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01-11-2009 | Case Report

Response of an adult patient with pineoblastoma to vorinostat and retinoic acid

Authors: Rebecca DeBoer, Hunt Batjer, Maryanne Marymont, Stewart Goldman, Matthew Walker, Numa Gottardi-Littell, Jeffrey Raizer

Published in: Journal of Neuro-Oncology | Issue 2/2009

Abstract

We report the case of an adult patient with pineoblastoma (PBL) who had a complete radiographic response following treatment with vorinostat and retinoic acid. This regimen was used to treat bulky residual tumor that persisted despite radiation therapy (RT) and two cycles of cytotoxic chemotherapy. Vorinostat and retinoic acid were chosen as an alternative to cytotoxic chemotherapy, which our patient was unable to tolerate, based on preclinical data suggesting efficacy of this combination. MRI demonstrated a complete response to this regimen, which continues to remain stable without evidence of recurrence.

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Title: Response of an adult patient with pineoblastoma to vorinostat and retinoic acid
Authors: Rebecca DeBoer
Hunt Batjer
Maryanne Marymont
Stewart Goldman
Matthew Walker
Numa Gottardi-Littell
Jeffrey Raizer
Publication date: 01-11-2009
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2009
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-009-9921-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Response of an adult patient with pineoblastoma to vorinostat and retinoic acid

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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