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01-07-2007 | Lab Investigation

Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines

Authors: Tobias Birnbaum, Julia Roider, Christoph J. Schankin, Claudio S. Padovan, Christian Schichor, Roland Goldbrunner, Andreas Straube

Published in: Journal of Neuro-Oncology | Issue 3/2007

Abstract

The transplantation of progenitor cells is a promising new approach for the treatment of gliomas. Marrow stromal cells (MSC) are possible candidates for such a cell-based therapy, since they are readily and autologously available and show an extensive tropism to gliomas in vitro and in vivo. However, the signals that guide the MSC are still poorly understood. In this study, we show that gliomas have the capacity to actively attract MSC by secreting a multitude of angiogenic cytokines. We demonstrate that interleukin-8 (IL-8), transforming growth factor-ß1 (TGF-ß1) and neurotrophin-3 (NT-3) contribute to this glioma-directed tropism of human MSC. Together with the finding that vascular endothelial growth factor (VEGF) is another MSC-attracting factor secreted by glioma cells, these data support the hypothesis that gliomas use their angiogenic pathways to recruit mesenchymal progenitor cells.

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Title: Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines
Authors: Tobias Birnbaum
Julia Roider
Christoph J. Schankin
Claudio S. Padovan
Christian Schichor
Roland Goldbrunner
Andreas Straube
Publication date: 01-07-2007
Publisher: Kluwer Academic Publishers-Plenum Publishers
Published in: Journal of Neuro-Oncology / Issue 3/2007
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-007-9332-4

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Malignant gliomas actively recruit bone marrow stromal cells by secreting angiogenic cytokines

Abstract

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Abstract

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