Skip to main content
Top
Published in: Journal of Immigrant and Minority Health 3/2014

01-06-2014 | Original Paper

Type 2 Diabetes is Associated with Vertebral Fractures in a Sample of Clinic- and Hospital-Based Latinos

Authors: K. L. Kilpadi, R. ElDabaje, J. E. Schmitz, B. Ehler, T. A. Thames, A. P. Joshi, J. W. Simmons III, J. E. Michalek, R. J. Fajardo

Published in: Journal of Immigrant and Minority Health | Issue 3/2014

Login to get access

Abstract

Latinos are the fastest growing ethnic population in the United States and type 2 diabetes is a major health burden in this population, but little effort has been made to study the prevalence of diabetic vertebral fragility in Latinos. We performed a cross-sectional study to determine vertebral fracture prevalence in a hospital-based population of South Texas residents (N = 296). We defined fractures in X-rays as a >20 % reduction in vertebral body height. Numerous variables were recorded, including age, body mass index, indicators of diabetes management and others. 71 % of the sample (N = 296) was Latino. The prevalence of vertebral fracture was increased in diabetic subjects relative to non-diabetic subjects (diabetic 27.9 %, non-diabetic 13.8 %) and, regardless of sex and diabetics status, decreased in Latinos relative to non-Latinos (Latino 16.7 %, non-Latino 26.4 %). These data suggest that vertebral fractures may be a growing concern for diabetic Latinos as well as diabetics of any racial/ethnic background.
Literature
2.
go back to reference Ross PD, Davis JW, Epstein RS, Wasnich RD. Pre-existing fractures and bone mass predict vertebral fracture incidence in women. Ann Intern Med. 1991;114:919–23.PubMedCrossRef Ross PD, Davis JW, Epstein RS, Wasnich RD. Pre-existing fractures and bone mass predict vertebral fracture incidence in women. Ann Intern Med. 1991;114:919–23.PubMedCrossRef
3.
go back to reference Ross PD, Genant HK, Davis JW, Miller PD, Wasnich RD. Predicting vertebral fracture incidence from prevalent fractures and bone density among non-black, osteoporotic women. Osteoporos Int. 1993;3:120–6.PubMedCrossRef Ross PD, Genant HK, Davis JW, Miller PD, Wasnich RD. Predicting vertebral fracture incidence from prevalent fractures and bone density among non-black, osteoporotic women. Osteoporos Int. 1993;3:120–6.PubMedCrossRef
4.
go back to reference Cauley JA, Palermo L, Vogt M, Ensrud KE, Ewing S, Hochberg M, Nevitt MC, Black DM. Prevalent vertebral fractures in black women and white women. J Bone Miner Res. 2008;23:1458–67.PubMedCentralPubMedCrossRef Cauley JA, Palermo L, Vogt M, Ensrud KE, Ewing S, Hochberg M, Nevitt MC, Black DM. Prevalent vertebral fractures in black women and white women. J Bone Miner Res. 2008;23:1458–67.PubMedCentralPubMedCrossRef
5.
go back to reference Strotmeyer ES, Cauley JA, Schwartz AV, Nevitt MC, Resnick HE, Bauer DC, Tylavsky FA, de Rekeneire N, Harris TB, Newman AB. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the Health, Aging, and Body Composition Study. Arch Intern Med. 2005;165:1612–7.PubMedCrossRef Strotmeyer ES, Cauley JA, Schwartz AV, Nevitt MC, Resnick HE, Bauer DC, Tylavsky FA, de Rekeneire N, Harris TB, Newman AB. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the Health, Aging, and Body Composition Study. Arch Intern Med. 2005;165:1612–7.PubMedCrossRef
6.
go back to reference Bonds DE, Larson JC, Schwartz AV, Strotmeyer ES, Robbins J, Rodriguez BL, Johnson KC, Margolis KL. Risk of fracture in women with type 2 diabetes: the Women’s Health Initiative Observational Study. J Clin Endocrinol Metab. 2006;91:3404–10.PubMedCrossRef Bonds DE, Larson JC, Schwartz AV, Strotmeyer ES, Robbins J, Rodriguez BL, Johnson KC, Margolis KL. Risk of fracture in women with type 2 diabetes: the Women’s Health Initiative Observational Study. J Clin Endocrinol Metab. 2006;91:3404–10.PubMedCrossRef
