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01-02-2012 | Original Paper

The Association Forecasting of 13 Variants Within Seven Asthma Susceptibility Genes on 3 Serum IgE Groups in Taiwanese Population by Integrating of Adaptive Neuro-fuzzy Inference System (ANFIS) and Classification Analysis Methods

Authors: Cheng-Hang Wang, Baw-Jhiune Liu, Lawrence Shih-Hsin Wu

Published in: Journal of Medical Systems | Issue 1/2012

Abstract

Asthma is one of the most common chronic diseases in children. It is caused by complicated coactions between various genetic factors and environmental allergens. The study aims to integrate the concept of implementing adaptive neuro-fuzzy inference system (ANFIS) and classification analysis methods for forecasting the association of asthma susceptibility genes on 3 serum IgE groups. The ANFIS model was trained and tested with data sets obtained from 425 asthmatic subjects and 483 non-asthma subjects from the Taiwanese population. We assessed 13 single-nucleotide polymorphisms (SNPs) in seven well-known asthma susceptibility genes; firstly, the proposed ANFIS model learned to reduce input features from the 13 SNPs. And secondly, the classification will be used to classify the serum IgE groups from the simulated SNPs results. The performance of the ANFIS model, classification accuracies and the results confirmed that the integration of ANFIS and classified analysis has potential in association discovery.

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Title: The Association Forecasting of 13 Variants Within Seven Asthma Susceptibility Genes on 3 Serum IgE Groups in Taiwanese Population by Integrating of Adaptive Neuro-fuzzy Inference System (ANFIS) and Classification Analysis Methods
Authors: Cheng-Hang Wang
Baw-Jhiune Liu
Lawrence Shih-Hsin Wu
Publication date: 01-02-2012
Publisher: Springer US
Published in: Journal of Medical Systems / Issue 1/2012
Print ISSN: 0148-5598
Electronic ISSN: 1573-689X
DOI: https://doi.org/10.1007/s10916-010-9457-4

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The Association Forecasting of 13 Variants Within Seven Asthma Susceptibility Genes on 3 Serum IgE Groups in Taiwanese Population by Integrating of Adaptive Neuro-fuzzy Inference System (ANFIS) and Classification Analysis Methods

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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