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Published in: Maternal and Child Health Journal 6/2012

01-08-2012

Fetal Alcohol Spectrum Disorders: A Population Based Study of Premature Mortality Rates in the Mothers

Authors: Qing Li, Wayne W. Fisher, Chun-Zi Peng, Andrew D. Williams, Larry Burd

Published in: Maternal and Child Health Journal | Issue 6/2012

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Abstract

Fetal alcohol spectrum disorders (FASD) are associated with an increase in risk for mortality for people with an FASD and their siblings. In this study we examine mortality rates of birth mothers of children with FASD, using a retrospective case control methodology. We utilized the North Dakota FASD Registry to locate birth certificates for children with FASD which we used to identify birth mothers. We then searched for mothers’ death certificates. We then compared the mortality rates of the birth mothers with an age matched control group comprised of all North Dakota women who were born and died in the same year as the birth mother. The birth mothers of children with FASD had a mortality rate of 15/304 = 4.93%; (95% CI 2.44–7.43%). The mortality rate for control mothers born in same years as the FASD mothers was 126/114,714 = 0.11% (95% CI 0.09–0.13%). Mothers of children with an FASD had a 44.82 fold increase in mortality risk and 87% of the deaths occurred in women under the age of 50. Three causes of death (cancer, injuries, and alcohol related disease) accounted for 67% of the deaths in the mothers of children with FASD. A diagnosis of FASD is an important risk marker for premature death in the mothers of children diagnosed with an FASD. These women should be encouraged to enter substance abuse treatment.
Literature
1.
go back to reference Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009). Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet, 373(9682), 2223–2233.PubMedCrossRef Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009). Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet, 373(9682), 2223–2233.PubMedCrossRef
2.
go back to reference Durkin, A., Connolly, S., & O’Reilly, D. (2010). Quantifying alcohol-related mortality: Should alcohol-related contributory causes of death be included? Alcohol Alcohol, 45(4), 374–378. Durkin, A., Connolly, S., & O’Reilly, D. (2010). Quantifying alcohol-related mortality: Should alcohol-related contributory causes of death be included? Alcohol Alcohol, 45(4), 374–378.
3.
go back to reference Smith, L. A., & Foxcroft, D. R. (2009). The effect of alcohol advertising, marketing and portrayal on drinking behaviour in young people: Systematic review of prospective cohort studies. BMC Public Health, 9, 51.PubMedCrossRef Smith, L. A., & Foxcroft, D. R. (2009). The effect of alcohol advertising, marketing and portrayal on drinking behaviour in young people: Systematic review of prospective cohort studies. BMC Public Health, 9, 51.PubMedCrossRef
4.
go back to reference Zaridze, D., Brennan, P., Boreham, J., Boroda, A., Karpov, R., Lazarev, A., et al. (2009). Alcohol and cause-specific mortality in Russia: A retrospective case-control study of 48, 557 adult deaths. Lancet, 373(9682), 2201–2214.PubMedCrossRef Zaridze, D., Brennan, P., Boreham, J., Boroda, A., Karpov, R., Lazarev, A., et al. (2009). Alcohol and cause-specific mortality in Russia: A retrospective case-control study of 48, 557 adult deaths. Lancet, 373(9682), 2201–2214.PubMedCrossRef
5.
go back to reference Di, C. A., Costanzo, S., Bagnardi, V., Donati, M. B., Iacoviello, L., & de Gaetano, G. (2006). Alcohol dosing and total mortality in men and women: An updated meta-analysis of 34 prospective studies. Annals of Internal Medicine, 166(22), 2437–2445.CrossRef Di, C. A., Costanzo, S., Bagnardi, V., Donati, M. B., Iacoviello, L., & de Gaetano, G. (2006). Alcohol dosing and total mortality in men and women: An updated meta-analysis of 34 prospective studies. Annals of Internal Medicine, 166(22), 2437–2445.CrossRef
6.
go back to reference Baker, A., & Rooney, C. (2003). Recent trends in alcohol-related mortality, and the impact of ICD-10 on the monitoring of these deaths in England and Wales. Health Statistics Quarterly, 17, 5–14. Baker, A., & Rooney, C. (2003). Recent trends in alcohol-related mortality, and the impact of ICD-10 on the monitoring of these deaths in England and Wales. Health Statistics Quarterly, 17, 5–14.
