Top

Journal of Assisted Reproduction and Genetics

Published in:

01-04-2008 | Assisted Reproduction

Male age influences oocyte-donor program results

Authors: Eliezer Girsh, Nathan Katz, Leonid Genkin, Ofer Girtler, Jaron Bocker, Sofa Bezdin, Ilya Barr

Published in: Journal of Assisted Reproduction and Genetics | Issue 4/2008

Abstract

Background

The purpose of our research was to examine the relationship between male age and semen parameters in a range of ages (from 20s to 60s) in Egg Donation Program (EDP) cycles. EDP provides a pool of high quality oocytes, thus allowing better analysis of the sperm efficacy.

Discussion

The retrospective study population consisted of 484 male partners of patients undergoing EDP in in-vitro fertilization (IVF) treatments. A comparison was made of male age and sperm parameters within two groups: cycles resulting in a pregnancy (pregnant group) and cycles which failed to achieve a pregnancy (non-pregnant group). The men involved in the pregnant group were found to be significantly younger 43.2 ± 8.1 than those of the non-pregnant group 46.8 ± 7.8 (p = 0.003). Analysis of sperm morphology revealed a significant prevalence of teratozoospermia in males of the non-pregnant group, as compared to the males of the pregnant group (29% vs. 11%, respectively). The results also demonstrate that sperm parameters are apparently not diminished until men reach the age of 40. However, between 40–50 years old semen parameters deteriorate. Male age was found to be related to a reduction in sperm strict criteria: 44.8 in normozoospermia, 47.9 (p = 0.02), 48.4 (p = 0.04) and 51.9 (p = 0.001) years old in mild teratozoospermia, moderate teratozoospermia and severe teratozoospermia, respectively. Additionally, the results showed that the percentage of “healthy” embryos on day 3 of embryo culture was lower in the non-pregnant group (26%), as compared with the pregnant group (34%; p = 0.01).

Conclusion

Our study confirms that sperm parameters are reduced by age and suggests that this age-dependent effect could be a reason for failures in IVF cycles even in EDP couples.

Joffe M, Li Z. Male and female factors in fertility. Am J Epidemiol 1994;140:921–9.PubMed

Lansac J. Delayed parenting. Is delayed childbearing a good thing? Hum Reprod 1995;10:1033–5.PubMed

Ventura S, Martin J, Curtin S, Mathews T. Report of Final Natality Statistics, 1995. Monthly Vital Statistics Report. Vol. 45, no. 11, suppl. National enters for Health Statistics, Hyattsville, MD, 1997

Kidd SA, Eskenazi B, Wyrobek AJ. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 2001;75:237–48.PubMedCrossRef

Schwartz D, Mayaux M-J, Spira A, Moscato M-L, Jouannet P, Czyglik F, et al. Semen characteristics as a function of age in 833 fertile men. Fertil Steril 1983;39:530–5.PubMed

Spandorfer SD, Avrech OM, Colombero LT, Palermo GD, Rosenwaks Z. Effect of paternal age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection. Hum Reprod 1998;13:334–8.PubMedCrossRef

de La Rochebrochard E, Mouzon J, Thepot F, Thonneau P; FIVNAT. Fathers over 40 and increased failure to conceive: the lessons of in vitro fertilization in France. Fertil Steril 2006;85:1420–4.PubMedCrossRef

World Health Organization. WHO laboratory manual for the examination of human semen and semen-cervical mucus interaction. Cambridge, UK: Cambridge University Press; 1992.

Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Veeck LL, Morshedi M, Brugo S. New method of evaluating sperm morphology with predictive value for human in vitro fertilization. Urology 1987;30:248–51.PubMedCrossRef

10.

Stolwijk AM, Zielhuis GA, Sauer MV, Hamilton CJ, Paulson RJ. The impact of the woman’s age on the success of standard and donor in vitro fertilization. Fertil Steril 1997;67:702–10.PubMedCrossRef

11.

American Society for Reproductive Medicine (ASRM). Guidelines for gametes and embryo donation. A practice committee report. Guidelines and minimum standards, ASRM 1997

12.

Muasher SJ, Oehninger S, Simonetti S, Matta J, Ellis LM, Liu HC, et al. The value of basal and/or stimulated serum gonadotropin levels in prediction of stimulation response and in vitro fertilization outcome. Fertil Steril 1988;50:298–307.PubMed

13.

Borini A, Violini F, Bianchi L, Bafalo MG, Trevisi MR, Flamigni C. Improvement of pregnancy and implantation rates in cyclic women undergoing oocyte donation after long-term down-regulation. Hum Reprod 1995;10:3018–21.PubMed

14.

Paulson RJ, Hatch IE, Lobo RA, Sauer MV. Cumulative conception and live birth rates after oocyte donation: implications regarding endometrial receptivity. Hum Reprod 1997;12:835–9.PubMedCrossRef

15.

