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Journal of Assisted Reproduction and Genetics

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01-02-2011 | Genetics

Cytogenetic abnormalities in 1162 couples with recurrent miscarriages in Southern region of India: report and review

Authors: Usha R. Dutta, P. Rajitha, Vijaya Kumar Pidugu, Ashwin B. Dalal

Published in: Journal of Assisted Reproduction and Genetics | Issue 2/2011

Abstract

Purpose

The purpose of the present study was to investigate the contribution of chromosomal anomalies and the frequency of a particular type of aberration in couples with recurrent miscarriages.

Methods

A total of 1,162 couples with recurrent miscarriages were analyzed using G-banding and Fluorescence in situ hybridization where ever necessary.

Results

Chromosomal anomalies were detected in 78 cases. This study describes majority of the cases with balanced reciprocal translocations. Among the abnormal karyotypes we also report for the first time three unique translocations involving (3;14), (18;22) and (X;22) chromosomes which were confirmed by molecular cytogenetic methods.

Conclusions

The review of literature and the overall incidence of the abnormalities suggest that chromosomal analysis in couples with recurrent miscarriages should be taken up by all the practioners at all levels. This not only helps to check the cytological abnormalities but also helps to correlate the recurrent abnormalities in a given population. Thus establishing and correlating the environmental and genetic condition of that particular phenotype and genotype.

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Title: Cytogenetic abnormalities in 1162 couples with recurrent miscarriages in Southern region of India: report and review
Authors: Usha R. Dutta
P. Rajitha
Vijaya Kumar Pidugu
Ashwin B. Dalal
Publication date: 01-02-2011
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 2/2011
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-010-9492-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cytogenetic abnormalities in 1162 couples with recurrent miscarriages in Southern region of India: report and review

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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