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Journal of Mammary Gland Biology and Neoplasia

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01-09-2007 | Preface

Breast Cancer Progression: Controversies and Consensus in the Molecular Mechanisms of Metastasis and EMT

Authors: Pamela Cowin, Danny R. Welch

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 2-3/2007

Excerpt

Breast cancer is the second most frequent form of female cancer and a major source of cancer death worldwide. Although breast cancer has long been part of the human condition, appearing in the writings of ancient Egyptians, modern breast cancer shows a disturbing statistical increase from 1 per 20 women in the 1960s to one in eight today [1]. Although early detection by mammography and adjuvant therapies has improved survival, the absence of good prognostic criteria continues to result in overtreatment of patients with benign disease and failure to identify and eliminate the source of metastatic breast cancer. …

American Cancer Society: Cancer Facts and Figures. http://www.cancer.org/docroot/STT/content/STT_1x_Cancer_Facts__Figures_2006.asp.

Tarin D, Thompson EW, Newgreen DF. The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res 2005;65(14):5996–6000; discussion 6000-1.PubMedCrossRef

Thompson EW, Newgreen DF, Tarin D. Carcinoma invasion and metastasis: a role for epithelial–mesenchymal transition? Cancer Res 2005;65(14):5991–5; discussion 5995.PubMedCrossRef

Yang J, Mani SA, Weinberg RA. Exploring a new twist on tumor metastasis. Cancer Res 2006;66(9):4549–52.PubMedCrossRef

Thiery JP, Sleeman JP. Complex networks orchestrate epithelial–mesenchymal transitions. Nat Rev Mol Cell Biol 2006;7(2):131–42.PubMedCrossRef

Thiery JP. Epithelial–mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003;15(6):740–6.PubMedCrossRef

Huber MA, Kraut N, Beug H. Molecular requirements for epithelial–mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005;17(5):548–58.PubMedCrossRef

Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, et al. The transcription factor snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000;2(2):76–83.PubMedCrossRef

Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000;2(2):84–9.PubMedCrossRef

10.

Hajra KM, Chen DY, Fearon ER. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res 2002;62(6):1613–8.PubMed

11.

Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004;117(7):927–39.PubMedCrossRef

12.

Berx G, Cleton-Jansen AM, Nollet F, de Leeuw WJ, van de Vijver M, Cornelisse C, et al. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. Embo J 1995;14(24):6107–15.PubMed

13.

Behrens J, Mareel MM, Van Roy FM, Birchmeier W. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell–cell adhesion. J Cell Biol 1989;108(6):2435–47.PubMedCrossRef

14.

Behrens J, Birchmeier W, Goodman SL, Imhof BA. Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin. J Cell Biol 1985;101(4):1307–15.PubMedCrossRef

15.

Cowin P, Rowlands TM, Hatsell SJ. Cadherins and catenins in breast cancer. Curr Opin Cell Biol 2005;17(5):499–508.PubMedCrossRef

16.

Saffell JL, Walsh FS, Doherty P. Expression of NCAM containing VASE in neurons can account for a developmental loss in their neurite outgrowth response to NCAM in a cellular substratum. J Cell Biol 1994;125(2):427–36.PubMedCrossRef

17.

Williams EJ, Furness J, Walsh FS, Doherty P. Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin. Neuron 1994;13(3):583–94.PubMedCrossRef

18.

Wheelock MJ, Soler AP, Knudsen KA. Cadherin junctions in mammary tumors. J Mammary Gland Biol Neoplasia 2001;6(3):275–85.PubMedCrossRef

19.

Nieman MT, Prudoff RS, Johnson KR, Wheelock MJ. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 1999;147(3):631–44.PubMedCrossRef

20.

Hazan RB, Phillips GR, Qiao RF, Norton L, Aaronson SA. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol 2000;148(4):779–90.PubMedCrossRef

21.

Hatsell SJ, Cowin P. Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development 2006;133(18):3661–70.PubMedCrossRef

22.

Mukherjee S, Frolova N, Sadlonova A, Novak Z, Steg A, Page GP. Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer. Cancer Biol Ther 2006;5(6):674–83.PubMedCrossRef

23.

Nguyen DX, Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet 2007;8(5):341–52.PubMedCrossRef

Title: Breast Cancer Progression: Controversies and Consensus in the Molecular Mechanisms of Metastasis and EMT
Authors: Pamela Cowin
Danny R. Welch
Publication date: 01-09-2007
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 2-3/2007
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-007-9041-9

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Differential Cadherin Expression: Potential Markers for Epithelial to Mesenchymal Transformation During Tumor Progression

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