7.
go back to reference Hemström, Ö. (2002). Alcohol-related deaths contribute to socioeconomic differentials in mortality in Sweden. The European Journal of Public Health, 12(4), 254–262.CrossRef Hemström, Ö. (2002). Alcohol-related deaths contribute to socioeconomic differentials in mortality in Sweden. The European Journal of Public Health, 12(4), 254–262.CrossRef
8.
go back to reference Mäkelä, P. I. A. (1998). Alcohol-related mortality by age and sex and its impact on life expectancy. The European Journal of Public Health, 8(1), 43–51.CrossRef Mäkelä, P. I. A. (1998). Alcohol-related mortality by age and sex and its impact on life expectancy. The European Journal of Public Health, 8(1), 43–51.CrossRef
9.
go back to reference Di Castelnuovo, A., Costanzo, S., Bagnardi, V., Donati, M. B., Iacoviello, L., & de Gaetano, G. (2006). Alcohol dosing and total mortality in men and women: An updated meta-analysis of 34 prospective studies. Annals of Internal Medicine, 166(22), 2437–2445.CrossRef Di Castelnuovo, A., Costanzo, S., Bagnardi, V., Donati, M. B., Iacoviello, L., & de Gaetano, G. (2006). Alcohol dosing and total mortality in men and women: An updated meta-analysis of 34 prospective studies. Annals of Internal Medicine, 166(22), 2437–2445.CrossRef
10.
go back to reference Miller, N. S. (1999). Mortality risks in alcoholism and effects of abstinence and addiction treatment. Psychiatric Clinics of North America, 22(2), 371–383.PubMedCrossRef Miller, N. S. (1999). Mortality risks in alcoholism and effects of abstinence and addiction treatment. Psychiatric Clinics of North America, 22(2), 371–383.PubMedCrossRef
11.
go back to reference Centers for Disease Control, Prevention. (2004). Alcohol-attributable deaths and years of potential life lost—United States, 2001. Morbidity and Mortality Weekly Report (WWMR), 53(37), 866–870. Centers for Disease Control, Prevention. (2004). Alcohol-attributable deaths and years of potential life lost—United States, 2001. Morbidity and Mortality Weekly Report (WWMR), 53(37), 866–870.
12.
go back to reference Centers for Disease Control, Prevention. (2009). Alcohol use among pregnant and nonpregnant women of childbearing age—United States, 1991–2005. Morbidity and Mortality Weekly Report (WWMR), 58(19), 529–532. Centers for Disease Control, Prevention. (2009). Alcohol use among pregnant and nonpregnant women of childbearing age—United States, 1991–2005. Morbidity and Mortality Weekly Report (WWMR), 58(19), 529–532.
13.
go back to reference Caetano, R., Ramisetty-Mikler, S., Floyd, L. R., & McGrath, C. (2006). The epidemiology of drinking among women of child-bearing age. Alcoholism, Clinical and Experimental Research, 30(6), 1023–1030.PubMedCrossRef Caetano, R., Ramisetty-Mikler, S., Floyd, L. R., & McGrath, C. (2006). The epidemiology of drinking among women of child-bearing age. Alcoholism, Clinical and Experimental Research, 30(6), 1023–1030.PubMedCrossRef
14.