7.
go back to reference Yamamoto M, Yamaguchi T, Yamauchi M, Kaji H, Sugimoto T. Diabetic patients have an increased risk of vertebral fractures independent of BMD or diabetic complications. J Bone Miner Res. 2009;24:702–9.PubMedCrossRef Yamamoto M, Yamaguchi T, Yamauchi M, Kaji H, Sugimoto T. Diabetic patients have an increased risk of vertebral fractures independent of BMD or diabetic complications. J Bone Miner Res. 2009;24:702–9.PubMedCrossRef
8.
go back to reference Harris MI. Racial and ethnic differences in health care access and health outcomes for adults with type 2 diabetes. Diabetes Care. 2001;24:454–9.PubMedCrossRef Harris MI. Racial and ethnic differences in health care access and health outcomes for adults with type 2 diabetes. Diabetes Care. 2001;24:454–9.PubMedCrossRef
9.
go back to reference Umpierrez GE, Gonzalez A, Umpierrez D, Pimentel D. Diabetes mellitus in the Hispanic/Latino population: an increasing health care challenge in the United States. Am J Med Sci. 2007;334:274–82.PubMedCrossRef Umpierrez GE, Gonzalez A, Umpierrez D, Pimentel D. Diabetes mellitus in the Hispanic/Latino population: an increasing health care challenge in the United States. Am J Med Sci. 2007;334:274–82.PubMedCrossRef
10.
go back to reference Carter JS, Pugh JA, Monterrosa A. Non-insulin-dependent diabetes mellitus in minorities in the United States. Ann Intern Med. 1996;125:221–32.PubMedCrossRef Carter JS, Pugh JA, Monterrosa A. Non-insulin-dependent diabetes mellitus in minorities in the United States. Ann Intern Med. 1996;125:221–32.PubMedCrossRef
11.
go back to reference Bauer RL, Deyo RA. Low risk of vertebral fracture in Mexican American women. Arch Intern Med. 1987;147:1437–9.PubMedCrossRef Bauer RL, Deyo RA. Low risk of vertebral fracture in Mexican American women. Arch Intern Med. 1987;147:1437–9.PubMedCrossRef
12.
go back to reference Ottenbacher KJ, Ostir GV, Peek MK, Goodwin JS, Markides KS. Diabetes mellitus as a risk factor for hip fracture in Mexican American older adults. J Gerontol A Biol Sci Med Sci. 2002;57:M648–53.PubMedCrossRef Ottenbacher KJ, Ostir GV, Peek MK, Goodwin JS, Markides KS. Diabetes mellitus as a risk factor for hip fracture in Mexican American older adults. J Gerontol A Biol Sci Med Sci. 2002;57:M648–53.PubMedCrossRef
13.
go back to reference United States Census Bureau. Geneaology data: frequently occurring surnames from Census 2000. 2007. United States Census Bureau. Geneaology data: frequently occurring surnames from Census 2000. 2007.
14.
go back to reference Wei II, Virnig BA, John DA, Morgan RO. Using a Spanish surname match to improve identification of Hispanic women in Medicare administrative data. Health Serv Res. 2006;41:1469–81.PubMedCentralPubMed Wei II, Virnig BA, John DA, Morgan RO. Using a Spanish surname match to improve identification of Hispanic women in Medicare administrative data. Health Serv Res. 2006;41:1469–81.PubMedCentralPubMed
15.
go back to reference Genant HK, Jergas M, Palermo L, Nevitt M, Valentin RS, Black D, Cummings SR. Comparison of semiquantitative visual and quantitative morphometric assessment of prevalent and incident vertebral fractures in osteoporosis. The Study of Osteoporotic Fractures Research Group. J Bone Miner Res. 1996;11:984–96.PubMedCrossRef Genant HK, Jergas M, Palermo L, Nevitt M, Valentin RS, Black D, Cummings SR. Comparison of semiquantitative visual and quantitative morphometric assessment of prevalent and incident vertebral fractures in osteoporosis. The Study of Osteoporotic Fractures Research Group. J Bone Miner Res. 1996;11:984–96.PubMedCrossRef
