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Journal of Mammary Gland Biology and Neoplasia

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Open Access 01-09-2010

Diverse and Active Roles for Adipocytes During Mammary Gland Growth and Function

Authors: Russell C. Hovey, Lucila Aimo

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 3/2010

Abstract

The mammary gland is unique in its requirement to develop in close association with a depot of adipose tissue that is commonly referred to as the mammary fat pad. As discussed throughout this issue, the mammary fat pad represents a complex stromal microenvironment that includes a variety of cell types. In this article we focus on adipocytes as local regulators of epithelial cell growth and their function during lactation. Several important considerations arise from such a discussion. There is a clear and close interrelationship between different stromal tissue types within the mammary fat pad and its adipocytes. Furthermore, these relationships are both stage- and species-dependent, although many questions remain unanswered regarding their roles in these different states. Several lines of evidence also suggest that adipocytes within the mammary fat pad may function differently from those in other fat depots. Finally, past and future technologies present a variety of opportunities to model these complexities in order to more precisely delineate the many potential functions of adipocytes within the mammary glands. A thorough understanding of the role for this cell type in the mammary glands could present numerous opportunities to modify both breast cancer risk and lactation performance.

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Title: Diverse and Active Roles for Adipocytes During Mammary Gland Growth and Function
Authors: Russell C. Hovey
Lucila Aimo
Publication date: 01-09-2010
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 3/2010
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-010-9187-8

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