go back to reference Floyd, R. L., Decoufle, P., & Hungerford, D. W. (1999). Alcohol use prior to pregnancy recognition. American Journal of Preventive Medicine, 17(2), 101–107.PubMedCrossRef Floyd, R. L., Decoufle, P., & Hungerford, D. W. (1999). Alcohol use prior to pregnancy recognition. American Journal of Preventive Medicine, 17(2), 101–107.PubMedCrossRef
15.
go back to reference Stratton, K. R., Howe, C. J., Battaglia, F. C., & Institute of Medicine. (1996). Fetal alcohol syndrome-diagnosis, epidemiology, prevention, and treatment. Washington: National Academy Press. Stratton, K. R., Howe, C. J., Battaglia, F. C., & Institute of Medicine. (1996). Fetal alcohol syndrome-diagnosis, epidemiology, prevention, and treatment. Washington: National Academy Press.
16.
go back to reference Sampson, P. D., Streissguth, A. P., Bookstein, F. L., Little, R. E., Clarren, S. K., Dehaene, P., et al. (1997). Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder. Teratology, 56(5), 317–326.PubMedCrossRef Sampson, P. D., Streissguth, A. P., Bookstein, F. L., Little, R. E., Clarren, S. K., Dehaene, P., et al. (1997). Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder. Teratology, 56(5), 317–326.PubMedCrossRef
17.
go back to reference Poitra, B. A., Marion, S., Dionne, M., Wilkie, E., Dauphinais, P., Wilkie-Pepion, M., et al. (2003). A school based screening program for fetal alcohol syndrome. Neurotoxicology and Teratology, 25(6), 731–736.CrossRef Poitra, B. A., Marion, S., Dionne, M., Wilkie, E., Dauphinais, P., Wilkie-Pepion, M., et al. (2003). A school based screening program for fetal alcohol syndrome. Neurotoxicology and Teratology, 25(6), 731–736.CrossRef
18.
go back to reference May, P. A., Gossage, J. P., Marais, A. S., Adnams, C. M., Hoyme, H. E., Jones, K. L., et al. (2007). The epidemiology of fetal alcohol syndrome and partial FAS in a South African community. Drug and Alcohol Dependence, 88(2–3), 259–271.PubMedCrossRef May, P. A., Gossage, J. P., Marais, A. S., Adnams, C. M., Hoyme, H. E., Jones, K. L., et al. (2007). The epidemiology of fetal alcohol syndrome and partial FAS in a South African community. Drug and Alcohol Dependence, 88(2–3), 259–271.PubMedCrossRef
19.
go back to reference Burd, L., & Wilson, H. (2004). Fetal infant, and child mortality in a context of alcohol use. American Journal of Medical Genetics Part C Seminars in Medical Genetics, 127(1), 51–58. Burd, L., & Wilson, H. (2004). Fetal infant, and child mortality in a context of alcohol use. American Journal of Medical Genetics Part C Seminars in Medical Genetics, 127(1), 51–58.
20.
go back to reference Burd, L., Klug, M. G., Bueling, R., Martsolf, J., Olson, M., & Kerbeshian, J. (2008). Mortality rates in subjects with fetal alcohol spectrum disorders and their siblings. Birth Defects Research Part A Clinical and Molecular Teratology, 82(4), 217–223.CrossRef Burd, L., Klug, M. G., Bueling, R., Martsolf, J., Olson, M., & Kerbeshian, J. (2008). Mortality rates in subjects with fetal alcohol spectrum disorders and their siblings. Birth Defects Research Part A Clinical and Molecular Teratology, 82(4), 217–223.CrossRef
21.
go back to reference Clarren, S. K., & Smith, D. W. (1978). The fetal alcohol syndrome. The New England Journal of Medicine, 298(19), 1063–1067.PubMedCrossRef Clarren, S. K., & Smith, D. W. (1978). The fetal alcohol syndrome. The New England Journal of Medicine, 298(19), 1063–1067.PubMedCrossRef
22.