16.
go back to reference Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T. Combination of obesity with hyperglycemia is a risk factor for the presence of vertebral fractures in type 2 diabetic men. Calcif Tissue Int. 2008;83:324–31.PubMedCrossRef Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T. Combination of obesity with hyperglycemia is a risk factor for the presence of vertebral fractures in type 2 diabetic men. Calcif Tissue Int. 2008;83:324–31.PubMedCrossRef
17.
go back to reference Schwartz AV, Garnero P, Hillier TA, Sellmeyer DE, Strotmeyer ES, Feingold KR, Resnick HE, Tylavsky FA, Black DM, Cummings SR, Harris TB, Bauer DC. Pentosidine and increased fracture risk in older adults with type 2 diabetes. J Clin Endocrinol Metab. 2009;94:2380–6.PubMedCentralPubMedCrossRef Schwartz AV, Garnero P, Hillier TA, Sellmeyer DE, Strotmeyer ES, Feingold KR, Resnick HE, Tylavsky FA, Black DM, Cummings SR, Harris TB, Bauer DC. Pentosidine and increased fracture risk in older adults with type 2 diabetes. J Clin Endocrinol Metab. 2009;94:2380–6.PubMedCentralPubMedCrossRef
18.
go back to reference Bailey GR, Barner JC, Weems JK, Leckbee G, Solis R, Montemayor D, Pope ND. Assessing barriers to medication adherence in underserved patients with diabetes in Texas. Diabetes Educ. 2012;38:271–9.PubMedCrossRef Bailey GR, Barner JC, Weems JK, Leckbee G, Solis R, Montemayor D, Pope ND. Assessing barriers to medication adherence in underserved patients with diabetes in Texas. Diabetes Educ. 2012;38:271–9.PubMedCrossRef
19.
go back to reference Fajardo RJ, Kilpadi K, ElDabaje R, Schmitz JE, Louden C, Sotillo J, Thames TA, Joshi A, Michalek J, Simmons JW. Preliminary Analysis of Vertebral Fracture Risk Among Type 2 Diabetic Latinos in San Antonio, TX. San Diego, CA: American Society for Bone and Mineral Research Annual Meeting; 2011. Fajardo RJ, Kilpadi K, ElDabaje R, Schmitz JE, Louden C, Sotillo J, Thames TA, Joshi A, Michalek J, Simmons JW. Preliminary Analysis of Vertebral Fracture Risk Among Type 2 Diabetic Latinos in San Antonio, TX. San Diego, CA: American Society for Bone and Mineral Research Annual Meeting; 2011.
20.
go back to reference Sardone LD, Renlund R, Willett TL, Fantus IG, Grynpas MD. Effect of rosiglitazone on bone quality in a rat model of insulin resistance and osteoporosis. Diabetes. 2011;60:3271–8.PubMedCentralPubMedCrossRef Sardone LD, Renlund R, Willett TL, Fantus IG, Grynpas MD. Effect of rosiglitazone on bone quality in a rat model of insulin resistance and osteoporosis. Diabetes. 2011;60:3271–8.PubMedCentralPubMedCrossRef
21.
go back to reference Schwartz AV, Sellmeyer DE, Vittinghoff E, Palermo L, Lecka-Czernik B, Feingold KR, Strotmeyer ES, Resnick HE, Carbone L, Beamer BA, Park SW, Lane NE, Harris TB, Cummings SR. Thiazolidinedione use and bone loss in older diabetic adults. J Clin Endocrinol Metab. 2006;91:3349–54.PubMedCentralPubMedCrossRef Schwartz AV, Sellmeyer DE, Vittinghoff E, Palermo L, Lecka-Czernik B, Feingold KR, Strotmeyer ES, Resnick HE, Carbone L, Beamer BA, Park SW, Lane NE, Harris TB, Cummings SR. Thiazolidinedione use and bone loss in older diabetic adults. J Clin Endocrinol Metab. 2006;91:3349–54.PubMedCentralPubMedCrossRef
22.
go back to reference Kanazawa I, Yamaguchi T, Yamamoto M, Sugimoto T. Relationship between treatments with insulin and oral hypoglycemic agents versus the presence of vertebral fractures in type 2 diabetes mellitus. J Bone Miner Metab. 2010;28:554–60.PubMedCrossRef Kanazawa I, Yamaguchi T, Yamamoto M, Sugimoto T. Relationship between treatments with insulin and oral hypoglycemic agents versus the presence of vertebral fractures in type 2 diabetes mellitus. J Bone Miner Metab. 2010;28:554–60.PubMedCrossRef
