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06-03-2023 | Irritable Bowel Syndrome | Original Article

Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome

Authors: Kosar Namakin, Meysam Hassani Moghaddam, Sara Sadeghzadeh, Maryam Mehranpour, Kimia Vakili, Mobina Fathi, Ahmadreza Golshan, Amir-Hossein Bayat, Amir-Hossein Tajik, Neda Eskandari, Ibrahim Mohammadzadeh, Soheila Zamanlui Benisi, Abbas Aliaghaei, Mohammad-Amin Abdollahifar

Published in: Metabolic Brain Disease | Issue 5/2023

Abstract

Irritable bowel syndrome (IBS) is related to a problem in the gut-brain axis. This experimental research aimed to shed light on the potential therapeutic application of elderberry (EB), which can work on the axis and get better the IBS symptoms. There were three groups (36 Sprague-Dawley rats) in this experiment, including control, IBS, and IBS with EB diet (IBS + EB). Making use of intracolonic instillation of 1 ml of 4% acetic acid for 30 s, IBS was induced. 7 days later, the EB extract (2%) was added to the diets of all animals for 8 weeks. Some histological, behavioral, and stereological techniques were used to detect the effects of EB on the gut and brain tissues. The findings showed that the EB diet improved locomotion and decreased anxiety-like behavior in the rat models of IBS. Moreover, the diet dropped the expression of TNF-α and increased mucosal layer thickness and the number of goblet and mast cells in colon tissue samples. In the hippocampal samples, administration of EB prevented astrogliosis and astrocyte reactivity. Although hippocampal and cortical neurons decreased markedly in the IBS group, EB prevented the drop in the number of neurons. Although lots of research is needed to elucidate the effectiveness of EB in IBS and its exact molecular mechanism, the result of this study showed that EB as an antioxidant and immune-modulatory agent could be a promising research target to prevent the impairment in the gut-brain axis, and could ameliorative classic IBS symptoms.

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Title: Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome
Authors: Kosar Namakin
Meysam Hassani Moghaddam
Sara Sadeghzadeh
Maryam Mehranpour
Kimia Vakili
Mobina Fathi
Ahmadreza Golshan
Amir-Hossein Bayat
Amir-Hossein Tajik
Neda Eskandari
Ibrahim Mohammadzadeh
Soheila Zamanlui Benisi
Abbas Aliaghaei
Mohammad-Amin Abdollahifar
Publication date: 06-03-2023
Publisher: Springer US
Keyword: Irritable Bowel Syndrome
Published in: Metabolic Brain Disease / Issue 5/2023
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-023-01187-6

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Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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