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01-10-2019 | Glioblastoma | Clinical Study

Surgery for temporal glioblastoma: lobectomy outranks oncosurgical-based gross-total resection

Authors: Matthias Schneider, Anna-Laura Potthoff, Vera C. Keil, Ági Güresir, Johannes Weller, Valeri Borger, Motaz Hamed, Andreas Waha, Hartmut Vatter, Erdem Güresir, Ulrich Herrlinger, Patrick Schuss

Published in: Journal of Neuro-Oncology | Issue 1/2019

Abstract

Objective

Supra-total glioblastoma resection has gained growing attention with regard to superior long-term disease control. However, aggressive onco-surgical approaches—geared beyond conventional gross total resections (GTR)—are limited by the impairment of adjacent eloquent areas at risk that may entail severe postoperative functional morbidity. Against this backdrop we analyzed our institutional database with regard to potential survival benefits of anterior temporal lobectomy as a paradigm for supra-total resection in patients with precisely temporal-located, non-eloquent glioblastoma.

Methods

Between 2012 and 2017, 38 patients with isolated temporal glioblastoma underwent GTR or temporal lobectomy at the authors’ institution. Both groups of differing resection modalities were compared with regard to postoperative Karnofsky performance score (KPS), progression-free survival (PFS), and overall survival (OS).

Results

Patients with temporal lobectomy exhibited significantly superior median KPS at the 12 months follow-up compared to the GTR group (median KPS of 80 vs. 60, p = 0.04). Temporal lobectomy was associated with significantly prolonged PFS (p = 0.005) and OS (p = 0.002) coming up to 15 months (95% CI 9.7–22.1) and 23 months (95% CI 14.8–34.5) compared to 7 months (95% CI 3.3–8.3) and 11 months (95% CI 9.2–17.9) for the GTR group. Multivariate analysis revealed temporal lobectomy as the only predictor for both superior PFS (p = 0.037, OR 7.3, 95% CI 1.1–47.4) and OS (p = 0.04, OR 7.8, 95% CI 1.1–55.2).

Conclusions

These results strongly suggest temporal lobectomy as an aggressive supra-total resection policy to constitute the surgical modality of choice for isolated temporal-located glioblastoma.

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Title: Surgery for temporal glioblastoma: lobectomy outranks oncosurgical-based gross-total resection
Authors: Matthias Schneider
Anna-Laura Potthoff
Vera C. Keil
Ági Güresir
Johannes Weller
Valeri Borger
Motaz Hamed
Andreas Waha
Hartmut Vatter
Erdem Güresir
Ulrich Herrlinger
Patrick Schuss
Publication date: 01-10-2019
Publisher: Springer US
Keywords: Glioblastoma
Glioblastoma
Glioblastoma
Published in: Journal of Neuro-Oncology / Issue 1/2019
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-019-03281-1

2024 ASCO Annual Meeting

Springer Medicine

Surgery for temporal glioblastoma: lobectomy outranks oncosurgical-based gross-total resection

Abstract

Objective

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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