23.
go back to reference Luisetto G, Camozzi V. Statins, fracture risk, and bone remodeling. J Endocrinol Invest. 2009;32:32–7.PubMed Luisetto G, Camozzi V. Statins, fracture risk, and bone remodeling. J Endocrinol Invest. 2009;32:32–7.PubMed
24.
go back to reference Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret GY. Effects of statins on bone mineral density: a meta-analysis of clinical studies. Bone. 2007;40:1581–7.PubMedCrossRef Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret GY. Effects of statins on bone mineral density: a meta-analysis of clinical studies. Bone. 2007;40:1581–7.PubMedCrossRef
25.
go back to reference Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res. 2007;22:465–75.PubMedCrossRef Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res. 2007;22:465–75.PubMedCrossRef
26.
go back to reference Berkson J. Limitations of the application of fourfold table analysis to hospital data. Biometrics. 1946;2:47–53.PubMedCrossRef Berkson J. Limitations of the application of fourfold table analysis to hospital data. Biometrics. 1946;2:47–53.PubMedCrossRef
28.
go back to reference Texas Diabetes Council. The burden of diabetes in Texas. 2008;1–31. Texas Diabetes Council. The burden of diabetes in Texas. 2008;1–31.
29.
go back to reference Connolly V, Unwin N, Sherriff P, Bilous R, Kelly W. Diabetes prevalence and socioeconomic status: a population based study showing increased prevalence of type 2 diabetes mellitus in deprived areas. J Epidemiol Community Health. 2000;54:173–7.PubMedCentralPubMedCrossRef Connolly V, Unwin N, Sherriff P, Bilous R, Kelly W. Diabetes prevalence and socioeconomic status: a population based study showing increased prevalence of type 2 diabetes mellitus in deprived areas. J Epidemiol Community Health. 2000;54:173–7.PubMedCentralPubMedCrossRef
30.
go back to reference Pleis J, Lucas J, Ward BW. Summary health statistics for U.S. adults: National Health Interview Survery, 2008. Vital Health Stat. 2009;10:1–157. Pleis J, Lucas J, Ward BW. Summary health statistics for U.S. adults: National Health Interview Survery, 2008. Vital Health Stat. 2009;10:1–157.
31.
go back to reference Agency for Healthcare Research and Quality. 2010 National healthcare disparities report. Rockville, MD. 2011. Agency for Healthcare Research and Quality. 2010 National healthcare disparities report. Rockville, MD. 2011.
32.
go back to reference Walton JW, Snead CA, Collinsworth AW, Schmidt KL. Reducing diabetes disparities through the implementation of community health worker-led diabetes self-management and education program. Fam Community Health. 2012;35:161–71.PubMedCrossRef Walton JW, Snead CA, Collinsworth AW, Schmidt KL. Reducing diabetes disparities through the implementation of community health worker-led diabetes self-management and education program. Fam Community Health. 2012;35:161–71.PubMedCrossRef
33.
go back to reference Health Resources and Services Administration. Health Professional Shortage Area (HPSA). Rockvilled, MD. 2012. Health Resources and Services Administration. Health Professional Shortage Area (HPSA). Rockvilled, MD. 2012.
Metadata
Title
Type 2 Diabetes is Associated with Vertebral Fractures in a Sample of Clinic- and Hospital-Based Latinos
Authors
K. L. Kilpadi
R. ElDabaje
J. E. Schmitz
B. Ehler
T. A. Thames
A. P. Joshi
J. W. Simmons III
J. E. Michalek
R. J. Fajardo
Publication date
01-06-2014
Publisher
Springer US
Published in
Journal of Immigrant and Minority Health / Issue 3/2014
Print ISSN: 1557-1912
Electronic ISSN: 1557-1920
DOI
https://doi.org/10.1007/s10903-013-9833-5

Other articles of this Issue 3/2014

Journal of Immigrant and Minority Health 3/2014 Go to the issue