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Journal of Assisted Reproduction and Genetics

Published in:

11-07-2022 | Fertility | Assisted Reproduction Technologies

Similar reproductive outcomes between lesbian-shared IVF (ROPA) and IVF with autologous oocytes

Authors: Pedro Brandão, Nathan Ceschin, Fábio Cruz, Ricardo Sousa-Santos, Sérgio Reis-Soares, José Bellver

Published in: Journal of Assisted Reproduction and Genetics | Issue 9/2022

Abstract

Purpose

To compare reproductive outcomes of the ROPA method (reception of oocytes from partner) to IVF with autologous oocytes. To study the impact of the absence of a genetic link between the embryo and its recipient in reproductive outcomes.

Methods

Retrospective multicentric cohort study performed from January 2011 to December 2020 in 18 fertility clinics in Spain. A total of 99 ROPA (73 couples) and 2929 non-ROPA cycles (2334 couples or single patients) of women younger than 38 years old with no known female fertility disorder were included. Clinical outcomes were compared between both groups and included positive pregnancy test, clinical pregnancy, miscarriage, ectopic pregnancy, pre-term birth, live birth, weeks of gestation at birth, and newborn weight at birth.

Results

No differences were found between groups in clinical outcomes. The total clinical pregnancy rates per embryo transfer were 57% and 50.2% (p = 0.15) and the live-birth rates were 46.1% and 40.9% (p = 0.14) for the ROPA and non-ROPA groups, respectively. When adjusted to age and BMI of donors and recipients, there were also no differences in live-birth rates between both groups. The cumulative live-birth rate per ROPA cycle was 73.7% and the cumulative live-birth rate per couple was 78.3%.

Conclusion

Clinical outcomes following the ROPA method and IVF with autologous oocytes were found to be similar. These findings suggest no impact of the absence of genetic ties between the embryo and the uterus on reproductive treatments’ outcomes. Data regarding the outcomes of the ROPA method are reassuring.

Carpinello OJ, Jacob MC, Nulsen J, Benadiva C. Utilization of fertility treatment and reproductive choices by lesbian couples. Fertil Steril. 2016;106:1709-1713.e4. https://doi.org/10.1016/j.fertnstert.2016.08.050.CrossRefPubMed

Heo HJ, Kim YY, Lee JH, Lee HG, Baek SM, Kim KM. Comparison of chemical pregnancy rates according to the anesthetic method during ultrasound-guided transvaginal oocyte retrieval for in vitro fertilization: a retrospective study. Anesth Pain Med [Internet]. 2020;15:49–52. Available from: https://www.anesth-pain-med.org/journal/view.php?id=10.17085/apm.2020.15.1.49.

Hodson K, Meads C, Bewley S. Lesbian and bisexual women’s likelihood of becoming pregnant: a systematic review and meta-analysis. BJOG An Int J Obstet Gynaecol. 2017;124:393–402.CrossRef

Soares SR, Cruz M, Vergara V, Requena A, García-Velasco JA. Donor IUI is equally effective for heterosexual couples, single women and lesbians, but autologous IUI does worse. Hum Reprod [Internet]. 2019;34:2184–92. Available from: https://academic.oup.com/humrep/article/34/11/2184/5613884.

Wrande T, Kristjansdottir BH, Tsiartas P, Hadziosmanovic N, Rodriguez-Wallberg KA. Live birth, cumulative live birth and perinatal outcome following assisted reproductive treatments using donor sperm in single women vs. women in lesbian couples: a prospective controlled cohort study. J Assist Reprod Genet [Internet]. 2022; Available from: https://link.springer.com/10.1007/s10815-022-02402-6.

Bodri D, Nair S, Gill A, Lamanna G, Rahmati M, Arian-Schad M, et al. Shared motherhood IVF: high delivery rates in a large study of treatments for lesbian couples using partner-donated eggs. Reprod Biomed Online. 2018;36:130–6. https://doi.org/10.1016/j.rbmo.2017.11.006.CrossRefPubMed

Dempsey D, Power J, Kelly F. A perfect storm of intervention? Lesbian and cisgender queer women conceiving through Australian fertility clinics. Crit Public Health [Internet]. 2020;1–11. Available from: https://www.tandfonline.com/doi/full/10.1080/09581596.2020.1810636.

Di NE, Di Nucci E. IVF, same-sex couples and the value of biological ties. J Med Ethics Engl. 2016;42:784–7.CrossRef

Getrajdman C, Lee JA, Copperman AB. Co-IVF for same-sex female couples. Semin Reprod Med United States. 2017;35:415–9.CrossRef

10.

Downing JM. Pathways to pregnancy for sexual minority women in same-sex marriages. Am J Obstet Gynecol. 2019;221:281–2. https://doi.org/10.1016/j.ajog.2019.04.019.CrossRefPubMed

11.

Zeiler K, Malmquist A. Lesbian shared biological motherhood: the ethics of IVF with reception of oocytes from partner. Med Health Care Philos Netherlands. 2014;17:347–55.CrossRef

12.

Eyler AE, Pang SC, Clark A. LGBT assisted reproduction: current practice and future possibilities. LGBT Heal United States. 2014;1:151–6.CrossRef

13.

Power J, Dempsey D, Kelly F, Lau M. Use of fertility services in Australian lesbian, bisexual and queer women’s pathways to parenthood. Aust New Zeal J Obstet Gynaecol. 2020;60:610–5.CrossRef

14.

