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Published in: Metabolic Brain Disease 3-4/2007

01-12-2007 | ORIGINAL PAPER

Controversies in ammonia metabolism: implications for hepatic encephalopathy

Author: Alan H. Lockwood

Published in: Metabolic Brain Disease | Issue 3-4/2007

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Excerpt

There have almost always been controversial aspects concerning the role of ammonia in the production of hepatic encephalopathy (HE). This was true 50 years ago and is certainly true now. This review will address some of these controversies. …
Literature
go back to reference Ahl B, Weissenborn K, van den Hoff J, Fischer-Wasels D, Kostler H, Hecker H, Burchert W (2004). Regional differences in cerebral blood flow and cerebral ammonia metabolism in patients with cirrhosis. Hepatology 40:73–79PubMedCrossRef Ahl B, Weissenborn K, van den Hoff J, Fischer-Wasels D, Kostler H, Hecker H, Burchert W (2004). Regional differences in cerebral blood flow and cerebral ammonia metabolism in patients with cirrhosis. Hepatology 40:73–79PubMedCrossRef
go back to reference Cerra FB, Cheung NK, Fischer JE, Kaplowitz N, Schiff ER, Dienstag JL, Bower RH, Mabry CD, Leevy CM, Kiernan T (1985) Disease-specific amino acid infusion (F080) in hepatic encephalopathy: a prospective, randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr 9:288–295PubMed Cerra FB, Cheung NK, Fischer JE, Kaplowitz N, Schiff ER, Dienstag JL, Bower RH, Mabry CD, Leevy CM, Kiernan T (1985) Disease-specific amino acid infusion (F080) in hepatic encephalopathy: a prospective, randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr 9:288–295PubMed
go back to reference Cooper AJ, McDonald JM, Gelbard AS, Gledhill RF, Duffy TE (1979) The metabolic fate of 13N-labeled ammonia in rat brain. J Biol Chem 254:4982–4992PubMed Cooper AJ, McDonald JM, Gelbard AS, Gledhill RF, Duffy TE (1979) The metabolic fate of 13N-labeled ammonia in rat brain. J Biol Chem 254:4982–4992PubMed
go back to reference Eriksson LS, Conn HO (1989) Branched-chain amino acids in the management of hepatic encephalopathy: an analysis of variants. Hepatology 10:228–246PubMedCrossRef Eriksson LS, Conn HO (1989) Branched-chain amino acids in the management of hepatic encephalopathy: an analysis of variants. Hepatology 10:228–246PubMedCrossRef
go back to reference Fischer JE, Yoshimura N, Aguirre A, James JH, Cummings MG, Abel RM, Deindoerfer F (1974) Plasma amino acids in patients with hepatic encephalopathy. Effects of amino acid infusions. Am J Surg 127:40–47PubMedCrossRef Fischer JE, Yoshimura N, Aguirre A, James JH, Cummings MG, Abel RM, Deindoerfer F (1974) Plasma amino acids in patients with hepatic encephalopathy. Effects of amino acid infusions. Am J Surg 127:40–47PubMedCrossRef
go back to reference Fischer JE, Rosen HM, Ebeid AM, James JH, Keane JM, Soeters PB (1976) The effect of normalization of plasma amino acids on hepatic encephalopathy in man. Surgery 80:77–91PubMed Fischer JE, Rosen HM, Ebeid AM, James JH, Keane JM, Soeters PB (1976) The effect of normalization of plasma amino acids on hepatic encephalopathy in man. Surgery 80:77–91PubMed
go back to reference Gjedde A, Lockwood AH, Duffy TE, Plum F (1978) Cerebral blood flow and metabolism in chronically hyperammonemic rats: effect of an acute ammonia challenge. Ann Neurol 3:325–330PubMedCrossRef Gjedde A, Lockwood AH, Duffy TE, Plum F (1978) Cerebral blood flow and metabolism in chronically hyperammonemic rats: effect of an acute ammonia challenge. Ann Neurol 3:325–330PubMedCrossRef
go back to reference Gratton JA, Abraham MH, Bradbury MW, Chadha HS (1997) Molecular factors influencing drug transfer across the blood–brain barrier. J Pharm Pharmacol 49:1211–1216PubMed Gratton JA, Abraham MH, Bradbury MW, Chadha HS (1997) Molecular factors influencing drug transfer across the blood–brain barrier. J Pharm Pharmacol 49:1211–1216PubMed
go back to reference Harmar AJ, Horn AS (1976) Octopamine in mammalian brain: rapid post mortem increase and effects of drugs. J Neurochem 26:987–993PubMedCrossRef Harmar AJ, Horn AS (1976) Octopamine in mammalian brain: rapid post mortem increase and effects of drugs. J Neurochem 26:987–993PubMedCrossRef
go back to reference Keiding S, Sørensen M, Bender D, Munk OL, Ott P, Vilstrup H (2006) Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by positron emission tomography. Hepatology 43:42–50PubMedCrossRef Keiding S, Sørensen M, Bender D, Munk OL, Ott P, Vilstrup H (2006) Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by positron emission tomography. Hepatology 43:42–50PubMedCrossRef
