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01-10-2012 | Clinical Study - Patient Study

Expression of VAV1 in the tumour microenvironment of glioblastoma multiforme

Authors: Juan Luis Garcia, Jose Couceiro, Juan Antonio Gomez-Moreta, J. M. Gonzalez Valero, Angel Santos Briz, Vincent Sauzeau, Eva Lumbreras, Manuel Delgado, Cristina Robledo, Monica Lara Almunia, Xose R. Bustelo, Jesus M. Hernandez

Published in: Journal of Neuro-Oncology | Issue 1/2012

Abstract

Even though much progress has been made towards understanding the molecular nature of glioma, the survival rates of patients affected by this tumour have not changed significantly over recent years. Better knowledge of this malignancy is still needed in order to predict its outcome and improve patient treatment. VAV1 is an GDP/GTP exchange factor for Rho/Rac proteins with oncogenic potential that is involved in the regulation of cytoskeletal dynamics and cell migration. Here we report its overexpression in 59 patients diagnosed with high-grade glioma, and the associated upregulation of a number of genes coding for proteins also involved in cell invasion- and migration-related processes. Unexpectedly, immunohistochemical experiments revealed that VAV1 is not expressed in glioma cells. Instead, VAV1 is found in non-tumoural astrocyte-like cells that are located either peritumouraly or perivascularly. We propose that the expression of VAV1 is linked to synergistic signalling cross-talk between cancer and infiltrating cells. Interestingly, we show that the pattern of expression of VAV1 could have a role in the neoplastic process in glioblastoma tumours.

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Title: Expression of VAV1 in the tumour microenvironment of glioblastoma multiforme
Authors: Juan Luis Garcia
Jose Couceiro
Juan Antonio Gomez-Moreta
J. M. Gonzalez Valero
Angel Santos Briz
Vincent Sauzeau
Eva Lumbreras
Manuel Delgado
Cristina Robledo
Monica Lara Almunia
Xose R. Bustelo
Jesus M. Hernandez
Publication date: 01-10-2012
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 1/2012
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-012-0936-y

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Expression of VAV1 in the tumour microenvironment of glioblastoma multiforme

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