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Journal of Assisted Reproduction and Genetics

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01-12-2013 | Genetics

Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: A meta-analysis

Authors: Hai-xia Meng, Mu-ge Qi, Yuan-yuan Yi, Ya-ping Liu

Published in: Journal of Assisted Reproduction and Genetics | Issue 12/2013

Abstract

Purpose

The association between apolipoprotein E (ApoE) gene polymorphism and the risk of recurrent pregnancy loss (RPL) remains controversial. The present meta-analysis was performed to derive a precise estimate of the relationship.

Method(s)

We searched the PubMed, Embase, and Web of Science data- bases for studies related to the association between the ApoE genotype and the risk of RPL. We estimated the summary odds ratio (OR) with 95% confidence interval (CI) to assess the association.

Result(s)

Seven studies, including 2,090 RPL cases and 742 control samples, were identified. The results showed a significant association between ApoE E4 mutation and RPL risk (for E4 allele: OR =1.98, 95 %CI =1.14–3.43, P=0.499; for E2E3 vs. E3E3: OR =1.33, 95%CI =1.12–1.42, P=0.008; for E2E4 vs. E3E3: OR =1.26, 95 % CI =1.07–1.49, P=0.005).

Conclusion(s)

The meta-analysis suggests an association between ApoE E4 mutation and increased risk of RPL.

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Title: Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: A meta-analysis
Authors: Hai-xia Meng
Mu-ge Qi
Yuan-yuan Yi
Ya-ping Liu
Publication date: 01-12-2013
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 12/2013
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-013-0118-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: A meta-analysis

Abstract

Purpose

Method(s)

Result(s)

Conclusion(s)

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Method(s)

Result(s)

Conclusion(s)

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