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01-05-2008 | Lab. Investigation-Human/Animal Tissue

ATRA-inhibited proliferation in glioma cells is associated with subcellular redistribution of β-catenin via up-regulation of Axin

Authors: Jianrong Lu, Feng Zhang, Daqing Zhao, Liu Hong, Jie Min, Liying Zhang, Fanfan Li, Yan Yan, Hang Li, Yu Ma, Qing Li

Published in: Journal of Neuro-Oncology | Issue 3/2008

Abstract

Retinoic acid (RA) is a major chemopreventive agent which exerts strong anti-tumor activity partly by trans-repressing the Wnt/β-catenin signaling pathway in some tumor cell lines. However, the definite mechanism of RA trans-repression of the Wnt/β-catenin signaling pathway has not been elucidated clearly. In this work, we found that all-trans retinoic acid (ATRA) significantly inhibited proliferation of glioma cells, accompanied by up-regulation of expression of Axin and altered subcellular distribution of β-catenin. Transfecting C6 cells with rAxin further confirmed that increased expression of Axin is obligate for inhibition of proliferation and the increase of the cytoplasmic β-catenin. Our results suggested that Axin might play an important role in RA-mediated anti-proliferative effects of glioma cell lines.

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Title: ATRA-inhibited proliferation in glioma cells is associated with subcellular redistribution of β-catenin via up-regulation of Axin
Authors: Jianrong Lu
Feng Zhang
Daqing Zhao
Liu Hong
Jie Min
Liying Zhang
Fanfan Li
Yan Yan
Hang Li
Yu Ma
Qing Li
Publication date: 01-05-2008
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 3/2008
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-008-9518-4

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ATRA-inhibited proliferation in glioma cells is associated with subcellular redistribution of β-catenin via up-regulation of Axin

Abstract

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Springer Medicine

Abstract

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