Anaesthesiology, 17(7), 448–455.PubMedCrossRef
go back to reference Silveri, M. M., Pollack, M. H., Diaz, C. I., Nassar, L. E., Mendelson, J. H., Yurgelun-Todd, D. A., et al. (2004). Cerebral phosphorus metabolite and transverse relaxation time abnormalities in heroin-dependent subjects at onset of methadone maintenance treatment. Psychiatry Research, 131(3), 217–226.PubMedCrossRef Silveri, M. M., Pollack, M. H., Diaz, C. I., Nassar, L. E., Mendelson, J. H., Yurgelun-Todd, D. A., et al. (2004). Cerebral phosphorus metabolite and transverse relaxation time abnormalities in heroin-dependent subjects at onset of methadone maintenance treatment. Psychiatry Research, 131(3), 217–226.PubMedCrossRef
go back to reference Sklair-Tavron, L., Shi, W. X., Lane, S. B., Harris, H. W., Bunney, B. S., & Nestler, E. J. (1996). Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proceedings of the National Academy of Sciences of the United States of America, 93(20), 11202–11207. Sklair-Tavron, L., Shi, W. X., Lane, S. B., Harris, H. W., Bunney, B. S., & Nestler, E. J. (1996). Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proceedings of the National Academy of Sciences of the United States of America, 93(20), 11202–11207.
go back to reference Stapleton, J. M., Morgan, M. J., Phillips, R. L., Wong, D. F., Yung, B. C., Shaya, E. K., et al. (1995). Cerebral glucose utilization in polysubstance abuse. Neuropsychopharmacology, 13(1), 21–31.PubMedCrossRef Stapleton, J. M., Morgan, M. J., Phillips, R. L., Wong, D. F., Yung, B. C., Shaya, E. K., et al. (1995). Cerebral glucose utilization in polysubstance abuse. Neuropsychopharmacology, 13(1), 21–31.PubMedCrossRef
go back to reference Strain, E. C., Stitzer, M. L., Liebson, I. A., & Bigelow, G. E. (1994). Comparison of buprenorphine and methadone in the treatment of opioid dependence. American Journal of Psychiatry, 151(7), 1025–1030.PubMed Strain, E. C., Stitzer, M. L., Liebson, I. A., & Bigelow, G. E. (1994). Comparison of buprenorphine and methadone in the treatment of opioid dependence. American Journal of Psychiatry, 151(7), 1025–1030.PubMed
go back to reference Strain, E. C., Stoller, K., Walsh, S. L., & Bigelow, G. E. (2000). Effects of buprenorphine versus buprenorphine/naloxone tablets in non-dependent opioid abusers. Psychopharmacology (Berl), 148(4), 374–383.CrossRef Strain, E. C., Stoller, K., Walsh, S. L., & Bigelow, G. E. (2000). Effects of buprenorphine versus buprenorphine/naloxone tablets in non-dependent opioid abusers. Psychopharmacology (Berl), 148(4), 374–383.CrossRef
go back to reference Strang, J., & Gurling, H. (1989). Computerized tomography and neuropsychological assessment in long-term high-dose heroin addicts. British Journal of Addiction, 84(9), 1011–1019.PubMedCrossRef Strang, J., & Gurling, H. (1989). Computerized tomography and neuropsychological assessment in long-term high-dose heroin addicts. British Journal of Addiction, 84(9), 1011–1019.PubMedCrossRef
go back to reference Tassain, V., Attal, N., Fletcher, D., Brasseur, L., Degieux, P., Chauvin, M., et al. (2003). Long term effects of oral sustained release morphine on neuropsychological performance in patients with chronic non-cancer pain. Pain, 104(1–2), 389–400.PubMedCrossRef Tassain, V., Attal, N., Fletcher, D., Brasseur, L., Degieux, P., Chauvin, M., et al. (2003). Long term effects of oral sustained release morphine on neuropsychological performance in patients with chronic non-cancer pain. Pain, 104(1–2), 389–400.PubMedCrossRef
go back to reference Trujillo, K. A. (1995). Effects of noncompetitive N-methyl-D-aspartate receptor antagonists on opiate tolerance and physical dependence. Neuropsychopharmacology, 13(4), 301–307.PubMedCrossRef Trujillo, K. A. (1995). Effects of noncompetitive N-methyl-D-aspartate receptor antagonists on opiate tolerance and physical dependence. Neuropsychopharmacology, 13(4), 301–307.PubMedCrossRef
go back to reference Trujillo, K. A. (2000). Are NMDA receptors involved in opiate-induced neural and behavioral plasticity? A review of preclinical studies. Psychopharmacology (Berl), 151(2–3), 121–141.CrossRef Trujillo, K. A. (2000). Are NMDA receptors involved in opiate-induced neural and behavioral plasticity? A review of preclinical studies. Psychopharmacology (Berl), 151(2–3), 121–141.CrossRef