Yaunis JS, Simon A, Laufer N. Endometrial preparation: lessons from oocyte donation. Fertil Steril 1996;66:873–84.

16.

Paulson RJ, Milligan RC, Sokol RZ. The lack of influence of age on male fertility. Am J Obstet Gynecol 2001;184:818–22.PubMedCrossRef

17.

Kahraman S, Findikli N, Biricik A, Oncu N, Ogur C, Sertyel S, et al. Preliminary FISH studies on spermatozoa and embryos in patients with variable degree of teratozoospermia and history of poor prognosis. Reprod Biomed Online 2006;12(6):752–71.PubMed

18.

Rosenbusch B, Sterzik K. Sperm chromosomes and habitual abortion. Fertil Steril 1991;56:370–2.PubMed

19.

Enginsu ME, Dumoulin JC, Pieters MH, Bras M, Evers JL, Geraedts JP. Evaluation of human sperm morphology using strict criteria after Diff-Quik staining: correlation of morphology with fertilization in vitro. Hum Reprod 1991;6:854–8.PubMed

20.

Host E, Ernst E, Lindenberg S, Smidt-Jensen S. Morphology of spermatozoa used in IVF and ICSI from oligozoospermic men. Reprod Biomed Online 2001;3:212–5.PubMed

21.

McKenzie LJ, Kovanci E, Amato P, Cisneros P, Lamb D, Carson SA. Pregnancy outcome of in vitro fertilization/intracytoplasmic sperm injection with profound teratospermia. Fertil Steril 2004;82:847–9.PubMedCrossRef

22.

Bianchi PG, Manicardi GC, Urner F, Campana A, Sakkas D. Chromatin packaging and morphology in ejaculated human spermatozoa: evidence of hidden anomalies in normal spermatozoa. Mol Hum Reprod 1996;2:139–44.PubMedCrossRef

23.

Martin H, Rademaker AW, Greene C, Ko E, Hoang T, Barclay L, Chernos J. A comparison of the frequency of sperm chromosome abnormalities in men with mild, moderate, and severe oligozoospermia. Biol Reprod 2003;69:535–9.PubMedCrossRef

24.

Benchaib M, Braun V, Lornage J, Hadj S, Salle B, Lejeune H, Guerin JF. Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique. Hum Reprod 2003;18:1023–8.PubMedCrossRef

25.

Singh NP, Muller CH, Berger RE. DNA damage and apoptosis in human sperm. Fertil Steril 2003;80:1420–30.PubMedCrossRef

26.

Berkovitz A, Eltes F, Lederman H, Peer S, Ellenbogen A, Feldberg B, Bartoov B. How to improve IVF-ICSI outcome by sperm selection. Reprod Biomed Online 2006;5:634–8.CrossRef

27.

Jung A, Schuppe HC, Schill WB. Comparison of semen quality in older and younger men attending an Andrology clinic. Andrology 2002;34:116–22.CrossRef

28.

Dondero F, Mazzilli F, Giovenco P, Lenzi A, Cerasaro M. Fertility in older men. J Endocrinol Invest 1985;8:87–91.PubMed

29.

Singer R, Sagiv M, Levinsky H, Allalouf D. Andrological parameters in men with high sperm counts and possible correlation with age. Arch Androl 1990;24:107–11.PubMedCrossRef

30.

Eskenazi B, Wyrobek AJ, Sloter E, Kidd SA, Moore L, Young S, et al. The association of age and semen quality in healthy men. Hum Reprod 2003;18:447–54.PubMedCrossRef

31.

Sauer MV. The impact of age on reproductive potential: lessons learned from oocyte donation. Maturitas 1998;30:221–5.PubMedCrossRef

Title: Male age influences oocyte-donor program results
Authors: Eliezer Girsh
Nathan Katz
Leonid Genkin
Ofer Girtler
Jaron Bocker
Sofa Bezdin
Ilya Barr
Publication date: 01-04-2008
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 4/2008
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-008-9215-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Male age influences oocyte-donor program results

Abstract

Background

Discussion

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Discussion

Conclusion

Please log in to get access to this content

Other articles of this Issue 4/2008

Growth hormone co-treatment within a GnRH agonist long protocol in patients with poor ovarian response: a prospective, randomized, clinical trial

The decrease of serum luteinizing hormone level by a gonadotropin-releasing hormone antagonist following the mild IVF stimulation protocol for IVF and its clinical outcome

Effect of the size of zona pellucida opening by laser assisted hatching on clinical outcome of frozen cleaved embryos that were cultured to blastocyst after thawing in women with multiple implantation failures of embryo transfer: a retrospective study

Growth hormone and in vitro maturation of rhesus macaque oocytes and subsequent embryo development

Association of progesterone receptor polymorphisms with recurrent implantation failure after in vitro fertilization and embryo transfer

Egg sharing in return for subsidized fertility treatment—ethical challenges and pitfalls