Pelka S. Observing multiple mothering: a case study of childrearing in a U.S. lesbian-led family. Ethos [Internet]. 2010;38:422–40. Available from: https://onlinelibrary.wiley.com/doi/10.1111/j.1548-1352.2010.01159.x.

15.

Saus-Ortega C. La maternidad biológica compartida en parejas lesbianas. La técnica de fertilización «in vitro» con el método de recepción de ovocitos de la pareja (ROPA). Matronas profesión. 2018;19:64–70.

16.

Marina S, Marina D, Marina F, Fosas N, Galiana N, Jové I. Sharing motherhood: biological lesbian co-mothers, a new IVF indication. Hum Reprod England. 2010;25:938–41.CrossRef

17.

Berntsen S, Larsen EC, la Cour Freiesleben N, Pinborg A. Pregnancy outcomes following oocyte donation. Best Pract Res Clin Obstet Gynaecol. 2020;1–11. https://doi.org/10.1016/j.bpobgyn.2020.07.008.

18.

Storgaard M, Loft A, Bergh C, Wennerholm UB, Söderström-Anttila V, Romundstad LB, et al. Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta-analysis. BJOG An Int J Obstet Gynaecol [Internet]. Blackwell Publishing Ltd; 2017 [cited 2021 Nov 30];124:561–72. Available from: https://onlinelibrary.wiley.com/doi/10.1111/1471-0528.14257.

19.

Keukens A, van Wely M, van der Meulen C, Mochtar MH. Pre-eclampsia in pregnancies resulting from oocyte donation, natural conception or IVF: a systematic review and meta-analysis. Hum Reprod [Internet]. 2022;37:586–99. Available from: https://academic.oup.com/humrep/article/37/3/586/6472729.

20.

Esteves A, Rozon C, Clancy J, Liao Y, Wen SW, Fung KF-K, et al. Abnormal placental pathological findings and adverse clinical outcomes of oocyte donation. Placenta [Internet]. 2020;101:169–75. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0143400420303027.

21.

Savasi VM, Mandia L, Laoreti A, Cetin I. Maternal and fetal outcomes in oocyte donation pregnancies. Hum Reprod Update [Internet]. 2016;22:620–33. Available from: https://academic.oup.com/humupd/article-lookup/doi/10.1093/humupd/dmw012.

22.

Blazquez A, García D, Vassena R, Figueras F, Rodriguez A. Risk of preeclampsia in pregnancies resulting from double gamete donation and from oocyte donation alone. Pregnancy Hypertens [Internet]. 2018;13:133–7. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2210778917304877.

23.

Kennedy AL, Stern CJ, Tong S, Hastie R, Agresta F, Walker SP, et al. The incidence of hypertensive disorders of pregnancy following sperm donation in IVF: an Australian state-wide retrospective cohort study. Hum Reprod [Internet]. 2019;34:2541–8. Available from: https://academic.oup.com/humrep/article/34/12/2541/5681792.

24.

González-Comadran M, Avila JU, Tascón AS, Jimenéz R, Solà I, Brassesco M, et al. The impact of donor insemination on the risk of preeclampsia: a systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol [Internet]. 2014;182:160–6. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0301211514004990.

25.

Núñez A, Garciá D, Giménez-Bonafé P, Vassena R, Rodríguez A. Reproductive outcomes in lesbian couples undergoing reception of oocytes from partner versus autologous in vitro fertilization/intracytoplasmic sperm injection. LGBT Heal [Internet]. 2021;8:367–71. Available from: https://www.liebertpub.com/doi/10.1089/lgbt.2020.0282.

26.

Mizrachi Y, Horowitz E, Farhi J, Raziel A, Weissman A. Ovarian stimulation for freeze-all IVF cycles: a systematic review. Hum Reprod Update [Internet]. 2020;26:119–36. Available from: https://academic.oup.com/humupd/article/26/1/119/5684984.

27.

Wykes KA. Fertility services for same-sex couples: policy and practice. Br J Nurs England. 2012;21:871–5.CrossRef

28.

Ferrara R, Balet JG, Grudzinskas. Intrauterine donor insemination in single women and lesbian couples: a comparative study of pregnancy rates. Hum Reprod [Internet]. 2000;15:621–5. Available from: https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/15.3.621.

29.

Brandão P, Ceschin N, Gómez VH. The pathway of female same-sex couples in a fertility clinic. Rev Bras Ginecol e Obstet. 2022;in press.

30.

Moreno - Sepulveda J, Checa MA. Risk of adverse perinatal outcomes after oocyte donation: a systematic review and meta-analysis. J Assist Reprod Genet [Internet]. 2019;36:2017–37. Available from: http://link.springer.com/10.1007/s10815-019-01552-4.

Title: Similar reproductive outcomes between lesbian-shared IVF (ROPA) and IVF with autologous oocytes
Authors: Pedro Brandão
Nathan Ceschin
Fábio Cruz
Ricardo Sousa-Santos
Sérgio Reis-Soares
José Bellver
Publication date: 11-07-2022
Publisher: Springer US
Keywords: Fertility
Ectopic Pregnancy
Miscarriage
Published in: Journal of Assisted Reproduction and Genetics / Issue 9/2022
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-022-02560-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Similar reproductive outcomes between lesbian-shared IVF (ROPA) and IVF with autologous oocytes

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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