go back to reference Verdejo, A., Toribio, I., Orozco, C., Puente, K. L., & Perez-Garcia, M. (2005). Neuropsychological functioning in methadone maintenance patients versus abstinent heroin abusers. Drug and Alcohol Dependence, 78(3), 283–288.PubMedCrossRef Verdejo, A., Toribio, I., Orozco, C., Puente, K. L., & Perez-Garcia, M. (2005). Neuropsychological functioning in methadone maintenance patients versus abstinent heroin abusers. Drug and Alcohol Dependence, 78(3), 283–288.PubMedCrossRef
go back to reference Volkow, N. D., Fowler, J. S., Wang, G. J., & Swanson, J. M. (2004). Dopamine in drug abuse and addiction: Results from imaging studies and treatment implications. Molecular Psychiatry, 9(6), 557–569.PubMedCrossRef Volkow, N. D., Fowler, J. S., Wang, G. J., & Swanson, J. M. (2004). Dopamine in drug abuse and addiction: Results from imaging studies and treatment implications. Molecular Psychiatry, 9(6), 557–569.PubMedCrossRef
go back to reference Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Hitzemannn, R., Gatley, S. J., et al. (1996). Cocaine uptake is decreased in the brain of detoxified cocaine abusers. Neuropsychopharmacology, 14(3), 159–168.PubMedCrossRef Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Hitzemannn, R., Gatley, S. J., et al. (1996). Cocaine uptake is decreased in the brain of detoxified cocaine abusers. Neuropsychopharmacology, 14(3), 159–168.PubMedCrossRef
go back to reference Warner, L. A., Kessler, R. C., Hughes, M., Anthony, J. C., & Nelson, C. B. (1995). Prevalence and correlates of drug use and dependence in the United States. Results from the National Comorbidity Survey. Archives of General Psychiatry, 52(3), 219–229.PubMed Warner, L. A., Kessler, R. C., Hughes, M., Anthony, J. C., & Nelson, C. B. (1995). Prevalence and correlates of drug use and dependence in the United States. Results from the National Comorbidity Survey. Archives of General Psychiatry, 52(3), 219–229.PubMed
go back to reference Wiesbeck, G. A., & Taeschner, K. L. (1991). A cerebral computed tomography study of patients with drug-induced psychoses. European Archives of Psychiatry and Clinical Neuroscience, 241(2), 88–90.PubMedCrossRef Wiesbeck, G. A., & Taeschner, K. L. (1991). A cerebral computed tomography study of patients with drug-induced psychoses. European Archives of Psychiatry and Clinical Neuroscience, 241(2), 88–90.PubMedCrossRef
go back to reference Wise, R. A. (1987). The role of reward pathways in the development of drug dependence. Pharmacology & Therapeutics, 35(1–2), 227–263.CrossRef Wise, R. A. (1987). The role of reward pathways in the development of drug dependence. Pharmacology & Therapeutics, 35(1–2), 227–263.CrossRef
go back to reference Zacny, J. P. (2003). Characterizing the subjective, psychomotor, and physiological effects of a hydrocodone combination product (Hycodan) in non-drug-abusing volunteers. Psychopharmacology (Berl), 165(2), 146–156. Zacny, J. P. (2003). Characterizing the subjective, psychomotor, and physiological effects of a hydrocodone combination product (Hycodan) in non-drug-abusing volunteers. Psychopharmacology (Berl), 165(2), 146–156.
go back to reference Zacny, J. P. (2005). Profiling the subjective, psychomotor, and physiological effects of tramadol in recreational drug users. Drug and Alcohol Dependence, 80(2), 273–278.PubMedCrossRef Zacny, J. P. (2005). Profiling the subjective, psychomotor, and physiological effects of tramadol in recreational drug users. Drug and Alcohol Dependence, 80(2), 273–278.PubMedCrossRef
go back to reference Zacny, J. P., & Gutierrez, S. (2003). Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteers. Psychopharmacology (Berl), 170(3), 242–254.CrossRef Zacny, J. P., & Gutierrez, S. (2003). Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteers. Psychopharmacology (Berl), 170(3), 242–254.CrossRef
go back to reference Zacny, J. P., Gutierrez, S., & Bolbolan, S. A. (2005). Profiling the subjective, psychomotor, and physiological effects of a hydrocodone/acetaminophen product in recreational drug users. Drug and Alcohol Dependence, 78(3), 243–252.PubMedCrossRef Zacny, J. P., Gutierrez, S., & Bolbolan, S. A. (2005). Profiling the subjective, psychomotor, and physiological effects of a hydrocodone/acetaminophen product in recreational drug users. Drug and Alcohol Dependence, 78(3), 243–252.PubMedCrossRef
Metadata
Title
Neuropsychological Consequences of Opiate Use
Authors
Staci A. Gruber
Marisa M. Silveri
Deborah A. Yurgelun-Todd
Publication date
01-09-2007
Publisher
Springer US
Published in
Neuropsychology Review / Issue 3/2007
Print ISSN: 1040-7308
Electronic ISSN: 1573-6660
DOI
https://doi.org/10.1007/s11065-007-9041-y

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