go back to reference Olegard, R., Sabel, K. G., Aronsson, M., Sandin, B., Johansson, P. R., Carlsson, C., et al. (1979). Effects on the child of alcohol abuse during pregnancy. Retrospective and prospective studies. Acta Paediatrica, 68, 112–121.CrossRef Olegard, R., Sabel, K. G., Aronsson, M., Sandin, B., Johansson, P. R., Carlsson, C., et al. (1979). Effects on the child of alcohol abuse during pregnancy. Retrospective and prospective studies. Acta Paediatrica, 68, 112–121.CrossRef
23.
go back to reference Streissguth, A. P., LaDue, R., & Randelsk, S. (1987). Indian adolescents and adults with fetal alcohol syndrome: Findings and recommendations. IHS Primary Care Provider, 12, 89–91. Streissguth, A. P., LaDue, R., & Randelsk, S. (1987). Indian adolescents and adults with fetal alcohol syndrome: Findings and recommendations. IHS Primary Care Provider, 12, 89–91.
24.
go back to reference Berg, J. P., Lynch, M. E., & Coles, C. D. (2008). Increased mortality among women who drank alcohol during pregnancy. Alcohol, 42(7), 603–610.PubMedCrossRef Berg, J. P., Lynch, M. E., & Coles, C. D. (2008). Increased mortality among women who drank alcohol during pregnancy. Alcohol, 42(7), 603–610.PubMedCrossRef
25.
go back to reference Kvigne, V. L., Leonardson, G. R., Borzelleca, J., Brock, E., Neff-Smith, M., & Welty, T. K. (2003). Characteristics of mothers who have children with fetal alcohol syndrome or some characteristics of fetal alcohol syndrome. Journal of the American Board of Family Practice, 16(4), 296–303.PubMedCrossRef Kvigne, V. L., Leonardson, G. R., Borzelleca, J., Brock, E., Neff-Smith, M., & Welty, T. K. (2003). Characteristics of mothers who have children with fetal alcohol syndrome or some characteristics of fetal alcohol syndrome. Journal of the American Board of Family Practice, 16(4), 296–303.PubMedCrossRef
26.
go back to reference Abel, E. L. (1998). Fetal alcohol abuse syndrome. New York: Plenum Press. Abel, E. L. (1998). Fetal alcohol abuse syndrome. New York: Plenum Press.
27.
go back to reference Astley, S. J. (2010). Profile of the first 1, 400 patients receiving diagnostic evaluations for fetal alcohol spectrum disorder at the Washington state fetal alcohol syndrome diagnostic and prevention network. The Canadian Journal of Clinical Pharmacology, 17(1), e132–e164.PubMed Astley, S. J. (2010). Profile of the first 1, 400 patients receiving diagnostic evaluations for fetal alcohol spectrum disorder at the Washington state fetal alcohol syndrome diagnostic and prevention network. The Canadian Journal of Clinical Pharmacology, 17(1), e132–e164.PubMed
28.
go back to reference Burd, L., Klug, M. G., Li, Q., Kerbeshian, J., & Martsolf, J. T. (2010). Diagnosis of fetal alcohol spectrum disorders: A validity study of the fetal alcohol syndrome checklist. Alcohol, 44, 605–614.PubMedCrossRef Burd, L., Klug, M. G., Li, Q., Kerbeshian, J., & Martsolf, J. T. (2010). Diagnosis of fetal alcohol spectrum disorders: A validity study of the fetal alcohol syndrome checklist. Alcohol, 44, 605–614.PubMedCrossRef
29.
go back to reference Hoyme, H. E., May, P. A., Kalberg, W. O., Kodituwakku, P., Gossage, J. P., Trujillo, P. M., et al. (2005). A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: Clarification of the 1996 institute of medicine criteria. Pediatrics, 115(1), 39–47.PubMed Hoyme, H. E., May, P. A., Kalberg, W. O., Kodituwakku, P., Gossage, J. P., Trujillo, P. M., et al. (2005). A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: Clarification of the 1996 institute of medicine criteria. Pediatrics, 115(1), 39–47.PubMed
30.
go back to reference Revisions of the International Classification of Diseases (ICD-9, ICD-10). (1996). Impact on health statistics. Epidemiology Bulletin, 17(2), 1–5. Revisions of the International Classification of Diseases (ICD-9, ICD-10). (1996). Impact on health statistics. Epidemiology Bulletin, 17(2), 1–5.
