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Journal of Assisted Reproduction and Genetics

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01-02-2018 | Assisted Reproduction Technologies

Combined advanced parental age has an additive negative effect on live birth rates—data from 4057 first IVF/ICSI cycles

Authors: Nicole O. McPherson, Deirdre Zander-Fox, Andrew D. Vincent, Michelle Lane

Published in: Journal of Assisted Reproduction and Genetics | Issue 2/2018

Abstract

Purpose

The purpose of this study is to determine if there is an additive effect of combined advanced maternal and paternal age on pregnancy and live birth rates.

Methods

Retrospective data analysis of 4057 first cycles at a fertility centre between 2009 and 2013 was compiled. Donor, preimplantation genetic screening and double embryo transfer cycles were excluded. Main outcomes measured were clinical pregnancy, viable pregnancy, live birth and term birth.

Results

Logistic regression indicated strong negative associations for maternal ages exceeding 27 years with clinical pregnancies (p < 0.001), viable pregnancies (p < 0.001), live births (p < 0.001) and term births (p < 0.001). There was evidence of negative associations between paternal age and both viable pregnancies (p = 0.06) and live births (p = 0.04), such that the probability of pregnancy was 10% further reduced for women who were 35 years with a partner over 40 years vs. women aged 35 years with a partner under 30 years. There was evidence of an interaction between maternal age and the paternal age on term births (p = 0.02) such that advanced paternal age’s effect on the probability of a term birth was only evident in couples where the maternal age ranged between ~27 and 35 years.

Conclusions

There is an additive effect to pregnancy and live birth rates when both partners are of an advanced age, thus highlighting the need for pre-conception public health messaging and a combined approach to ART counselling assessing both parental ages in combination.

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Title: Combined advanced parental age has an additive negative effect on live birth rates—data from 4057 first IVF/ICSI cycles
Authors: Nicole O. McPherson
Deirdre Zander-Fox
Andrew D. Vincent
Michelle Lane
Publication date: 01-02-2018
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 2/2018
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-017-1054-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Combined advanced parental age has an additive negative effect on live birth rates—data from 4057 first IVF/ICSI cycles

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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