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Published in: Journal of Assisted Reproduction and Genetics 2/2011

01-02-2011 | Genetics

Long Y chromosome is not a fetal loss risk

Authors: Hongchuan Nie, Guangxiu Lu

Published in: Journal of Assisted Reproduction and Genetics | Issue 2/2011

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Abstract

Purpose

To assess the long Y chromosome genetic effect on human pregnancy outcomes.

Methods

We studied all records of pregnancies by human sperm donors after artificial insemination or in vitro fertilization at the Reproductive and Genetic Hospital of Citic-Xiangya. Fetal losses were compared from two groups of sperm donors: the observation group (with long Y chromosome) and the control group (without long Y chromosome).

Results

2885 pregnancies were achieved with donor sperm by artificial insemination and 1746 by in vitro fertilization. The rates of fetal loss, congenital malformation and donor fecundity in the observation group after both assisted reproductive technique were the same as for the control group.

Conclusions

A long Y chromosome may therefore be considered as a normal variant.
Literature
1.
go back to reference Hsu LY, Benn PA, Tannenbaum HL, Perlis TE, Carlson AD. Chromosomal polymorphisms of 1, 9, 16, and Y in 4 major ethnic groups: a large prenatal study. Am J Med Genet. 1987;26:95–101.PubMedCrossRef Hsu LY, Benn PA, Tannenbaum HL, Perlis TE, Carlson AD. Chromosomal polymorphisms of 1, 9, 16, and Y in 4 major ethnic groups: a large prenatal study. Am J Med Genet. 1987;26:95–101.PubMedCrossRef
2.
go back to reference Bhasin MK. Human population cytogenetics: a review. Int J Hum Genet. 2005;5:83–152. Bhasin MK. Human population cytogenetics: a review. Int J Hum Genet. 2005;5:83–152.
3.
go back to reference Verma RS, Huq A, Dosik H. Racial variation of a non-fluorescent segment of the Y chromosome in East Indians. J Med Genet. 1983;20:102–6.PubMedCrossRef Verma RS, Huq A, Dosik H. Racial variation of a non-fluorescent segment of the Y chromosome in East Indians. J Med Genet. 1983;20:102–6.PubMedCrossRef
4.
go back to reference Evans HJ, Gosden JR, Mitchell AR, Buckland RA. Location of human satellite DNAs on the Y chromosome. Nature. 1974;251:346–7.CrossRef Evans HJ, Gosden JR, Mitchell AR, Buckland RA. Location of human satellite DNAs on the Y chromosome. Nature. 1974;251:346–7.CrossRef
5.
go back to reference Human cytogenetics: constitutional analysis. Rooney DE, editors. Oxford: Oxford University Press; 2001. p. 4. Human cytogenetics: constitutional analysis. Rooney DE, editors. Oxford: Oxford University Press; 2001. p. 4.
6.
go back to reference Mattei MG, Luciani J. Heterochromatin, from chromosome to protein. Atlas Genet Cytogenet Oncol Haematol. 2003;7:284–99. Mattei MG, Luciani J. Heterochromatin, from chromosome to protein. Atlas Genet Cytogenet Oncol Haematol. 2003;7:284–99.
7.
go back to reference Ghosh PK, Singh IP. Morphological variability of the human chromosomes in two Indian populations—Rajputs and Punjabis. Humangenetik. 1975;29:67–78.PubMedCrossRef Ghosh PK, Singh IP. Morphological variability of the human chromosomes in two Indian populations—Rajputs and Punjabis. Humangenetik. 1975;29:67–78.PubMedCrossRef
8.
go back to reference Rodriguez-Gomez MT, Martin-Sempere MJ, Abrisqueta JA. C-band length variability and reproductive wastage. Hum Genet. 1987;75:56–61.PubMed Rodriguez-Gomez MT, Martin-Sempere MJ, Abrisqueta JA. C-band length variability and reproductive wastage. Hum Genet. 1987;75:56–61.PubMed
9.
go back to reference Verma RS, Shah JV, Dosik H. Size of Y chromosome not associated with abortion risk. Obstet Gynecol. 1983;61:633–4.PubMed Verma RS, Shah JV, Dosik H. Size of Y chromosome not associated with abortion risk. Obstet Gynecol. 1983;61:633–4.PubMed
10.
go back to reference Shen WY. 152 cases of Y chromosome length in Han ethnic population. kong jun zong yi yuan xue bao. 1989;5:3. Shen WY. 152 cases of Y chromosome length in Han ethnic population. kong jun zong yi yuan xue bao. 1989;5:3.
11.
go back to reference Zhaowen D. Cytogentical study on a family with big y chromosome. Hereditas. 1984;6:2. Zhaowen D. Cytogentical study on a family with big y chromosome. Hereditas. 1984;6:2.
12.
