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Journal of Clinical Monitoring and Computing

Published in:

01-08-2013 | Review

Translational applications of evaluating physiologic variability in human endotoxemia

Authors: Jeremy D. Scheff, Panteleimon D. Mavroudis, Steve E. Calvano, Ioannis P. Androulakis

Published in: Journal of Clinical Monitoring and Computing | Issue 4/2013

Abstract

Dysregulation of the inflammatory response is a critical component of many clinically challenging disorders such as sepsis. Inflammation is a biological process designed to lead to healing and recovery, ultimately restoring homeostasis; however, the failure to fully achieve those beneficial results can leave a patient in a dangerous persistent inflammatory state. One of the primary challenges in developing novel therapies in this area is that inflammation is comprised of a complex network of interacting pathways. Here, we discuss our approaches towards addressing this problem through computational systems biology, with a particular focus on how the presence of biological rhythms and the disruption of these rhythms in inflammation may be applied in a translational context. By leveraging the information content embedded in physiologic variability, ranging in scale from oscillations in autonomic activity driving short-term heart rate variability to circadian rhythms in immunomodulatory hormones, there is significant potential to gain insight into the underlying physiology.

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Title: Translational applications of evaluating physiologic variability in human endotoxemia
Authors: Jeremy D. Scheff
Panteleimon D. Mavroudis
Steve E. Calvano
Ioannis P. Androulakis
Publication date: 01-08-2013
Publisher: Springer Netherlands
Published in: Journal of Clinical Monitoring and Computing / Issue 4/2013
Print ISSN: 1387-1307
Electronic ISSN: 1573-2614
DOI: https://doi.org/10.1007/s10877-012-9418-1

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Translational applications of evaluating physiologic variability in human endotoxemia

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