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Journal of Assisted Reproduction and Genetics

Published in:

01-11-2008 | ASSISTED REPRODUCTION

Clinical outcome of frozen blastocyst transfer; single vs. double transfer

Authors: Atsushi Yanaihara, Takeshi Yorimitsu, Hiroshi Motoyama, Motohiro Ohara, Toshihiro Kawamura

Published in: Journal of Assisted Reproduction and Genetics | Issue 11-12/2008

Abstract

Purpose

Frozen embryo transfer has been established as an indispensable ART procedure for both the effective use of surplus embryos and the prevention of ovarian hyperstimulation syndrome. The frequency of frozen embryo transfer is increasing in our clinic, and we report that frozen embryo transfer is effective for patients with repeat failures. We present our clinical outcome of frozen blastocyst transfer (FBT).

Methods

In 2006, 470 patients received FBT (562 cycles (IVF: 354 cycles; ICSI: 208 cycles)). One frozen blastocyst was transferred in 412 cycles (335 patients) and two blastocysts were transferred in 150 cycles (135 patients). Assisted hatching was performed in all cases.

Results

In 412 cycles (average age: 34.6 years) who received a single FBT, the rate of clinical pregnancy per cycle was 40.7%, the live birth rate was 29.1%, the abortion rate was 21.6%, the ectopic pregnancy rate was 1.2%, the frequency of monochorionic twins was 2.3%, and the cesarean section rate was 38.3%. In 150 cycles (average patient age 34.8 years) who received two FBTs, the clinical pregnancy rate was 46%, the live birth rate was 35.3%, the abortion rate was 16.3%, the ectopic pregnancy rate was 4.4%, the frequency of twins was 15.9% and the cesarean section rate was 39.6%. A significant difference in the ectopic pregnancy rate and the twinning rate was found between single transfers and double transfers (P < 0.05). When IVF and ICSI were compared, there was no statistically significant difference in the abortion rate, the ectopic pregnancy rate, and the cesarean section rate.

Conclusions

The clinical pregnancy rate was similar for the transfer of one and two blastocysts. Single FBT decreases obstetrical risk without reducing the pregnancy rate.

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Title: Clinical outcome of frozen blastocyst transfer; single vs. double transfer
Authors: Atsushi Yanaihara
Takeshi Yorimitsu
Hiroshi Motoyama
Motohiro Ohara
Toshihiro Kawamura
Publication date: 01-11-2008
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 11-12/2008
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-008-9275-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical outcome of frozen blastocyst transfer; single vs. double transfer

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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