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Journal of Clinical Immunology

Published in:

01-09-2008

15-Deoxy-Δ^12,14-Prostaglandin J₂ and Curcumin Modulate the Expression of Toll-like Receptors 4 and 9 in Autoimmune T Lymphocyte

Authors: Wanida Chearwae, John J. Bright

Published in: Journal of Clinical Immunology | Issue 5/2008

Abstract

Introduction

Experimental allergic encephalomyelitis (EAE) is a T cell-mediated autoimmune disease model for multiple sclerosis (MS). We have shown earlier that 15-deoxy-Δ^12,14-prostaglandin J₂ (15d-PGJ₂) and curcumin ameliorate EAE by modulating inflammatory signaling pathways in T lymphocytes. Toll-like receptors (TLRs), expressed primarily in innate immune cells, play critical roles in the pathogenesis of EAE. T lymphocytes also express TLRs and function as costimulatory receptors to upregulate proliferation and cytokine production in response to specific agonists.

Discussion

In this study, we show that naïve CD4⁺ and CD8⁺ T cells express detectable levels of TLR4 and TLR9 and that increase after the induction of EAE in SJL/J and C57BL/6 mice by immunization with PLPp139–151 and MOGp35–55 antigen, respectively. It is interesting to note that in vivo treatment with 15d-PGJ2 or curcumin results in a significant decrease in TLR4 and TLR9 expression in CD4⁺ and CD8⁺ T cells in association with the amelioration of EAE.

Conclusion

Although the exact mechanisms are not known, the modulation of TLR expression in T lymphocytes by 15d-PGJ₂ and curcumin suggests new therapeutic targets in the treatment of T cell-mediated autoimmune diseases.

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Title: 15-Deoxy-Δ12,14-Prostaglandin J2 and Curcumin Modulate the Expression of Toll-like Receptors 4 and 9 in Autoimmune T Lymphocyte
Authors: Wanida Chearwae
John J. Bright
Publication date: 01-09-2008
Publisher: Springer US
Published in: Journal of Clinical Immunology / Issue 5/2008
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-008-9202-7

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