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Published in: Journal of Neuro-Oncology 1/2016

01-10-2016 | Laboratory Investigation

Completeness of required site-specific factors for brain and CNS tumors in the Surveillance, Epidemiology and End Results (SEER) 18 database (2004–2012, varying)

Authors: Quinn T. Ostrom, Haley Gittleman, Carol Kruchko, David N. Louis, Daniel J. Brat, Mark R. Gilbert, Valentina I. Petkov, Jill S. Barnholtz-Sloan

Published in: Journal of Neuro-Oncology | Issue 1/2016

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Abstract

Cancer registries are an important source of population-level information on brain tumor incidence and survival. Surveillance, Epidemiology, and End Results (SEER) registries currently collect data on specific required factors related to brain tumors as defined by the American Joint Commission on Cancer, including World Health Organization (WHO) grade, MGMT methylation and 1p/19q codeletion status. We assessed ‘completeness’, defined as having valid values over the time periods that they have been collected, overall, by year, histology, and registry. Data were obtained through a SEER custom data request for four factors related to brain tumors for the years 2004–2012 (3/4 factors were collected only from 2010 to 2012). SEER*Stat was used to generate frequencies of ‘completeness’ for each factor overall, and by year, histology and registry. The four factors varied in completeness, but increased over time. WHO grade has been collected the longest, and showed significant increases in completeness. Completeness of MGMT and 1p/19q codeletion was highest for glioma subtypes for which testing is recommended by clinical practice guidelines. Completeness of all factors varied by histology and cancer registry. Overall, several of the factors had high completeness, and all increased in completeness over time. With increasing focus on ‘precision medicine’ and the incorporation of molecular parameters into the 2016 WHO CNS tumor classification, it is critical that the data are complete, and factors collected at the population level are fully integrated into cancer reporting. It is critical that cancer registries continue to collect established and emerging prognostic and predictive factors.
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Metadata
Title
Completeness of required site-specific factors for brain and CNS tumors in the Surveillance, Epidemiology and End Results (SEER) 18 database (2004–2012, varying)
Authors
Quinn T. Ostrom
Haley Gittleman
Carol Kruchko
David N. Louis
Daniel J. Brat
Mark R. Gilbert
Valentina I. Petkov
Jill S. Barnholtz-Sloan
Publication date
01-10-2016
Publisher
Springer US
Published in
Journal of Neuro-Oncology / Issue 1/2016
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI
https://doi.org/10.1007/s11060-016-2217-7

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