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Journal of Assisted Reproduction and Genetics

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01-04-2009 | GENETICS

Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome

Authors: Tugba Unsal, Ece Konac, Ediz Yesilkaya, Akin Yilmaz, Aysun Bideci, Hacer Ilke Onen, Peyami Cinaz, Adnan Menevse

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2009

Abstract

Background

Polycystic ovary syndrome (PCOS), whose genetic basis is not completely well understood, is the most common endocrine disorder in women and it typically develops during adolescence. The aim of this study is to investigate the possible association between single nucleotide polymorphisms (SNPs) of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes and PCOS in adolescent girls.

Methods

DNA samples from forty-four adolescent girls with PCOS and 50 healthy controls were analyzed by PCR-RFLP and direct DNA sequencing to determine the genotypic frequency of 17 different polymorphic loci on the FSHR (A307T, N680S), CYP17 (−34 T/C), CYP1A1 (T6235C), CAPN10 (44, 43, 19, 63), INSR (exon 17 C/T), SERPINE1 (4G/5G) genes. Genotyping of exon 12 (six polymorphisms) and intron 12 (one polymorphism) of INSR gene by direct DNA sequencing was performed for the first time in this study.

Results

No significant differences were observed in the genotype and allele distributions of above mentioned polymorphisms between cases and control groups.

Conclusion

Our data does not support an association between SNPs of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes and susceptibility to PCOS or related traits in Turkish adolescent girls.

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Title: Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome
Authors: Tugba Unsal
Ece Konac
Ediz Yesilkaya
Akin Yilmaz
Aysun Bideci
Hacer Ilke Onen
Peyami Cinaz
Adnan Menevse
Publication date: 01-04-2009
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 4/2009
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-009-9308-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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