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Journal of Assisted Reproduction and Genetics

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01-01-2014 | Gonadal physiology and disease

Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice

Authors: Shu Li, DanDan Lu, Yaling Zhang, Yi Zhang

Published in: Journal of Assisted Reproduction and Genetics | Issue 1/2014

Abstract

Purpose

The present study was designed to test the hypothesis that long-term treatment with hydrogen-rich saline abated testicular oxidative stress induced by nicotine in mice.

Methods

The effects of hydrogen-rich saline (6 ml/kg, i.p.), vitamin C (60 mg/kg, i.p.) and vitamin E (100 mg/kg, i.p.) on reproductive system and testicular oxidative levels in nicotine-treated (4.5 mg/kg, s.b.) mice were investigated.

Results

It was found that vitamin C and vitamin E attenuated serum oxidative level, but did not lower testicular oxidative levels in mice subjected to chronic nicotine treatment, and did not improve the male reproductive damage and apoptosis induced by nicotine. Different from normal antioxidants, vitamin C and vitamin E, hydrogen-rich saline abated oxidative stress in testis, and protected against nicotine-induced male reproductive damages.

Conclusion

Our results first demonstrated that long-term treatment with hydrogen-rich saline attenuated testicular oxidative level and improved male reproductive function in nicotine-treated mice.

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Title: Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice
Authors: Shu Li
DanDan Lu
Yaling Zhang
Yi Zhang
Publication date: 01-01-2014
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 1/2014
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-013-0102-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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