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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 4/2019

01-04-2019 | Preimplantation Genetic Diagnostics | Assisted Reproduction Technologies

Single best euploid versus single best unknown-ploidy blastocyst frozen embryo transfers: a randomized controlled trial

Authors: Kemal Ozgur, Murat Berkkanoglu, Hasan Bulut, Gonul Didem Akay Yoruk, Nevrah Nal Candurmaz, Kevin Coetzee

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2019

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Abstract

Purpose

This paper aims to investigate the efficacy of IVF with preimplantation genetic testing for aneuploidy (PGT-A), using only best-scoring blastocysts from young (≤ 35 years) infertile patients undergoing single blastocyst frozen embryo transfers (FET).

Method

In this randomized controlled trial (RCT) registered 29 March 2017, 302 infertile patient-couples eligible to participate underwent autologous ICSI blastocyst freeze-all cycles. Two-hundred and twenty patient-couples satisfied the inclusion criteria (i.e., female age ≤ 35 years, two-day 5 ≥ 2BB blastocysts) and were randomized to either the PGT-A (PGT-A group, n = 109) selection arm or morphology score (morphology group, n = 111) selection arm. In both arms, the highest ranking (by morphological score) blastocysts were selected for FET.

Results

Of the 109 best-scoring blastocysts that underwent PGT-A, 80 were predicted to be euploid (73.4%) and were transferred in FET (euploid subgroup). There was no statistical difference in LB rate between the euploid subgroup and morphology group (56.3% vs 58.6%, odds ratio 0.91 (95% CI 0.51–1.63), p = 0.750). In a multiple logistic regression, the transfer of euploid blastocysts was not found to be a significant predictor of LB when adjusting for female age, infertility duration, antral follicle count, and blastocyst quality, with the independent odds expressed as 0.91 (95% CI 0.50–1.66, p = 0.760).

Conclusion

In young (≤ 35 years) infertile patients with at least two ≥ 2BB blastocysts, PGT-A blastocyst selection does not result in an enhanced LB rate, with the evidence suggesting that the effectivity of PGT-A may be limited by the effectivity of TE biopsy.
Trial registration: ClinicalTrials.​gov ID: NCT03095053.
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Metadata
Title
Single best euploid versus single best unknown-ploidy blastocyst frozen embryo transfers: a randomized controlled trial
Authors
Kemal Ozgur
Murat Berkkanoglu
Hasan Bulut
Gonul Didem Akay Yoruk
Nevrah Nal Candurmaz
Kevin Coetzee
Publication date
01-04-2019
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 4/2019
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-018-01399-1

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