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Journal of Assisted Reproduction and Genetics

Published in:

01-03-2009 | ASSISTED REPRODUCTION

IVF/ICSI outcomes between cycles with luteal estradiol (E₂) pre-treatment before GnRH antagonist protocol and standard long GnRH agonist protocol: a prospective and randomized study

Authors: Hong Ye, Guo-ning Huang, Ping-hong Zeng, Li Pei

Published in: Journal of Assisted Reproduction and Genetics | Issue 2-3/2009

Abstract

Objective

To study if luteal E₂ pre-treatment before GnRH antagonist protocol improves IVF/ICSI outcomes compared with standard long GnRH agonist protocol.

Design

A prospective, randomized and controlled study.

Setting

ART center of a state public hospital

Patient(s)

Two hundred twenty infertile women underwent IVF/ICSI treatments.

Intervention(s)

Participants received oral Estradiol Valerate 4 mg/day preceding the IVF cycle from day 21 until day 2 of next cycle before GnRH antagonist protocol (E₂ pre-treatment group n = 109) or received standard long GnRH agonist protocol as control group (n = 111).

Main outcome measure(s)

Number of oocytes collected, MII oocytes, fertilization, implantation, live birth and early pregnancy rate, and hormone profiles.

Result(s)

E₂ pre-treatment exerted a significant suppressive effect on FSH but not LH secretion compared with basal FSH and LH levels. In E₂ pre-treatment group serum LH level was significantly higher during COH and serum P was also significantly higher on the day of HCG injection compared with control group. Five patients from E₂ pre-treatment group had elevated LH at all time (≥10 IU/L) and also a concomitantly high P (>1 ng/mL). Two of the five women achieved pregnancy but had early pregnancy loss. Overall, IVF/ICSI outcomes such as implantation, clinical pregnancy and live birth rates were similar between E₂ pre-treatment and control groups.

Conclusion(s)

Luteal E₂ pre-treatment before GnRH antagonist protocol significantly increases serum LH level and incidence rate of premature LH but no significant effect is observed on implantation, clinical pregnancy, live birth and early pregnancy loss rates compared with long GnRH agonist protocol. However, more studies in large numbers of cycles are needed to confirm that increased serum LH level by E₂ pre-treatment during COH has no negative effect on the IVF/ICSI outcomes.

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Title: IVF/ICSI outcomes between cycles with luteal estradiol (E2) pre-treatment before GnRH antagonist protocol and standard long GnRH agonist protocol: a prospective and randomized study
Authors: Hong Ye
Guo-ning Huang
Ping-hong Zeng
Li Pei
Publication date: 01-03-2009
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 2-3/2009
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-009-9300-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

IVF/ICSI outcomes between cycles with luteal estradiol (E₂) pre-treatment before GnRH antagonist protocol and standard long GnRH agonist protocol: a prospective and randomized study

Abstract

Objective

Design

Setting

Patient(s)

Intervention(s)

Main outcome measure(s)

Result(s)

Conclusion(s)

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design

Setting

Patient(s)

Intervention(s)

Main outcome measure(s)

Result(s)

Conclusion(s)

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