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Journal of Mammary Gland Biology and Neoplasia

Published in:

01-03-2007

Mammary Gland Involution as a Multi-step Process

Authors: Torsten Stein, Nathan Salomonis, Barry A. Gusterson

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 1/2007

Abstract

Mammary gland involution is a highly complex multi-step process in which the lactating gland returns to a morphologically near pre-pregnant state. This developmental stage is characterized by a high degree of epithelial cell death, redevelopment of the mammary adipose tissue and tissue remodelling. Many factors involved have been described and these have been reviewed intensively in this journal (Furth, P. A., J. Mammary Gland Biol. Neoplasia, 4:123–127, 1999) and elsewhere. Microarray analysis technology has now not only allowed us to identify genes not previously associated with involution (Stein, T., Morris, J.S., Davis, C.R.,Weber-Hall, S.J., Duffy, M.A., Heath, V.J., et al., Breast Cancer Res., 6: R75–R91, 2004; Clarkson, R.W., Wayland, M.T., Lee, J., Freeman, T., Watson, C.J., Breast Cancer Res., 6: R92–R109, 2004; Clarkson, R.W., Watson, C.J., J. Mammary Gland Biol. Neoplasia, 8: 309–319, 2003), it has also enabled us to define multiple phases of the controlled regulatory response to forced weaning on the basis of their transcriptional profiles. This review provides a synthesis of published data, integrating the time course of transcriptional activity in the mouse mammary gland with a gene ontology approach to identify the pathways involved.

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Title: Mammary Gland Involution as a Multi-step Process
Authors: Torsten Stein
Nathan Salomonis
Barry A. Gusterson
Publication date: 01-03-2007
Publisher: Kluwer Academic Publishers-Plenum Publishers
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 1/2007
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-007-9035-7

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The Declining Phase of Lactation: Peripheral or Central, Programmed or Pathological?

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