31.
go back to reference Arias, E., MacDorman, M. F., Strobino, D. M., & Guyer, B. (2003). Annual summary of vital statistics-2002. Pediatrics, 112(6 Pt 1), 1215–1230.PubMedCrossRef Arias, E., MacDorman, M. F., Strobino, D. M., & Guyer, B. (2003). Annual summary of vital statistics-2002. Pediatrics, 112(6 Pt 1), 1215–1230.PubMedCrossRef
32.
go back to reference Cipriani, F., Cucinelli, M. L., Dimauro, P. E., Angioli, D., Conte, M., Voller, F., et al. (2001). Mortality in a cohort of alcoholics from Arezzo in 1979–1997. Epidemiologia e Prevenzione, 25(2), 63–70.PubMed Cipriani, F., Cucinelli, M. L., Dimauro, P. E., Angioli, D., Conte, M., Voller, F., et al. (2001). Mortality in a cohort of alcoholics from Arezzo in 1979–1997. Epidemiologia e Prevenzione, 25(2), 63–70.PubMed
33.
go back to reference Feuerlein, W., Kufner, H., & Flohrschutz, T. (1995). The mortality rate of alcoholic patients 4 years after inpatient treatment. Versicherungsmedizin, 47(1), 10–14.PubMed Feuerlein, W., Kufner, H., & Flohrschutz, T. (1995). The mortality rate of alcoholic patients 4 years after inpatient treatment. Versicherungsmedizin, 47(1), 10–14.PubMed
34.
go back to reference Stinson, F. S., & DeBakey, S. F. (1992). Alcohol-related mortality in the United States, 1979–1988. British Journal of Addiction, 87(5), 777–783.PubMedCrossRef Stinson, F. S., & DeBakey, S. F. (1992). Alcohol-related mortality in the United States, 1979–1988. British Journal of Addiction, 87(5), 777–783.PubMedCrossRef
35.
go back to reference Gual, A., Lligona, A., Costa, S., Segura, L., & Colom, J. (2004). Long term impact of treatment in alcoholics. Results from a 10 year longitudinal follow-up study of 850 patients. Medicina Clinica (Barcelona), 123(10), 364–369.CrossRef Gual, A., Lligona, A., Costa, S., Segura, L., & Colom, J. (2004). Long term impact of treatment in alcoholics. Results from a 10 year longitudinal follow-up study of 850 patients. Medicina Clinica (Barcelona), 123(10), 364–369.CrossRef
36.
go back to reference Martin, J. A., Hamilton, B. E., Sutton. P. D., Ventura, S. J., Mathews, T. J., Kirmeyer, S., et al. (2010). Births: Final data for 2007. Hyattsville: National Center for Health Statistics. Report No. 58. Martin, J. A., Hamilton, B. E., Sutton. P. D., Ventura, S. J., Mathews, T. J., Kirmeyer, S., et al. (2010). Births: Final data for 2007. Hyattsville: National Center for Health Statistics. Report No. 58.
Metadata
Title
Fetal Alcohol Spectrum Disorders: A Population Based Study of Premature Mortality Rates in the Mothers
Authors
Qing Li
Wayne W. Fisher
Chun-Zi Peng
Andrew D. Williams
Larry Burd
Publication date
01-08-2012
Publisher
Springer US
Published in
Maternal and Child Health Journal / Issue 6/2012
Print ISSN: 1092-7875
Electronic ISSN: 1573-6628
DOI
https://doi.org/10.1007/s10995-011-0844-3

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