go back to reference Yi L. Karyotyping analysis on 447 couples with fetal loss history in Jinan Region. Chin J Birth Health Hered. 1999;7:3. Yi L. Karyotyping analysis on 447 couples with fetal loss history in Jinan Region. Chin J Birth Health Hered. 1999;7:3.
13.
go back to reference Hu XD, Zeng Y, Mo ML, Lin Q, Cai J, Guo CP, et al. Big Y chromosome not significantly influences outcomes of in vitro fertilization and embryo transfer. Zhonghua Nan Ke Xue. 2006;12:1088–90.PubMed Hu XD, Zeng Y, Mo ML, Lin Q, Cai J, Guo CP, et al. Big Y chromosome not significantly influences outcomes of in vitro fertilization and embryo transfer. Zhonghua Nan Ke Xue. 2006;12:1088–90.PubMed
14.
15.
go back to reference Wang XR, Deng JX, Li JJ. The relationship between clinical outcomes of reproductive abnormalities and chromosome polymorphism. Yi Chuan. 2007;29:1362–6.PubMed Wang XR, Deng JX, Li JJ. The relationship between clinical outcomes of reproductive abnormalities and chromosome polymorphism. Yi Chuan. 2007;29:1362–6.PubMed
16.
go back to reference Patil SR, Lubs HA. A possible association of long Y chromosomes and fetal loss. Hum Genet. 1977;35:233–5.PubMedCrossRef Patil SR, Lubs HA. A possible association of long Y chromosomes and fetal loss. Hum Genet. 1977;35:233–5.PubMedCrossRef
17.
go back to reference World Health Organization. WHO laboratory manual for the examination of human semen and sperm–cervical mucus interactions. 4th ed. Cambridge: Cambridge University Press; 1999. World Health Organization. WHO laboratory manual for the examination of human semen and sperm–cervical mucus interactions. 4th ed. Cambridge: Cambridge University Press; 1999.
18.
go back to reference Zhu WB, Lu GX. Influence of different proportioning cryoprotectant on viability of Post-Thaw human spermatozoa. Fertil Steril. 2005;84:S216. Zhu WB, Lu GX. Influence of different proportioning cryoprotectant on viability of Post-Thaw human spermatozoa. Fertil Steril. 2005;84:S216.
19.
go back to reference Ministry of Health of the People’s Republic of China announcement on modifying the guidelines, rules, and ethics principles of human sperm bank. Bulletin of Ministry of Health of the People’s Republic of China 2003 Ministry of Health of the People’s Republic of China announcement on modifying the guidelines, rules, and ethics principles of human sperm bank. Bulletin of Ministry of Health of the People’s Republic of China 2003
20.
go back to reference Linden JV, Centola G. New American association of tissue banks standards for semen banking. Fertil Steril. 1997;68:597–600.PubMedCrossRef Linden JV, Centola G. New American association of tissue banks standards for semen banking. Fertil Steril. 1997;68:597–600.PubMedCrossRef
22.
go back to reference Zhou HG, Xia JH, Zhang SZ. Human chromosome 1987;1:61. Zhou HG, Xia JH, Zhang SZ. Human chromosome 1987;1:61.
23.
go back to reference Gong D, Liu YL, Zheng Z, Tian YF, Li Z. An overview on ethical issues about sperm donation. Asian J Androl. 2009;11:645–52.PubMedCrossRef Gong D, Liu YL, Zheng Z, Tian YF, Li Z. An overview on ethical issues about sperm donation. Asian J Androl. 2009;11:645–52.PubMedCrossRef
24.
go back to reference Hercz P, Walker SM, Wells C, Gregory L. A pilot study of gonadotrophin releasing hormone agonist (GnRHa)/superovulation/donor intrauterine insemination (IUI) after unsuccessful artificial insemination with donor sperm (DI). J Assist Reprod Genet. 1994;11:278–80.PubMedCrossRef Hercz P, Walker SM, Wells C, Gregory L. A pilot study of gonadotrophin releasing hormone agonist (GnRHa)/superovulation/donor intrauterine insemination (IUI) after unsuccessful artificial insemination with donor sperm (DI). J Assist Reprod Genet. 1994;11:278–80.PubMedCrossRef
25.
go back to reference Li LJ, Lu GX. How medical ethical principles are applied in treatment with artificial insemination by donors (AID) in Hunan, China: effective practice at the Reproductive and Genetic Hospital of CITIC-Xiangya. J Med Ethics. 2005;31:333–7.PubMedCrossRef Li LJ, Lu GX. How medical ethical principles are applied in treatment with artificial insemination by donors (AID) in Hunan, China: effective practice at the Reproductive and Genetic Hospital of CITIC-Xiangya. J Med Ethics. 2005;31:333–7.PubMedCrossRef
26.
