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Journal of Assisted Reproduction and Genetics

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01-11-2013 | Gonadal Physiology and Disease

HOXA-11 mediated dysregulation of matrix remodeling during implantation window in women with endometriosis

Authors: Saikat Kumar Jana, Priyanka Banerjee, Rashmi Mukherjee, Baidyanath Chakravarty, Koel Chaudhury

Published in: Journal of Assisted Reproduction and Genetics | Issue 11/2013

Abstract

Purpose

To investigate the Homeobox genes HOXA-10 and HOXA-11 mediated endometrial molecular defects during implantation window in endometriosis-associated infertility cases.

Methods

Endometrial biopsies were obtained during implantation window from 31 infertile women with endometriosis (age < 35 years) and 26 age and BMI-matched infertile women without endometriosis were included in the study for comparison purposes. Endometrial expression of HOXA-10 and HOXA-11 genes, MMP-2, -9, α_vβ₃ integrin, leukemia inhibitory factor and surface characteristics including average roughness and topology were assessed.

Results

A significantly lower expression of HOXA-10 and HOXA-11 were observed in endometriotic women compared to non-endometriotic controls. Further, a significantly higher endometrial expression of MMP-2 and −9 were observed in women with endometriosis when compared with controls. Interestingly, endometrial surface were observed to be grossly affected in terms of average roughness and topology in women with endometriosis compared to controls.

Conclusions

The findings suggest that aberrant expression of HOXA-10 and −11 genes adversely affects endometrial remodelling and expression of receptivity markers.

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Title: HOXA-11 mediated dysregulation of matrix remodeling during implantation window in women with endometriosis
Authors: Saikat Kumar Jana
Priyanka Banerjee
Rashmi Mukherjee
Baidyanath Chakravarty
Koel Chaudhury
Publication date: 01-11-2013
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 11/2013
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-013-0088-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

HOXA-11 mediated dysregulation of matrix remodeling during implantation window in women with endometriosis

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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