go back to reference Lockwood AH, McDonald JM, Reiman RE, Gelbard AS, Laughlin JS, Duffy TE, Plum F (1979) The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia. J Clin Invest 63:449–460PubMedCrossRef Lockwood AH, McDonald JM, Reiman RE, Gelbard AS, Laughlin JS, Duffy TE, Plum F (1979) The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia. J Clin Invest 63:449–460PubMedCrossRef
go back to reference Lockwood AH, Finn RD, Campbell JA, Richman TB (1980) Factors that affect the uptake of ammonia by the brain: the blood–brain pH gradient. Brain Res 181:259–266PubMedCrossRef Lockwood AH, Finn RD, Campbell JA, Richman TB (1980) Factors that affect the uptake of ammonia by the brain: the blood–brain pH gradient. Brain Res 181:259–266PubMedCrossRef
go back to reference Lockwood AH, Yap EW, Wong WH (1991) Cerebral ammonia metabolism in patients with severe liver disease and minimal hepatic encephalopathy. J Cereb Blood Flow Metab 11:337–341PubMed Lockwood AH, Yap EW, Wong WH (1991) Cerebral ammonia metabolism in patients with severe liver disease and minimal hepatic encephalopathy. J Cereb Blood Flow Metab 11:337–341PubMed
go back to reference Michel H, Solere M, Granier P, Cauvet G, Bali JP, Pons F, Bellet-Herman H (1980) Treatment of cirrhotic hepatic encephalopathy with L-DOPA, a controlled trial. Gastroenterology 79:207PubMed Michel H, Solere M, Granier P, Cauvet G, Bali JP, Pons F, Bellet-Herman H (1980) Treatment of cirrhotic hepatic encephalopathy with L-DOPA, a controlled trial. Gastroenterology 79:207PubMed
go back to reference Michel H, Bories P, Aubin JP, Pomier Layrargues G, Bauret P, Bellet Herman H (1985) Treatment of acute hepatic encephalopathy in cirrhotics with a branched-chain amino acids enriched versus a conventional amino acids mixture. A controlled study of 70 patients. Liver 5:282–289PubMed Michel H, Bories P, Aubin JP, Pomier Layrargues G, Bauret P, Bellet Herman H (1985) Treatment of acute hepatic encephalopathy in cirrhotics with a branched-chain amino acids enriched versus a conventional amino acids mixture. A controlled study of 70 patients. Liver 5:282–289PubMed
go back to reference Phelps ME, Hoffman EJ, Raybaud C (1977) Factors which affect cerebral uptake and retention of 13NH3. Stroke 8:694–702PubMed Phelps ME, Hoffman EJ, Raybaud C (1977) Factors which affect cerebral uptake and retention of 13NH3. Stroke 8:694–702PubMed
go back to reference Raichle ME, Larson KB (1981) The significance of the NH3–\( {\text{NH}}^{{\text{ + }}}_{{\text{4}}} \) equilibrium on the passage of 13N–ammonia from blood to brain. Circ Res 48:913–937PubMed Raichle ME, Larson KB (1981) The significance of the NH3\( {\text{NH}}^{{\text{ + }}}_{{\text{4}}} \) equilibrium on the passage of 13N–ammonia from blood to brain. Circ Res 48:913–937PubMed
go back to reference Sørensen M, Keiding S (2006) Response to Lockwood and Wack: The brain permeability-surface product for ammonia. Hepatology 43:1053–1056CrossRef Sørensen M, Keiding S (2006) Response to Lockwood and Wack: The brain permeability-surface product for ammonia. Hepatology 43:1053–1056CrossRef
go back to reference Uribe M, Garcia-Ramos G, Ramos M, Valverde C, Marquez MA, Farca A, Guevara L (1983) Standard and higher doses of bromocriptine for severe chronic portal-systemic encephalopathy. Am J Gastroenterol 78:517–522PubMed Uribe M, Garcia-Ramos G, Ramos M, Valverde C, Marquez MA, Farca A, Guevara L (1983) Standard and higher doses of bromocriptine for severe chronic portal-systemic encephalopathy. Am J Gastroenterol 78:517–522PubMed
go back to reference Wahren K, Denis J, Desurmont P, Eriksson LS, Escoffier J-M, Gauthier AP, Hagenfeldt L, Michel H, Opolon P, Paris J-C, Veyrac M (1983) Is intravenous administration of branched chain amino acids effective in the treatment of hepatic encephalopathy? A multicenter study. Hepatology 3:475–480PubMedCrossRef Wahren K, Denis J, Desurmont P, Eriksson LS, Escoffier J-M, Gauthier AP, Hagenfeldt L, Michel H, Opolon P, Paris J-C, Veyrac M (1983) Is intravenous administration of branched chain amino acids effective in the treatment of hepatic encephalopathy? A multicenter study. Hepatology 3:475–480PubMedCrossRef
go back to reference Zieve L, Olsen RL (1977) Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine? Gut 18:688–691PubMedCrossRef Zieve L, Olsen RL (1977) Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine? Gut 18:688–691PubMedCrossRef
Metadata
Title
Controversies in ammonia metabolism: implications for hepatic encephalopathy
Author
Alan H. Lockwood
Publication date
01-12-2007
Publisher
Springer US
Published in
Metabolic Brain Disease / Issue 3-4/2007
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI
https://doi.org/10.1007/s11011-007-9059-0

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