go back to reference el-Khazen N, Puissant F, Camus M, Lejeune B, Leroy F. A comparison between multiple and single pregnancies obtained by in-vitro fertilization. Hum Reprod. 1986;1:251–4.PubMed el-Khazen N, Puissant F, Camus M, Lejeune B, Leroy F. A comparison between multiple and single pregnancies obtained by in-vitro fertilization. Hum Reprod. 1986;1:251–4.PubMed
27.
go back to reference Lansac J, Royere D. Follow-up studies of children born after frozen sperm donation. Hum Reprod Update. 2001;7:33–7.PubMedCrossRef Lansac J, Royere D. Follow-up studies of children born after frozen sperm donation. Hum Reprod Update. 2001;7:33–7.PubMedCrossRef
28.
go back to reference Repping S, van Daalen SK, Brown LG, Korver CM, Lange J, Marszalek JD, et al. High mutation rates have driven extensive structural polymorphism among human Y chromosomes. Nat Genet. 2006;38:463–7.PubMedCrossRef Repping S, van Daalen SK, Brown LG, Korver CM, Lange J, Marszalek JD, et al. High mutation rates have driven extensive structural polymorphism among human Y chromosomes. Nat Genet. 2006;38:463–7.PubMedCrossRef
29.
30.
go back to reference Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, et al. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature. 2003;423:825–37.PubMedCrossRef Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, et al. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature. 2003;423:825–37.PubMedCrossRef
31.
go back to reference Bishop A, Blank CE, Hunter H. Heritable variation in the human Y chromosome. Lancet 1962;18–20 Bishop A, Blank CE, Hunter H. Heritable variation in the human Y chromosome. Lancet 1962;18–20
32.
go back to reference Griepenberg U. Size variation and orientation of the human Y chromosome. Chromosoma. 1964;15:618–29.CrossRef Griepenberg U. Size variation and orientation of the human Y chromosome. Chromosoma. 1964;15:618–29.CrossRef
33.
go back to reference Park J, Antley RM. C-band chromosomal polymorphism in Orientals. Am J Hum Genet. 1974;26:65A. Park J, Antley RM. C-band chromosomal polymorphism in Orientals. Am J Hum Genet. 1974;26:65A.
34.
go back to reference Kadotani T, Oama K, Takahara H, Makino S. Studies on the Y chromosome in human males from fertile and infertile couples. Jinrui Idengaku Zasshi. 1971;16:35–41.PubMed Kadotani T, Oama K, Takahara H, Makino S. Studies on the Y chromosome in human males from fertile and infertile couples. Jinrui Idengaku Zasshi. 1971;16:35–41.PubMed
35.
go back to reference Sahin FI, Yilmaz Z, Yuregir OO, Bulakbasi T, Ozer O, Zeyneloglu HB. Chromosome heteromorphisms: an impact on infertility. J Assist Reprod Genet. 2008;25:191–5.PubMedCrossRef Sahin FI, Yilmaz Z, Yuregir OO, Bulakbasi T, Ozer O, Zeyneloglu HB. Chromosome heteromorphisms: an impact on infertility. J Assist Reprod Genet. 2008;25:191–5.PubMedCrossRef
36.
go back to reference Beltran IC, Robertson FW, Page BM. Human Y chromosome variation in normal and abnormal babies and their fathers. Ann Hum Genet. 1979;42:315–25.PubMedCrossRef Beltran IC, Robertson FW, Page BM. Human Y chromosome variation in normal and abnormal babies and their fathers. Ann Hum Genet. 1979;42:315–25.PubMedCrossRef
37.
go back to reference Hou JW, Wang TR. Study of human Y chromosome polymorphism in Taiwan. Acta Paediatr Taiwan. 1999;40:302–4.PubMed Hou JW, Wang TR. Study of human Y chromosome polymorphism in Taiwan. Acta Paediatr Taiwan. 1999;40:302–4.PubMed
38.
go back to reference Westlake JR, Robertson R, Leddet I, Funderburk SJ, Sparkes RS. Y chromosome length related to fetal loss. Clin Genet. 1983;24:413–9.PubMedCrossRef Westlake JR, Robertson R, Leddet I, Funderburk SJ, Sparkes RS. Y chromosome length related to fetal loss. Clin Genet. 1983;24:413–9.PubMedCrossRef
39.
go back to reference Madon PF, Athalye AS, Parikh FR. Polymorphic variants on chromosomes probably play a significant role in infertility. Reprod Biomed Online. 2005;11:726–32.PubMedCrossRef Madon PF, Athalye AS, Parikh FR. Polymorphic variants on chromosomes probably play a significant role in infertility. Reprod Biomed Online. 2005;11:726–32.PubMedCrossRef
Metadata
Title
Long Y chromosome is not a fetal loss risk
Authors
Hongchuan Nie
Guangxiu Lu
Publication date
01-02-2011
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 2/2011
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-010-9497-1

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